Daniel Steinberg

powered by
COS Expertise®
University of California, San Diego
School of Medicine
Medicine
Endocrinology/Metabolism
Professor

Mailing Address

1080 BSB
University of California, San Diego
La Jolla, California 92093
United States

Contact Information

Phone: (858) 534-0569
Fax: (858) 534-2005
dsteinberg@ucsd.edu

Qualifications

Ph.D., Harvard Medical School, 1951.
M.D., Wayne State University, School Of Medicine, 1944.

Expertise and Research Interests

Biosynthesis, secretion and catabolism of the plasma lipoproteins; physiologic and pharmacalogic regulation of plasma cholesterol levels; interactions between lipoproteins and the cellular components of the artery wall in relationship to atherogenesis; biology of the macrophage/foam cell; molecular biology of receptors involved in lipoprotein uptake.

Keywords

COS Keywords:

Biosynthesis, Blood Diseases, Cardiology, Cardiopulmonary Chest Medicine, Cardiovascular System, Cell Biology, Cholesterol, Lipoproteins, Metabolism, Molecular Biology, Molecular Cellular Entities, Pulmonary Diseases, Respiratory Diseases.

Additional Terms:

Atherosclerosis, Lipoproteins, Metabolism.

Memberships

American Heart Association
American Society for Biochemistry and Molecular Biology
American Society for Clinical Investigation
Association of American Physicians
National Academy of Sciences

Previous Positions

1951-1968, Chief,, National Institute of Health (NIH), Laboratory of Metabolism, NHLBI

Funding Received

  • National Institutes of Health (NIH), 5 P50 HL14197-25, SCOR IN ARTERIOSCLEROSIS, $2,444,252, 1996

