Dr. M. Tevfik Dorak

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HUMIGEN LLC, The Institute for Genetic Immunology
Genomic Immunoepidemiology Division
Head of DivisionAppointed: 2007
Professional Headshot of M. Tevfik Dorak

Mailing Address

Humigen LLC
2439 Kuser Road
Hamilton, New Jersey 08690
United States

Contact Information

dorakmt@lycos.com
http://www.dorak.info

Qualifications

Ph.D., University of Wales, Medicine, 2000.
B.A. (Hons), Open University, 1998.
M.D., Hacettepe University, Medicine, 1982.

Expertise and Research Interests

Molecular Genetics
Cancer Genetic Epidemiology
Genomic Immunoepidemiology of Childhood Leukemia
Genetic Susceptibility to Leukemia and Cancer Mediated by Iron-related Genes
Non-HLA Genes of the Extended HLA Complex

Other Expertise

Immunogenetic Analysis of HIV-related Kaposi's Sarcoma
Population Genetics of the HLA Genes

Future Research

Genetic Basis of Gender Effect in Childhood Cancers
Genetic Basis of Birthweight and Miscarriage Associations in Childhood Leukaemia

Keywords

COS Keywords:

Biostatistics, Bone Marrow Transplantation, Cancer or Carcinogenesis, Epidemiology, Genetics, Hematology, Human Population and Genetics, Immunogenetics, Leukemia, Organ Transplantation, Pediatrics, Surgery.

Additional Terms:

Childhood Cancer Epidemiology, Genetic Epidemiology, Immunogenetics, Leukaemia, Population Genetics.

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)
Turkish: (Fluent, Fluent, Fluent)

Memberships

British Society for Histocompatibility and Immunogenetics
European Association for Cancer Research
European Federation for Immunogenetics
Genetical Society of Great Britain

Honors and Awards

2005, HFE Gene Expert, NIH Genetic Associations Database
2003, Editorial Board Member, Genes & Immunity
2002, Best Overseas Abstract, BSHI, Immunogenetics
1994, Outstanding Abstract, ASHI Scholar, ASHI, Immunogenetics
1988-1989, Clinical Fellowship, British Council, Glasgow University, Bone Marrow Transplantation

Previous Positions

2004-2007, Principal Research Associate, University of Newcastle upon Tyne, School of Clinical Medical Sciences, Child Health
2001-2004, Assistant Professor, University of Alabama at Birmingham, Public Health, Epidemiology, Program in Epidemiology of Infection and Immunity
2000-2001, Assistant Professor, University of Tennessee, Medicine, Surgery, Transplantation
1992-2000, Lecturer, University of Wales College of Medicine, Medicine, Haematology

Funding Received

  • Tyneside Leukaemia Research Association (UK): Establishing a DNA collection for case-control studies in childhood A.L.L, £20,273, 2006 to 2007.
  • Children with Leukaemia (UK): Genes Influencing Body Iron Content and Childhood Leukaemia Risk, £98,912, 2005 to 2007.

