David Hewett-Emmett

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University of Texas Health Science Center at Houston
School of Public Health
Human Genetics Center
Associate ProfessorAppointed: 1984
University of Texas Health Science Center at Houston
Graduate School of Biomedical Sciences
Appointed: 1985
University of Texas Health Science Center at Houston
School of Public Health
Epidemiology
Associate ProfessorAppointed: 1984
University of Texas Health Science Center at Houston
School of Public Health
Occup. Hlth. Sciences
Associate ProfessorAppointed: 1984
University of Texas Health Science Center at Houston
School of Public Health
Disease Control & Environ.
Associate ProfessorAppointed: 1984
Professional Headshot of David Hewett-Emmett

Mailing Address

RAS E-517 UTSPH
P.O. Box 20186
University of Texas Health Science Center at Houston
Houston, Texas 77225-0186
United States

Contact Information

Phone: (713) 500-9835
Fax: (713) 500-0900
David.Hewett-Emmett@uth.tmc.edu

Qualifications

Ph.D., University College London, Biochemistry, 1973.
M.Sc., University College London, Biochemistry, 1969.
B.A., Christ's College, Cambridge, England, Biochemistry, 1968.

Expertise and Research Interests

Research interests: Organization, expression and evolution of the carbonic anhydrases; protein and DNA polymorphisms as genetic markers; molecular evolution.

My main interests center around the evolution of multigene families with focus on the implications of evolutionary conservatism of different regions of a gene for structure, function, and expression of the gene product. Evolutionary conserved regions can be identified that are: shared by different members of a gene family, or restricted to a particular gene (i.e. invariant in sequences of this gene derived from different species). Such families include the carbonic anhydrases, the serine proteases and both the skin and visual pigment genes. The newest members (CARPs) of the alpha-carbonic anhydrase gene family are highly conserved between species, yet lack key active-site amino acids, indicating they have different yet important functions. Such evolutionary studies of promotor and upstream regions of biomedically important genes leads to the identification of 'phylogenetic footprints', which Gumucio and her colleagues in Michigan (in the case of the globins) have shown bind previously unrecognized transcription factors. This approach can also identify locus control regions.

Other Expertise

Academic Experience:
Editorial Reviewer:
American Journal Human Genetics
Genomics
Molecular Biology and Evolution
Science

Editorial Board Membership:
Molecular Phylogenetics and Evolution

Keywords

COS Keywords:

Biochemistry, Evolutionary Biology, Genetics, Molecular Cellular Entities, Proteins and Macromolecules, Recombinant Dna.

Additional Terms:

Evolutionary Genetics, Human Biochemical Genetics, Molecular Evolution, Multigene Families.

Languages

(Reading, Writing, Speaking)

French: (Basic, Basic, Basic)

Memberships

American Society for Biochemistry and Molecular Biology
American Society of Human Genetics
Society for Molecular Biology and Evolution

Previous Positions

2005-2007, Co-Chair, UTHSC Interfaculty Council Sub-Committee on Faculty Status, Rights & Responsibilities, University of Texas Health Science Center at Houston
2005-2006, Chair, University of Texas Health Science Center at Houston, Graduate School of Biomedical Sciences, Student Affairs Committee
2004-2007, Chair, Admissions Committee, University of Texas Health Science Center at Houston, School of Public Health
2001-2004, Director, University of Texas Health Science Center at Houston, Graduate School of Biomedical Sciences, Program in Human & Molecular Genetics
1999-2000, Chair, University of Texas Health Science Center at Houston, Graduate School of Biomedical Sciences, Academic Standards Committee
1996-1998, Convenor, University of Texas Health Science Center at Houston, School of Public Health, Biological Sciences
1992-1995, Director, University of Texas Health Science Center at Houston, Graduate School of Biomedical Sciences, Program in Genetics
1978-1984, Assistant Research Scientist, University of Michigan, Medical School, Human Genetics
1976-1978, Post-Doctoral Research Assistant, University of Bristol, Medicine, Biochemistry, Molecular Enzymology Laboratory
1973-1976, Research Associate, Wayne State University, School of Medicine, Physiology
1969-1973, Graduate Research Assistant, University College London, Physical Anthropology/Biochemistry

