Prof. Anneclaire J. De Roos

powered by
COS Expertise®
Fred Hutchinson Cancer Research Center
Public Health Sciences
Epidemiology
Assistant MemberAppointed: 2003
University of Washington
School of Public Health and Community Medicine
Environmental and Occupational Health Sciences
Adjunct Assistant ProfessorAppointed: 2005
University of Washington
School of Public Health and Community Medicine
Epidemiology
Assistant ProfessorAppointed: 2003

Mailing Address

1100 Fairview Avenue N.
P.O. Box 19024
M4-B874
Seattle, Washington 98109-1024
United States

Contact Information

Phone: (206) 667-7315
Fax: (206) 667-4787
deroos@u.washington.edu

Qualifications

Ph.D., University of North Carolina at Chapel Hill, Epidemiology, 2000.
M.P.H., University of California, Berkeley, Epidemiology/Biostatistics, 1995.
B.A., University of California, Los Angeles, Geography, 1990.

Expertise and Research Interests

Dr. De Roos's research interests and experience are primarily in the study of occupational and environmental exposures to chemicals and radiation as risk factors for cancer, other chronic diseases, and intermediate biologic effects. She has conducted population-based case-control studies of occupation and environmental exposures as risk factors for childhood neuroblastoma, adult brain tumors, and lymphomas.

A focus of Dr. De Roos' research is in health effects of exposure to persistent organic pollutants (POPs). In a study (Cancer Res, 2005) of POPs in plasma as contributors to non-Hodgkin lymphoma (NHL) risk, Dr. De Roos and colleagues found that certain moderate- and highly-chlorinated polychlorinated biphenyl (PCB) congeners were associated with approximately three-fold increased risk of NHL (comparing extreme quartiles). Each of the furan congeners they measured was associated with risk of NHL, as were total furans, with a significant trend across quartiles (p=0.006). The toxic equivalency quotient (TEQ), a summed metric that weights congeners by their dioxin-like potency, was associated with NHL, with 35% increased risk per 10 TEQ units. The results suggest that exposure to POPs, particularly certain PCBs and furans, significantly contributes to NHL risk.

In a new project, Dr. De Roos will investigate how PCB concentrations change during weight loss in a group of women participating in an exercise intervention trial, and how PCBs released from adipose tissue to blood during weight loss may affect immune function in these women.

Several of Dr. De Roos's studies are exploring the use of geographic information systems and historical geographically-referenced environmental surveillance data to estimate individual-level exposures. One project focuses on environmental exposure to industrial pollution as a risk factor for NHL, using data on current and historical industry locations, wind patterns, and census data. Another study focuses on air pollution in relation to immune function in the Puget Sound region, in collaboration with other investigators in the Fred Hutchinson Cancer Research Center.

Keywords

COS Keywords:

Autoimmunity, Biostatistics, Cancer Or Carcinogenesis, Environmental Health, Epidemiology, Lymphoma.

Additional Terms:

Autoimmune Disease, Cancer Epidemiology, Environmental Health, Lymphoma, Myeloma.

Memberships

International Society for Environmental Epidemiology

Honors and Awards

2001-2001, Intramural Research Award, Division of Cancer Epidemiology and Genetics, National Cancer Institute
2000-2000, Delta Omega National Honor Society in Public Health, Delta Omega National Honor Society

Previous Positions

2000-2002, Postdoctoral Fellow, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch
1990-1992, Environmental Scientist, AeroVironment, Inc.

Funding Received

  • National Institutes of Health/NIEHS: Energy Balance, Organochlorine Exposure, and Possible Toxicologic Effects, $100,000, 2007 to 2009.
  • Amgen, Inc: Descriptive Epidemiology of Clinical Couse of Myelodysplastic Syndromes (MDS) in a Health Maintenance Organization, $257,768, 2006 to 2008.
  • Transdisciplinary Research in Energetics and Cancer pilot award program/NCI: Energy Balance, Polychlorinated Biphenyl (PCB) Exposure and Possible Toxicologic Effects, $25,000, 2006 to 2007.
  • Fred Hutchinson Cancer Research Center, Hartwell Innovation Fund: Immunotoxicology of Persistent Organochlorine Pollutant Exposure from Weight Loss, $50,000, 2006 to 2007.
  • National Institutes of Health/NCI: Industrial Pollutants and Risk of Non-Hodgkin's Lymphoma, $100,000, 2005 to 2007.
  • NCI/SEER: Descriptive Epidemiology of Myelodysplastic Syndromes and Potential Space-Time Clustering in Incidence, $69,114, 2005 to 2006.
  • National Institutes of Health/NCI: Industrial Pollution and Risk of Non-Hodgkin's Lymphoma, $24,900, 2004 to 2005.
  • The Arthritis Foundation: Predictors of Work Disability in Rheumatoid Arthritis, $20,000, 1997 to 1999.

