Prof. Donghoon Lee

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University of Washington
School of Medicine
Department of Radology
Research Assistant ProfessorAppointed: 2004
Professional Headshot of Donghoon Lee

Mailing Address

University of Washington
Department of Radiology
Room AA-035, Box 357115
1959 Pacific Ave. NE
Seattle, Washington 98195
United States

Contact Information

Phone: (206) 685-2357
Fax: (206) 543-3495
dhoonlee@u.washington.edu

Qualifications

Ph.D., Brown University, Physics, 1991.
M.S., Brown University, Physics, 1988.
B.S., Sogang University, Physics, 1985.

Expertise and Research Interests

My research has been focused on absolute quantification using MR signal injection method, small animal MRI and MRS, and design of nonlinear gradient coils for MR.
* Absolute quantification: we have developed a novel, non-invasive method and device to accurately quantify metabolite concentrations in magnetic resonance (MR) measurements both in vitro and in vivo. Our approach uses synthetic reference signal injection method that uses inductively coupled MR-like signals. The method has several important advantages over other MR quantification methods including easier calibration and automatic adjustment for variable coil loading conditions.
* Animal MRI and MRS: the main goal of this interdisciplinary research is to develop smart MR contrast agents using functionalized nanoparticles and to achieve non-invasive target MR imaging for pediatric brain cancer and Huntington's disease. Also, we are interested in noninvasive MRI and MRS to investigate inflammatory and histopathological changes in muscular dystrophic animal models of dog and mouse.
* Gradient enhanced perfusion: the goal of this project is to build and test a combined RF/nonlinear gradient probe to improve time resolution and reduce tissue heating in FAWSETS perfusion measurements in skeletal muscle.

Other Expertise

Magnetic Resonance for Muscular Dystrophy
Magnetic Resonance Thermometry

Keywords

COS Keywords:

Magnetic Resonance, Magnetic Resonance Imaging, Physics, Radiology.

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)
Korean: (Fluent, Fluent, Fluent)

Memberships

International Society for Magnetic Resonance in Medicine
Korean Physical Society
Korean Society of Magnetic Resonance in Medicine
Korean Society of Medical and Biological Engineering

Honors and Awards

1991, Sigma Xi Award for Outstanding Research in Physics, Sigman Xi, Brown University
1985, Magna Cum Laude, Sogang University, Sogang University, Seoul, Korea

Previous Positions

2002-2004, Professor, Pai Chai University, Physics
1997-2002, Associate Professor, Pai Chai University, Physics
1993-1997, Assistant Professor, Pai Chai University, Physics
1992-1993, Visiting Scientist, University of California, Santa Barbara, Chemical and Nuclear Engineering
1991-1992, Research Fellow, Harvard University, Medicine, Pulmonary Unit and Critical Care
1991-1992, Post doctoral Fellow, Massachusetts Institute of Technology, Francis Bitter National Magnet Laboratory

Funding Received

  • National Institutes of Health (NIH): New Reference Signal Injection Method for In Vivo Quantification, 2009 to 2011.

