Jos Domen

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Medical College of Wisconsin
Surgery
Cardiothoracic Surgery
Assistant ProfessorAppointed: 2007
Professional Headshot of Jos Domen

Mailing Address

CRI/TBRC Rm 4460
8701 Watertown Plank Road
Milwaukee, Wisconsin 53226
United States

Contact Information

Phone: (414) 955-2498
Fax: (414) 266-2075
adomen@mcw.edu

Qualifications

Ph.D., Netherlands Cancer Institute/University of Amsterdam, Oncology, 1993.

Expertise and Research Interests

Basic:
Development of the hematolymphoid system
Hematopoietic stem cell biology
Myeloid Progenitors
Cell culture model systems/embryonic stem cell differentiation
Apoptosis - esp. in the regulation of HSC
Lymphomagenesis/Leukemogenesis

Applied:
Hematopoietic stem cell/bone marrow transplantation
Hematopoietic Cell Transplantation and Tolerance induction
The role of apoptosis in HSC regulation during transplantation, irradiation, and chemotherapy

Keywords

COS Keywords:

Apoptosis, Bone Marrow, Cancer or Carcinogenesis, Cell Cloning, Health and Medicine, Hematology, Immune System, Immunology, Leukemia, Lymphoma, Oncology, Transgenics.

Additional Terms:

Apoptosis, Hematopoietic Stem Cells.

Languages

(Reading, Writing, Speaking)

Dutch: (Fluent, Fluent, Fluent)
English: (Fluent, Fluent, Fluent)

Memberships

American Association for the Advancement of Science
American Association of Immunologists
American Society for Bone Marrow Transplantation
American Society of Hematology
International Society for Stem Cell Research

Previous Positions

2005-2007, Research Assitant Professor, University of Arizona, Medicine, Surgery, Cardiovascular Surgery
2004-2005, Staff Scientist, Cellerant Therapeutics, San Carlos, CA
1999-2004, Assistant Research Professor, Duke University, Medical Center, Medicine, Cellular Therapy

Patents

Methods and compositions for modulating lifespan of hematolymphoid cells., Patent Number: 5614397, , Institution-owned, United States.

Funding Received

  • National Institutes of Health (NIH): FACS high throughput screening (F-HTS) of hematopoiesis (co-PI), Oct 2000 to Sep 2004.
  • Sydney Kimmel Foundation for Cancer Research: Altered susceptibility to apoptosis: consequences for donor and host cells in stem cell transplantation, Jul 2001 to Jun 2003.
  • National Institutes of Health (NIH): Application of expanded progenitors against infections, , 2005 to 2006.

