Dr. Buel Dantese Rodgers

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Washington State University
College of Sciences
School of Molecular Biosciences
Washington State University
College of Agriculture Human and Natural Resource Sciences
Department of Animal Sciences
Associate Professor
Professional Headshot of Buel Dantese Rodgers

Mailing Address

124 ASLB
P.O. Box 646351
Department of Animal Sciences
Pullman, Washington 99164-6351
United States

Contact Information

Phone: (509) 335-2991
Fax: (509) 335-4246
danrodgers@wsu.edu
http://www.ansci.wsu.edu/people/rodgers/faculty.asp

Qualifications

Postdoctoral fellow, Johns Hopkins University, Endocrinology, 2000.
Postdoctoral fellow, National Institute of Health (NIH), Biochemistry & Molecular Biology, 1998.
Ph.D., University of California, Berkeley, Endocrinology, 1995.
B.A., University of Hawaii at Manoa, Zoology, 1990.

Expertise and Research Interests

I am primarily interested in the underlying physiological and molecular mechanisms that regulate muscle growth and development and how such knowledge can improve the clinical treatment of different muscular dystrophies, myopathies and heart failure. I am also interested in how this knowledge can, in a broader sense, explain fundamental evolutionary processes. The research projects currently being conducted in my laboratory are not only exploratory, but are developing novel therapeutics to treat these different muscle growth disorders in humans and animals.

Other Expertise

Molecular and endocrine regulation of somatic tissue growth, development and metabolism, particularly as it relates to obesity and type 2 diabetes mellitus.

Future Research

My lab is substantially expanding it's biomedical focus with investigations of cardiac and skeletal muscle repair mechanisms, although we continue to use comparative model systems to answer fundamental questions relevant to the evolution of muscle growth regulatory networks. We are also seeking support to develop the Washington Center for Muscle Biology, a bi-institutional center that includes faculty at Washington State University and the University of Washington.

Industrial Relevance

My laboratory is currently developing methods to improve skeletal and cardiac muscle growth via gene therapy. Such technological advances have broad appeal to both biomedical and agricultural communities and could help advance biotech development in the Pacific Northwest.

Keywords

COS Keywords:

Animal Development, Diabetes, Endocrinology, Muscular Dystrophy.

Additional Terms:

Gene Therapy, Heart Failure, Muscle Development, Myocardial Infarction, Zebrafish.

Languages

(Reading, Writing, Speaking)

Spanish: (Functional, Functional, Functional)

Memberships

Endocrine Society
Society for Developmental Biology
Society for Endocrinology

Honors and Awards

2009, Graduate Mentor Academy, Graduate School, Washington State University
2005-2006, Advisor/Mentor of the Year, Graduate & Professional Student Association, Washington State University
2004, Endocrine Society Travel Award, Endocrine Society
1997, National Institute of Health Fellows Award for Research Excellence, National Institutes of Health (NIH), National Institute on Aging
1996, Endocrine Society Travel Award, Endocrine Society
1996, National Institute on AgingĀ’s Nathan W. Shock Award, National Institutes of Health (NIH), National Institute on Aging
1995, Howard A. Bern Award for Excellence in Graduate Student Research, Graduate Group in Endocrinology, University of California, Berkeley
1994, Outstanding Graduate Student Instructor Award, Department of Integrative Biology, University of California, Berkeley
1991-1995, Cancer Research Laboratory pre-doctoral fellowship, National Institutes of Health (NIH), University of California, Berkeley
1988-1990, Minority Access to Research Careers undergraduate fellowship, National Institutes of Health (NIH), University of Hawaii

Previous Positions

2003-2009, Assistant Professor, Washington State University, Department of Animal Sciences & School of Molecular Biosciences
2000-2003, Instructor, Johns Hopkins University, School of Medicine, Pediatrics, Endocrinology
1998-2000, Research Fellow, Johns Hopkins University, School of Medicine, Endocrinology
1995-1998, Research Fellow, National Institute on Aging, Diabetes Section, Laboratory of Clinical Investigation

