Dr. Thomas E. DeCoursey

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Rush University Medical Center
Rush Medical College
Molecular Biophysics and Physiology
ProfessorAppointed: 1998

Mailing Address

Department of Molecular Biophysics and Physiology
Rush University Medical Center
1750 West Harrison
Chicago, Illinois 60612
United States

Contact Information

Phone: (312) 942-3267
Fax: (312) 942-8711
tdecours@rush.edu
http://www2.phys.rush.edu/TomD/physiotd.html

Qualifications

Ph.D., University of Cincinnati, Pharmacology and Biophysics, 1979.
B.A., McPherson College, Biology, 1974.

Expertise and Research Interests

Voltage-gated ion channels, patch-clamp, electrophysiology of nonexcitable cells. I am especially interested in voltage-gated proton-selective channels in phagocytes and alveolar epithelial cells. The interrelationships between NADPH oxidase and proton channels in the phagocyte respiratory burst are a continuing interest.

Keywords

COS Keywords:

Biophysics, Electrophysiology, Ion Channels, Molecular Physics, Physiology.

Additional Terms:

NADPH Oxidase, Proton Channels, Respiratory Burst.

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)
German: (Functional, Basic, Basic)

Memberships

American Physiological Society
Biophysical Society
Physiological Society
Society for Leukocyte Biology
Society of General Physiologists

Honors and Awards

1987-1992, Research Career Development Award, NIH, Rush Presbyterian St. Luke's Medical Center, alveolar epithelial ion channels
1980-1981, Postdoctoral Fellow, Muscular Dystrophy Association, University of Glasgow, ion channels
1980-1981, Honorary Research Fellow, University of Glasgow, ion channels
1976-1979, Fellow, Albert J. Ryan Foundation, University of Cincinnati

Previous Positions

1990-1998, Associate Professor, Rush University Medical Center, Rush Medical College, Molecular Biophysics and Physiology
1985-1990, Assistant Professor, Rush University Medical Center, Rush Medical College, Molecular Biophysics and Physiology

Funding Received

  • Philip Morris External Research Program: Proton Channels in Pulmonary and Immune Cell Response, 2007 to 2009.
  • National Institutes of Health (NIH): Voltage-gated Proton Channels in Human Neutrophils, 2000 to present.
  • National Institutes of Health (NIH): Voltage-activated Proton Channels in Alveolar Epithelium, 1995 to 2004.
  • American Heart Association (AHA): Hydrogen Ion Currents in Rat Alveolar Epithelial Cells, 1992 to 1995.
  • National Institutes of Health (NIH): Pulmonary Type II Epithelial Cells: Role of Ion Channels, 1987 to 1992.
  • American Heart Association (AHA): Ion Channels in Pulmonary Type II Epithelial Cells, 1986 to 1988.
  • Muscular Dystrophy Association: Chloride Current Noise Analysis in Amphibian and Mammalian Muscle, 1980 to 1981.