Publications

  • Gandy, K., Domen, J., Copeland, J. (2007) Tolerance in heart transplantation: Current and future role, Immune Dysfunction and Immunotherapy in heart disease, Oxford, Blackwell Publishing (bookchapter)
  • Domen, J., Wagers, A., Weissman, I.L., Hematopoietic Stem Cells, Stem Cells: Scientific Progress and Futrure Research Directions at http://stemcells.nih.gov/info/scireport/2006report.htm, 2006
  • Federov, L.M., Muller, A.M., Amann, K., Schubert, H., Thomas, W.H., Domen, J., Kneitz, B. (2006) Renal failure causes early death of bcl-2 deficient mice, Mech. Aging Dev., 127, 600-609
  • Bouton LA, Ramirez CD, Bailey DP, Yeatman CF, Yue J, Wright HV, Domen J, Rosato RR, Grant S, Fischer-Stenger K, Ryan JJ (Dec 2004) Costimulation with interleukin-4 and interleukin-10 induces mast cell apoptosis and cell-cycle arrest: the role of p53 and the mitochondrion., Experimental Hematology, 32 (12), 1137-45 Abstract
  • Chen BJ, Cui X, Sempowski GD, Domen J, Chao NJ (Jun 2004) Hematopoietic stem cell dose correlates with the speed of immune reconstitution after stem cell transplantation., Blood, 103 (11), 4344-52 Abstract
  • Bailey DP, Kashyap M, Mirmonsef P, Bouton LA, Domen J, Zhu J, Dessypris EN, Ryan JJ, Interleukin-4 elicits apoptosis of developing mast cells via a Stat6-dependent mitochondrial pathway, Experimental Hematology, 32(1), 52-9, 2004 Abstract
  • Domen J, Weissman IL, Hematopoietic stem cells and other hematopoietic cells show broad resistance to chemotherapeutic agents in vivo when overexpressing bcl-2, Experimental Hematology, 31(7), 631-9, 2003 Abstract
  • Reya T, Duncan AW, Ailles L, Domen J, Scherer DC, Willert K, Hintz L, Nusse R, Weissman IL, A role for Wnt signalling in self-renewal of haematopoietic stem cells, Nature, 423(6938), 409-14, 2003 Abstract
  • Freeman JG, Ryan JJ, Shelburne CP, Bailey DP, Bouton LA, Narasimhachari N, Domen J, Simeon N, Couderc F, Stewart JK, Catecholamines in murine bone marrow derived mast cells, Journal of Neuroimmunology, 119(2), 231-8, October 2001 Abstract
  • Domen J, The role of apoptosis in regulating hematopoietic stem cell numbers, Apoptosis : an International Journal On Programmed Cell Death, 6(4), 239-52, August 2001 Abstract
  • Mebius RE, Miyamoto T, Christensen J, Domen J, Cupedo T, Weissman IL, Akashi K, The fetal liver counterpart of adult common lymphoid progenitors gives rise to all lymphoid lineages, CD45+CD4+CD3- cells, as well as macrophages, Journal of Immunology (baltimore, Md. : 1950), 166(11), 6593-601, June 2001 Abstract
  • Domen J, The role of apoptosis in regulating hematopoiesis and hematopoietic stem cells, Immunologic Research, 22(2-3), 83-94, March 2001 Abstract
  • Domen J, Weissman IL, Hematopoietic stem cells need two signals to prevent apoptosis, Journal of Experimental Medicine, 192(12), 1707-18, 2000 Abstract
  • Domen J, Cheshier SH, Weissman IL, The role of apoptosis in the regulation of hematopoietic stem cells: Overexpression of Bcl-2 increases both their number and repopulation potential, Journal of Experimental Medicine, 191(2), 253-64, 2000 Abstract
  • Gandy KL, Domen J, Aguila H, Weissman IL, CD8 TCR and CD8 TCR- cells in whole bone marrow facilitate the engraftment of hematopoietic stem cells across allogeneic barriers, Immunity, 11(5), 579-90, November 1999 Abstract
  • Ye SK, Maki K, Kitamura T, Sunaga S, Akashi K, Domen J, Weissman IL, Honjo T, Ikuta K, Induction of germline transcription in the TCRgamma locus by Stat5: implications for accessibility control by the IL-7 receptor, Immunity, 11(2), 213-23, August 1999 Abstract
  • Domen J, Weissman IL, Self-renewal, differentiation or death: regulation and manipulation of hematopoietic stem cell fate, Molecular Medicine Today, 5(5), 201-8, May 1999 Abstract
  • Akashi K, Kondo M, Cheshier S, Shizuru J, Gandy K, Domen J, Mebius R, Traver D, Weissman IL, Lymphoid development from stem cells and the common lymphocyte progenitors, Cold Spring Harbor Symposia On Quantitative Biology, 64, 1-12, 1999 Abstract
  • De Vivo I, Cui X, Domen J, Cleary ML, Growth stimulation of primary B cell precursors by the anti-phosphatase Sbf1, Proceedings of the National Academy of Sciences (USA), 95(16), 9471-6, 1998 Abstract
  • Domen J, Gandy KL, Weissman IL, Systemic overexpression of BCL-2 in the hematopoietic system protects transgenic mice from the consequences of lethal irradiation, Blood, 91(7), 2272-82, 1998 Abstract
  • Allen JD, Verhoeven E, Domen J, van der Valk M, Berns A, Pim-2 transgene induces lymphoid tumors, exhibiting potent synergy with c-myc, Oncogene, 15(10), 1133-41, 1997 Abstract
