Dr. Stephen P. Daiger

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University of Texas Health Science Center at Houston
School of Public Health
Human Genetics Center
ProfessorAppointed: 1981
The Texas A&M Health Science Center
Baylor College of Medicine
Medicine
Pediatrics
Adjunct ProfessorAppointed: 1981
University of Texas Health Science Center at Houston
Medical School
Ophthalmology and Visual Science
Adjunct Professor
Professional Headshot of Stephen P. Daiger

Mailing Address

Human Genetics Center, School of Public Health, RAS W522
Univ. of Texas Health Science Center
1200 Herman Pressler St.
Houston, Texas 77030
United States

Contact Information

Phone: (713) 500-9829
Fax: (713) 500-0900
stephen.p.daiger@uth.tmc.edu
http://www.sph.uth.tmc.edu/RetNet/

Qualifications

Ph.D., Stanford University, Genetics, 1976.
A.B., Johns Hopkins University, Experimental Psychology, 1965.

Expertise and Research Interests

Research interests:
Human molecular genetics
Human population genetics
Molecular basis of inherited eye diseases
Retinal degeneration and retinitis pigmentosa (RP)
Human linkage mapping and gene cloning
Mutation testing
Human Genome Project

The principal goal of our research is to determine the genes and mutations causing inherited retinal degeneration in humans. The specific diseases we are studying are retinitis pigmentosa (RP), Leber congenital amaurosis (LCA), macular degeneration and related conditions. These progressive, degenerative diseases often lead to severe visual impairment or blindness. For mutation studies, I direct the Laboratory for Molecular Diagnosis of Inherited Eye Diseases, a joint project of the Human Genetics Center and the Dept. of Ophthalmology and Visual Science, UT-Houston, CLIA approval #45D0935007. The Diagnostic Laboratory tests for mutations in genes known to cause RP and related disorders, using blood samples from affected individuals. In addition to mutation testing, we conduct linkage mapping in families with autosomal dominant RP to find the chromosomal location of the disease-causing gene in each family. Also, based on earlier findings of ours, we are doing follow-up research on genes we identified earlier, such as RP1 on 8q and IMPDH1 (RP10) on 7q, using antibody localization, protein-protein interaction studies, and molecular analyses.

These studies are supported by grants from the Foundation Fighting Blindness, the George Gund Foundation, the National Institutes of Health - National Eye Institute, the William Stamps Farish Fund, the M.D. Anderson Foundation and the John S. Dunn Research Foundation. Data on inherited retinal diseases can be found at our Web site, RetNet, http://www.sph.uth.tmc.edu/RetNet.

Also, I have provided testimony as an expert witness on DNA fingerprinting and served as an advisor to the Federal Bureau of Investigation on this subject.

Other Expertise

Academic Experience:
Committees:
NIH-NEI, Special Study Section Member and Ad Hoc member
UT-Houston, Intellectual Property Advisory Committee
UT-Houston, Awards Committee (Chair) (1993-95)
UT-Houston, Institutional Effectiveness Committee (Chair)(1992-92)
UT-Houston, School of Public Health, Convener, Biological Sciences Discipline
UT-Houston, School of Public Health, Financial Aid Committee

Office:
President, Texas Genetics Society (1994)
Faculty President, Graduate School of Biomedical Sciences, UTHSC-Houston (2005-2007)

Advisor:
Federal Bureau of Investigation
National RP Foundation Advisory Board, Houston-Gulf Coast Chapter
Texas Neurofibromatosis Foundation Medical Advisory Board
Member, Scientific Advisory Board, Foundation Fighti8ng Blindness
Chair, Genetics Committee, Foundation Fighting Blindness

Awards:
Outstanding Faculty Award, GSBS, UT-Houston, 1990
Dean's Excellence Award, GSBS, UT-Houston, 1994-2001

Editorial Experience:
First Editor, Molecular Genetics Section, Archives of Ophthalmology
Member Editorial Review Board, Molecular Vision
HUGO (Human Genome Organization), Elected Member

Industrial Relevance

Postdoctoral Fellowship, Medical Genetics, University of Washington

Keywords

COS Keywords:

Biochemical Genetics, DNA Replication, Eye Diseases, Gene Mapping, Genetics, Human Genome, Inherited Diseases, Medical Genetics, Molecular Genetics, Retinitis Pigmentosa.

