Dr. Jose Costa

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Yale University
Yale Comprehensive Cancer Center
Deputy Director
Yale University
School of Medicine
Anatomical Pathology
Director
Yale University
School of Medicine
Pathology and Medicine
Pathology
Vice Chairman
Yale University
School of Medicine
Pathology and Medicine
Medical Oncology
Professor

Mailing Address

20 York Street, Room EP2-607
Yale University School of Medicine
New Haven, Connecticut 06520
United States

Contact Information

Phone: (203) 785-5803
Fax: (203) 785-3585
costa@biomed.med.yale.edu

Qualifications

M.D., University of Barcelona, 1967.
Residency, National Institute of Health (NIH).

Expertise and Research Interests

The laboratory studies the natural history of tumors using a variety of approaches and technologies that range from the interrogation of clinical material with comprehensive technologies to more directed hypothesis driven experiments in model systems. We look at the process of tumor development and tumor progression at the systems level in an attempt to understand the role of genetics, environment, and chance in these processes. Results obtained during the last decade indicate that during the pre-tumoral stage diversity among somatic cells is maintained by mutation and drift and that certain clones expand under the strength of selection. Although the majority of clones harboring mutations disappear, diversity is constantly generated by background levels of spontaneous mutation. In contrast, in overt tumors that often exhibit a "mutator phenotype" diversity is maintained by rules that are reminiscent of the ecological principles that govern diversity in macroscopic systems. Insights into the dynamics of tumor formation and tumor progression suggest new ways to utilize known therapeutic strategies and may afford novel ways to measure cancer risk.

Other Expertise

Fellowships, National Institutes of Health

I wish to be contacted by interested students (medical, graduate or undergraduates) as a potential research mentor/thesis advisor.

Keywords

COS Keywords:

Cancer Or Carcinogenesis, Colorectal Cancer, Gene Expression, Genetics, Oncology, Pathology, Tumors.

Additional Terms:

Colorectal Cancer, Loh, P16, Pancreatic Cancer, Prad, Quantitative Gene Expression, Ras Mutations.

Languages

(Reading, Writing, Speaking)

English (Spanish, French & German)

Memberships

American Association for the Advancement of Science
American Society for Investigative Pathology
Arthur Purdy Stout Society of Surgical Pathology
Association of Directors of Anatomic/Surgical Pathology
College of American Pathologists
Connecticut Society of Pathologists
European Society of Pathology
International Academy of Pathology
New England Cancer Society
Swiss Society of Oncology
Swiss Society of Pathology
United States & Canadian Academy of Pathology

Honors and Awards

2003, AAAS Fellow, American Association for the Advancement of Science, AAAS, Elected to Rank of AAAS Fellow
2002, Trueta Medal for Distinguished Health Services, Spain, Government of Catalonia
1967, M.D., Magna Cum Laude University of Barcelona

