Donald K. Clifton

powered by
COS Expertise®
University of Washington
School of Medicine
Obstetrics and Gynecology
ProfessorAppointed: 1993
Professional Headshot of Donald K. Clifton

Mailing Address

Box 356460
University of Washington
Seattle, Washington 98195
United States

Contact Information

Phone: (206) 685-1854
Fax: (206) 543-3915
don@u.washington.edu

Qualifications

Ph.D., University of California, Los Angeles, 1979.

Expertise and Research Interests

I am interested in the neuroendocrinology of reproduction, metabolism and growth. My laboratory uses in situ hybridization technology to study the neuropeptides and hormones that regulate pituitary function. Our current focus is on galanin-like peptide (GALP), galanin and leptin. The long-term goal of my research program is to develop an understanding the mechanisms that are responsible for the generation of pulsatile pituitary hormone secretion and to determine the neural elements that are involved in the feedback regulation of the pituitary.

Keywords

COS Keywords:

Brain, Central Nervous System, Endocrinology, Gene Expression, Genes, Growth Hormone, Nervous System, Neurobiology, Neuroendocrinology, Neurons, Obstetrics or Gynecology, Reproductive Biology, Reproductive Endocrinology.

Additional Terms:

Brain, Central Nervous System, Endocrinology, Female, Genes, Male, Nervous System, Neurobiology, Neurons, Regulation Gene Expression, Reproductive Biology.

Memberships

American Association for the Advancement of Science
Endocrine Society
Society for Neuroscience

Previous Positions

1987-1993, Associate Professor, University of Washington
1983-1987, Assistant Professor, University of Washington
1981-1982, Research Scientist, University of Washington
1979-1981, Postdoctoral Fellow, University of Washington
1972-1975, Biomedical Engineer, Oregon Regional Primate Research Center

