Ian David Dubé

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University of Toronto
Faculty of Medicine
Laboratory Medicine & Pathobiology
ProfessorAppointed: 1999
Professional Headshot of Ian David Dubé

Mailing Address

Pitangus Consulting Inc.
1440 Creekside Drive
Suite 504
Vancouver, British Columbia V6J 5B6
Canada

Contact Information

Phone: (604) 376-1431
iandube@shaw.ca
http://www.iandube.com

Qualifications

M.B.A., Queen's University School of Business, 2002.
Diploma, University of Toronto, Health Administration, 2001.
Certificate, Harvard University, Negotiation for Senior Executives, 2001.
Clinical Fellowship, Hospital for Sick Children, Medical Genetics, 1986.
Ph.D., University of British Columbia, Medical Genetics, 1984.
M.Sc., University of British Columbia, Medical Genetics, 1980.
B.Sc., University of British Columbia, Zoology, 1977.

Expertise and Research Interests

See www.iandube.com

Other Expertise

See http://www.iandube.com for a list of grants received

Industrial Relevance

Strategic consulting health care laboratory medicine

Keywords

COS Keywords:

Animal Models, Business Administration, Clinical Trial, Disease Model, Finance, Gene Therapy, Gene Transfer, Genetics, Genomics, Hematology, Hospital Administration, Laboratory Practice Or Procedure, Leukemia, Medical Disciplines or Fields, Medical Genetics, Molecular Cellular Entities, Molecular Pathology, Oncology, Pathobiology, Pathogenesis, Specialties of Medical and Allied Fields, Stem Cells, Strategic Planning, Transgenic Animals.

Additional Terms:

Business in Health Sciences, Clinical Diagnostic Laboratory, Management Consulting.

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)

Memberships

American Association for Cancer Research
American Association for the Advancement of Science
American Society of Hematology

Previous Positions

1999-2004, Professor, University of Toronto, Faculty of Medicine, Laboratory Medicine and Pathobiology
1996-2004, Senior Staff Scientist, Sunnybrook Hospital Research Institute
1995-2000, Head, University of Toronto, Sunnybrook Health Sciences Centre, Laboratory Medicine
1993-1995, Scientific Director, Toronto Hospital, Oncology Gene Therapy
1992-1999, Associate Professor, University of Toronto, Pathology
1986-1996, Staff Scientist, Toronto Hospital, Pathology
1986-1996, Staff Scientist, Hospital for Sick Children, Hematology and Oncology
1986-1995, Director, University of Toronto, Teaching Hospitals, Pathology, Cancer Cytogenetics and Molecular Oncology
1984-1986, Research Fellow, Hospital for Sick Children, Clinical
1984-1986, Fellowship, Hospital for Sick Children, Genetics and Hematology
1977-1984, Graduate Student, University of British Columbia, Terry Fox Laboratory, Medical Genetics

Patents

Early response genes in hematopoiesis, Patent Number: , 1999, Institution-owned, United States of America.
HOX11 transgenic mice, Patent Number: , 1998, Institution-owned, United States of America.
Method of Gene Transfer into Cells, Patent Number: , 1994, Institution-owned, United States of America.