Additional Terms:

Biochemical Genetics, DNA Fingerprinting, DNA Linkage Analysis, Human Chromosome 8, Human Gene Mapping, Human Genetics, Inherited Diseases, Macular Degeneration, Medical Genetics, Molecular Genetics, Molecular Genetics, Eye, Retinal Degeneration, Retinitis Pigmentosa, Usher Syndrome.

Memberships

American Association for the Advancement of Science
American Society of Human Genetics
Association for Research in Vision and Ophthalmology
HUGO (Human Genome Organization), Elected Member
Institute of Electrical and Electronics Engineers
Texas Genetics Society (TGS)

Honors and Awards

2004, Thomas Stull Matney Professor of Environmental and Genetic Sciences, UTHSC-Houston SPH/GSBS

Patents

Mutations in a Novel Photoreceptor-Pineal Gene on 17p Cause Congenital Amaurosis (LCA9), Patent Number: 09/765061, 2001, United States of America.

Publications

  • Daiger SP (Apr 2005) Genetics. Was the Human Genome Project worth the effort?, Science, 308 (5720), 362-4 Abstract
  • Daiger SP, Identifying retinal disease genes: how far have we come, how far do we have to go?, Novartis Foundation Symposium, 255, 17-27; discussion 27, 2004 Abstract
  • Sullivan LS, Zhao X, Bowne SJ, Xu X, Daiger SP, Yee SB, Yee RW, Exclusion of the human collagen type XVII (COL17A1) gene as the cause of Thiel-Behnke corneal dystrophy (CDB2) on chromosome 10q23-q25, Current Eye Research, 27(4), 223-6, October 2003 Abstract
  • Khani SC, Karoukis AJ, Young JE, Ambasudhan R, Burch T, Stockton R, Lewis RA, Sullivan LS, Daiger SP, Reichel E, Ayyagari R, Late-onset autosomal dominant macular dystrophy with choroidal neovascularization and nonexudative maculopathy associated with mutation in the RDS gene, Investigative Ophthalmology & Visual Science, 44(8), 3570-7, August 2003 Abstract
  • Bowne SJ, Daiger SP, Malone KA, Heckenlively JR, Kennan A, Humphries P, Hughbanks-Wheaton D, Birch DG, Liu Q, Pierce EA, Zuo J, Huang Q, Donovan DD, Sullivan LS, Characterization of RP1L1, a highly polymorphic paralog of the retinitis pigmentosa 1 (RP1) gene, Molecular Vision [electronic Resource], 9, 129-37, April 2003 Abstract
  • Daiger SP, Sullivan LS, Bowne SJ, Kennan A, Humphries P, Birch DG, Heckenlively JR, RP1 Consortium, Identification of the RP1 and RP10 (IMPDH1) genes causing autosomal dominant RP, Advances in Experimental Medicine and Biology, 533, 1-11, 2003 Abstract
  • Kennan A, Aherne A, Bowne SJ, Daiger SP, Farrar GJ, Kenna PF, Humphries P, On the role of IMPDH1 in retinal degeneration, Advances in Experimental Medicine and Biology, 533, 13-8, 2003 Abstract
  • Akey DT, Zhu X, Dyer M, Li A, Sorensen A, Fukada-Kamitani T, Daiger SP, Craft C, Kamitani T, Sohocki MM, Functional studies of AIPL1: potential role of AIPL1 in cell cycle exit and/or differentiation of photoreceptors, Advances in Experimental Medicine and Biology, 533, 287-95, 2003 Abstract
  • Akey DT, Zhu X, Dyer M, Li A, Sorensen A, Blackshaw S, Fukuda-Kamitani T, Daiger SP, Craft CM, Kamitani T, Sohocki MM, The inherited blindness associated protein AIPL1 interacts with the cell cycle regulator protein NUB1, Human Molecular Genetics, 11(22), 2723-33, October 2002 Abstract
  • Gao J, Cheon K, Nusinowitz S, Liu Q, Bei D, Atkins K, Azimi A, Daiger SP, Farber DB, Heckenlively JR, Pierce EA, Sullivan LS, Zuo J, Progressive photoreceptor degeneration, outer segment dysplasia, and rhodopsin mislocalization in mice with targeted disruption of the retinitis pigmentosa-1 (Rp1) gene, Proceedings of the National Academy of Sciences (USA), 99(8), 5698-703, April 2002 Abstract