Publications

  • Krasnow SM, Fraley GS, Schuh SM, Baumgartner JW, Clifton DK, Steiner RA, A role for galanin-like Peptide in the integration of feeding, body weight regulation, and reproduction in the mouse, Endocrinology, 144(3), 813-22, March 2003
  • Jureus A, Cunningham MJ, Li D, Johnson LL, Krasnow SM, Teklemichael DN, Clifton DK, Steiner RA, Distribution and regulation of galanin-like peptide (GALP) in the hypothalamus of the mouse, Endocrinology, 142(12), 5140-4, December 2001
  • Cheung CC, Thornton JE, Nurani SD, Clifton DK, Steiner RA, A reassessment of leptin's role in triggering the onset of puberty in the rat and mouse, Neuroendocrinology, 74(1), 12-21, July 2001 Abstract
  • Steiner RA, Hohmann JG, Holmes A, Wrenn CC, Cadd G, Jureus A, Clifton DK, Luo M, Gutshall M, Ma SY, Mufson EJ, Crawley JN, Galanin transgenic mice display cognitive and neurochemical deficits characteristic of Alzheimer's disease, Proceedings of the National Academy of Sciences (USA), 98(7), 4184-9, 2001 Abstract
  • Finn PD, Cunningham MJ, Rickard DG, Clifton DK, Steiner RA, Serotonergic neurons are targets for leptin in the monkey, Journal of Clinical Endocrinology and Metabolism, 86(1), 422-6, Jan 2001 Abstract
  • Cheung CC, Hohmann JG, Clifton DK, Steiner RA, Distribution of galanin messenger RNA-expressing cells in murine brain and their regulation by leptin in regions of the hypothalamus, Neuroscience, 103(2), 423-32, 2001 Abstract
  • Huizinga CT, Oudejans CB, Steiner RA, Clifton DK, Delemarre-van de Waal HA, Effects of intrauterine and early postnatal growth restriction on hypothalamic somatostatin gene expression in the rat, Pediatric Research, 48(6), 815-20, December 2000 Abstract
  • Finn PD, Pau KY, Spies HG, Cunningham MJ, Clifton DK, Steiner RA, Galanin's functional significance in the regulation of the neuroendocrine reproductive axis of the monkey, Neuroendocrinology, 71(1), 16-26, Jan 2000 Abstract
  • Hohmann JG, Teal TH, Clifton DK, Davis J, Hruby VJ, Han G, Steiner RA, Differential role of melanocortins in mediating leptin's central effects on feeding and reproduction, American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 278(1), R50-9, Jan 2000 Abstract
  • Cheung CC, Clifton DK, Steiner RA, Perspectives on leptin's role as a metabolic signal for the onset of puberty, Frontiers of Hormone Research, 26, 87-105, 2000 Abstract
  • Cunningham MJ, Clifton DK, Steiner RA, Leptin''s actions on the reproductive axis: perspectives and mechanisms., Biology of Reproduction, 60(2), 216-22, February 1999 Abstract
  • Hohmann JG, Clifton DK, Steiner RA, Galanin: analysis of its coexpression in gonadotropin-releasing hormone and growth hormone-releasing hormone neurons., Annals of the New York Academy of Sciences, 863, 221-35, 21 Dec 1998 Abstract
  • Finn P D, Steiner R A, Clifton D K, Temporal patterns of gonadotropin-releasing hormone (GnRH), c-fos, and galanin gene expression in GnRH neurons relative to the luteinizing hormone surge in the rat., Journal of Neuroscience, 18(2), 713-9, 15 Jan 1998 Abstract
  • Finn PD, Steiner RA, Clifton DK, Temporal patterns of gonadotropin-releasing hormone \(GnRH\), c-fos, and galanin gene expression in GnRH neurons relative to the luteinizing hormone surge in the rat., Journal of Neuroscience, 18(2), 713-9, 15 1998 Abstract
  • Thornton J E, Cheung C C, Clifton D K, Steiner R A, Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice., Endocrinology, 138(11), 5063-6, November 1997 Abstract
  • Cheung C C, Clifton D K, Steiner R A, Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus., Endocrinology, 138(10), 4489-92, October 1997 Abstract
  • Cheung C C, Thornton J E, Kuijper J L, Weigle D S, Clifton D K, Steiner R A, Leptin is a metabolic gate for the onset of puberty in the female rat., Endocrinology, 138(2), 855-8, February 1997 Abstract
  • Chan Y Y, Grafstein-Dunn E, Delemarre-van de Waal H A, Burton K A, Clifton D K, Steiner R A, The role of galanin and its receptor in the feedback regulation of growth hormone secretion., Endocrinology, 137(12), 5303-10, December 1996 Abstract
  • Finn P D, McFall T B, Clifton D K, Steiner R A, Sexual differentiation of galanin gene expression in gonadotropin-releasing hormone neurons., Endocrinology, 137(11), 4767-72, November 1996 Abstract
  • Barash I A, Cheung C C, Weigle D S, Ren H, Kabigting E B, Kuijper J L, Clifton D K, Steiner R A, Leptin is a metabolic signal to the reproductive system., Endocrinology, 137(7), 3144-7, July 1996 Abstract