Publications

  • Chen E, Kwon YT, Lim MS, Dubé ID, Hough MR (Sep 2006) Loss of Ubr1 promotes aneuploidy and accelerates B-cell lymphomagenesis in TLX1/HOX11-transgenic mice., Oncogene, 25 (42), 5752-63 Abstract
  • Chen E, Kwon YT, Lim MS, Dubé ID, Hough MR (Sep 2006) Loss of Ubr1 promotes aneuploidy and accelerates B-cell lymphomagenesis in TLX1/HOX11-transgenic mice., Oncogene, 25 (42), 5752-63 Abstract
  • Chen E, Lim MS, Rosic-Kablar S, Liu J, Jolicoeur P, Dubé ID, Hough MR (Apr 2006) Dysregulated expression of mitotic regulators is associated with B-cell lymphomagenesis in HOX11-transgenic mice., Oncogene, 25 (18), 2575-87 Abstract
  • Chen E, Lim MS, Rosic-Kablar S, Liu J, Jolicoeur P, Dubé ID, Hough MR (Apr 2006) Dysregulated expression of mitotic regulators is associated with B-cell lymphomagenesis in HOX11-transgenic mice., Oncogene, 25 (18), 2575-87 Abstract
  • Zhao Y, Chen E, Li L, Gong B, Xie W, Nanji S, Dube ID, Hough MR (Oct 2004) Gene expression profiling in the inductive human hematopoietic microenvironment, Biochem Biophys Res Commun, 323 (2), 703-11
  • Zhao Y, Chen E, Li L, Gong B, Xie W, Nanji S, Dube ID, Hough MR (Oct 2004) Gene expression profiling in the inductive human hematopoietic microenvironment., Biochemical and Biophysical Research Communications, 323 (2), 703-11 Abstract
  • Zhao Y, Chen E, Li L, Gong B, Xie W, Nanji S, Dubé ID, Hough MR (Oct 2004) Gene expression profiling in the inductive human hematopoietic microenvironment., Biochemical and biophysical research communications, 323 (2), 703-11 Abstract
  • Zhao Y, Chen E, Li L, Gong B, Xie W, Nanji S, Dubé ID, Hough MR (Oct 2004) Gene expression profiling in the inductive human hematopoietic microenvironment., Biochemical and biophysical research communications, 323 (2), 703-11 Abstract
  • Elenitoba-Johnson KS, Jenson SD, Abbott RT, Palais RA, Bohling SD, Lin Z, Tripp S, Shami PJ, Wang LY, Coupland RW, Buckstein R, Perez-Ordonez B, Perkins SL, Dube ID, Lim MS, Involvement of multiple signaling pathways in follicular lymphoma transformation: p38-mitogen-activated protein kinase as a target for therapy, Proceedings of the National Academy of Sciences of the United States of America., 100(12), 7259-64, June 2003 Abstract
  • Elenitoba-Johnson KS, Jenson SD, Abbott RT, Palais RA, Bohling SD, Lin Z, Tripp S, Shami PJ, Wang LY, Coupland RW, Buckstein R, Perez-Ordonez B, Perkins SL, Dube ID, Lim MS (Jun 2003) Involvement of multiple signaling pathways in follicular lymphoma transformation: p38-mitogen-activated protein kinase as a target for therapy., Proceedings of the National Academy of Sciences of the United States of America, 100 (12), 7259-64 Abstract
  • Elenitoba-Johnson KS, Jenson SD, Abbott RT, Palais RA, Bohling SD, Lin Z, Tripp S, Shami PJ, Wang LY, Coupland RW, Buckstein R, Perez-Ordonez B, Perkins SL, Dube ID, Lim MS (Jun 2003) Involvement of multiple signaling pathways in follicular lymphoma transformation: p38-mitogen-activated protein kinase as a target for therapy., Proceedings of the National Academy of Sciences of the United States of America, 100 (12), 7259-64 Abstract
  • Meertens L, Zhao Y, Rosic-Kablar S, Li L, Chan K, Dobson H, Gartley C, Lutzko C, Hopwood J, Kohn D, Kruth S, Hough MR, Dube ID, In Utero Injection of alpha-L-Iduronidase-Carrying Retrovirus in Canine Mucopolysaccharidosis Type I: Infection of Multiple Tissues and Neonatal Gene Expression, Human Gene Therapy, 13(15), 1809-20, October 2002 Abstract
  • Meertens L, Zhao Y, Rosic-Kablar S, Li L, Chan K, Dobson H, Gartley C, Lutzko C, Hopwood J, Kohn D, Kruth S, Hough MR, Dubé ID (Oct 2002) In utero injection of alpha-L-iduronidase-carrying retrovirus in canine mucopolysaccharidosis type I: infection of multiple tissues and neonatal gene expression., Human gene therapy, 13 (15), 1809-20 Abstract