Publications

  • Khokhlova TD, Canney MS, Lee D, Marro KI, Crum LA, Khokhlova VA, Bailey MR (Apr 2009) Magnetic resonance imaging of boiling induced by high intensity focused ultrasound., The Journal of the Acoustical Society of America, 125 (4), 2420-31 Abstract
  • Marro KI, Lee D, Shankland EG, Mathis CM, Hayes CE, Amara CE, Kushmerick MJ (Sep 2008) Synthetic signal injection using inductive coupling., Journal of magnetic resonance (San Diego, Calif. : 1997), 194 (1), 67-75 Abstract
  • Sun C, Fang C, Stephen Z, Veiseh O, Hansen S, Lee D, Ellenbogen RG, Olson J, Zhang M (Aug 2008) Tumor-targeted drug delivery and MRI contrast enhancement by chlorotoxin-conjugated iron oxide nanoparticles., Nanomedicine (London, England), 3 (4), 495-505 Abstract
  • Sun C, Veiseh O, Gunn J, Fang C, Hansen S, Lee D, Sze R, Ellenbogen RG, Olson J, Zhang M (Mar 2008) In vivo MRI detection of gliomas by chlorotoxin-conjugated superparamagnetic nanoprobes., Small (Weinheim an der Bergstrasse, Germany), 4 (3), 372-9 Abstract
  • Hatton BA, Villavicencio EH, Tsuchiya KD, Pritchard JI, Ditzler S, Pullar B, Hansen S, Knoblaugh SE, Lee D, Eberhart CG, Hallahan AR, Olson JM (Mar 2008) The Smo/Smo model: hedgehog-induced medulloblastoma with 90% incidence and leptomeningeal spread., Cancer research, 68 (6), 1768-76 Abstract
  • Marro KI, Lee D, Hyyti OM (Mar 2007) Nonlinear magnetic field gradients can reduce SAR in flow-driven arterial spin labeling measurements., Journal of magnetic resonance (San Diego, Calif. : 1997), 185 (1), 94-102 Abstract
  • Marcinek DJ, Schenkman KA, Ciesielski WA, Lee D, Conley KE (Dec 2005) Reduced mitochondrial coupling in vivo alters cellular energetics in aged mouse skeletal muscle., The Journal of physiology, 569 (Pt 2), 467-73 Abstract
  • Marro KI, Lee D, Hyyti OM (Aug 2005) Gradient-enhanced FAWSETS perfusion measurements., Journal of magnetic resonance (San Diego, Calif. : 1997), 175 (2), 185-92 Abstract
  • Veiseh O, Sun C, Gunn J, Kohler N, Gabikian P, Lee D, Bhattarai N, Ellenbogen R, Sze R, Hallahan A, Olson J, Zhang M (Jun 2005) Optical and MRI multifunctional nanoprobe for targeting gliomas., Nano letters, 5 (6), 1003-8 Abstract
  • Y. I. Lee, D. Y. Han, D. H. Lee, A. J. Woo, S. H. Lee, Y. K. Kim (2002) 11B NMR of Boron-doped Graphite as the Negative Electrode of a Lithium Secondary Battery, Carbon, 40, 403-408
  • D. H. Lee, S. H. Kim, S. T. Baek (2000) Design and Construction of Cylindrical Multi-Loop Z-gradient Coil for Linearity. Improvement in MRI, J Korea Soc Med Biol Eng, 21 (6), 583-589
  • Youngil Lee, Duk-young Han, Donghoon Lee, Ae Ja Woo, Sam Hyeon Lee, Kyung Han Kim, Man Ho Lee (1999) 11B Quadrupole Interaction Studies of Boron-doped Graphite Electrode for Lithium Rechargeable Battery, J Korean Magn Reson Soc, 3, 90-99
  • Donghoon Lee, Philip J Bray, Terry L. Aselage (1999) The NQR and NMR Studies of Icosahedral Borides, J Phys: Condensed Matter, 11 (22), 4435-4450
  • D. H. Lee, D. Y. Han (1998) Characterization of Borate Glasses Using Solid State Nutation NMR, J Korean Phys Soc, 32 (1), 93-96, Unpublished
  • D. H. Lee, J. I. Kim, H.K. Kim (1998) Investigation of Biochemical Changes in Skin Layers by NMR Microscopy, Skin Res and Techn, 4, 142-146
  • Tae-Sub Chung, Choong-Ki Eun, Jung-Ho Suh, Yoon-Chul Rhim, Donghoon Lee, Eun-Hao Jin (1997) An Experimental Study on Optimization of Parameter Values for Magnetic Resonance Angiography Using Phantom Model of Ulcerated Stenotic Internal Carotid Artery, J Korean Radiol Soc, 36, 545-552
  • D. H. Lee, S. S. Kim, Z. H. Cho, Y. B. Kim (1997) Application of NMR Microscopy for the Study of the Swelling Effect in Biopolymers, J. Korean Soc Med Biol Eng, 18 (2), 167-172
  • D. H. Lee, R. K. Ko, S. H. Yuk, Y. B. Kim (1997) Noninvasive Study of Drug Delivery Systems Using Nuclear Magnetic Resonance Microimaging, J Korean Soc Med Biol Eng, 18 (2), 173-178
  • T. S. Chung, D. H. Lee, K. S. Hong, D. G. Kim, D. Chien, T. Frenzel, and H. J. Weinmann (1997) What is optimal dose of Gd-DTPA in aortic blood during breath-hold 3D-TOF MRA?, High-power gradient MRI, Berlin, Vienna, Blackwell Wissenschafts-Verlag, 313-315 pages (bookchapter)
  • D. H. Lee, Z. H. Cho (1996) Observation of the Time Dependent Drug Release in a Drug Delivery System Using NMR Microimaging, J Korean Phys Soc, 29 (5), 682-685
  • D. H. Lee, R. K. Ko, Z. H. Cho, S. S. Kim (1996) Applications of NMR Imaging to the Time Dependent Swelling Effect in Polymers, Bio-Med Mat Eng: Internat J, 6 (5), 313-322
  • D. H. Lee, R. K. Ko, E. K. Jeong (1995) Development of Inside-out Probes for Both Nuclear Magnetic Resonance Imaging and Nuclear Magnetic Resonance Spectroscopy, J Korean Soc Med Biol Eng, 16, 309-316
  • Tae-Sub Chung, Eun-Kee Jeong, Yoon-Chul Rhim, Sung-Bin Kim, Donghoon Lee, Dae-In Kim (1994) Experimental Study on Blood Flow Patterns through the Phantoms of the Intracranial Arterial Aneurysms Using Color Doppler Imaging, J Korean Soc Med Ultrasound, 13, 217-223
  • E. W. McFarland, D Lee (1993) NMR Microscopy of Absorbed Protons in Palladium, J Magn Reson, 102A, 231-234
  • P. J. Bray, Donghoon Lee, Degen Mao (1992) NQR Studies of the Structure of Glasses and Crystalline Compounds, Z Naturforsch, 47a, 30-38
  • P. J. Bray, J. F. Emerson, Donghoon Lee (1991) NMR and NQR Studies of Glasses structure, J Noncrystal Solids, 129, 240-248
  • Donghoon Lee, P. J. Bray (1991) 27Al Nuclear Quadrupole Resonance (NQR) Study of Crystalline Aluminosilicates, J Magn Reson, 94, 51-58
  • Donghoon Lee, S. J. Gravina, P. J. Bray (1990) NQR Studies of Atomic Arrangements and Chemical Bonding in Glasses, Z Naturforsch, 45a, 268-272

Profile Details

Last Updated: 6/16/2009

COS Expertise ID #245347
Reference this profile directly: http://myprofile.cos.com/dhlee