Publications

  • Searles Nielsen S, Mueller BA, De Roos AJ, Checkoway H (2007) Newborn screening archives as a specimen source for epidemiologic studies: Feasibility and potential for bias, Ann Epidemiol, In Press
  • Gold L, Ward MH, Dosemeci M, De Roos AJ (2007) Systemic autoimmune disease mortality and occupational exposures, Arthritis Rheum, In Press
  • Carlsten C, De Roos AJ, Kaufman JD, Checkoway H, Wener M, Seixas N (2007) Cell markers, cytokines, and immune parameters in cement mason apprentices, Arthritis Rheum, 51 (1), 147-53
  • Lee WJ, Purdue M, Stewart P, Schenk M, De Roos AJ, Cerhan JR, Severson RK, Cozen W, Hartge P, Blair A (2006) Occupational exposures to pesticides, asthma history, and the risk of non-Hodgkin lymphoma, Int J of Cancer, 118, 3174-6
  • De Roos AJ, Rothman N, Brown M, Bell DA, Pittman GS, Shapiro WR, Selker RG, Fine HA, Black PM, Inskip PD (2006) Variation in genes relevant to aromatic hydrocarbon metabolism and the risk of adult brain tumors, Neuro-Oncol, 8, 145-55
  • Gold L, De Roos AJ, Ray R, Wernli K, Fitzgibbons ED, Gao DL, Astrakianakis G, Thomas DB, Checkoway H (2006) Brain cancer and occupational exposures in a cohort of female textile workers in Shanghai, China, Scand J Work Environ Health, 32 (3), 178-84
  • Wernli KJ, Ray RM, Gao DL, De Roos AJ, Thoman DB, Checkoway H (2006) Reproductive risk factors and endometrial cancer, Cancer Causes Control, 17 (7), 949-55
  • De Roos AJ, Gold LS, Wang S, Harge P, Cerhan J, Cozen W, Yeager M, Chanock S, Severson R, Rothman N (2006) Metabolic gene variants and risk of non-Hodgkin lymphoma, Cancer Epidemiol Biomarkers Prev, 15, 1647-53
  • Checkoway H, Bhatti P, De Roos AJ (2006) Epidemiologic Approaches In Costa LG, Eaton DL (eds), Gene-Environment Interactions: Fundamentals of Ecogenetics, Hoboken, NJ, John Wiley & Sons (bookchapter)
  • De Roos AJ, Baris D, Weiss N, Herrinton L (2006) Multiple Myeloma In Schottenfeld D, Fraumeni JF Jr (eds), Cancer Epidemiology and Prevention, New York, NY, Oxford University Press, Inc. (bookchapter)
  • Searles Nielsen S, Mueller BA, De Roos AJ, Viernes HA, Farin FM, Checkoway H (2005) Risk of brain tumors in children and susceptibility to organophosphorus insecticides: The potential role of paraoxanase (PON1), Environ Health Perspect, 113, 909-13
  • Fesinmeyer MD, Austin MA, Li CI, De Roos AJ, Bowen DJ (2005) Differences in survival by histologic type of pancreatic cancer, Cancer Epidemiol Biomarkers Prev, 14 (7), 1766-73
  • Svec MA, Ward MH, Dosemeci M, Checkoway H, De Roos AJ (2005) Risk of lymphatic or hematopoietic cancer mortality with occupational exposure to animals or the public, Occup Environ Med, 62 (10), 726-35
  • De Roos AJ, Ray R, Gao DL, Wernli K, Fitzgibbons ED, Feng Z, Thomas DB, Checkoway H (2005) Colorectal cancer incidence among female textile workers in Shanghai, China: a case-cohort analysis of occupational exposures, Cancer Causes Control, 16 (10), 1177-88
  • De Roos AJ, Cooper GS, Alavanja MC, Sandler DP (2005) Rheumatoid arthritis among women in the Agricultural Health Study: Risk associated with farming activities and exposures, Ann Epidemiol, 15 (10), 762-70
  • De Roos AJ, Hartge P, Lubin J, Colt JS, Davis S, Cerhan JR, Patterson DG Jr, Severson R, Rothman N (2005) Persistent organochlorine chemicals in plasma and the risk of non-Hodgkin's lymphoma, Cancer Res, 65 (23), 11214-26
  • De Roos AJ, Blair A, Rusiecki J, Hoppin JA, Svec M, Dosemeci M, Sandler D, Alavanja MC (2005) Cancer Incidence Among Glyphosate-exposed Pesticide Applicators in the Agricultural Health Study Cohort, Environ Health Perspect (113), 49-54
  • Trivers K, De Roos AJ, Gammon MD, Vaughan TL, Risch HA, Olshan AF, Schoenberg JB, Mayne ST, Dubrow R, Stanford JL, Abrahamson P, Rotterdam H, West AB, Fraumeni JF Jr, Chow WH (2005) Demographic and Lifestyle Predictors of Survival in Patients With Esophageal Or Gastric Cancers, Clin Gastroenterol Hepatol (3), 225-30