  • Bowne SJ, Sullivan LS, Blanton SH, Cepko CL, Blackshaw S, Birch DG, Hughbanks-Wheaton D, Heckenlively JR, Daiger SP, Mutations in the inosine monophosphate dehydrogenase 1 gene (IMPDH1) cause the RP10 form of autosomal dominant retinitis pigmentosa, Human Molecular Genetics, 11(5), 559-68, March 2002 Abstract
  • Liu Q, Zhou J, Daiger SP, Farber DB, Heckenlively JR, Smith JE, Sullivan LS, Zuo J, Milam AH, Pierce EA, Identification and subcellular localization of the RP1 protein in human and mouse photoreceptors, Investigative Ophthalmology and Visual Science, 43(1), 22-32, January 2002 Abstract
  • Sears JE, Aaberg TA Sr, Daiger SP, Moshfeghi DM, Splice site mutation in the peripherin/RDS gene associated with pattern dystrophy of the retina, American Journal of Ophthalmology, 132(5), 693-9, November 2001 Abstract
  • Sohocki MM, Sullivan LS, Tirpak DL, Daiger SP, Comparative analysis of aryl-hydrocarbon receptor interacting protein-like 1 (Aipl1), a gene associated with inherited retinal disease in humans, Mammalian Genome : Official Journal of the International Mammalian Genome Society., 12(7), 566-8, July 2001 Abstract
  • Tzekov RT, Liu Y, Sohocki MM, Zack DJ, Daiger SP, Heckenlively JR, Birch DG, Autosomal dominant retinal degeneration and bone loss in patients with a 12-bp deletion in the CRX gene, Investigative Ophthalmology and Visual Science, 42(6), 1319-27, May 2001 Abstract
  • Sohocki MM, Daiger SP, Bowne SJ, Rodriquez JA, Northrup H, Heckenlively JR, Birch DG, Mintz-Hittner H, Ruiz RS, Lewis RA, Saperstein DA, Sullivan LS, Prevalence of mutations causing retinitis pigmentosa and other inherited retinopathies, Human Mutation, 17(1), 42-51, 2001 Abstract
  • Mears AJ, Hiriyanna S, Vervoort R, Yashar B, Gieser L, Fahrner S, Daiger SP, Heckenlively JR, Sieving PA, Wright AF, Swaroop A, Remapping of the RP15 locus for X-linked cone-rod degeneration to Xp11.4-p21.1, and identification of a de novo insertion in the RPGR exon ORF15, American Journal of Human Genetics, 67(4), 1000-3, October 2000 Abstract
  • Tzekov RT, Sohocki MM, Daiger SP, Birch DG, Visual phenotype in patients with Arg41Gln and ala196 1bp mutations in the CRX gene, Ophthalmic Genetics, 21(2), 89-99, June 2000 Abstract
  • Sohocki MM, Perrault I, Leroy BP, Payne AM, Dharmaraj S, Bhattacharya SS, Kaplan J, Maumenee IH, Koenekoop R, Meire FM, Birch DG, Heckenlively JR, Daiger SP, Prevalence of AIPL1 mutations in inherited retinal degenerative disease, Molecular Genetics and Metabolism, 70(2), 142-50, June 2000 Abstract
  • Bowne SJ, Sullivan LS, Ding L, Traer E, Prescott SM, Birch DG, Kennan A, Humphries P, Daiger SP, Evaluation of human diacylglycerol kinase(iota), DGKI, a homolog of Drosophila rdgA, in inherited retinopathy mapping to 7q, Molecular Vision, 6, 6-9, 2000 Abstract
  • Sohocki MM, Bowne SJ, Sullivan LS, Blackshaw S, Cepko CL, Payne AM, Bhattacharya SS, Khaliq S, Qasim Mehdi S, Birch DG, Harrison WR, Elder FF, Heckenlively JR, Daiger SP, Mutations in a new photoreceptor-pineal gene on 17p cause Leber congenital amaurosis., Nat. Genet., 24(1), 79-83, 2000 Abstract
  • Daiger SP, Gene table: Inherited retinal diseases in humans, European Journal of Paediatric Neurology : Ejpn : Official Journal of the European Paediatric Neurology Society, 4(3), 135-40, 2000 Abstract
  • Bowne SJ, Daiger SP, Hims MM, Sohocki MM, Malone KA, McKie AB, Heckenlively JR, Birch DG, Inglehearn CF, Bhattacharya SS, Bird A, Sullivan LS, Mutations in the RP1 gene causing autosomal dominant retinitis pigmentosa., Human Molecular Genetics, 8(11), 2121-8, October 1999 Abstract