Publications

  • Kurushima H, Ramprasad M, Kondratenko N, Foster DM, Quehenberger O, Steinberg D, Surface expression and rapid internalization of macrosialin \(mouse CD68\) on elicited mouse peritoneal macrophages., Journal of Leukocyte Biology, 67(1), 104-8, 2000 Abstract
  • Steinberg D, At last, direct evidence that lipoxygenases play a role in atherogenesis [comment, Journal of Clinical Investigation, 103(11), 1487-8, June 1999 Abstract
  • Yoshida H, Kondratenko N, Green S, Steinberg D, Quehenberger O, Identification of the lectin-like receptor for oxidized low-density lipoprotein in human macrophages and its potential role as a scavenger receptor., Biochemical Journal, 334 ( Pt 1), 9-13, 15 Aug 1998 Abstract
  • Yoshida H, Quehenberger O, Kondratenko N, Green S, Steinberg D, Minimally oxidized low-density lipoprotein increases expression of scavenger receptor A, CD36, and macrosialin in resident mouse peritoneal macrophages., Arteriosclerosis, Thrombosis, and Vascular Biology, 18(5), 794-802, May 1998 Abstract
  • Bird D A, Tangirala R K, Fruebis J, Steinberg D, Witztum J L, Palinski W, Effect of probucol on LDL oxidation and atherosclerosis in LDL receptor-deficient mice., Journal of Lipid Research, 39(5), 1079-90, May 1998 Abstract
  • Terpstra V, Bird D A, Steinberg D, Evidence that the lipid moiety of oxidized low density lipoprotein plays a role in its interaction with macrophage receptors., Proceedings of the National Academy of Sciences (USA), 95(4), 1806-11, 17 Feb 1998 Abstract
  • Sambrano G R, Terpstra V, Steinberg D, Independent mechanisms for macrophage binding and macrophage phagocytosis of damaged erythrocytes. Evidence of receptor cooperativity., Arteriosclerosis, Thrombosis, and Vascular Biology, 17(12), 3442-8, December 1997 Abstract
  • Steinberg D, Low density lipoprotein oxidation and its pathobiological significance., Journal of Biological Chemistry, 272(34), 20963-6, 22 Aug 1997 Abstract
  • Terpstra V, Kondratenko N, Steinberg D, Macrophages lacking scavenger receptor A show a decrease in binding and uptake of acetylated low-density lipoprotein and of apoptotic thymocytes, but not of oxidatively damaged red blood cells., Proceedings of the National Academy of Sciences (USA), 94(15), 8127-31, 22 Jul 1997 Abstract
  • Murao K, Terpstra V, Green S R, Kondratenko N, Steinberg D, Quehenberger O, Characterization of CLA-1, a human homologue of rodent scavenger receptor BI, as a receptor for high density lipoprotein and apoptotic thymocytes., Journal of Biological Chemistry, 272(28), 17551-7, 11 Jul 1997 Abstract
  • Steinberg D, A critical look at the evidence for the oxidation of LDL in atherogenesis., Atherosclerosis, 131 Suppl, S5-7, June 1997 Abstract
  • Steinberg D, Khoo J C, Glass C K, Palinski W, Almazan F, A new approach to determining the rates of recruitment of circulating leukocytes into tissues: application to the measurement of leukocyte recruitment into atherosclerotic lesions., Proceedings of the National Academy of Sciences (USA), 94(8), 4040-4, 15 Apr 1997 Abstract
  • Steinberg D, Lewis A. Conner Memorial Lecture. Oxidative modification of LDL and atherogenesis., Circulation, 95(4), 1062-71, 18 Feb 1997 Abstract
  • Steinberg, D, Oxidative modification of LDL and atherogenesis., Circulation, 95, 1062-1071, 1997
  • Steinberg, D,,Khoo JC, Glass, CK, Palinski W, Almazan F, A new approach to determining the rates of recruitment of circulating monocytes into tissues, Proceedings of the National Academy of Sciences, 94, 4040-4044, 1997
  • Ramprasad M P, Terpstra V, Kondratenko N, Quehenberger O, Steinberg D, Cell surface expression of mouse macrosialin and human CD68 and their role as macrophage receptors for oxidized low density lipoprotein., Proceedings of the National Academy of Sciences (USA), 93(25), 14833-8, 10 Dec 1996 Abstract
  • Steinberg D, Oxidized low density lipoprotein--an extreme example of lipoprotein heterogeneity., Israel Journal of Medical Sciences, 32(6), 469-72, June 1996 Abstract