  • Lutzko C, Meertens L, Li L, Zhao Y, Abrams-Ogg A, Woods JP, Kruth S, Hough MR, Dube ID, Human hematopoietic progenitors engraft in fetal canine recipients and expand with neonatal injection of fibroblasts expressing human hematopoietic cytokines, Experimental Hematology, 30(7), 801-8, July 2002 Abstract
  • Lutzko C, Meertens L, Li L, Zhao Y, Abrams-Ogg A, Woods JP, Kruth S, Hough MR, Dubé ID (Jul 2002) Human hematopoietic progenitors engraft in fetal canine recipients and expand with neonatal injection of fibroblasts expressing human hematopoietic cytokines., Experimental hematology, 30 (7), 801-8 Abstract
  • Rosic-Kablar S, Chan K, Reis MD, Dube ID, Hough MR, Induction of tolerance to immunogenic tumor antigens associated with lymphomagenesis in HOX11 transgenic mice, Proceedings of the National Academy of Sciences (USA), 97(24), 13300-5, 2000 Abstract
  • Shahnavaz SA, Regezi JA, Bradley G, Dube ID, Jordan RC, p53 gene mutations in sequential oral epithelial dysplasias and squamous cell carcinomas [see comments], Journal of Pathology, 190(4), 417-22, March 2000 Abstract
  • Lutzko C, Abrams-Ogg ACG, Li L, Zhao Y, Lau K, Kruth S, Dube ID., Fractionation of gene modified hematopoietic autografts into multiple weekly infusions does not improve engraftment in unconditioned canine recipients, Hematology, 499-503, 2000
  • Omori F, Juopperi T, Chan CK, Chang YN, Phipps S, Nanji S, Zhao Y, Stewart AK, Dube ID, Retroviral-mediated transfer and expression of the multidrug resistance protein 1 gene (MRP1) protect human hematopoietic cells from antineoplastic drugs, Journal of Hematotherapy and Stem Cell Research, 8(5), 503-14, October 1999 Abstract
  • Buckstein R, Imrie K, Spaner D, Potichnyj A, Robinson JB, Nanji S, Pennel N, Reis M, Pinkerton P, Dube I, Hewitt K, Berinstein NL, Stem cell function and engraftment is not affected by 'in vivo purging' with rituximab for autologous stem cell treatment for patients with low-grade non-Hodgkin's lymphoma, Seminars in Oncology, 26(5 Suppl 14), 115-22, October 1999 Abstract
  • Stewart AK, Sutherland DR, Nanji S, Zhao Y, Lutzko C, Nayar R, Peck B, Ruedy C, McGarrity G, Tisdale J, Dube ID, Engraftment of gene-marked hematopoietic progenitors in myeloma patients after transplant of autologous long-term marrow cultures, Human Gene Therapy, 10(12), 1953-64, August 1999 Abstract
  • Lutzko C, Omori F, Abrams-Ogg AC, Shull R, Li L, Lau K, Ruedy C, Nanji S, Gartley C, Dobson H, Foster R, Kruth S, Dube ID, Gene therapy for canine alpha-L-iduronidase deficiency: in utero adoptive transfer of genetically corrected hematopoietic progenitors results in engraftment but not amelioration of disease., Human Gene Therapy, 10(9), 1521-32, 10 Jun 1999 Abstract
  • Lutzko C, Dube ID, Stewart AK, Recent progress in gene transfer into hematopoietic stem cells, Critical Reviews in Oncology and Hematology, 30(2), 143-58, April 1999 Abstract
  • Lutzko C, Kruth S, Abrams-Ogg AC, Lau K, Li L, Clark BR, Ruedy C, Nanji S, Foster R, Kohn D, Shull R, Dube ID, Genetically corrected autologous stem cells engraft, but host immune responses limit their utility in canine alpha-L-iduronidase deficiency, Blood, 93(6), 1895-905, March 1999 Abstract
  • Omori F, Lutzko C, Abrams-Ogg A, Lau K, Gartley C, Dobson H, Nanji S, Ruedy C, Singaraja R, Li L, Stewart AK, Kruth S, Dube ID, Adoptive transfer of genetically modified human hematopoietic stem cells into preimmune canine fetuses, Experimental Hematology, 27(2), 242-9, February 1999 Abstract
  • Omori F, Lutzko C, Abrams-Ogg A, Lau K, Gartley C, Dobson H, Nanji S, Ruedy C, Singaraja R, Li L, Stewart AK, Kruth S, Dube ID, Adoptive transfer of genetically modified human hematopoietic stem cells into preimmune canine fetuses., Experimental Hematology, 27(2), 242-9, February 1999 Abstract
  • Hummel JL, Wells RA, Dube ID, Licht JD, Kamel-Reid S, Deregulation of NPM and PLZF in a variant t(5;17) case of acute promyelocytic leukemia, Oncogene, 18(3), 633-41, Jan 1999 Abstract