  • Sullivan LS, Heckenlively JR, Bowne SJ, Zuo J, Hide WA, Gal A, Denton M, Inglehearn CF, Blanton SH, Daiger SP, Mutations in a novel retina-specific gene cause autosomal dominant retinitis pigmentosa, Nature Genetics, 22(3), 255-9, July 1999 Abstract
  • Sohocki MM, Malone KA, Sullivan LS, Daiger SP, Localization of retina/pineal-expressed sequences: identification of novel candidate genes for inherited retinal disorders., Genomics, 58(1), 29-33, 15 May 1999 Abstract
  • Malone K, Sohocki MM, Sullivan LS, Daiger SP, Identifying and mapping novel retinal-expressed ESTs from humans, Molecular Vision, 5, 5, May 1999 Abstract
  • Sohocki MM, Sullivan LS, Mintz-Hittner HA, Birch D, Heckenlively JR, Freund CL, McInnes RR, Daiger SP, A range of clinical phenotypes associated with mutations in CRX, a photoreceptor transcription-factor gene, American Journal of Human Genetics, 63(5), 1307-15, November 1998 Abstract
  • Yee RW, Sullivan LS, Lai HT, Stock EL, Lu Y, Khan MN, Blanton SH, Daiger SP, Linkage mapping of Thiel-Behnke corneal dystrophy (CDB2) to chromosome 10q23-q24, Genomics, 46(1), 152-4, November 1997 Abstract
  • Sohocki M M, Sullivan L S, Mintz-Hittner H A, Small K, Ferrell R E, Daiger S P, Exclusion of atypical vitelliform macular dystrophy from 8q24.3 and from other known macular degenerative loci [letter], American Journal of Human Genetics, 61(1), 239-41, July 1997 Abstract
  • Rodriguez J A, Evans R L, Daiger S P, Northrup H, Molecular analysis of the human vitamin D binding protein (group specific component, Gc) in tuberous sclerosis complex (TSC)., Journal of Medical Genetics, 34(6), 509-11, June 1997 Abstract
  • McGuire RE, Daiger SP, Green ED, Localization and characterization of the human ADP-ribosylation factor 5 (ARF5) gene, Genomics, 41(3), 481-4, May 1997 Abstract
  • Sohocki MM, Sullivan LS, Harrison WR, Sodergren EJ, Elder FF, Weinstock G, Tanase S, DAIGER SP, Human glutamate pyruvate transaminase (GPT): localization to 8q24.3, cDNA and genomic sequences, and polymorphic sites, Genomics, 40(2), 247-52, March 1997 Abstract
  • Xu S Y, Denton M, Sullivan L, Daiger S P, Gal A, Genetic mapping of RP1 on 8q11-q21 in an Australian family with autosomal dominant retinitis pigmentosa reduces the critical region to 4 cM between D8S601 and D8S285., Human Genetics, 98(6), 741-3, December 1996 Abstract
  • Sullivan LS, Daiger SP, Inherited retinal degeneration: exceptional genetic and clinical heterogeneity, Molecular Medicine Today, 2(9), 380-6, September 1996 Abstract
  • McGuire RE, Jordan SA, Braden VV, Bouffard GG, Humphries P, Green ED, Daiger SP, Mapping the RP10 locus for autosomal dominant retinitis pigmentosa on 7q: refined genetic positioning and localization within a well-defined YAC contig, Genome Research, 6(4), 255-66, April 1996 Abstract
  • Leach R J, Banga S S, Ben-Othame K, Chughtai S, Clarke R, Daiger S P, Kolehmainen J, Kumar S, Kuo M, Macoska J, Mada N, Naylor S L, Nunes M, O'Connell P, Pebusque M J, Pekkel V, Porter C J, Simons C T, Sohocki M M, Trapman J, Wells D, Westbrook C, Wood S, Report of the Third International Workshop on Human Chromosome 8 Mapping. San Antonio, Texas, October 25-27, 1996., Cytogenetics and Cell Genetics, 75(2-3), 71-84, 1996 Abstract
  • McGuire RE, Sullivan LS, Blanton SH, Church MW, Heckenlively JR, Daiger SP, X-linked dominant cone-rod degeneration: linkage mapping of a new locus for retinitis pigmentosa (RP 15) to Xp22.13-p22.11, American Journal of Human Genetics, 57(1), 87-94, July 1995 Abstract
  • McGuire RE, Gannon AM, Sullivan LS, Rodriguez JA, DAIGER SP, Evidence for a major gene (RP10) for autosomal dominant retinitis pigmentosaon chromosome 7q: linkage mapping in a second, unrelated family, Human Genetics, 95(1), 71-4, January 1995 Abstract