Publications

  • Morgan D, Capasso M, Musset B, Cherny VV, Ríos E, Dyer MJ, DeCoursey TE (Oct 2009) Voltage-gated proton channels maintain pH in human neutrophils during phagocytosis., Proceedings of the National Academy of Sciences of the United States of America, 106 (42), 18022-7 Abstract
  • Musset B, Cherny VV, Morgan D, DeCoursey TE (Jan 2009) The intimate and mysterious relationship between proton channels and NADPH oxidase., FEBS letters, 583 (1), 7-12 Abstract
  • DeCoursey TE (Jan 2009) Unintended consequences at NIH., Science (New York, N.Y.), 323 (5911), 209 Abstract
  • DeCoursey TE (Nov 2008) Voltage-gated proton channels: what's next?, The Journal of Physiology, 586 (Pt 22), 5305-24 Abstract
  • Musset B, Morgan D, Cherny VV, MacGlashan DW, Thomas LL, Ríos E, DeCoursey TE (Aug 2008) A pH-stabilizing role of voltage-gated proton channels in IgE-mediated activation of human basophils., Proceedings of the National Academy of Sciences of the United States of America, 105 (31), 11020-5 Abstract
  • DeCoursey TE (Aug 2008) Voltage-gated proton channels., Cellular and molecular life sciences : CMLS, 65 (16), 2554-73 Abstract
  • Musset B, Cherny VV, Morgan D, Okamura Y, Ramsey IS, Clapham DE, DeCoursey TE (May 2008) Detailed comparison of expressed and native voltage-gated proton channel currents., The Journal of Physiology, 586 (10), 2477-86 Abstract
  • DeCoursey TE (Jul 2007) Electrophysiology of the phagocyte respiratory burst. Focus on "Large-conductance calcium-activated potassium channel activity is absent in human and mouse neutrophils and is not required for innate immunity"., American Journal of Physiology. Cell Physiology, 293 (1), C30-2 Abstract
  • Morgan D, Cherny VV, Finnegan A, Bollinger J, Gelb MH, DeCoursey TE (Mar 2007) Sustained activation of proton channels and NADPH oxidase in human eosinophils and murine granulocytes requires PKC but not cPLA2 alpha activity., The Journal of Physiology, 579 (Pt 2), 327-44 Abstract
  • DeCoursey TE, Cherny VV (2007) Pharmacology of voltage-gated proton channels., Current Pharmaceutical Design, 13 (23), 2400-20 Abstract
  • Morgan D, Cherny VV, Morgan D, Finnegan A, Bollinger J, Gelb MH, DeCoursey TE (2007) Sustained activation of proton channels and NADPH oxidase in human eosinophils and murine granulocytes requires PKC but not cPLA2-alpha activity, Journal of Physiology, 579, 327-344
  • Morgan D, DeCoursey TE (2007) Analysis of electrophysiological properties and responses of neutrophils, Neutrophil Methods and Protocols. M.T. Quinn, F.R. DeLeo, and G.M. Bokoch, Eds. (Vol. 138), First Edition, Totowa, NJ, USA, Humana Press, 139-175 pages (bookchapter)
  • DeCoursey TE (2006) Is Bush science's nemesis?, Scientist, 20 (12), 15
  • Murphy R, DeCoursey TE (Aug 2006) Charge compensation during the phagocyte respiratory burst., Biochimica et Biophysica Acta, 1757 (8), 996-1011 Abstract
  • Femling JK, Cherny VV, Morgan D, Rada B, Davis AP, Czirják G, Enyedi P, England SK, Moreland JG, Ligeti E, Nauseef WM, DeCoursey TE (Jun 2006) The antibacterial activity of human neutrophils and eosinophils requires proton channels but not BK channels., The Journal of General Physiology, 127 (6), 659-72 Abstract
  • DeCoursey TE (Feb 2006) It's difficult to publish contradictory findings., Nature, 439 (7078), 784 Abstract
  • Morgan D, Cherny VV, Murphy R, Katz BZ, DeCoursey TE (Dec 2005) The pH dependence of NADPH oxidase in human eosinophils., The Journal of Physiology, 569 (Pt 2), 419-31 Abstract
  • DeCoursey TE, Ligeti E (Oct 2005) Regulation and termination of NADPH oxidase activity., Cellular and molecular life sciences : CMLS, 62 (19-20), 2173-93 Abstract
  • Murphy R, Cherny VV, Morgan D, DeCoursey TE (Feb 2005) Voltage-gated proton channels help regulate pHi in rat alveolar epithelium., American Journal of Physiology. Lung Cellular and Molecular Physiology, 288 (2), L398-408 Abstract
  • DeCoursey TE (May 2004) During the respiratory burst, do phagocytes need proton channels or potassium channels, or both?, Science's STKE : signal transduction knowledge environment, 2004 (233), pe21 Abstract