  • Hough MR, Reis MD, Singaraja R, Bryce DM, Kamel-Reid S, Dardick I, Breitman ML, Dube ID, A model for spontaneous B-lineage lymphomas in IgHmu-HOX11 transgenic mice, Proceedings of the National Academy of Sciences (USA), 95(23), 13853-8, November 1998 Abstract
  • Tisdale JF, Stewart AK, Dickstein B, Little RF, Dube I, Cappe D, Dunbar CE, Brown KE, Molecular and serological examination of the relationship of human herpesvirus 8 to multiple myeloma: orf 26 sequences in bone marrow stroma are not restricted to myeloma patients and other regions of, Blood, 92(8), 2681-7, October 1998 Abstract
  • Catzavelos C, Ruedy C, Stewart A K, Dube I, A novel method for the direct quantification of gene transfer into cells using PCR in situ., Gene Therapy, 5(6), 755-60, June 1998 Abstract
  • Chu P, Lutzko C, Stewart A K, Dube I D, Retrovirus-mediated gene transfer into human hematopoietic stem cells., Journal of Molecular Medicine, 76(3-4), 184-92, March 1998 Abstract
  • Imrie K R, Dube I, Prince H M, Girouard C, Crump M, Keating A, New clonal karyotypic abnormalities acquired following autologous bone marrow transplantation for acute myeloid leukemia do not appear to confer an adverse prognosis., Bone Marrow Transplantation, 21(4), 395-9, February 1998 Abstract
  • Stewart A K, Schimmer A D, Bailey D J, Dube I D, Cappe D, Moen R C, Gauldie J, Graham F L, In vivo adenoviral-mediated gene transfer of interleukin-2 in cutaneous plasmacytoma, Blood, 91(3), 1095-7, 1 Feb 1998 Abstract
  • McKeithan T W, Takimoto G S, Ohno H, Bjorling V S, Morgan R, Hecht B K, Dube I, Sandberg A A, Rowley J D, BCL3 rearrangements and t(14;19) in chronic lymphocytic leukemia and other B-cell malignancies: a molecular and cytogenetic study., Genes, Chromosomes and Cancer, 20(1), 64-72, September 1997 Abstract
  • Stewart A K, Lassam N J, Graham F L, Gauldie J, Addison C L, Bailey D J, Dessureault S, Dube I D, Gallenger S, Krajden M, Rotstein L E, Quirt I C, Moen R, A phase I study of adenovirus mediated gene transfer of interleukin 2 cDNA into metastatic breast cancer or melanoma., Human Gene Therapy, 8(11), 1403-14, 20 Jul 1997 Abstract
  • Perkins D, Brennan S, Carstairs K, Bailey D, Pantalony D, Poon A, Fernandes B, Dube I, Regional cancer cytogenetics: a report on 1,143 diagnostic cases., Cancer Genetics and Cytogenetics, 96(1), 64-80, 1 Jul 1997 Abstract
  • Stewart A K, Prince H M, Cappe D, Chu P, Lutzko C, Sutherland D R, Dube I D, In vitro maintenance and retroviral transduction of human myeloma cells in long-term marrow cultures., Cancer Gene Therapy, 4(3), 148-56, May 1997 Abstract
  • Allan DS, Dube ID, Retroviral-mediated gene transfer into long-term cultures of human bone marrow: Progress towards human gene therapy, Health Sciences Journal - Queen's University, 1(1), 46-52, 1997
  • Dube I D, Kruth S, Abrams-Ogg A, Kamel-Reid S, Lutzko C, Nanji S, Ruedy C, Singaraja R, Wild A, Krygsman P, Chu P, Messner H, Reddy V, McGarrity G, Stewart A K, Preclinical assessment of human hematopoietic progenitor cell transduction in long-term marrow cultures., Human Gene Therapy, 7(17), 2089-100, 10 Nov 1996 Abstract
  • Allan D S, De Koven A, Wild A, Kamel-Reid S, Dube I D, Endogenous murine leukemia virus DNA sequences in murine cell lines: implications for gene therapy safety testing by PCR., Leukemia and Lymphoma, 23(3-4), 375-81, October 1996 Abstract
  • Borrow J, Stanton V P Jr, Andresen J M, Becher R, Behm F G, Chaganti R S, Civin C I, Disteche C, Dube I, Frischauf A M, Horsman D, Mitelman F, Volinia S, Watmore A E, Housman D E, The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein, Nature Genetics, 14(1), 33-41, September 1996 Abstract
  • Hummel J L, Lichty B D, Reis M, Dube I, Kamel-Reid S, Engraftment of human chronic lymphocytic leukemia cells in SCID mice: in vivo and in vitro studies., Leukemia, 10(8), 1370-6, August 1996 Abstract