Publications

  • Zhou H, Bouwman K, Schotanus M. Verwij C, Marrero JA, Dillon D, Costa JC, Two-color, rolling-circle amplification on antibody microarrays for sensitive, multiplexed serum-protein measurements, Genome Biology, 5(R28), 2004
  • Lage JM, Leamon HJ, Pejovic T, Hamann S, Costa JC, et al, Whole genome analysis of genetic alterations in small DNA samples using hyperbranched strand displacement amplification and array-CGH, Genome Research, 13, 294-307, 2003
  • Garcia-Rostan G, Zhao H, Camp RL, Costa JC, et al, Ras mutations are associated with aggressive tmor phototypes and poor prognosis in thyroid cancer, Journal of Clinical Oncology, 21(17), 3226-3235, 2003
  • Gonzalez-Garcia I, Sole RV, Costa JC, Metapopulation dynamics and spatial heterogeneity in cancer, PNAS, 99(20), 13085-13089, October 2002
  • Crisi Gm, Emanuel JR, Johnson C, Crotty P, Costa JC, et al, Semi-reannealing, single-stranded conformational polymorphism: A novel and effective tool for the diagnosis of T-cell clonality, Diagnostic Molecular Pathology, 11(2), 67-74, 2002
  • Dillon Da, Hipolito E, Zheng K, Rimm DL, Costa JC, P53 mutations as tumor markers in fine needle aspirates of palpable breast masses, ACTA Cytol, 46(5), 841-847, 2002
  • Costa JC, Cordon-Cardo C, Cancer Diagnosis: Molecular Pathology in Cancer Principles & Practice on Oncology, 6th Ed (DeVita VT, Hellman S, Rosenberg SA, 617-658, 2002
  • Andreyev HJ, Norman R, Cuningham D, Oates J, Costa JC, Kirsten ras mutations in patients with colorectal cancer: the "RASCAL II" study, British Journal of Cancer, 85(5), 692-6, September 2001
  • Rimm DL, Camp RL, Charette LA, Costa JC, Olsen DA, Reiss M, Tisue Microarray: A new technology for amplification of tissue resources, Microarrray, Cancer journal, 7(1), Jan 2001
  • Dillon D, Zheng K, Costa JC, Rapid, efficient genotyping of clinical tumor samples by laser-capture microdissection/PCR/SSCP, Experimental Molecular Pathology, 70, 195-200, 2001
  • Doolittle BR, Emanuel J, Tuttle C, Costa JC, Detection of the mutated K-ras biomarker in colorectal carcinoma, Experimental and Molecular Pathology, 70, 289-301, 2001
  • Ladner DP, Leamon JH, Hamann A, Tarafa G, Costa JC, et al, Multiplex detection of hotspot mutations by rolling circle-enabled universal microarrays, Laboratory Investigation, 81(8), 1079-1086, 2001
  • Musulen E, Costa JC (DeVita VT, Hellman S, Rosenberg SA), Progress in the Molecular Diagnosis of Cancer in Progress in Oncology 2001, 16-28, 2001
  • Leaman JH, Hamann S, Costa JC, Ward DC, Lizardi PM, Rolling Circle Amplification Technology: potential Applications in Cancer Research and Clinical Oncology, Progress in Oncology 2001 (DeVita VT, Hellman S, Rosenberg SA, 46-71, 2001
  • Dillon D, Johnson CC, Topazian MD, Tallini G, Rimm DL, Costa JC, The Utility of Ki-ras mutation analysis in the cytologic diagnosis of pancratobiliary neoplasms, Cancer Journal, 6(5), 294-301, September 2000
  • Powsner SM, Costa JC, Homer RJ, Clinicians are from mars and Pathologists are from Venus: Clinician Interpretation of Pathology Reports, Archives of Pathology & Laboratory Medicine, 124, 1040-1046, 2000
  • Caca K, Lilligs FT, Ji X, Hayes M, Qian JM, Yahanda A, Rimm DL, Costa JC Fearon ER, B- and gcatenin mutations, but not E-cdherin alternations, underlie Tcf/Lef transcriptional deregulation in gastric and pancreatic cncer, Cell Growth & Diffeentiation, 10(6), 369-76, June 1999
  • Costa JC, Translational Research (Editorial), Oncologia (Spain), 1999
  • Tallini G, Ghossein R A, Emanuel J, Gill J, Kinder B, Dimich A B, Costa J, Robbins R, Burrow G N, Rosai J, Detection of thyroglobulin, thyroid peroxidase, and RET/PTC1 mRNA transcripts in the peripheral blood of patients with thyroid disease, Journal of Clinical Oncology, 16(3), 1158-66, March 1998
  • Dillon DA, Howe CL, Bosari S, Costa J, The molecular biology of breast cancer: accelerating clinical applications, Crit Rev Oncog, 9(2), 125-40, 1998
  • Lopez-Labrador F X, Ampurdanes S, Forns X, Castells A, Saiz J C, Costa J, Bruix J, Sanchez Tapias J M, Jimenez de Anta M T, Rodes J, Hepatitis C virus (HCV) genotypes in Spanish patients with HCV infection: relationship between HCV genotype 1b, cirrhosis and hepatocellular carcinoma., Journal of Hepatology, 27(6), 959-65, December 1997 Abstract