  • DeCoursey TE (Nov 2003) Interactions between NADPH oxidase and voltage-gated proton channels: why electron transport depends on proton transport., FEBS Letters, 555 (1), 57-61 Abstract
  • Morgan D, DeCoursey TE (Sep 2003) Diversity of voltage gated proton channels., Frontiers in bioscience : a journal and virtual library, 8, s1266-79 Abstract
  • Morgan, D. V.V. Cherny, R. Murphy, W. Xu, L.L. Thomas, and T.E. DeCoursey, Temperature dependence of NADPH oxidase in human eosinophils, Journal of Physiology, 550(2), 447-458, 15 Jul 2003
  • Morgan D, Cherny VV, Murphy R, Xu W, Thomas LL, DeCoursey TE (Jul 2003) Temperature dependence of NADPH oxidase in human eosinophils., The Journal of Physiology, 550 (Pt 2), 447-58 Abstract
  • Cherny VV, Murphy R, Sokolov V, Levis RA, DeCoursey TE (Jun 2003) Properties of single voltage-gated proton channels in human eosinophils estimated by noise analysis and by direct measurement., The Journal of General Physiology, 121 (6), 615-28 Abstract
  • DeCoursey TE, Voltage-gated proton channels and other proton transfer pathways, Physiological Reviews, 83(2), 475-579, April 2003
  • DeCoursey TE (Apr 2003) Voltage-gated proton channels and other proton transfer pathways., Physiological Reviews, 83 (2), 475-579 Abstract
  • DeCoursey TE, Morgan D, Cherny VV (Apr 2003) The voltage dependence of NADPH oxidase reveals why phagocytes need proton channels., Nature, 422 (6931), 531-4 Abstract
  • DeCoursey TE, Morgan D, Cherny VV (Dec 2002) The gp91phox component of NADPH oxidase is not a voltage-gated proton channel., The Journal of General Physiology, 120 (6), 773-9 Abstract
  • Schilling T, Gratopp A, DeCoursey TE, Eder C (Nov 2002) Voltage-activated proton currents in human lymphocytes., The Journal of Physiology, 545 (Pt 1), 93-105 Abstract
  • Morgan D, Cherny VV, Price MO, Dinauer MC, DeCoursey TE (Jun 2002) Absence of proton channels in COS-7 cells expressing functional NADPH oxidase components., The Journal of General Physiology, 119 (6), 571-80 Abstract
  • DeCoursey TE, Cherny VV, Morgan D, Katz BZ, Dinauer MC (Sep 2001) The gp91phox component of NADPH oxidase is not the voltage-gated proton channel in phagocytes, but it helps., The Journal of Biological Chemistry, 276 (39), 36063-6 Abstract
  • DeCoursey TE, Cherny VV, DeCoursey AG, Xu W, Thomas LL (Sep 2001) Interactions between NADPH oxidase-related proton and electron currents in human eosinophils., The Journal of Physiology, 535 (Pt 3), 767-81 Abstract
  • Cherny VV, Henderson LM, Xu W, Thomas LL, DeCoursey TE (Sep 2001) Activation of NADPH oxidase-related proton and electron currents in human eosinophils by arachidonic acid., The Journal of Physiology, 535 (Pt 3), 783-94 Abstract
  • Eder C, DeCoursey TE (Jun 2001) Voltage-gated proton channels in microglia., Progress in Neurobiology, 64 (3), 277-305 Abstract
  • Schilling T, Quandt FN, Cherny VV, Zhou W, Heinemann U, DeCoursey TE, Eder C (Oct 2000) Upregulation of Kv1.3 K(+) channels in microglia deactivated by TGF-beta., American Journal of Physiology. Cell Physiology, 279 (4), C1123-34 Abstract
  • DeCoursey TE, Cherny VV, Zhou W, Thomas LL (Jun 2000) Simultaneous activation of NADPH oxidase-related proton and electron currents in human neutrophils., Proceedings of the National Academy of Sciences of the United States of America, 97 (12), 6885-9 Abstract
  • DeCoursey TE, Cherny VV (May 2000) Common themes and problems of bioenergetics and voltage-gated proton channels., Biochimica et Biophysica Acta, 1458 (1), 104-19 Abstract
  • DeCoursey TE (Jan 2000) Hypothesis: do voltage-gated H(+) channels in alveolar epithelial cells contribute to CO(2) elimination by the lung?, American Journal of Physiology. Cell Physiology, 278 (1), C1-C10 Abstract
  • Cherny VV, DeCoursey TE (Dec 1999) pH-dependent inhibition of voltage-gated H(+) currents in rat alveolar epithelial cells by Zn(2+) and other divalent cations., The Journal of General Physiology, 114 (6), 819-38 Abstract