Funding Received

  • National Science Foundation (NSF): Physiological Mechanisms of Myostatin Functional Divergence, $510,722, 2009 to 2012.
  • National Institutes of Health (NIH): Nuclear Actions of IGFBP-3 in Muscle Cells, $223,400, 2007 to 2010.
  • United States Department of Agriculture (USDA): Identification of Transcriptional Regulatory Elements within the Rainbow Trout Myostatin Gene Promoters., $105,000, 2004 to 2007.
  • United States Department of Agriculture (USDA): Endocrine Regulation of Rainbow Trout Myosatellite Proliferation and Differentiation., $43,000, 2004 to 2005.
  • Washington State University Office of Grants and Research Development: Animal Genomics Laboratory., $5,000, 2004 to 2005.
  • Washington State University Foundation: Intracellular Delivery of Peptides Suitable for Treating Muscular Dystrophies., $20,000, 2004 to 2006.
  • United States Department of Agriculture (USDA): The control of skeletal muscle growth and development in the tilapia, Oreochromis mossambicus,, $185,000, 2000 to 2003.
  • Private Endowment & National Science Foundation: Co-investigator Projects, $1,372,500, 2000 to 2003.

Publications

  • B.D. Rodgers (2009) Myostatin suppresses physiological hypertrophy and excitation-contraction coupling in cardiac muscle., Journal of Physiology, In Press
  • B.D. Rodgers (2008) Letter to the Editor: Overexpression of Myostatin2 in zebrafish reduces the expression of dystrophin associated protein complex (DAPC) which leads to muscle dystrophy., Journal of Biomedical Science, 15 (6), 841
  • B.D. Rodgers, D.K. Garikipati (2008) Clinical, agricultural and evolutionary biology of myostatin; a comparative review., Endocrine Reviews, 29 (5), 513-34
  • L.K. Davis, B.D. Rodgers, K.M. Kelley (2008) Angiotensin II- and glucose-stimulated extracellular matrix production is mediated by the insulin-like growth factor (IGF) axis in a murine mesangial cell line., Endocrine, 33 (1), 32-9
  • B.D. Rodgers, E.H. Roalson, C. Thompson (2008) Phylogenetic analysis of the insulin-like growth factor binding protein (IGFBP) and IGFBP-related protein gene families., General and Comparative Endocrinology, 155 (1), 201-7
  • D. Garikipati, S.A. Ghar, E.H. Roalson, B.D. Rodgers (2007) Characterization of rainbow trout myostatin-2 genes (rtMSTN-2a & -2b): genomic organization, differential expression and psuedogenization., Endocrinology, 148 (5), 210-15
  • M. Lin, M. Al-Holy, H. Al-Qadiri, S.S. Chang, D.H. Kang, B.D. Rodgers, B.A. Rasco (2007) Phylogenetic and Spectroscopic Analysis of Alicyclobacillus Isolates by 16S rDNA Sequencing and Mid-Infrared spectroscopy., Sensing and Instrumentation for Food Safety and Quality, 151, 11-17
  • D.L.I. Helterline, D. Garikipati, D.L. Stenkamp, B.D. Rodgers (2007) Embryonic and Tissue-specific Regulation of Myostatin-1 and -2 Gene Expression in Zebrafish., General and Comparative Endocrinology, 151 (12), 90-97
  • B.D. Rodgers, E.H. Roalson, G.M. Weber, S.B. Roberts, F.W. Goetz (2006) A Proposed Nomenclature Consensus for the Myostatin Gene Family., American Journal of Physiology; Endocrinology and Metabolism, 292, E371-2
  • D. Garikipati, S.A. Ghar, B.D. Rodgers (2006) Identification, Characterization and Quantitative Expression Analysis of Rainbow Trout Myostatin-1a and -1b Genes., Journal of Endocrinology, 190 (3), 879-88
  • M. Oufattole, B. Liu, S.W.J. Lin, D. Mascarenhas, P. Cohen, B.D. Rodgers (2006) RNA polymerase II subunit 3 (Rpb3), a potential nuclear target of IGFBP-3., Endocrinology, 147 (5), 2138-46
  • B.D. Rodgers (2005) Insulin-like Growth Factor-I Downregulates Embryonic Myosin Heavy Chain (eMyHC) Protein in Myoblast Nuclei, Growth Hormone & IGF Research, 15 (06), 377-383
  • T. Kerr, E.H. Roalson, B.D. Rodgers (2005) Phylogenetic Analysis of the Myostatin Gene Sub-family and the Differential Expression of a Novel Member in Zebrafish, Evolution and Development, 7 (5), 391-401