  • Tangirala R K, Mol M J, Steinberg D, Macrophage oxidative modification of low density lipoprotein occurs independently of its binding to the low density lipoprotein receptor., Journal of Lipid Research, 37(4), 835-43, April 1996 Abstract
  • Green S, Steinberg D, Quehenberger O, Cloning and expression in Xenopus oocytes of a mouse homologue of the human acylcoenzyme A: cholesterol acyltransferase and its potential role in metabolism of oxidized LDL., Biochemical and Biophysical Research Communications, 218(3), 924-9, 26 Jan 1996 Abstract
  • Steinberg D, A docking receptor for HDL cholesterol esters [comment], Science, 271(5248), 460-1, 26 Jan 1996 Abstract
  • Ramprasad M P, Fischer W, Witztum J L, Sambrano G R, Quehenberger O, Steinberg D, The 94- to 97-kDa mouse macrophage membrane protein that recognizes oxidized low density lipoprotein and phosphatidylserine-rich liposomes is identical to macrosialin, the mouse homologue of human CD6, Proceedings of the National Academy of Sciences (USA), 92(21), 9580-4, 10 Oct 1995 Abstract
  • Tangirala R K, Casanada F, Miller E, Witztum J L, Steinberg D, Palinski W, Effect of the antioxidant N,N'-diphenyl 1,4-phenylenediamine (DPPD) on atherosclerosis in apoE-deficient mice., Arteriosclerosis, Thrombosis, and Vascular Biology, 15(10), 1625-30, October 1995 Abstract
  • Ezaki M, Witztum J L, Steinberg D, Lipoperoxides in LDL incubated with fibroblasts that overexpress 15-lipoxygenase., Journal of Lipid Research, 36(9), 1996-2004, September 1995 Abstract
  • Steinberg D, Clinical trials of antioxidants in atherosclerosis: are we doing the right thing?, Lancet, 346(8966), 36-8, 1 Jul 1995 Abstract
  • Benz D J, Mol M, Ezaki M, Mori-Ito N, Zelan I, Miyanohara A, Friedmann T, Parthasarathy S, Steinberg D, Witztum J L, Enhanced levels of lipoperoxides in low density lipoprotein incubated with murine fibroblast expressing high levels of human 15-lipoxygenase., Journal of Biological Chemistry, 270(10), 5191-7, 10 Mar 1995 Abstract
  • Sambrano G R, Steinberg D, Recognition of oxidatively damaged and apoptotic cells by an oxidized low density lipoprotein receptor on mouse peritoneal macrophages: role of membrane phosphatidylserine., Proceedings of the National Academy of Sciences (USA), 92(5), 1396-400, 28 Feb 1995 Abstract
  • Ottnad E, Parthasarathy S, Sambrano G R, Ramprasad M P, Quehenberger O, Kondratenko N, Green S, Steinberg D, A macrophage receptor for oxidized low density lipoprotein distinct from the receptor for acetyl low density lipoprotein: partial purification and role in recognition of oxidatively damaged cells., Proceedings of the National Academy of Sciences (USA), 92(5), 1391-5, 28 Feb 1995 Abstract
  • Steinberg, D, Clinical trials of antioxidants in atherosclerosis. Are we doing the right thing?, Lancet, 346, 36-38, 1995
  • Steinberg D, Role of oxidized LDL and antioxidants in atherosclerosis., Advances In Experimental Medicine and Biology, 369, 39-48, 1995 Abstract
  • Lehr H A, Olofsson A M, Carew T E, Vajkoczy P, von Andrian U H, Hubner C, Berndt M C, Steinberg D, Messmer K, Arfors K E, P-selectin mediates the interaction of circulating leukocytes with platelets and microvascular endothelium in response to oxidized lipoprotein in vivo., Laboratory Investigation, 71(3), 380-6, September 1994 Abstract
  • Fruebis J, Steinberg D, Dresel H A, Carew T E, A comparison of the antiatherogenic effects of probucol and of a structural analogue of probucol in low density lipoprotein receptor-deficient rabbits., Journal of Clinical Investigation, 94(1), 392-8, July 1994 Abstract
  • Sasahara M, Raines E W, Chait A, Carew T E, Steinberg D, Wahl P W, Ross R, Inhibition of hypercholesterolemia-induced atherosclerosis in the nonhuman primate by probucol. I. Is the extent of atherosclerosis related to resistance of LDL to oxidation?, Journal of Clinical Investigation, 94(1), 155-64, July 1994 Abstract
  • Brown M S, Goldstein J L, Havel R J, Steinberg D, Gene therapy for cholesterol [letter; comment], Nature Genetics, 7(3), 349-50, July 1994 Abstract