  • Spurr N K, Blanton S, Bookstein R, Clarke R, Cottingham R, Daiger S, Drayna D, Faber P, Horrigan S, Kas K, et al, Report and abstracts of the second international workshop on human chromosome 8 mapping 1994. Oxford, United Kingdom, September 16-18, 1994., Cytogenetics and Cell Genetics, 68(3-4), 147-64, 1995 Abstract
  • McGuire RE, Gannon AM, Sullivan LS, Rodriguez JA, Daiger SP, Evidence for a major gene \(RP10\) for autosomal dominant retinitis pigmentosa on chromosome 7q: linkage mapping in a second, unrelated family., Human Genetics, 95(1), 71-4, 1995 Abstract
  • Ni L, Wagner M J, Kimberling W J, Pembrey M E, Grundfast K M, Kumar S, Daiger S P, Wells D E, Johnson K, Smith R J, Refined localization of the branchiootorenal syndrome gene by linkage and haplotype analysis., American Journal of Medical Genetics, 51(2), 176-84, 1 Jun 1994 Abstract
  • Sullivan L S, Parrish J, Wagner M J, Wells D, Blanton S H, Daiger S P, Tetranucleotide repeat polymorphism (D8S582) for human EST00680 (D8S340E)., Human Molecular Genetics, 3(2), 386, February 1994 Abstract
  • Hecht JT, Wang Y, Connor B, Blanton SH, Daiger SP, Nonsyndromic cleft lip and palate: no evidence of linkage to HLA or factor 13A, American Journal of Human Genetics, 52(6), 1230-3, June 1993 Abstract
  • Wood S, Ben Othmane K, Bergerheim U S, Blanton S H, Bookstein R, Clarke R A, Daiger S P, Donis-Keller H, Drayna D, Kumar S, et al, Report and abstracts of the First International Workshop on Human Chromosome 8 Mapping. Vancouver, British Columbia, May 2-4, 1993., Cytogenetics and Cell Genetics, 64(3-4), 134-46, 1993 Abstract
  • Chakraborty R, Srinivasan M R, Daiger S P, Evaluation of standard error and confidence interval of estimated multilocus genotype probabilities, and their implications in DNA forensics., American Journal of Human Genetics, 52(1), 60-70, January 1993 Abstract
  • Rodriguez JA, Herrera CA, Birch DG, Daiger SP, A leucine to arginine amino acid substitution at codon 46 of rhodopsin is responsible for a severe form of autosomal dominant retinitis pigmentosa, Human Mutation, 2(3), 205-13, 1993 Abstract
  • Gu J, Sadler L, Daiger S, Wells D, Wagner M, Dinucleotide repeat polymorphism at the CRH gene, Human Molecular Genetics, 2(1), 85, January 1993 Abstract
  • Smith R J, Lee E C, Kimberling W J, Daiger S P, Pelias M Z, Keats B J, Jay M, Bird A, Reardon W, Guest M, et al, Localization of two genes for Usher syndrome type I to chromosome 11., Genomics, 14(4), 995-1002, December 1992 Abstract
  • Hecht J T, Blanton S H, Wang Y, Daiger S P, Horton W A, Rhodes C, Yamada Y, Francomano C A, Exclusion of human proteoglycan link protein (CRTL1) and type II collagen (COL2A1) genes in pseudoachondroplasia., American Journal of Medical Genetics, 44(4), 420-4, 1 Nov 1992 Abstract
  • Northrup H, Kwiatkowski D J, Roach E S, Dobyns W B, Lewis R A, Herman G E, Rodriguez E Jr, Daiger S P, Blanton S H, Evidence for genetic heterogeneity in tuberous sclerosis: one locus on chromosome 9 and at least one locus elsewhere., American Journal of Human Genetics, 51(4), 709-20, October 1992 Abstract
  • Tomfohrde J, Wood S, Schertzer M, Wagner M J, Wells D E, Parrish J, Sadler L A, Blanton S H, Daiger S P, Wang Z, et al, Human chromosome 8 linkage map based on short tandem repeat polymorphisms: effect of genotyping errors., Genomics, 14(1), 144-52, September 1992 Abstract
  • Smith R J, Pelias M Z, Daiger S P, Keats B, Kimberling W, Hejtmancik J F, Clinical variability and genetic heterogeneity within the Acadian Usher population., American Journal of Medical Genetics, 43(6), 964-9, 1 Aug 1992 Abstract