Publications

  • Lindley TE, LabergeT, Hall A, Hewett-Emmett D, Walsh PJ, Anderson PM, Sequence, expression and evolutionary relationships of carbamoyl phosphate synthetase I in the toad Xenopus laevis., J. Exp. Zoology Part A: Ecology, Genetics & Physiology, 307, 163-175, 2007
  • Li G, Yin W, Chamberlain R, Hewett-Emmett D, Roberts JN, Yang X, Lippmann SM, Clifford JL, Identification and characterization of the human retinoid X receptor alpha gene promoter, Gene, 372, 118-127, 2006
  • Kleinke T, Wagner S, John H, Hewett-Emmett D, Parkkila S, Forssmann WG, Gros G, A Distinct Carbonic Anhydrase in the Mucus of the Colon of Humans and Other Mammals., J. Exp. Biol., 208, 487-496, 2005
  • Zhao Z, Fu Y-X, Hewett-Emmett D, Boerwinkle E, Investigating Single Nucleotide Polymorphism (SNP) Density in the Human Genome and Its Implications for Molecular Evolution, Gene, 312, 207-213, 2003
  • Wu H, Wang H, Li H, Akey J, Xiao F, Ke Y, Xu H, Xiao J, Lu D, Parra D, Shriver M, Xiong M, Barton SA, Hewett-Emmett D, Liu W, Jin L, Skin reflectance in the Han Chinese and Tibetan populations, Human Biology, 73, 461-466, 2001
  • Shah GN, Hewett-Emmett D, Grubb JH, Migas MC, Fleming RE, Waheed A, Sly WS, Mitochondrial carbonic anhydrase CA VB: Differences in tissue distribution and pattern of evolution from those of CA VA suggest distinct physiological roles, Proceedings of the National Academy of Sciences (USA), 97, 1677-1682, 2000 Abstract
  • Yang H, Hewett-Emmett D, Tashian RE, Absence or reduction of carbonic anhydrase II in the red cells of the beluga whale and llama: Implications for adaptation to hypoxia, Biochemical Genetics, 38, 241-252, 2000
  • Hewett-Emmett D, Evolution and distribution of the carbonic anhydrase gene families, In: Carbonic Anhydrases: New Horizons (eds. W.R. Chegwidden, N.D. Carter & Y.H. Edwards), Birkhauser, Basel, pp. 29-76, 2000
  • Tashian RE, Hewett-Emmett D, Carter ND, Bergenhem NCH, Carbonic anhydrase (CA)-related proteins, and transmembrane proteins with CA or CA-like domains, Carbonic Anhydrases: New Horizons (eds. W.R. Chegwidden, N.D. Carter & Y.H. Edwards), Birkhauser, Basel, pp. 105-120, 2000
  • Li W-H, Tan Y, Boissinot S, Shyue S-K, Hewett-Emmett D, Genetic diversity of color vision in primates, In: The Biology of Biodiversity (ed. M. Kato), Springer, New York, pp. 259-274, 2000
  • Li W-H, Boissinot S, Tan Y, Shyue S-K, Hewett-Emmett D, Evolutionary genetics of primate color vision. Recent progress and potential limits to knowledge, In: Evolutionary Biology (eds. M.T. Clegg, M.K.Hecht & R.J.MacIntyre), Kluwer Academic/Plenum Press, New York, Vol. 32, pp. 151-178, 2000
  • Rana BK, Hewett-Emmett D, Jin L, Chang BH-J, Sambuughin N, Lin M, Watkins S, Bamshad M, Jorde LB, Ramsay M, Jenkins T, Li W-H, High polymorphism at the human melanocortin 1 receptor locus, Genetics, 151, 1547-1557, 1999 Abstract
  • Deere M, Dieguez JL, Yoon SJ, Hewett-Emmett D, de la Chapelle A, Hecht JT, Genomic characterization of human DSPG3, Genome Research, 9, 449-456, 1999 Abstract
  • Zhao Z, Hewett-Emmett D, Li W-H, Frequent gene conversion between human red and green opsin genes, Journal of Molecular Evolution, 46, 494-496, 1998 Abstract
  • Gu X, Hewett-Emmett D, Li W-H, Directional mutational pressure affects the amino acid composition and hydrophobicity of proteins in bacteria, Genetica, 102/103, 383-391, 1998 Abstract
  • Shyue S-K, Boissinot S, Schneider H, Sampaio I, Schneider MP, Abee CR, Williams L, Hewett-Emmett D, Sperling HG, Cowing JA, Dulai KS, Hunt DM, Li W-H, Molecular genetics of spectral tuning in New World monkey color vision, Journal of Molecular Evolution, 46, 697-702, 1998 Abstract