  • Kondo M, Akashi K, Domen J, Sugamura K, Weissman IL, Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common gamma chain-deficient mice, Immunity, 7(1), 155-62, July 1997 Abstract
  • Aguila HL, Akashi K, Domen J, Gandy KL, Lagasse E, Mebius RE, Morrison SJ, Shizuru J, Strober S, Uchida N, Wright DE, Weissman IL, From stem cells to lymphocytes: biology and transplantation, Immunological Reviews, 157, 13-40, June 1997 Abstract
  • Acton D, Jacobs H, Domen J, Berns A, Bcl-2 reduces lymphomagenesis in deltaV-TCRbeta transgenic mice, Oncogene, 14(21), 2497-501, 1997 Abstract
  • van der Lugt NM, Domen J, Verhoeven E, Linders K, van der Gulden H, Allen J, Berns A, Proviral tagging in E mu-myc transgenic mice lacking the Pim-1 proto-oncogene leads to compensatory activation of Pim-2, Embo Journal, 14(11), 2536-44, 1995 Abstract
  • van der Lugt NM, Domen J, Linders K, van Roon M, Robanus-Maandag E, te Riele H, van der Valk M, Deschamps J, Sofroniew M, van Lohuizen M, Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene, Genes and Development, 8(7), 757-69, 1994 Abstract
  • Berns A, van der Lugt N, Alkema M, van Lohuizen M, Domen J, Acton D, Allen J, Laird PW, Jonkers J, Mouse model systems to study multistep tumorigenesis, Cold Spring Harbor Symposia On Quantitative Biology, 59, 435-47, 1994 Abstract
  • Domen J, van der Lugt NM, Acton D, Laird PW, Linders K, Berns A, Pim-1 levels determine the size of early B lymphoid compartments in bone marrow, Journal of Experimental Medicine, 178(5), 1665-73, 1993 Abstract
  • Laird PW, van der Lugt NM, Clarke A, Domen J, Linders K, McWhir J, Berns A, Hooper M, In vivo analysis of Pim-1 deficiency, Nucleic Acids Research, 21(20), 4750-5, 1993 Abstract
  • Domen J, van der Lugt NM, Laird PW, Saris CJ, Clarke AR, Hooper ML, Berns A, Impaired interleukin-3 response in Pim-1-deficient bone marrow-derived mast cells, Blood, 82(5), 1445-52, 1993 Abstract
  • Domen J, van der Lugt NM, Laird PW, Saris CJ, Berns A, Analysis of Pim-1 function in mutant mice, Leukemia, 7 Suppl 2, S108-12, August 1993 Abstract
  • de Wind N, Domen J, Berns A, Herpesviruses encode an unusual protein-serine/threonine kinase which is nonessential for growth in cultured cells, Journal of Virology, 66(9), 5200-9, September 1992 Abstract
  • Acton D, Domen J, Jacobs H, Vlaar M, Korsmeyer S, Berns A, Collaboration of pim-1 and bcl-2 in lymphomagenesis, Current Topics in Microbiology and Immunology, 182, 293-8, 1992 Abstract
  • Saris CJ, Domen J, Berns A, The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUG, Embo Journal, 10(3), 655-64, March 1991 Abstract
  • Verbeek S, van Lohuizen M, van der Valk M, Domen J, Kraal G, Berns A, Mice bearing the E mu-myc and E mu-pim-1 transgenes develop pre-B-cell leukemia prenatally, Molecular and Cellular Biology, 11(2), 1176-9, February 1991 Abstract
  • van Lohuizen M, Verbeek S, Krimpenfort P, Domen J, Saris C, Radaszkiewicz T, Berns A, Predisposition to lymphomagenesis in pim-1 transgenic mice: cooperation with c-myc and N-myc in murine leukemia virus-induced tumors, Cell, 56(4), 673-82, 1989 Abstract
  • Domen J, Von Lindern M, Hermans A, Breuer M, Grosveld G, Berns A, Comparison of the human and mouse PIM-1 cDNAs: nucleotide sequence and immunological identification of the in vitro synthesized PIM-1 protein, Oncogene Research, 1(1), 103-12, June 1987 Abstract
  • Selten G, Cuypers HT, Boelens W, Robanus-Maandag E, Verbeek J, Domen J, van Beveren C, Berns A, The primary structure of the putative oncogene pim-1 shows extensive homology with protein kinases, Cell, 46(4), 603-11, 1986 Abstract
  • Domen J, van Leen RW, Lubsen NH, Schoenmakers JG, A vital staining method for measuring the efficiency of transfection of eucaryotic cells, Analytical Biochemistry, 155(2), 379-84, June 1986 Abstract
  • van Kuppevelt TH, Cremers FP, Domen JG, van Beuningen HM, van den Brule AJ, Kuyper CM, Ultrastructural localization and characterization of proteoglycans in human lung alveoli, European Journal of Cell Biology, 36(1), 74-80, January 1985 Abstract
  • Van Kuppevelt TH, Domen JG, Cremers FP, Kuyper CM, Staining of proteoglycans in mouse lung alveoli. I. Ultrastructural localization of anionic sites, Histochemical Journal, 16(6), 657-69, June 1984 Abstract
  • van Kuppevelt TH, Cremers FP, Domen JG, Kuyper CM, Staining of proteoglycans in mouse lung alveoli. II. Characterization of the Cuprolinic blue-positive, anionic sites, Histochemical Journal, 16(6), 671-86, June 1984 Abstract

Profile Details

Last Updated: 10/10/2007

COS Expertise ID #946115
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