Dr. Christopher Carlson

powered by
COS Expertise®
Fred Hutchinson Cancer Research Center
Public Health Sciences
Cancer Prevention
Assistant Member
University of Washington
Public Health
Epidemiology
Affiliate Assistant ProfessorAppointed: 2006
Professional Headshot of Christopher Carlson

Mailing Address

1100 Fairview Ave. N.
Mail Stop M4-B402
Seattle, Washington 98109-1024
United States

Contact Information

Phone: (206) 667-7034
Fax: (206) 667-7850
ccarlson@fhcrc.org

Qualifications

Ph.D., Stanford University, Genetics, 2000.
B.A., Pomona College, Molecular Biology, 1992.

Expertise and Research Interests

Our laboratory focuses on analysis of correlations between genetic variation and common diseases, including cancer, cardiovascular disease, and neurological disease. Our lab uses in silico tools to identify statistical correlations between variation and disease, molecular biology benchwork to explore the underlying molecular mechanisms for these correlations, and molecular evolutionary analysis to understand the natural history of functional variants. The lab is currently focused on two major projects. The first extends our previous work on the genetic epidemiology of variation at the C reactive protein locus and the mechanisms by which these variants correlate with plasma CRP levels. The second seeks to identify evolutionarily advantageous polymorphisms responsible for strong, recent selective pressure on the human species, and to determine whether these evolutionarily important variants are important to public health in a modern environment.

Other Expertise

Computational Expertise: C++, R statistical language, relational database design, STRUCTURE, PHASE, Polyphred, MEGA2, Arlequin

Keywords

COS Keywords:

Cancer Prevention, Epidemiology, Evolutionary Biology, Genetics.

Additional Terms:

Evolutionary Biology, Genetic Epidemiology.