  • Hunt DM, Dulai KS, Cowing JA, Julliot C, Mollon JD, Bowmaker JK, Li W-H, Hewett-Emmett D, Molecular evolution of trichromacy in primates, Vision Research, 38, 3299-3306, 1998 Abstract
  • Boissinot S, Tan Y, Shyue S-K, Schneider H, Sampaio I, Neiswanger K, Hewett-Emmett D, Li W-H, Origins and antiquity of X-linked triallelic color vision systems in New World monkeys, Proceedings of the National Academy of Sciences (USA), 95, 13749-13754, 1998 Abstract
  • Lovejoy DA, Hewett-Emmett D, Porter CA, Cepoi D, Sheffield A, Vale WV and Tashian RE, Evolutionarily conserved, 'acatalytic' carbonic anhydrase-related protein XI contains a sequence motif present in the neuropeptide sauvagine. The human CA-RP XI gene (CA11) is embedded between the Sec, Genomics, 54, 484-493, 1998
  • Sun H, Rodin A, Zhou Y-H, Dickinson DP, Harper DE, Hewett-Emmett D, Li W-H, Evolution of paired domains: Isolation and sequencing of jellyfish and hydra Pax genes related to Pax-5 and Pax-6, Proceedings of the National Academy of Sciences (USA), 94, 5156-5161, 1997 Abstract
  • Huang W, Chang BH-J, Gu X, Hewett-Emmett D, Li W-H, Sex differences in mutation rate in higher primates estimated from AMG intron sequences, Journal of Molecular Evolution, 44, 463-465, 1997 Abstract
  • Zhou,Y.-H., Hewett-Emmett,D. and Li,W.-H., Unexpected conservation of the X-linked color vision gene in nocturnal primates: Evidence from two bush babies, Journal of Molecular Evolution, 45, 610-618, 1997
  • Li W-H, Ellsworth DL, Krushkal J, Chang BH-J and Hewett-Emmett D, Rates of nucleotide substitution in primates and rodents and the generation-time hypothesis, Molecular Phylogenetics and Evolution, 5, 182-187, 1996 Abstract
  • Hewett-Emmett D, Tashian RE, Functional diversity, conservation, and convergence in the evolution of the alpha-, beta-, and gamma-carbonic anhydrase gene families, Molecular Phylogenetics and Evolution, 5, 50-77, 1996 Abstract
  • Shyue S-K, Hewett-Emmett D, Sperling HG, Hunt DM, Bowmaker JK, Mollon JD, Li W-H, Adaptive evolution of color vision genes in higher primates, Science, 269, 1265-1267, 1995 Abstract
  • Hopkins PJ, Bergenhem NC, Venta PJ, Hewett-Emmett D, Tashian RE, Characterization of the gene encoding carbonic anhydrase I from the pigtail macaque, Gene, 152, 265-269, 1995 Abstract
  • Ellsworth D L, Hewett-Emmett D, Li W-H, Evolution of base composition in the insulin and insulin-like growth factor genes, Molecular Biology and Evolution, 11, 875-885, 1994 Abstract
  • Chang,B.H.-J., Shimmin,L.C., Shyue,S.-K., Hewett-Emmett,D., and Li,W.-H., Weak male-driven evolution in rodents, Proceedings of the National Academy of Sciences (USA), 91, 827-831, 1994
  • Ellsworth D L, Hewett-Emmett D, Li W-H, Insulin-like growth factor II intron sequences support the hominoid rate-slowdown hypothesis, Molecular Phylogenetics and Evolution, 2, 315-321, 1993 Abstract
  • Shimmin LC, Chang B H-J, Hewett-Emmett D, Li W-H, Potential problems in estimating the male-to-female mutation rate ratio from DNA sequence data, Journal of Molecular Evolution, 37, 160-166, 1993 Abstract
  • Lomax M I, Hewett-Emmett D, Yang T L, Grossman L I, Rapid evolution of the human gene for cytochrome c oxidase subunit IV, Proceedings of the National Academy of Sciences (USA), 89, 5266-5270, 1992 Abstract
  • Mueller WH, Wear ML, Hanis CL, Emerson JB, Barton SA, Hewett-Emmett D, Schull WJ, Which measure of body fat distribution is best for epidemiologic research?, American Journal of Epidemiology, 133, 858-869, 1991 Abstract