  • Sambrano G R, Parthasarathy S, Steinberg D, Recognition of oxidatively damaged erythrocytes by a macrophage receptor with specificity for oxidized low density lipoprotein., Proceedings of the National Academy of Sciences (USA), 91(8), 3265-9, 12 Apr 1994 Abstract
  • Palinski W, Ord V A, Plump A S, Breslow J L, Steinberg D, Witztum J L, ApoE-deficient mice are a model of lipoprotein oxidation in atherogenesis. Demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehyde-lysine in serum., Arteriosclerosis and Thrombosis, 14(4), 605-16, April 1994 Abstract
  • Yla-Herttuala S, Palinski W, Butler S W, Picard S, Steinberg D, Witztum J L, Rabbit and human atherosclerotic lesions contain IgG that recognizes epitopes of oxidized LDL., Arteriosclerosis and Thrombosis, 14(1), 32-40, January 1994 Abstract
  • Khoo J C, Reue K, Steinberg D, Schotz M C, Expression of hormone-sensitive lipase mRNA in macrophages., Journal of Lipid Research, 34(11), 1969-74, November 1993 Abstract
  • Stamler J, Stamler R, Brown W V, Gotto A M, Greenland P, Grundy S, Hegsted D M, Luepker R V, Neaton J D, Steinberg D, et al, Serum cholesterol. Doing the right thing [editorial; comment] [see comments], Circulation, 88(4 Pt 1), 1954-60, October 1993 Abstract
  • McMurray H F, Parthasarathy S, Steinberg D, Oxidatively modified low density lipoprotein is a chemoattractant for human T lymphocytes., Journal of Clinical Investigation, 92(2), 1004-8, August 1993 Abstract
  • Wieland E, Parthasarathy S, Steinberg D, Peroxidase-dependent metal-independent oxidation of low density lipoprotein in vitro: a model for in vivo oxidation?, Proceedings of the National Academy of Sciences (USA), 90(13), 5929-33, 1 Jul 1993 Abstract
  • Steinberg D, Antioxidant vitamins and coronary heart disease [editorial; comment] [see comments], New England Journal of Medicine, 328(20), 1487-9, 20 May 1993 Abstract
  • Steinberg D, Modified forms of low-density lipoprotein and atherosclerosis., Journal of Internal Medicine, 233(3), 227-32, March 1993 Abstract
  • Reaven P, Parthasarathy S, Grasse B J, Miller E, Steinberg D, Witztum J L, Effects of oleate-rich and linoleate-rich diets on the susceptibility of low density lipoprotein to oxidative modification in mildly hypercholesterolemic subjects., Journal of Clinical Investigation, 91(2), 668-76, February 1993 Abstract
  • Fruebis J, Parthasarathy S, Steinberg D, Evidence for a concerted reaction between lipid hydroperoxides and polypeptides., Proceedings of the National Academy of Sciences (USA), 89(22), 10588-92, 15 Nov 1992 Abstract
  • Khoo J C, Miller E, Pio F, Steinberg D, Witztum J L, Monoclonal antibodies against LDL further enhance macrophage uptake of LDL aggregates., Arteriosclerosis and Thrombosis, 12(11), 1258-66, November 1992 Abstract
  • Rosenfeld M E, Carew T E, von Hodenberg E, Pittman R C, Ross R, Steinberg D, Autoradiographic analysis of the distribution of 125I-tyramine-cellobiose-LDL in atherosclerotic lesions of the WHHL rabbit., Arteriosclerosis and Thrombosis, 12(8), 985-95, August 1992 Abstract
  • Steinberg D, Aspen Bile Acid/Cholesterol Conference 1991. Report of a conference., Journal of Lipid Research, 33(6), 937-42, June 1992 Abstract
  • Steinberg D, Antioxidants in the prevention of human atherosclerosis. Summary of the proceedings of a National Heart, Lung, and Blood Institute Workshop: September 5-6, 1991, Bethesda, Maryland., Circulation, 85(6), 2337-44, June 1992 Abstract
  • Rosenfeld M E, Yla-Herttuala S, Lipton B A, Ord V A, Witztum J L, Steinberg D, Macrophage colony-stimulating factor mRNA and protein in atherosclerotic lesions of rabbits and humans., American Journal of Pathology, 140(2), 291-300, February 1992 Abstract
  • Parthasarathy S, Steinberg D, Witztum J L, The role of oxidized low-density lipoproteins in the pathogenesis of atherosclerosis., Annual Review of Medicine, 43, 219-25, 1992 Abstract
  • Witztum J L, Steinberg D, Role of oxidized low density lipoprotein in atherogenesis., Journal of Clinical Investigation, 88(6), 1785-92, December 1991 Abstract