  • Kirrane EF, Hoppin JA, Kamel F, Umbach DM, Boyes WK, De Roos AJ, Alavanja M, Sandler DP (2005) Retinal Degeneration and Other Eye Disorders in Wives of Farmer Pesticide Applicators Enrolled in the Agricultural Health Study, Am J Epidemiol, 161, 1020-9
  • Rajaraman P, De Roos AJ, Stewart PA, Linet MS, Fine HA, Shapiro WR, Selker RG, Black PM, Inskip PD (2004) Occupation and Risk of Meningioma and Acoustic Neuroma in the United States, Am J Indust Med, 45 (5), 395-407
  • Jordan JM, De Roos AJ, Renner JB, Luta G, Cohen A, Craft N, Helmick CG, Hochberg MC, Arab L (2004) A Case-control Study of Serum Tocopherols and the Alpha- to Gamma-tocopherol Ratio in Radiographic Knee Osteoarthritis: the Johnston County Osteoarthritis Project, Am J Epidemiol, 159 (10), 968-77
  • Rusiecki J, De Roos A, Lee WJ, Dosemeci M, Lubin J, Hoppin JA, Blair A, Alavanja MC (2004) Cancer Incidence Among Pesticide Applicators Exposed to Atrazine in the Agricultural Health Study, J Natl Cancer Inst, 96 (18), 1375-82
  • De Roos AJ, Baris D, Weiss N, Herrinton L (2004) Epidemiology of Multiple Myeloma In Malpas JS, Bergsagel DE, Kyle RA, Anderson DC (eds), Multiple Myeloma, USA, Elsevier, Inc. (bookchapter)
  • De Roos AJ (2004) Toxicological Considerations in the Application and Interpretation of Susceptibility Biomarkers in Epidemiolgical Studies, Mechanisms of Carcinogenesis - Contributions of Molecular Epidemiology, Lyon, France, IARC (bookchapter)
  • De Roos AJ, Rothman N, Inskip PD, Linet MS, Shapiro WR, Selker RG, Fine HA, Black PM, Pittman G, Bell D (2003) Genetic Polymorphisms in GSTM1, -P1, -T1 and CYP2E1 and the Risk of Adult Brain Tumors, Cancer Epidemiol Biomarkers Prev, 12 (1), 14-22
  • De Roos AJ, Stewart PA, Linet MS, Heineman EF, Dosemeci M, Wiklcosky T, Shapiro WR, Selker RG, Fine HA, Black PM, Inskip PD (2003) Occupation and Adult Glioma in the United States, Cancer Causes Control, 14 (2), 139-50
  • De Roos AJ, Zahm SH, Cantor KP, Weisenburger DD, Holmes FF, Burmeister LF, Blair A (2003) Integrative Assessment of Multiple Pesticides As Risk Factors for Non-Hodgkin's Lymphoma Among Men, Occup Environ Med, 60 (9), E11
  • De Roos AJ, Ward MH, Cantor KP, Lynch C (2003) Nitrate in Public Water Supplies and the Risk of Colon and Rectum Cancers, Epidemiology (14), 640-9
  • Travier N, Gridley G, De Roos AJ, Plato N, Moradi T, Boffetta P (2002) Cancer Incidence in Female and Male Dry Cleaning, Laundry or Ironing Workers: a Record-linkage Study in Sweden, Scand J Work Environ Health, 28 (5), 341-8
  • De Roos AJ, Teschke K, Savitz D, Poole C, Castleberry BH, Grufferman S, Olshan AF (2001) Parental Occupational Exposures to Electromagnetic Fields and Radiation and the Incidence of Neuroblastoma in Offspring, Epidemiology, 12 (5), 508-17
  • De Roos AJ, Poole C, Teschke K, Olshan AF (2001) An Application of Hierarchical Regression in the Investigation of Multiple Paternal Occupational Exposures and Neuroblastoma in Offspring, Am J Ind Med (39), 477-86
  • De Roos AJ, Olshan AF, Teschke K, Poole C, Savitz D, Blatt J, Castleberry B, Bonde M (2001) Am J Epidemiol, Parental Occupational Exposures to Chemicals and the Incidence of Neuroblastoma in Offspring (154), 106-14
  • De Roos AJ, Kohlmeier L, Luta G, Craft N, Renner J, Jordan JM (2001) Serum Carotenoids and Radiographic Knee Osteoarthritis: the Johnston County Osteoarthritis Project, Public Health Nutr, 4 (5), 935-42
  • Olshan AF, De Roos AJ, Teschke K, Neglia JP, Stram DO, Pollock BP, Castleberry RP (1999) Neuroblastoma and Parental Occupation, Cancer Causes Control (10), 539-49
  • De Roos AJ, Callahan LF (1999) Differences By Sex in Correlates of Work Status in Rheumatoid Arthritis Patients, Arthritis Care Res, 12 (6), 381-91

Profile Details

Last Verified: 8/20/2007

COS Expertise ID #1190887
Reference this profile directly: http://myprofile.cos.com/deroosa