  • Hanis CL, Douglas TC, Hewett-Emmett D, Apolipoprotein A-IV protein polymorphism: frequency and effects on lipids, lipoproteins, and apolipoproteins among Mexican-Americans in Starr County, Texas, Human Genetics, 86, 323-325, 1991 Abstract
  • Shriver MD, Boerwinkle E, Hewett-Emmett D, Hanis CL, Frequency and effects of apolipoprotein E polymorphism in Mexican-American NIDDM subjects, Diabetes, 40, 334-337, 1991 Abstract
  • Hewett-Emmett D, Tashian RE, Structure and evolutionary origins of the carbonic anhydrase multigene family, In: The Carbonic Anhydrases: Cellular Physiology and Molecular Genetics (ed. S.J. Dodgson), Plenum, New York, pp. 15-32, 1991
  • Tashian RE, Hewett-Emmett D, Venta PJ, Diversity and evolution in the carbonic anhydrase gene family, In: Carbonic Anhydrase: From Biochemistry and Genetics to Physiology and Clinical Medicine (eds. F. Botre, G. Gros, B.T. Storey) VCH Publishers, New York, pp. 151-161, 1991
  • Frazier M L, Lilly B J, Wu E F, Ota T, Hewett-Emmett D, Carbonic anhydrase II gene expression in cell lines from human pancreatic adenocarcinoma, Pancreas, 5, 507-514, 1990 Abstract
  • Tashian R E, Venta P J, Nicewander P H, Hewett-Emmett D, Evolution, structure, and expression of the carbonic anhydrase multigene family, Progress In Clinical and Biological Research, 344, 159-175, 1990
  • Overturf ML, Smith SA, Hewett-Emmett D, Loose-Mitchell DS, Soma MR, Gotto AM Jr, Morrisett JD, Development and partial metabolic characterization of a dietary cholesterol-resistant colony of rabbits, Journal of Lipid Research, 30, 263-273, 1989 Abstract
  • Montgomery JC, Venta PJ, Tashian RE, Hewett-Emmett D, Nucleotide sequence of human liver carbonic anhydrase II cDNA [note], Nucleic Acids Research, 15, 4687, 1987 Abstract
  • Venta PJ, Montgomery JC, Hewett-Emmett D, Wiebauer K, Tashian RE, Structure and exon to protein domain relationships of the mouse carbonic anhydrase II gene, Journal of Biological Chemistry, 260, 12130-12135, 1985 Abstract
  • Sly WS, Whyte MP, Sundaram V, Tashian RE, Hewett-Emmett D, Guibaud P, Vainsel M, Baluarte HJ, Gruskin A, Al-Mosawi M, et al, Carbonic anhydrase II deficiency in 12 families with the autosomal recessive syndrome of osteopetrosis with renal tubular acidosis and cerebral calcification, New England Journal of Medicine, 313, 139-145, 1985 Abstract
  • Venta PJ, Montgomery JC, Hewett-Emmett D, Tashian RE, Comparison of the 5' regions of human and mouse carbonic anhydrase II genes and identification of possible regulatory elements, Biochimica et Biophysica Acta, 826, 195-201, 1985
  • Hewett-Emmett D, Hopkins PJ, Tashian RE, Czelusniak J, Origins and molecular evolution of the carbonic anhydrase isozymes, Annals of the New York Academy of Sciences, 429, 338-358, 1984 Abstract
  • Carter ND, Chegwidden WR, Hewett-Emmett D, Jeffery S, Shiels A, Tashian RE, Novel inhibition of carbonic anhydrase isozymes I, II and III by carbamoyl phosphate, FEBS Letters, 165, 197-200, 1984 Abstract
  • Tashian RE, Hewett-Emmett D (eds.), Biology and Chemistry of the Carbonic Anhydrases, Annals of the New York Academy of Sciences, 429, 640 pp., 1984
  • Tashian RE, Hewett-Emmett D, Goodman M, On the evolution and genetics of carbonic anhydrases I, II, and III, Isozymes: Current Topics in Biological Medical Research, 7, 79-100, 1983 Abstract
  • Hewett-Emmett D, Welty RJ, Tashian RE, A widespread silent polymorphism of human carbonic anhydrase III (31 Ile <-> Val): Implications for evolutionary genetics, Genetics, 105, 409-420, 1983 Abstract