  • DeCoursey, T.E., and V.V. Cherny, An electrophysiological comparison of voltage-gated proton channels, other ion channels, and other proton channels, Israel Journal of Chemistry, 39, 409-418, 1999
  • DeCoursey TE, Cherny VV (Oct 1998) Temperature dependence of voltage-gated H+ currents in human neutrophils, rat alveolar epithelial cells, and mammalian phagocytes., The Journal of general physiology, 112 (4), 503-22 Abstract
  • Zhou W, Cayabyab FS, Pennefather PS, Schlichter LC, DeCoursey TE (Jun 1998) HERG-like K+ channels in microglia., The Journal of general physiology, 111 (6), 781-94 Abstract
  • Pennefather PS, Zhou W, DeCoursey TE (Jun 1998) Idiosyncratic gating of HERG-like K+ channels in microglia., The Journal of general physiology, 111 (6), 795-805 Abstract
  • DeCoursey TE, Cherny VV (Apr 1997) Deuterium isotope effects on permeation and gating of proton channels in rat alveolar epithelium., The Journal of general physiology, 109 (4), 415-34 Abstract
  • DeCoursey, T.E., Type 'l' (Kv3.1) K+ channels in lymphocytes, Cellular Physiology and Biochemistry, 7, 172-178, 1997
  • Cherny VV, Henderson LM, DeCoursey TE (1997) Proton and chloride currents in Chinese hamster ovary cells., Membrane & cell biology, 11 (3), 337-47 Abstract
  • DeCoursey TE, Cherny VV, Effects of buffer concentration on voltage-gated H currents: does diffusion limit the conductance?, Biophysical Journal, 71(1), 182-193, July 1996 Abstract
  • Kim SY, Silver MR, DeCoursey TE, Ion channels in human THP-1 monocytes, Journal of Membrane Biology, 152(2), 117-130, July 1996 Abstract
  • DeCoursey TE, Cherny VV (Jul 1996) Effects of buffer concentration on voltage-gated H+ currents: does diffusion limit the conductance?, Biophysical journal, 71 (1), 182-93 Abstract
  • Kim SY, Silver MR, DeCoursey TE (Jul 1996) Ion channels in human THP-1 monocytes., The Journal of membrane biology, 152 (2), 117-30 Abstract
  • DeCoursey TE, Cherny VV (Jul 1996) Voltage-activated proton currents in human THP-1 monocytes., The Journal of membrane biology, 152 (2), 131-40 Abstract
  • DeCoursey TE, Kim SY, Silver MR, Quandt FN (Jul 1996) Ion channel expression in PMA-differentiated human THP-1 macrophages., The Journal of membrane biology, 152 (2), 141-57 Abstract
  • DeCoursey TE, Cherny VV (Dec 1995) Voltage-activated proton currents in membrane patches of rat alveolar epithelial cells., The Journal of physiology, 489 ( Pt 2), 299-307 Abstract
  • DeCoursey TE (Oct 1995) Mechanism of K+ channel block by verapamil and related compounds in rat alveolar epithelial cells., The Journal of general physiology, 106 (4), 745-79 Abstract
  • Cherny VV, Markin VS, DeCoursey TE (Jun 1995) The voltage-activated hydrogen ion conductance in rat alveolar epithelial cells is determined by the pH gradient., The Journal of general physiology, 105 (6), 861-96 Abstract
  • DeCoursey TE, Cherny VV, Voltage-activated hydrogen ion currents, Journal of Membrane Biology, 141(3), 203-23, September 1994 Abstract
  • DeCoursey TE, Cherny VV (May 1994) Na(+)-H+ antiport detected through hydrogen ion currents in rat alveolar epithelial cells and human neutrophils., The Journal of general physiology, 103 (5), 755-85 Abstract
  • Silver MR, Shapiro MS, DeCoursey TE (Apr 1994) Effects of external Rb+ on inward rectifier K+ channels of bovine pulmonary artery endothelial cells., The Journal of general physiology, 103 (4), 519-48 Abstract
  • Pennefather PS, DeCoursey TE (Apr 1994) A scheme to account for the effects of Rb+ and K+ on inward rectifier K channels of bovine artery endothelial cells., The Journal of general physiology, 103 (4), 549-81 Abstract
  • DeCoursey TE, Cherny VV (Oct 1993) Potential, pH, and arachidonate gate hydrogen ion currents in human neutrophils., Biophysical journal, 65 (4), 1590-8 Abstract
  • DeCoursey TE (Nov 1991) Hydrogen ion currents in rat alveolar epithelial cells., Biophysical journal, 60 (5), 1243-53 Abstract
  • Shapiro MS, DeCoursey TE (Jun 1991) Selectivity and gating of the type L potassium channel in mouse lymphocytes., The Journal of general physiology, 97 (6), 1227-50 Abstract