Publications

  • Carlson CS, Thomas DJ, Eberle MA, Swanson JE, Livingston RJ, Rieder MJ, Nickerson DA (Nov 2005) Genomic regions exhibiting positive selection identified from dense genotype data., Genome Research, 15 (11), 1553-65 Abstract
  • Lygren B, Tasken K, Carlson CR (Oct 2005) A fast and sensitive method for isolation of detergent-resistant membranes from T cells., Journal of Immunological Methods, 305 (2), 199-205 Abstract
  • Sherman JJ, Carlson CR, Wilson JF, Okeson JP, McCubbin JA (Fall 2005) Post-traumatic stress disorder among patients with orofacial pain., Journal of Orofacial Pain, 19 (4), 309-17 Abstract
  • Carlson CB, Bernstein DA, Annis DS, Misenheimer TM, Hannah BL, Mosher DF, Keck JL (Oct 2005) Structure of the calcium-rich signature domain of human thrombospondin-2., Nature Structural & Molecular Biology, 12 (10), 910-4 Abstract
  • Ulrich CM, Carlson CS, Sibert J, Poole EM, Yu JH, Wang LH, Sparks R, Potter JD, Bigler J (Oct 2005) Thromboxane synthase (TBXAS1) polymorphisms in African-American and Caucasian populations: evidence for selective pressure., Human Mutation, 26 (4), 394-5 Abstract
  • de Leeuw R, Albuquerque R, Okeson J, Carlson C (Sep 2005) The contribution of neuroimaging techniques to the understanding of supraspinal pain circuits: implications for orofacial pain., Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics., 100 (3), 308-14 Abstract
  • Afanasev AV, Carlson CE (Jun 2005) Two-photon-exchange correction to parity-violating elastic electron-proton scattering., Physical Review Letters, 94 (21), 212301 Abstract
  • De Leeuw R, Bertoli E, Schmidt JE, Carlson CR (May 2005) Prevalence of post-traumatic stress disorder symptoms in orofacial pain patients., Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics., 99 (5), 558-68 Abstract
  • Carlson CS, Force Aldred S, Lee PK, Tracy RP, Schwartz SM, Rieder MJ, Liu K, Williams OD, Iribarren C, Lewis EC, Fornage M, Boerwinkle E, Gross M, Jaquish C, Nickerson DA, Myers RM, Siscovick DS, Reiner AP (2005) Polymorphisms Within the C-Reactive Protein (CRP) Promoter Region are Associated with Plasma CRP Levels, American Journal of Human Genetics, 77(1):64-77
  • Carlson C (Jan 2005) Accessing the microscopic world., Plos Biology, 3 (1), e12 Abstract
  • Brodsky SJ, Carlson CE, Hiller JR, Hwang DS (Jan 2005) Constraints on proton structure from precision atomic-physics measurements., Physical Review Letters, 94 (2), 022001 Abstract
  • Akey JM, Eberle MA, Rieder MJ, Carlson CS, Shriver MD, Nickerson DA, Kruglyak L (Oct 2004) Population history and natural selection shape patterns of genetic variation in 132 genes., Plos Biology, 2 (10), e286 Abstract
  • Ekwa-Ekoka C, Diaz GA, Calson C, Hasegawa T, Samudrala R, Lim KC, Yabu JM, Levy B, Schnapp LM (2004) Genomic Organization and Sequence Variation of the Human Integrin Subunit Alpha8 Gene (ITGA8), Matrix Biol., 23(7):487-96
  • Livingston RJ, Jegga AG, Crawford DC, Carlson CS, Rieder MJ, Gowrisankar S, Aronow BJ, Weiss RB, Nickerson DA (2004) Pattern of Sequence Variation Accross 213 Environmental Response Genes, Genome Res., 14(10A): 1821-31
  • Carlson CS, Eberle MA, Kruglyak L, Nickerson DA (2004) Mapping Complex Gene Loci in Whole Genome Association Studies, Nature, 429(6990): 446-52
  • Carlson CS, Eberle MA, Rieder MJ, Yi Q, Krugylak L, Nickerson DA (2004) Selecting a Maximally Informative Set of Single-Nucleotide Polymorphisms, American Journal of Human Genetics, 74(1): 106-20
  • Fullerton SM, Buchanon AV, Sonpar VA, Taylor SL, Smith JD, Carlson CS, Salomaa V, Stengard JH, Boerwinkle E, Clark AG, Nickerson DA, Weiss KM (2004) The Effects of Scale: Variation in teh APOA1/C3/A4/A5 Gene Cluster, Human Genetics, 115(1):36-56
  • Crawford DC, Carlson CS, Rieder MJ, Carrington DP, Yi Q, Smith JD, Eberle MA, Krugylak L, Nickerson DA (2004) Haplotype Diversity Accross 100 Candidate Genes for Inflammatory, Lipid Metabolism, and Blood Pressure Regulation in Two Population, Human Genetics, 74(4):610-22
  • Carlson CS, Eberle MA, Rieder MJ, Smith JD, Kruglyak L, Nickerson DA (2003) Additional SNP's and Linkage-Disequilibrium Analyses are Necessary for Whole-Genome Association Studies in Humans, Nat Genet., 33:518-21
  • Jarvik GP, Hatsukami TS, Carlson CS, Richter RJ, Jampsa R, Brophy VH, Margolin S, Rieder MJ, Nickerso DA, Schellenberg GD, Heagerty PJ, Furlong CE (2003) Paraoxonase Activity, But not Haplotype Utilizing the Linkage Disequilbirum Structure, Predicts Vascular Disease, Arterioscler Thromb Vasc Biol., 23:1465 - 1471
  • Jarvik GP, Jampsa E, Richter RJ, Carlson CS, Rieder MJ, Nickerson DA, Furlong CE (2003) Novel Paraoxonase (PON1) Nonsense and Missense Mutations Predicted by Functional Genomic Assay of PON1 Status, Pharmacogenetics, 13: 1-5
  • Li SS, Khalid N, Carlson C, Zhao LP (2003) Estimating Haplotype Frequencies and Standard Errors for Multiple Single Nucleotide Polymorphisms, Biostatistics, 4(4):513-22
  • Ulrich C, Bigler J, Sibert J, Green E, Sparks R, Carlson C, Potter J (2002) Cyclooxygenase 1 (COX1) Polymorphisms in African-American and Caucasian Populations, Human Mutation, 20:409-10
  • Olivier M, Bustos VI, Levy MR, Smick GA, Moreno I, Bushard JM, Almendras AA, Sheppard K, Zierten DL, Aggarwal A, Carlson CS, Foster BD, Vo N, Kelly L, Liu X, Cox DR (2001) Complex High-Resolution Linkage Disequilibrium and Haplotype Patterns of Single-Nucleotide Polymorphisms in 2.5 Mb of Sequence on Human Chromosome 21, Genomics, 78(1-2):64-72
  • Boysen C, Carlson C, Hood E, Hood L (1996) Identifying DNA Polymorphisms in Human TCRA/D Variable Genes by Direct Sequencing of PCR Products, Immunogenetics, 44(2):121-7
  • Kwok PY, Carlson C, Yager TD, Ankener W, Nickerson DA (1994) Comparative Analysis of Human DNA Variations by Fluorescence-Based Sequencing of PCR Products, Genomics, 23(1):138-44

Profile Details

Last Verified: 7/28/2006

COS Expertise ID #1226043
Reference this profile directly: http://myprofile.cos.com/csc47