Publications

  • Dorak MT (2007) Role of Natural Killer Cell and Killer Immunoglobulin-like Receptor Polymorphisms, Methods in Molecular Medicine Vol 134: Bone Marrow and Stem Cell Transplantation, New Jersey, Humana Press, 123-144 pages, ISBN=978-1-58829-5 (bookchapter)
  • Dorak MT, McNally RJQ, Parker L (2007) Childhood Acute Lymphoblastic Leukemia and Infections., American Journal of Epidemiology, In Press
  • Dorak MT, Pearce MS, Hammal DM, McNally RJQ, Parker L (2007) Examination of Gender Effect in Birth Weight and Miscarriage Associations with Childhood Cancer, Cancer Causes & Control, 18 (3), 219-28
  • Tang J, Tang S, Rivers CA, Dorak MT, Penman-Aguilar A, Aldrovandi A, Allen S, Karita E, Musonda R, Kaslow RA (2007) Distinct and evolving HLA class I profiles in native Africans with high prevalence of HIV/AIDS In Hansen JA, Dupont B (eds), HLA 2004: Immunobiology of the Human MHC. MHC: Proceedings of the 13th International Histocompatibility Workshop and Congress, Vol 2 Edition, Seattle, IHWG Press, 402-407 pages (bookchapter)
  • Dorak MT (2006) Commentary: HFE H63D variant and leukemia, Leukemia & Lymphoma, 47 (11), 2269-70
  • Dorak MT, Shao W, Machulla HKG, Lobashevsky ES, Tang J, Park MH, Kaslow RA (1 September 2006) Conserved extended haplotypes of the major histocompatibility complex: further characterization, Genes Immun, 7 (6), 450-67
  • Dorak MT (Ed.) (2006) Real-Time PCR, Advanced Methods Series, Oxford (UK), Taylor & Francis, ISBN=041537734X
  • Dorak MT, Burnett AK, Worwood M, HFE Gene Mutations in Susceptibility to Childhood Leukemia: HuGE Review, Genetics in Medicine, 7(3), 159-168, 18 March 2005
  • Dorak MT, Yee LJ, Tang J, Shao W, Lobashevsky ES, Jacobson LP, Kaslow RA, HLA-B, -DRB1/3/4/5 and -DQB1 Gene Polymorphisms in Human Immunodeficiency Virus-related Kaposi's Sarcoma, Journal of Molecular Virology, 76(3), 302-10, 18 May 2005
  • Tang J, Shao W, Dorak MT, Li Y, Miike R, Lobashevsky E, Wiencke JK, Wrensch M, Kaslow RA, Cobbs CS, Positive and Negative Associations of Human Leukocyte Antigen (HLA) Variants With the Onset and Prognosis of Adult Glioblastoma Multiforme (GBM), Cancer Epidemiology, Biomarkers & Prevention, 14(8), 2040-4, 1 Aug 2005
  • Kaslow RA, Dorak MT, Tang J, Influence of Host Genetic Variation on Susceptibility to HIV Type 1 Infection., Journal of Infectious Diseases, 191 Suppl 1, S68-77, Feb 2005 Abstract
  • Dorak MT, Tang J, Penman-Aguilar A, Westfall AO, Zulu IS, Lobashevsky ES, Schaen MM, Kancheya NG, Allen SA, Kaslow RA, Association of HLA-B Allele Sharing and Individual HLA Class I Markers with Transmission of HIV-1C in Serodiscordant Heterosexual Zambian Couples, Lancet, 363, 2137-9, 26 Jun 2004
  • Shao W, Tang J, Dorak MT, Song W, Lobashevsky E, Cobbs CS, Wrensch MR, Kaslow RA, Molecular typing of human leukocyte antigen and related polymorphisms following whole genome amplification, Tissue Antigens, 64(3), 286-92, 1 May 2004
  • Shao W, Lobashevsky ES, Kaslow RA, Dorak MT, MICA intron 1 sequences of conserved extended HLA haplotypes: Implications for sequencing-based typing, Genes & Immunity, 5(5), 371-4, April 2004
  • Uyar FA, Dorak MT, Saruhan-Direskeneli G, Human leukocyte antigen-A, -B and -C alleles and human leukocyte antigen haplotypes in Turkey: relationship to other populations, Tissue Antigens, 64(2), 180-7, 2004
  • Dorak MT, Tang J, Tang S, Penman-Aguilar A, Coutinho RA, Goedert JJ, Detels R, Kaslow RA, Influence of human leukocyte antigen-B22 alleles on the course of human immunodeficiency virus type 1 infection in 3 cohorts of white men, Journal of Infectious Diseases, 188(6), 856-63, 15 Sep 2003
  • Oguz FS, Kalayoglu S, Diler AS, Tozkir H, Sargin D, Carin M, Dorak MT, HLA system affects the age-at-onset in chronic myeloid leukemia, American Journal of Hematology, 73(4), 256-62, August 2003 Abstract
  • Machulla HK, Batnasan D, Steinborn F, Uyar FA, Saruhan-Direskeneli G, Oguz FS, Carin MN, Dorak MT, Genetic affinities among Mongol ethnic groups and their relationship to Turks, Tissue Antigens, 61(4), 292-9, April 2003 Abstract