  • Shapiro MS, DeCoursey TE (Jun 1991) Permeant ion effects on the gating kinetics of the type L potassium channel in mouse lymphocytes., The Journal of general physiology, 97 (6), 1251-78 Abstract
  • Jacobs ER, DeCoursey TE (Nov 1990) Mechanisms of potassium channel block in rat alveolar epithelial cells., The Journal of pharmacology and experimental therapeutics, 255 (2), 459-72 Abstract
  • Silver MR, DeCoursey TE (Jul 1990) Intrinsic gating of inward rectifier in bovine pulmonary artery endothelial cells in the presence or absence of internal Mg2+., The Journal of general physiology, 96 (1), 109-33 Abstract
  • DeCoursey TE, State-dependent inactivation of K currents in rat type II alveolar epithelial cells, Journal of General Physiology, 95(4), 617-46, April 1990 Abstract
  • Jacobs ER, DeCoursey TE (Mar 1989) Ion channels in the metabolic regulation of respiratory cells., Clinics in chest medicine, 10 (1), 25-36 Abstract
  • DeCoursey TE, Jacobs ER, Silver MR (Jan 1988) Potassium currents in rat type II alveolar epithelial cells., The Journal of physiology, 395, 487-505 Abstract
  • DeCoursey TE, Chandy KG, Gupta S, Cahalan MD (Mar 1987) Two types of potassium channels in murine T lymphocytes., The Journal of General Physiology, 89 (3), 379-404 Abstract
  • DeCoursey TE, Chandy KG, Gupta S, Cahalan MD (Mar 1987) Mitogen induction of ion channels in murine T lymphocytes., The Journal of General Physiology, 89 (3), 405-20 Abstract
  • Cahalan MD, Chandy KG, DeCoursey TE, Gupta S, Lewis RS, Sutro JB (1987) Ion channels in T lymphocytes., Advances in experimental medicine and biology, 213, 85-101 Abstract
  • Chandy KG, DeCoursey TE, Fischbach M, Talal N, Cahalan MD, Gupta S (Sep 1986) Altered K+ channel expression in abnormal T lymphocytes from mice with the lpr gene mutation., Science (New York, N.Y.), 233 (4769), 1197-200 Abstract
  • DeCoursey TE, Chandy KG, Gupta S, Cahalan MD (Nov 1985) Voltage-dependent ion channels in T-lymphocytes., Journal of neuroimmunology, 10 (1), 71-95 Abstract
  • Chandy KG, DeCoursey TE, Cahalan MD, Gupta S (Aug 1985) Electroimmunology: the physiologic role of ion channels in the immune system., Journal of immunology (Baltimore, Md. : 1950), 135 (2 Suppl), 787s-791s Abstract
  • Chandy KG, DeCoursey TE, Cahalan MD, Gupta S (Jan 1985) Ion channels in lymphocytes., Journal of clinical immunology, 5 (1), 1-6 Abstract
  • Cahalan MD, Chandy KG, DeCoursey TE, Gupta S (Jan 1985) A voltage-gated potassium channel in human T lymphocytes., The Journal of physiology, 358, 197-237 Abstract
  • Chandy KG, DeCoursey TE, Cahalan MD, McLaughlin C, Gupta S (Aug 1984) Voltage-gated potassium channels are required for human T lymphocyte activation., The Journal of experimental medicine, 160 (2), 369-85 Abstract
  • DeCoursey TE, Dempster J, Hutter OF (Apr 1984) Inward rectifier current noise in frog skeletal muscle., The Journal of physiology, 349, 299-327 Abstract
  • DeCoursey TE, Hutter OF (Apr 1984) Potassium current noise induced by barium ions in frog skeletal muscle., The Journal of physiology, 349, 329-51 Abstract
  • DeCoursey TE, Chandy KG, Gupta S, Cahalan MD, Voltage-gated K channels in human T lymphocytes: a role in mitogenesis?, Nature, 307(5950), 465-8, February 1984 Abstract
  • DeCoursey TE, Chandy KG, Gupta S, Cahalan MD (1984) Voltage-gated K+ channels in human T lymphocytes: a role in mitogenesis?, Nature, 307 (5950), 465-8 Abstract
  • DeCoursey TE, Bryant SH, Lipicky RJ (Oct 1982) Sodium currents in human skeletal muscle fibers., Muscle & nerve, 5 (8), 614-8 Abstract
  • DeCoursey TE, Bryant SH, Owenburg KM, Dependence of membrane potential on extracellular ionic concentrations in myotonic goats and rats, American Journal of Physiology, 240(1), C56-63, January 1981 Abstract
  • DeCoursey TE, Younkin SG, Bryant SH (Sep 1978) Neural control of chloride conductance in rat extensor digitorum longus muscle., Experimental neurology, 61 (3), 705-9 Abstract

Profile Details

Last Updated: 11/20/2009

COS Expertise ID #677552
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