  • Rossmanith W G, Clifton D K, Steiner R A, Galanin gene expression in hypothalamic GnRH-containing neurons of the rat: a model for autocrine regulation., Hormone and Metabolic Research, 28(6), 257-66, June 1996 Abstract
  • Chan Y Y, Steiner R A, Clifton D K, Regulation of hypothalamic neuropeptide-Y neurons by growth hormone in the rat., Endocrinology, 137(4), 1319-25, April 1996 Abstract
  • Rossmanith W G, Marks D L, Clifton D K, Steiner R A, Induction of galanin mRNA in GnRH neurons by estradiol and its facilitation by progesterone., Journal of Neuroendocrinology, 8(3), 185-91, March 1996 Abstract
  • Rossmanith W G, Marks D L, Steiner R A, Clifton D K, Inhibition of steroid-induced galanin mRNA expression in GnRH neurons by specific NMDA-receptor blockade., Journal of Neuroendocrinology, 8(3), 179-84, March 1996 Abstract
  • Chan Y Y, Clifton D K, Steiner R A, Role of NPY neurones in GH-dependent feedback signalling to the brain., Hormone Research, 45 Suppl 1, 12-4, 1996 Abstract
  • Klein N A, Battaglia D E, Clifton D K, Bremner W J, Soules M R, The gonadotropin secretion pattern in normal women of advanced reproductive age in relation to the monotropic FSH rise., Journal of The Society for Gynecologic Investigation, 3(1), 27-32, January 1996 Abstract
  • Chan, Y.Y., Steiner, R.A., and Clifton, D.K., Regulation of hypothalamic neuropeptide-Y neurons by growth hormone in the rat, Endocrinology, 1996
  • Burton K A, Kabigting E B, Steiner R A, Clifton D K, Identification of target cells for growth hormone's action in the arcuate nucleus., American Journal of Physiology, 269(4 Pt 1), E716-22, October 1995 Abstract
  • Burton, K.A., Kabigting, E.B., Steiner, R.A., and Clifton, D.K., Identification of target cells for growth hormone1s action in the arcuate nucleus, American Journal of Physiology, 269, E716-722, 1995
  • Grafstein-Dunn E, Clifton D K, Steiner R A, Regulation of galanin and gonadotropin-releasing hormone gene expression in the hypothalamus and basal forebrain of the rat., Hormones and Behavior, 28(4), 417-23, December 1994 Abstract
  • Steiner R A, Kabigting E, Lent K, Clifton D K, Diurnal rhythm in proopiomelanocortin mRNA in the arcuate nucleus of the male rat., Journal of Neuroendocrinology, 6(6), 603-8, December 1994 Abstract
  • Rossmanith W G, Marks D L, Clifton D K, Steiner R A, Induction of galanin gene expression in gonadotropin-releasing hormone neurons with puberty in the rat., Endocrinology, 135(4), 1401-8, October 1994 Abstract
  • Jordan J, Craig K, Clifton D K, Soules M R, Luteal phase defect: the sensitivity and specificity of diagnostic methods in common clinical use [see comments], Fertility and Sterility, 62(1), 54-62, July 1994 Abstract
  • Soules M R, Merriggiola M C, Steiner R A, Clifton D K, Toivola B, Bremner W J, Short-term fasting in normal women: absence of effects on gonadotrophin secretion and the menstrual cycle., Clinical Endocrinology, 40(6), 725-31, June 1994 Abstract
  • Marks D L, Lent K L, Rossmanith W G, Clifton D K, Steiner R A, Activation-dependent regulation of galanin gene expression in gonadotropin-releasing hormone neurons in the female rat [see comments], Endocrinology, 134(5), 1991-8, May 1994 Abstract
  • Delemarre-van de Waal H A, Burton K A, Kabigting E B, Steiner R A, Clifton D K, Expression and sexual dimorphism of galanin messenger ribonucleic acid in growth hormone-releasing hormone neurons of the rat during development., Endocrinology, 134(2), 665-71, February 1994 Abstract
  • Grossman A B, Rossmanith W G, Kabigting E B, Cadd G, Clifton D, Steiner R A, The distribution of hypothalamic nitric oxide synthase mRNA in relation to gonadotrophin-releasing hormone neurons., Journal of Endocrinology, 140(2), R5-8, February 1994 Abstract
  • Delemarre-van de Waal, H.A., Burton, K.A., Kabigting, E.B., Steiner, R.A., and Clifton, D.K., Expression and sexual dimorphism of galanin messenger ribonucleic acid in growth hormone-releasing hormone neurons of the rat during development, Endocrinology, 134, 665-671, 1994
  • Marks D L, Smith M S, Clifton D K, Steiner R A, Regulation of gonadotropin-releasing hormone (GnRH) and galanin gene expression in GnRH neurons during lactation in the rat [published erratum appears in Endocrinology 1994 Jan;134(1):498], Endocrinology, 133(3), 1450-8, September 1993 Abstract
  • Marks D L, Smith M S, Vrontakis M, Clifton D K, Steiner R A, Regulation of galanin gene expression in gonadotropin-releasing hormone neurons during the estrous cycle of the rat., Endocrinology, 132(4), 1836-44, April 1993 Abstract