  • Saiz J C, Sans M, Mas A, Olmedo E, Forns X, Lopez-Labrador F X, Restrepo J C, Costa J, Salmeron J M, Guilera M, Ampurdanes S, Sanchez-Tapias J M, Jimenez de Anta M T, Rodes J, Hepatitis G virus infection in fulminant hepatic failure, Gut, 41(5), 696-9, November 1997
  • Fazeli A, Steen R G, Dickinson S L, Bautista D, Dietrich W F, Bronson R T, Bresalier R S, Lander E S, Costa J, Weinberg R A, Effects of p53 mutations on apoptosis in mouse intestinal and human colonic adenomas, Proceedings of the National Academy of Sciences (USA), 94(19), 10199-204, 16 Sep 1997
  • Costa J, Caution neophiles! [editorial; comment], Laboratory Investigation, 77(3), 211-2, September 1997 Abstract
  • Forns X, Fernandez-Llama P, Costa J, Lopez-Labrador F X, Ampurdanes S, Olmedo E, Saiz J C, Guilera M, Lopez-Pedret J, Sanchez-Tapias J M, Darnell A, Jimenez de Anta M T, Ordinas A, Rodes J, Hepatitis G virus infection in a haemodialysis unit: prevalence and clinical implications, Nephrology, Dialysis, Transplantation, 12(5), 956-60, May 1997
  • Forns X, Fernandez-Llama P, Pons M, Costa J, Ampurdanes S, Lopez-Labrador F X, Olmedo E, Lopez-Pedret J, Darnell A, Revert L, Sanchez-Tapias J M, Rodes J, Incidence and risk factors of hepatitis C virus infection in a haemodialysis unit., Nephrology, Dialysis, Transplantation, 12(4), 736-40, April 1997 Abstract
  • Saiz J C, Ampurdanes S, Olmedo E, Lopez-Labrador F X, Forns X, Guilera M, Tassies D, Costa J, Sanchez-Tapias J M, Jimenez de Anta M T, Rodes J, Hepatitis G virus infection in chronic hepatitis C: Frequency, features and response to interferon therapy, Journal of Hepatology, 26(4), 787-93, April 1997
  • Tallini G, Costa J, Unraveling the pathogenesis of thyroid tumors using transgenic mice [editorial; comment], Laboratory Investigation, 76(3), 301-5, March 1997 Abstract
  • Pinto M M, Emanuel J R, Chaturvedi V, Costa J, Ki-ras mutations and the carcinoembryonic antigen level in fine needle aspirates of the pancreas, Acta Cytologica, 41(2), 427-34, March 1997
  • Guillou L, Coindre J M, Bonichon F, Nguyen B B, Terrier P, Collin F, Vilain M O, Mandard A M, Le Doussal V, Leroux A, Jacquemier J, Duplay H, Sastre-Garau X, Costa J, Comparative study of the National Cancer Institute and French Federation of Cancer Centers Sarcoma Group grading systems in a population of 410 adult patients with soft tissue sarcoma, Journal of Clinical Oncology, 15(1), 350-62, January 1997
  • Bautista D, Obrador A, Moreno V, Cabeza E, Canet R, Benito E, Bosch X, Costa J, Ki-ras mutation modifies the protective effect of dietary monounsaturated fat and calcium on sporadic colorectal cancer, Cancer Epidemiology, Biomarkers and Prevention, 6(1), 57-61, January 1997
  • Ampurdanes S, Olmedo E, Maluenda M D, Forns X, Lopez-Labrador F X, Costa J, Sanchez-Tapias J M, de Anta M T, Rodes J, Permanent response to alpha-interferon therapy in chronic hepatitis C is preceded by rapid clearance of HCV-RNA from serum, Journal of Hepatology, 25(6), 827-32, December 1996
  • Emanuel J R, Damico C, Ahn S, Bautista D, Costa J, Highly sensitive nonradioactive single-strand conformational polymorphism. Detection of Ki-ras mutations, Diagnostic Molecular Pathology, 5(4), 260-4, December 1996
  • Forns X, Maluenda M D, Lopez-Labrador F X, Ampurdanes S, Olmedo E, Costa J, Simmonds P, Sanchez-Tapias J M, Jimenez De Anta M T, Rodes J, Comparative study of three methods for genotyping hepatitis C virus strains in samples from Spanish patients, Journal of Clinical Microbiology, 34(10), 2516-21, October 1996
  • Bautista D, Emanuel J R, Granville C, Howard R, Costa J, Identification of mutations in the Ki-ras gene in human retinoblastoma, Investigative Ophthalmology and Visual Science, 37(11), 2313-7, October 1996
  • Pages J C, Sordat B, Bautista D, Costa J, Benhattar J, Detection of rare circulating human colon tumor cells in a nude mouse xenograft model, Cancer Letters, 106(1), 139-44, 23 Aug 1996