  • Hecht J T, Wang Y, Blanton S H, Daiger S P, Van der Woude syndrome and nonsyndromic cleft lip and palate [letter], American Journal of Human Genetics, 51(2), 442-4, August 1992 Abstract
  • Fei Y J, Blanton S H, Daiger S P, Luo C R, Linkage between Rh blood group and autosomal dominant retinitis pigmentosa in ten Chinese families., Chinese Medical Journal, 105(6), 486-9, June 1992 Abstract
  • Cottingham A W, Sadler L A, Blanton S H, Wagner M J, Wells D E, Heckenlively J R, Daiger S P, A tight linkage cluster, with two new RFLPs (D8S96 and D8S108), in the interval 8cen-q13., Nucleic Acids Research, 20(6), 1426, 25 Mar 1992 Abstract
  • Chakraborty R, De Andrade M, Daiger SP, Budowle B, Apparent heterozygote deficiencies observed in DNA typing data and their implications in forensic applications, Annals of Human Genetics, 56 ( Pt 1), 45-57, January 1992 Abstract
  • Blanton SH, Heckenlively JR, Cottingham AW, Friedman J, Sadler LA, Wagner M, Friedman LH, DAIGER SP, Linkage mapping of autosomal dominant retinitis pigmentosa (RP1) to the pericentric region of human chromosome 8, Genomics, 11(4), 857-69, December 1991 Abstract
  • Sadler L A, Blanton S H, Daiger S P, Dinucleotide repeat polymorphism at the human tissue plasminogen activator gene (PLAT)., Nucleic Acids Research, 19(21), 6058, 11 Nov 1991 Abstract
  • Chakraborty R, Daiger S P, Polymorphisms at VNTR loci suggest homogeneity of the white population of Utah., Human Biology, 63(5), 571-87, October 1991 Abstract
  • Daiger S P, DNA fingerprinting [letter; comment], American Journal of Human Genetics, 49(4), 897, 899-903, October 1991 Abstract
  • Cottingham A W, Blanton S H, Retief A E, Warnich L, Daiger S P, A new StyI RFLP and haplotypes with the HindIII RFLP at the D8S5 (TL11) locus., Nucleic Acids Research, 19(17), 4790, 11 Sep 1991 Abstract
  • Hecht J T, Wang Y P, Blanton S H, Michels V V, Daiger S P, Cleft lip and palate: no evidence of linkage to transforming growth factor alpha, American Journal of Human Genetics, 49(3), 682-6, September 1991 Abstract
  • Hecht J T, Wang Y P, Blanton S H, Michels V V, Daiger S P, Cleft lip and palate: no evidence of linkage to transforming growth factor alpha [see comments], American Journal of Human Genetics, 49(3), 682-6, September 1991 Abstract
  • Heckenlively JR, Rodriguez JA, Daiger SP, Autosomal dominant sectoral retinitis pigmentosa. Two families with transversion mutation in codon 23 of rhodopsin, Archives of Ophthalmology, 109(1), 84-91, January 1991 Abstract
  • Rodriguez J A, Liou G I, Daiger S P, PCR detection of the BgIII RFLP at the RBP3 locus., Nucleic Acids Research, 18(18), 5578, 25 Sep 1990 Abstract
  • Blanton S H, Cottingham A W, Giesenschlag N, Heckenlively J R, Humphries P, Daiger S P, Further evidence of exclusion of linkage between type II autosomal dominant retinitis pigmentosa (ADRP) and D3S47 on 3q., Genomics, 8(1), 179-81, September 1990 Abstract
  • Northrup H, Lathrop M, Lu S Y, Daiger S P, Beaudet A L, O'Brien W E, Multilocus linkage analysis with the human argininosuccinate synthetase gene., Genomics, 5(3), 442-4, October 1989 Abstract
  • Daiger S P, Reed L, Huang S S, Zeng Y T, Wang T, Lo W H, Okano Y, Hase Y, Fukuda Y, Oura T, et al, Polymorphic DNA haplotypes at the phenylalanine hydroxylase (PAH) locus in Asian families with phenylketonuria (PKU)., American Journal of Human Genetics, 45(2), 319-24, August 1989 Abstract