  • Bergendahl M, Wiemann J N, Clifton D K, Huhtaniemi I, Steiner R A, Short-term starvation decreases POMC mRNA but does not alter GnRH mRNA in the brain of adult male rats., Neuroendocrinology, 56(6), 913-20, December 1992 Abstract
  • Burton K A, Kabigting E B, Clifton D K, Steiner R A, Growth hormone receptor messenger ribonucleic acid distribution in the adult male rat brain and its colocalization in hypothalamic somatostatin neurons., Endocrinology, 131(2), 958-63, August 1992 Abstract
  • Burton, K.A., Kabigting, E.B., Clifton, D.K., and Steiner, R.A., Growth hormone receptor mRNA distribution in the adult male rat brain and its co-localization in hypothalamic somatostatin neurons, Endocrinology, 130, 958-963, 1992
  • Zeitler P, Tannenbaum G S, Clifton D K, Steiner R A, Ultradian oscillations in somatostatin and growth hormone-releasing hormone mRNAs in the brains of adult male rats [published erratum appears in Proc Natl Acad Sci U S A 1992 Mar 1;89(5):1997], Proceedings of the National Academy of Sciences (USA), 88(20), 8920-4, 15 Oct 1991 Abstract
  • Soules M R, Bremner W J, Steiner R A, Clifton D K, Prolactin secretion and corpus luteum function in women with luteal phase deficiency., Journal of Clinical Endocrinology and Metabolism, 72(5), 986-92, May 1991 Abstract
  • Argente J, Chowen J A, Zeitler P, Clifton D K, Steiner R A, Sexual dimorphism of growth hormone-releasing hormone and somatostatin gene expression in the hypothalamus of the rat during development., Endocrinology, 128(5), 2369-75, May 1991 Abstract
  • Soules M R, Bremner W J, Dahl K D, Rivier J E, Vale W W, Clifton D K, The induction of premature luteolysis in normal women--follicular phase luteinizing hormone secretion and corpus luteum function in the subsequent cycle., American Journal of Obstetrics and Gynecology, 164(4), 989-94; discussion 9, April 1991 Abstract
  • Adams L A, Vician L, Clifton D K, Steiner R A, Testosterone regulates pro-opiomelanocortin gene expression in the primate brain., Endocrinology, 128(4), 1881-6, April 1991 Abstract
  • Nakajima S T, McLachlan R I, Cohen N L, Clifton D K, Bremner W J, Soules M R, The immunoreactive inhibin secretion pattern in the midluteal phase: relationships with luteinizing hormone and progesterone., Clinical Endocrinology, 33(6), 709-17, December 1990 Abstract
  • Chowen J A, Argente J, Vician L, Clifton D K, Steiner R A, Pro-opiomelanocortin messenger RNA in hypothalamic neurons is increased by testosterone through aromatization to estradiol., Neuroendocrinology, 52(6), 581-8, December 1990 Abstract
  • Argente J, Chowen-Breed J A, Steiner R A, Clifton D K, Somatostatin messenger RNA in hypothalamic neurons is increased by testosterone through activation of androgen receptors and not by aromatization to estradiol., Neuroendocrinology, 52(4), 342-9, October 1990 Abstract
  • Zeitler P, Vician L, Chowen-Breed J A, Argente J, Tannenbaum G S, Clifton D K, Steiner R A, Regulation of somatostatin and growth hormone-releasing hormone gene expression in the rat brain., Metabolism: Clinical and Experimental, 39(9 Suppl 2), 46-9, September 1990 Abstract
  • Zeitler P, Argente J, Chowen-Breed J A, Clifton D K, Steiner R A, Growth hormone-releasing hormone messenger ribonucleic acid in the hypothalamus of the adult male rat is increased by testosterone., Endocrinology, 127(3), 1362-8, September 1990 Abstract
  • Wiemann J N, Clifton D K, Steiner R A, Gonadotropin-releasing hormone messenger ribonucleic acid levels are unaltered with changes in the gonadal hormone milieu of the adult male rat., Endocrinology, 127(2), 523-32, August 1990 Abstract
  • Fujimoto V Y, Clifton D K, Cohen N L, Soules M R, Variability of serum prolactin and progesterone levels in normal women: the relevance of single hormone measurements in the clinical setting [see comments], Obstetrics and Gynecology, 76(1), 71-8, July 1990 Abstract
  • Chowen-Breed J A, Steiner R A, Clifton D K, Sexual dimorphism and testosterone-dependent regulation of somatostatin gene expression in the periventricular nucleus of the rat brain., Endocrinology, 125(1), 357-62, July 1989 Abstract
  • Wiemann J N, Clifton D K, Steiner R A, Pubertal changes in gonadotropin-releasing hormone and proopiomelanocortin gene expression in the brain of the male rat., Endocrinology, 124(4), 1760-7, April 1989 Abstract

Profile Details

Last Updated: 2/26/2003

COS Expertise ID #307389
Reference this profile directly: http://myprofile.cos.com/donclifton