  • Sly WS, Hewett-Emmett D, Whyte MP, Yu Y-S, Tashian RE, Carbonic anhydrase II deficiency identified as the primary defect in the autosomal recessive syndrome of osteopetrosis with renal tubular acidosis and cerebral calcification, Proceedings of the National Academy of Sciences (USA), 80, 2752-2756, 1983 Abstract
  • Czelusniak J, Goodman M, Hewett-Emmett D, Weiss ML, Venta PJ, Tashian RE, Phylogenetic origins and adaptive evolution of avian and mammalian haemoglobin genes, Nature, 298, 297-300, 1982 Abstract
  • Hewett-Emmett D, Venta PJ, Tashian RE, Features of gene structure, organization and expression that are providing unique insights into molecular evolution and systematics, Macromolecular Sequences in Systematics and Evolutionary Biology (ed. M. Goodman), pp. 357-405, 1982
  • Hewett-Emmett D, Czelusniak J, Goodman M, The evolutionary relationship of the enzymes involved in blood coagulation and hemostasis, Annals of the New York Academy of Sciences, 370, 511-27, 1981 Abstract
  • Carter ND, Hewett-Emmett D, Jeffrey S, Tashian RE, Testosterone-induced, sulfonamide-resistant carbonic anhydrase isozyme of rat liver is indistinguishable from skeletal muscle carbonic anhydrase III, FEBS Letters, 128, 114-118, 1981 Abstract
  • Kageoka T, Hewett-Emmett D, Stroup SK, Yu Y-S, Tashian RE, Amino acid substitution and chemical characterization of a Japanese variant of carbonic anhydrase I: CA I Hiroshima-1 (86 Asp -> Gly), Biochemical Genetics, 19, 535-549, 1981 Abstract
  • Tashian RE, Hewett-Emmett D, Stroup SK, Goodman M, Yu Y-SL, Evolution of structure and function in the carbonic anhydrase isozymes of mammals, In: Biophysics and Physiology of Carbon Dioxide (eds. H. Bartels, C. Bauer & G. Gros), pp. 165-176, 1980
  • Hewett-Emmett D, Amino acid sequence homology and the vitamin K-dependent proteins, Bibliotheca Haematologica, 44, 94-104, 1977 Abstract
  • Walz DA, Hewett-Emmett D, Seegers WH, Amino acid sequence of human prothrombin fragments 1 and 2, Proceedings of the National Academy of Sciences (USA), 74, 1969-1972, 1977 Abstract
  • Beard JM, Barnicot NA, Hewett-Emmett D, Alpha and beta chains of the major haemoglobin and a note on the minor component of Tarsius, Nature, 259, 338-341, 1976 Abstract
  • Hewett-Emmett D, Cook CN, Barnicot NA, Old World monkey hemoglobins: Deciphering phylogeny from complex patterns of molecular evolution, In: Molecular Anthropology (eds. M. Goodman & R.E. Tashian), pp. 257-275, 1976
  • Hewett-Emmett D, Walz DA, Reuterby J, McCoy LE, Seegers WH, The amino acid sequence of PR fragment (NH2-terminal fragment) of bovine prothrombin, Thrombosis Research, 7, 227-234, 1975 Abstract
  • Hewett-Emmett D, McCoy LE, Hassouna HI, Reuterby J, Walz DA, Seegers WH, A partial gene duplication in the evolution of prothrombin?, Thrombosis Research, 5, 421-430, 1974 Abstract
  • Cook CN, Hewett-Emmett D, The uses of protein sequence data in systematics, In: Prosimian Biology (eds. R.D. Martin, G.A. Doyle & A.C. Walker), pp. 937-958, 1974
  • Barnicot NA, Hewett-Emmett D, Electrophoretic studies on prosimian blood proteins, In: Prosimian Biology (eds. R.D. Martin, G.A. Doyle & A.C. Walker), pp. 891-902, 1974
  • Hewett-Emmett D, Structural studies of Old World monkey haemoglobins in relation to phylogeny, Ph.D. thesis, University of London, 345 pp., 1973
  • Barnicot NA, Hewett-Emmett D, Red cell and serum proteins of Cercocebus, Presbytis, Colobus and certain other species, Folia Primatologica, 17, 442-457, 1972 Abstract
  • Barnicot NA, Hewett-Emmett D, Red cell and serum proteins of talapoin, patas and vervet monkeys, Folia Primatologica, 15, 65-76, 1971 Abstract

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