  • Daiger S P, Chakraborty R, Reed L, Fekete G, Schuler D, Berenssi G, Nasz I, Brdicka R, Kamaryt J, Pijackova A, et al, Polymorphic DNA haplotypes at the phenylalanine hydroxylase (PAH) locus in European families with phenylketonuria (PKU)., American Journal of Human Genetics, 45(2), 310-8, August 1989 Abstract
  • Sullivan SE, Moore SD, Connor JM, King M, Cockburn F, Steinmann B, Gitzelmann R, Daiger SP, Woo SL, Haplotype distribution of the human phenylalanine hydroxylase locus in Scotland and Switzerland, American Journal of Human Genetics, 44(5), 652-9, May 1989 Abstract
  • Bradley D G, Farrar G J, Sharp E M, Kenna P, Humphries M M, McConnell D J, Daiger S P, McWilliam P, Humphries P, Autosomal dominant retinitis pigmentosa: exclusion of the gene from the short arm of chromosome 1 including the region surrounding the rhesus locus., American Journal of Human Genetics, 44(4), 570-6, April 1989 Abstract
  • Zoghbi H Y, Sandkuyl L A, Ott J, Daiger S P, Pollack M, O'Brien W E, Beaudet A L, Assignment of autosomal dominant spinocerebellar ataxia (SCA1) centromeric to the HLA region on the short arm of chromosome 6, using multilocus linkage analysis., American Journal of Human Genetics, 44(2), 255-63, February 1989 Abstract
  • Daiger S P, Humphries M M, Giesenschlag N, Sharp E, McWilliam P, Farrer J, Bradley D, Kenna P, McConnell D J, Sparkes R S, et al, Linkage analysis of human chromosome 4: exclusion of autosomal dominant retinitis pigmentosa (ADRP) and detection of new linkage groups., Cytogenetics and Cell Genetics, 50(4), 181-7, 1989 Abstract
  • Smith RJ, Holcomb JD, Daiger SP, Caskey CT, Pelias MZ, Alford BR, Fontenot DD, Hejtmancik JF, Exclusion of Usher syndrome gene from much of chromosome 4, Cytogenetics and Cell Genetics, 50(2-3), 102-6, 1989 Abstract
  • Zoghbi HY, Pollack MS, Lyons LA, Ferrell RE, Daiger SP, Beaudet AL, Spinocerebellar ataxia: variable age of onset and linkage to human leukocyte antigen in a large kindred, Annals of Neurology, 23(6), 580-4, June 1988 Abstract
  • Zoghbi HY, Daiger SP, McCall A, O'Brien WE, Beaudet AL, Extensive DNA polymorphism at the factor XIIIa (F13A) locus and linkage to HLA, American Journal of Human Genetics, 42(6), 877-83, June 1988 Abstract
  • Daiger SP, Goode ME, Trowbridge BD, Evolution of nuclear gene families in primates. Copy-number variation in the argininosuccinate synthetase (ASS) pseudogene family and the anonymous DNA sequence, D1S1, Genetica, 73(1-2), 91-8, 1987 Abstract
  • Chakraborty R, Lidsky AS, Daiger SP, Guttler F, Sullivan S, Dilella AG, Woo SL, Polymorphic DNA haplotypes at the human phenylalanine hydroxylase locus and their relationship with phenylketonuria, Human Genetics, 76(1), 40-6, May 1987 Abstract
  • Daiger SP, Heckenlively JR, Lewis RA, Pelias MZ, DNA linkage studies of degenerative retinal diseases, Progress in Clinical and Biological Research, 247, 147-62, 1987 Abstract
  • Goode ME, vanTuinen P, Ledbetter DH, Daiger SP, The anonymous polymorphic DNA clone D1S1, previously mapped to human chromosome 1p36 by in situ hybridization, is from chromosome 3 and is duplicated on chromosome 1, American Journal of Human Genetics, 38(4), 437-46, April 1986 Abstract
  • Daiger SP, Lidsky AS, Chakraborty R, Koch R, Guttler F, Woo SL, Polymorphic DNA haplotypes at the phenylalanine hydroxylase locus in prenatal diagnosis of phenylketonuria, Lancet, 1(8475), 229-32, 1986 Abstract
  • Chan L, VanTuinen P, Ledbetter DH, Daiger SP, Gotto AM, Chen SH, The human apolipoprotein B-100 gene: a highly polymorphic gene that maps to the short arm of chromosome 2, Biochemical and Biophysical Research Communications, 133(1), 248-55, 1985 Abstract