  • Yla-Herttuala S, Lipton B A, Rosenfeld M E, Goldberg I J, Steinberg D, Witztum J L, Macrophages and smooth muscle cells express lipoprotein lipase in human and rabbit atherosclerotic lesions., Proceedings of the National Academy of Sciences (USA), 88(22), 10143-7, 15 Nov 1991 Abstract
  • Reaven P, Parthasarathy S, Grasse B J, Miller E, Almazan F, Mattson F H, Khoo J C, Steinberg D, Witztum J L, Feasibility of using an oleate-rich diet to reduce the susceptibility of low-density lipoprotein to oxidative modification in humans., American Journal of Clinical Nutrition, 54(4), 701-6, October 1991 Abstract
  • Steinberg D, Antioxidants and atherosclerosis. A current assessment [editorial], Circulation, 84(3), 1420-5, September 1991 Abstract
  • Yla-Herttuala S, Lipton B A, Rosenfeld M E, Sarkioja T, Yoshimura T, Leonard E J, Witztum J L, Steinberg D, Expression of monocyte chemoattractant protein 1 in macrophage-rich areas of human and rabbit atherosclerotic lesions., Proceedings of the National Academy of Sciences (USA), 88(12), 5252-6, 15 Jun 1991 Abstract
  • Steinberg D, Pearson T A, Kuller L H, Alcohol and atherosclerosis., Annals of Internal Medicine, 114(11), 967-76, 1 Jun 1991 Abstract
  • Yla-Herttuala S, Rosenfeld M E, Parthasarathy S, Sigal E, Sarkioja T, Witztum J L, Steinberg D, Gene expression in macrophage-rich human atherosclerotic lesions. 15-lipoxygenase and acetyl low density lipoprotein receptor messenger RNA colocalize with oxidation specific lipid-protein adducts., Journal of Clinical Investigation, 87(4), 1146-52, April 1991 Abstract
  • Rankin S M, Parthasarathy S, Steinberg D, Evidence for a dominant role of lipoxygenase(s) in the oxidation of LDL by mouse peritoneal macrophages., Journal of Lipid Research, 32(3), 449-56, March 1991 Abstract
  • Steinberg D, Witztum J L, Lipoproteins and atherogenesis. Current concepts., Jama, 264(23), 3047-52, 19 Dec 1990 Abstract
  • Yla-Herttuala S, Rosenfeld M E, Parthasarathy S, Glass C K, Sigal E, Witztum J L, Steinberg D, Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions., Proceedings of the National Academy of Sciences (USA), 87(18), 6959-63, September 1990 Abstract
  • Yla-Herttuala S, Palinski W, Rosenfeld M E, Steinberg D, Witztum J L, Lipoproteins in normal and atherosclerotic aorta., European Heart Journal, 11 Suppl E, 88-99, August 1990 Abstract
  • Parthasarathy S, Fong L G, Quinn M T, Steinberg D, Oxidative modification of LDL: comparison between cell-mediated and copper-mediated modification., European Heart Journal, 11 Suppl E, 83-7, August 1990 Abstract
  • Parthasarathy S, Khoo J C, Miller E, Barnett J, Witztum J L, Steinberg D, Low density lipoprotein rich in oleic acid is protected against oxidative modification: implications for dietary prevention of atherosclerosis., Proceedings of the National Academy of Sciences (USA), 87(10), 3894-8, May 1990 Abstract
  • Khoo J C, Miller E, McLoughlin P, Steinberg D, Prevention of low density lipoprotein aggregation by high density lipoprotein or apolipoprotein A-I., Journal of Lipid Research, 31(4), 645-52, April 1990 Abstract
  • Steinberg D, Arterial metabolism of lipoproteins in relation to atherogenesis., Annals of The New York Academy of Sciences, 598, 125-35, 1990 Abstract
  • Steinberg D, Parthasarathy S, Carew T E, Khoo J C, Witztum J L, Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity [see comments], New England Journal of Medicine, 320(14), 915-24, 6 Apr 1989 Abstract
  • Parthasarathy S, Wieland E, Steinberg D, A role for endothelial cell lipoxygenase in the oxidative modification of low density lipoprotein., Proceedings of the National Academy of Sciences (USA), 86(3), 1046-50, February 1989 Abstract
  • Witztum J L, Simmons D, Steinberg D, Beltz W F, Weinreb R, Young S G, Lester P, Kelly N, Juliano J, Intensive combination drug therapy of familial hypercholesterolemia with lovastatin, probucol, and colestipol hydrochloride., Circulation, 79(1), 16-28, January 1989 Abstract

Profile Details

Last Verified: 3/11/2009

COS Expertise ID #544452
Reference this profile directly: http://myprofile.cos.com/dsteinb1