  • Rodgers BD, Weber GM, Kelley KM, Levine MA (May 2003) Prolonged Fasting and Cortisol Reduce Myostatin MRNA Levels in Tilapia Larvae; Short-term Fasting Elevates, American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 284 (5), R1277-86
  • Marcell TJ, Harman SM, Urban RJ, Metz DD, Rodgers BD, Blackman MR (Dec 2001) Comparison of GH, IGF-I, and Testosterone With MRNA of Receptors And Myostatin in Skeletal Muscle in Older Men, American Journal of Physiology. Endocrinology and Metabolism, 281 (6), E1159-64
  • Rodgers BD, Weber GM (Jun 2001) Sequence Conservation Among Fish Myostatin Orthologues and The Characterization of Two Additional CDNA Clones From Morone Saxatilis And Morone Americana, Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology, 129 (2-3), 597-603
  • Rodgers BD, Weber GM, Sullivan CV, Levine MA (Apr 2001) Isolation and Characterization of Myostatin Complementary Deoxyribonucleic Acid Clones From Two Commercially Important Fish: Oreochromis Mossambicus and Morone Chrysops, Endocrinology, 142 (4), 1412-8
  • Rodgers BD, Bernier M, Levine MA (Mar 2001) Endocrine Regulation of G-protein Subunit Production in An Animal Model Of Type 2 Diabetes Mellitus, The Journal of Endocrinology, 168 (3), 509-15
  • Rodgers BD, Levine MA, Bernier M, Montrose-Rafizadeh C (Feb 2001) Insulin Regulation of a Novel WD-40 Repeat Protein in Adipocytes, The Journal of Endocrinology, 168 (2), 325-32
  • Rodgers BD, Taking Advantage of the Talent Pool, The Scientist, 14(12), 6, 2000
  • Yang H, Egan JM, Rodgers BD, Bernier M, Montrose-Rafizadeh C (Jun 1999) Differential Expression of a Novel Seven Transmembrane Domain Protein In Epididymal Fat From Aged and Diabetic Mice, Endocrinology, 140 (6), 2859-67
  • Montrose-Rafizadeh C, Avdonin P, Garant MJ, Rodgers BD, Kole S, Yang H, Levine MA, Schwindinger W, Bernier M (Mar 1999) Pancreatic Glucagon-like Peptide-1 Receptor Couples to Multiple G Proteins and Activates Mitogen-activated Protein Kinase Pathways in Chinese Hamster Ovary Cells, Endocrinology, 140 (3), 1132-40
  • Nicoll CS, Rodgers BD, Kelley KM (1999) Hormonal Regulation of Growth and Development of Nonmammalian Vertebrates, Handbook of Physiology; Hormonal Regulation of Growth, 5, 73-98
  • Montrose-Rafizadeh C, Yang H, Rodgers BD, Beday A, Pritchette LA, Eng J (Aug 1997) High Potency Antagonists of the Pancreatic Glucagon-like Peptide-1 Receptor, The Journal of Biological Chemistry, 272 (34), 21201-6
  • Rodgers BD (Sep 1996) Catabolic Hormones and Growth Hormone Resistance in Acquired Immunodeficiency Syndrome and Other Catabolic States, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (new York, N. Y.), 212 (4), 324-31
  • Rodgers BD, Strack AM, Dallman MF, Hwa L, Nicoll CS (Dec 1995) Corticosterone Regulation of Insulin-like Growth Factor I, IGF-binding Proteins, and Growth in Streptozotocin-induced Diabetic Rats, Diabetes, 44 (12), 1420-5
  • Rodgers BD, Bautista RM, Nicoll CS (Dec 1995) Regulation of Insulin-like Growth Factor-binding Proteins in Rats With Insulin-dependent Diabetes Mellitus, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (new York, N. Y.), 210 (3), 234-41
  • Rodgers BD, Lau AO, Nicoll CS (Nov 1994) Hypophysectomy Or Adrenalectomy of Rats With Insulin-dependent Diabetes Mellitus Partially Restores Their Responsiveness to Growth Hormone, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (new York, N. Y.), 207 (2), 220-6
  • Rodgers BD, Helms LM, Grau EG (Jun 1992) Effects of Fasting, Medium Glucose, and Amino Acid Concentrations On Prolactin and Growth Hormone Release, in Vitro, From the Pituitary of The Tilapia Oreochromis Mossambicus, General and Comparative Endocrinology, 86 (3), 344-51

Profile Details

Last Verified: 10/3/2009

COS Expertise ID #1187732
Reference this profile directly: http://myprofile.cos.com/danrodgers