  • Adida C, Ambrosini G, Plescia J, Crotty P L, Costa J, Altieri D C, Protease receptors in Hodgkin's disease: expression of the factor Xa receptor, effector cell protease receptor-1, in Reed-Sternberg cells, Blood, 88(4), 1457-64, 15 Aug 1996
  • Ahn S J, Costa J, Emanuel J R, PicoGreen quantitation of DNA: effective evaluation of samples pre- or post-PCR, Nucleic Acids Research, 24(13), 2623-5, 1 Jul 1996
  • Sanchez-Tapias J M, Forns X, Ampurdanes S, Tito L, Planas R, Viver J M, Acero D, Torres M, Mas P, Morillas R, Forne M, Espinos J, Llovet J M, Costa J, Olmedo E, Lopez-Labrador F X, Jimenez de Anta M T, Rodes J, Low dose alpha interferon therapy can be effective in chronic active hepatitis C. Results of a multicentre, randomised trial, Gut, 38(4), 603-9, April 1996
  • Banares R, Bory F, Costa J, Dal-Re R, Gonzalez A, Navasa M, Planas R, Sanso A, Vargas V, [Seroprevalence of hepatitis A antibodies in patients with chronic hepatitis (letter)], Gastroenterologia Y Hepatologia, 19(3), 183, March 1996 Abstract
  • Benhattar J, Delacretaz F, Martin P, Chaubert P, Costa J, Improved polymerase chain reaction detection of clonal T-cell lymphoid neoplasms, Diagnostic Molecular Pathology, 4(2), 108-12, June 1995
  • Gratacos E, Torres P J, Vidal J, Antolin E, Costa J, Jimenez de Anta M T, Cararach V, Alonso P L, Fortuny A, The incidence of human parvovirus B19 infection during pregnancy and its impact on perinatal outcome, Journal of Infectious Diseases, 171(5), 1360-3, May 1995
  • Speicher M R, Howe C, Crotty P, du Manoir S, Costa J, Ward D C, Comparative genomic hybridization detects novel deletions and amplifications in head and neck squamous cell carcinomas, Cancer Research, 55(5), 1010-3, 1 Mar 1995
  • Costa J, Lopez-Labrador F X, Sanchez-Tapias J M, Mas A, Vilella A, Olmedo E, Vidal J, Jimenez de Anta M T, Rodes J, Microwave treatment of serum facilitates detection of hepatitis B virus DNA by the polymerase chain reaction. Results of a study in anti-HBe positive chronic hepatitis B, Journal of Hepatology, 22(1), 35-42, January 1995
  • Chu, Peiguo, Costa, Jose Lachman, Mary F., Angiotropic large cell lymphoma - as a cause of primary adrenal insufficiency, Human Pathology, In Press, 1995
  • Gonzalez A, Bruguera M, Calbo Torrecillas F, Monge V, Dal-Re R, Costa J, [Seroepidemiologic survey of hepatitis A antibodies in the young adult Spanish population. Spanish Study Group on hepatitis A (1)], Medicina Clinica, 103(12), 445-8, 15 Oct 1994 Abstract
  • Murray A G, Petzelbauer P, Hughes C C, Costa J, Askenase P, Pober J S, Human T-cell-mediated destruction of allogeneic dermal microvessels in a severe combined immunodeficient mouse, Proceedings of the National Academy of Sciences (USA), 91(19), 9146-50, 13 Sep 1994
  • Lambruschini N, Costa J, Sanchez-Tapias J M, Olmedo E, Lopez-Labrador X, Vilardell J, Rodes J, Jimenez-de-Anta M T, Perinatal transmission of hepatitis C virus from a mother without detectable antibodies to the virus [letter], Clinical Infectious Diseases, 18(6), 1027, June 1994 Abstract
  • Chaubert P, Benhattar J, Saraga E, Costa J, K-ras mutations and p53 alterations in neoplastic and nonneoplastic lesions associated with longstanding ulcerative colitis, American Journal of Pathology, 144(4), 767-75, April 1994
  • Guillou L, de Luze P, Zysset F, Costa J, Papillary variant of low-grade mucoepidermoid carcinoma--an unusual bronchial neoplasm. A light microscopic, ultrastructural, and immunohistochemical study, American Journal of Clinical Pathology, 101(3), 269-74, March 1994
  • Rivas I, Furquet F, Costa J, Richart C, [Atrial myxoma associated with Streptococcus viridans bacteremia (letter)], Medicina Clinica, 102(1), 35-6, 15 Jan 1994 Abstract
  • Bruguera M, Amat L, Garcia O, Lambruschini N, Carnicer J, Bergada A, Martin Orte E, Costa J, Sanchez-Tapias J M, Rodes J, Treatment of chronic hepatitis B in children with recombinant alfa interferon. Different response according to age at infection, Journal of Clinical Gastroenterology, 17(4), 296-9, December 1993
  • Benhattar J, Losi L, Chaubert P, Givel J C, Costa J, Prognostic significance of K-ras mutations in colorectal carcinoma, Gastroenterology, 104(4), 1044-8, April 1993