  • Lidsky AS, Ledley FD, DiLella AG, Kwok SC, Daiger SP, Robson KJ, Woo SL, Extensive restriction site polymorphism at the human phenylalanine hydroxylase locus and application in prenatal diagnosis of phenylketonuria, American Journal of Human Genetics, 37(4), 619-34, July 1985 Abstract
  • Daiger SP, Hoffman NS, Wildin RS, Su TS, Multiple, independent restriction site polymorphisms in human DNA detected with a cDNA probe to argininosuccinate synthetase (AS), American Journal of Human Genetics, 36(4), 736-49, July 1984 Abstract
  • Daiger SP, Miller M, Chakraborty R, Heritability of quantitative variation at the group-specific component (Gc) locus, American Journal of Human Genetics, 36(3), 663-76, May 1984 Abstract
  • Lockwood DH, Coppenhaver DH, Ferrell RE, Daiger SP, X-linked, polymorphic genetic variation of thyroxin-binding globulin (TBG) in baboons and screening of additional primates, Biochemical Genetics, 22(1-2), 81-8, February 1984 Abstract
  • ten Kate LP, Boman H, Daiger SP, Motulsky AG, Increased frequency of coronary heart disease in relatives of wives of myocardial infarct survivors: assortative mating for lifestyle and risk factors?, American Journal of Cardiology, 53(4), 399-403, 1984 Abstract
  • Daiger SP, Chakravarti A, Deletion mapping of polymorphic loci by apparent parental exclusion, American Journal of Medical Genetics, 14(1), 43-8, January 1983 Abstract
  • ten Kate LP, Boman H, Daiger SP, Motulsky AG, Familial aggregation of coronary heart disease and its relation to known genetic risk factors, American Journal of Cardiology, 50(5), 945-53, November 1982 Abstract
  • Daiger SP, Wildin RS, Su TS, Sequences on the human Y chromosome homologous to the autosomal gene for argininosuccinate synthetase, Nature, 298(5875), 682-4, 1982 Abstract
  • Frater-Schroder M, Porck HJ, Eriksson AW, Daiger SP, Cavalli-Sforza LL, Standardization of nomenclature for transcobalamin II variants, Human Genetics, 61(2), 165-6, 1982 Abstract
  • Daiger SP, Wildin RS, Human thyroxine-binding globulin (TBG): heterogeneity within individuals and among individuals demonstrated by isoelectric focusing, Biochemical Genetics, 19(7-8), 673-85, August 1981 Abstract
  • Daiger SP, Rummel DP, Wang L, Cavalli-Sforza LL, Detection of genetic variation with radioactive ligands. IV. X-linked, polymorphic genetic variation of thyroxin-binding globulin (TBG), American Journal of Human Genetics, 33(4), 640-8, July 1981 Abstract
  • Daiger SP, Miller M, Romeo G, Parsons M, Cavalli-Sforza LL, Vitamin-D-binding protein in the Williams syndrome and idiopathic hypercalcemia, New England Journal of Medicine, 298(12), 687-8, 1978 Abstract
  • Daiger SP, Labowe ML, Parsons M, Wang L, Cavalli-Sforza LL, Detection of genetic variation with radioactive ligands. III. genetic polymorphism of transcobalamin II in human plasma, American Journal of Human Genetics, 30(2), 202-14, March 1978 Abstract
  • Daiger SP, Cavalli-Sforza LL, Detection of genetic variation with radioactive ligands. II. Genetic variants of vitamin D-labeled group-specific component (Gc) proteins, American Journal of Human Genetics, 29(6), 593-604, November 1977 Abstract
  • Cavalli-Sforza LL, Daiger SP, Rummel DP, Detection of genetic variation with radioactive ligands. I. Electrophoretic screening of plasma proteins with a selected panel of compounds, American Journal of Human Genetics, 29(6), 581-92, November 1977 Abstract
  • Daiger SP, Schanfield MS, Cavalli-Sforza LL, Group-specific component (Gc) proteins bind vitamin D and 25-hydroxyvitamin D, Proceedings of the National Academy of Sciences (USA), 72(6), 2076-80, June 1975 Abstract

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