  • Kotb M, Norrby-Teglund A, McGeer A, El-Sherbini H, Dorak MT, Khurshid A, Green K, Peeples J, Wade J, Thomson G, Schwartz B, Low DE, An immunogenetic and molecular basis for differences in outcomes of invasive group A streptococcal infections, Nature Medicine, 8(12), 1398-404, December 2002 Abstract
  • Sabek O, Dorak MT, Kotb M, Gaber AO, Gaber L, Quantitative detection of T-cell activation markers by real-time PCR in renal transplant rejection and correlation with histopathologic evaluation, Transplantation, 74(5), 701-7, September 2002 Abstract
  • Dorak MT, Lawson T, Machulla HK, Mills KI, Burnett AK, Increased heterozygosity for MHC class II lineages in newborn males, Genes and Immunity, 3(5), 263-9, Aug 2002 Abstract
  • Dorak MT, Oguz FS, Yalman N, Diler AS, Kalayoglu S, Anak S, Sargin D, Carin M, A male-specific increase in the HLA-DRB4 (DR53) frequency in high-risk and relapsed childhood ALL, Leukemia Research, 26(7), 651-6, July 2002 Abstract
  • Oguz FS, Yalman N, Diler AS, Oguz R, Anak S, Dorak MT, HLA-DRB1*15 and pediatric aplastic anemia, Haematologica, 87(7), 772-4, July 2002
  • Dorak MT, Burnett AK, Worwood M, Hemochromatosis gene in leukemia and lymphoma, Leukemia and Lymphoma, 43(3), 467-77, March 2002
  • Dorak MT, Book Review: Basic Immunology: Functions and Disorders of the Immune System by Abbas & Lichtman, American Journal of Epidemiology, 155(2), 185-6, January 2002
  • Dorak MT, Folayan GO, Niwas S, van Leeuwen DJ, Yee LJ, Tang J, Kaslow RA, C-C chemokine receptor 2 and C-C chemokine receptor 5 genotypes in patients treated for chronic hepatitis C virus infection, Immunologic Research, 26(1-3), 167-75, 2002 Abstract
  • Kaslow RA, Dorak MT, Tang J, Is protection in HIV infection due to Bw4 or not to Bw4?, Lancet Infectious Diseases, 1(4), 221-2, October 2001
  • Dorak MT, Sproul AM, Gibson BES, Burnett AK, Worwood M, The C282Y mutation of HFE is another male-specific risk factor for childhood ALL (letter), Blood, 94(11), 3957-8, December 1999
  • Dorak MT, Lawson T, Machulla HKG, Darke C, Mills KI, Burnett AK, Unravelling an HLA-DR association in childhood acute lymphoblastic leukemia, Blood, 94(2), 694-700, July 1999
  • Dorak MT & Poynton CH (1998) HLA Matching and Compatibility Testing In Barrett J & Treleaven J (eds), The Clinical Practice of Stem-Cell Transplantation, Oxford, Isis Medical Media Ltd, 325-50 pages (bookchapter)
  • Martin MP, Dorak MT, Carrington M (2007) Killer Immunoglobulin-like and related receptors: Genes, variation, and pathophysiologic mechanisms, Genetic Susceptibility to Infectious Diseases, Oxford, Oxford University Press, In Press (bookchapter)
  • Dorak MT, The implications for childhood leukemia of infection with adenovirus (review), Trends in Microbiology, 4, 60-3, 1996
  • Dorak MT, Machulla HKG, Hentschel M, Mills KI, Langner J, Burnett AK, The influence of homozygosity for HLA-DR53 on the age at onset in chronic lymphoid leukaemia, International Journal of Cancer, 65, 134-9, 1996
  • Dorak MT, Mills KI, Gaffney D, Wilson DW, Galbraith I, Henderson N, Burnett AK, Homozygous MHC genotypes and longevity, Human Heredity, 44, 271-8, 1994
  • Dorak MT & Burnett AK, Molecular mimicry of an HLA-DR53 epitope by viruses (letter), Immunology Today, 15, 138-9, 1994
  • Dorak MT, Chalmers EA, Gaffney D, Wilson DWL, Galbraith I, Henderson N, Worwood M, Mills KI, Burnett AK, Human major histocompatibility complex contains several leukemia susceptibility genes, Leukemia and Lymphoma, 12, 211-22, 1994
  • Dorak MT, Chalmers EA, Sproul AM, Mills KI, Wilson DWL, Galbraith I, Henderson N, Gibson BES, Burnett AK, MHC class III polymorphisms in selection of donors for bone marrow transplantation, Bone Marrow Transplantation, 11, 37-41, 1993

Profile Details

Last Verified: 8/7/2007

COS Expertise ID #321487
Reference this profile directly: http://myprofile.cos.com/dorakmt