  • Guillou L, Duvoisin B, Chobaz C, Chapuis G, Costa J, Combined small-cell and transitional cell carcinoma of the renal pelvis. A light microscopic, immunohistochemical, and ultrastructural study of a case with literature review [see comments], Archives of Pathology and Laboratory Medicine, 117(3), 239-43, March 1993 Abstract
  • Shaw P, Bovey R, Tardy S, Sahli R, Sordat B, Costa J, Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line, Proceedings of the National Academy of Sciences (USA), 89(10), 4495-9, 15 May 1992
  • Bruguera M, Cremades M, Salinas R, Costa J, Grau M, Sans J, Impaired response to recombinant hepatitis B vaccine in HIV-infected persons, Journal of Clinical Gastroenterology, 14(1), 27-30, January 1992
  • Losi L, Benhattar J, Costa J, Stability of K-ras mutations throughout the natural history of human colorectal cancer, European Journal of Cancer, 28A(6-7), 1115-20, 1992
  • Shaw P, Tardy S, Benito E, Obrador A, Costa J, Occurrence of Ki-ras and p53 mutations in primary colorectal tumors, Oncogene, 6(11), 2121-8, November 1991
  • Barrera J M, Bruguera M, Ercilla M G, Sanchez-Tapias J M, Gil M P, Costa J, Gelabert A, Rodes J, Castillo R, Incidence of non-A, non-B hepatitis after screening blood donors for antibodies to hepatitis C virus and surrogate markers, Annals of Internal Medicine, 115(8), 596-600, 15 Oct 1991
  • Guillou L, Sahli R, Chaubert P, Monnier P, Cuttat J F, Costa J, Squamous cell carcinoma of the lung in a nonsmoking, nonirradiated patient with juvenile laryngotracheal papillomatosis. Evidence of human papillomavirus-11 DNA in both carcinoma and papillomas, American Journal of Surgical Pathology, 15(9), 891-8, September 1991
  • Costa J, Guillou L, Pathology of soft tissue sarcomas, Cancer Treatment and Research, 56, 1-9, 1991
  • Guillou L, Lamoureux E, Masse S, Costa J, Alveolar soft-part sarcoma of the uterine corpus: histological, immunocytochemical and ultrastructural study of a case, Virchows Archives A, Pathological Anatomy and Histopathology, 418(5), 467-71, 1991
  • Mayans M V, Calvet X, Bruix J, Bruguera M, Costa J, Esteve J, Bosch F X, Bru C, Rodes J, Risk factors for hepatocellular carcinoma in Catalonia, Spain, International Journal of Cancer, 46(3), 378-81, 15 Sep 1990
  • Sanchez-Tapias J M, Barrera J M, Costa J, Ercilla M G, Pares A, Comalrrena L, Soley F, Bruix J, Calvet X, Gil M P, et al, Hepatitis C virus infection in patients with nonalcoholic chronic liver disease, Annals of Internal Medicine, 112(12), 921-4, 15 Jun 1990
  • Mas A, Buti M, Esteban R, Sanchez-Tapias J M, Costa J, Jardi R, Bruguera M, Guardia J, Rodes J, Hepatitis B virus and hepatitis D virus replication in HBsAg-positive fulminant hepatitis, Hepatology, 11(6), 1062-5, June 1990
  • Bruguera M, Vidal L, Sanchez-Tapias J M, Costa J, Revert L, Rodes J, Incidence and features of liver disease in patients on chronic hemodialysis, Journal of Clinical Gastroenterology, 12(3), 298-302, June 1990
  • Tito L, Sanchez Tapias J M, Mas A, Costa J, Bruguera M, Rodes J, [Severe acute hepatitis as initial manifestation of chronic hepatitis B virus infection], Medicina Clinica, 93(18), 702-4, 2 Dec 1989 Abstract
  • Vilar J H, Tejada R, Costa J, [Determination of HBV DNA in the serum and saliva of subjects with acute hepatitis caused by HBV], Revista Espanola De Las Enfermedades Del Aparato Digestivo, 76(5), 456-60, November 1989 Abstract
  • Bruix J, Barrera J M, Calvet X, Ercilla G, Costa J, Sanchez-Tapias J M, Ventura M, Vall M, Bruguera M, Bru C, et al, Prevalence of antibodies to hepatitis C virus in Spanish patients with hepatocellular carcinoma and hepatic cirrhosis [see comments], Lancet, 2(8670), 1004-6, 28 Oct 1989 Abstract
  • Shaw P, Costa J, Molecular biology of colon cancer (review), Anticancer Research, 9(1), 21-7, January 1989
  • Benhattar, Jean, Delacretaz, Francoise, Martin, Patricia, Chaubert, Pascal, Costa, Jose, Improved polymerase chain reaction detection of clonal T-cell lymphoid neoplasms, Diagnostic Molecular Pathology, 4(2), 108-12

Profile Details

Last Verified: 8/20/2004

COS Expertise ID #397249
Reference this profile directly: http://myprofile.cos.com/costaj49