  • Shull R, Lu X, Dube I, Lutzko C, Kruth S, Abrams-Ogg A, Kiem H P, Goehle S, Schuening F, Millan C, Carter R, Humoral immune response limits gene therapy in canine MPS I, Blood, 88(1), 377-9, 1 Jul 1996 Abstract
  • Wells R A, Hummel J L, De Koven A, Zipursky A, Kirby M, Dube I, Kamel-Reid S, A new variant translocation in acute promyelocytic leukaemia: molecular characterization and clinical correlation., Leukemia, 10(4), 735-40, April 1996 Abstract
  • Borrow J, Shearman A M, Stanton V P Jr, Becher R, Collins T, Williams A J, Dube I, Katz F, Kwong Y L, Morris C, Ohyashiki K, Toyama K, Rowley J, Housman D E, The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9, Nature Genetics, 12(2), 159-67, February 1996 Abstract
  • Dube ID, Stewart AK, Adoptive transfer of genetically modified hematopoietic stem cells, Transfusion Science, 17(1), 137-145, 1996
  • Stewart AK, Prince HM, Dube ID, Background and update to a phase 1 trial of stem cell gene marking in multiple myeloma, Transfusion Science, 17(1), 175-184, 1996
  • Lutzko C, Chu P, Dube ID, Hematopoietic stem cells for gene delivery, Transfusion Science, 17(1), 129-136, 1996
  • Dube ID, Gene Therapy in Canada - Editorial, Transfusion Science, 17(1), 3-5, 1996
  • Allan DS, Dube ID, Future prospects for gene therapy, Transfusion Science, 17(1), 203-205, 1996
  • Dube, I.D, Stewart, A.K., Adoptive transfer of genetically modified hematopoietic stem cells, Transfusion Science, 17, 137-145, 1996
  • Dube I D, Cournoyer D, Gene therapy: here to stay., Cmaj, 152(10), 1605-13, 15 May 1995 Abstract
  • Stewart A K, Dube I D, Kamel-Reid S, Keating A, A phase I study of autologous bone marrow transplantation with stem cell gene marking in multiple myeloma., Human Gene Therapy, 6(1), 107-19, January 1995 Abstract
  • Dube ID, Stewart K, Lutzko C, Kruth S, Abrams-Ogg A, Shull R, Kohn D, Reddy V, Chu P, Kamel-Reid S, Gene transfer into marrow-derived hematopoietic stem cells, Gene Therapy, 2, 579-580, 1995
  • Stewart AK, Dube ID, Monitoring cancer relapse with retroviral gene marked autologous blood or bone marrow cells, Gene Therapy, 2, 590-591, 1995
  • Lichty B D, Ackland-Snow J, Noble L, Kamel-Reid S, Dube I D, Dysregulation of HOX11 by chromosome translocations in T-cell acute lymphoblastic leukemia: a paradigm for homeobox gene involvement in human cancer., Leukemia and Lymphoma, 16(3-4), 209-15, January 1995 Abstract
  • Lau R C, Squire J, Brisson L, Kamel-Reid S, Grunberger T, Dube I, Letarte M, Shannon K, Freedman M H, Lymphoid blast crisis of B-lineage phenotype with monosomy 7 in a patient with juvenile chronic myelogenous leukemia (JCML)., Leukemia, 8(5), 903-8, May 1994 Abstract
  • Schnurr M W, Carter R F, Dube I D, Valli V E, Jacobs R M, Nonrandom chromosomal abnormalities in bovine lymphoma., Leukemia Research, 18(2), 91-9, February 1994 Abstract
  • Bienzle D, Abrams-Ogg A C, Kruth S A, Ackland-Snow J, Carter R F, Dick J E, Jacobs R M, Kamel-Reid S, Dube I D, Gene transfer into hematopoietic stem cells: long-term maintenance of in vitro activated progenitors without marrow ablation., Proceedings of the National Academy of Sciences (USA), 91(1), 350-4, 4 Jan 1994 Abstract
  • Choi B C, de Harven E, Bailey D J, Dube I D, Pantalony D, Cell type identification in leukemia: the level of agreement among four independent diagnostic methods., Cancer Detection and Prevention, 18(5), 383-91, 1994 Abstract
  • Hudoba M, Dube ID, Molecular and cytogenetic abnormalities in childhood acute lymphoblastic leukemia and their impact on outcome, DIagnostic Oncology, 4, 344-352, 1994
  • Raju K, Tang S, Dube I D, Kamel-Reid S, Bryce D M, Breitman M L, Characterization and developmental expression of Tlx-1, the murine homolog of HOX11., Mechanisms of Development, 44(1), 51-64, November 1993 Abstract
  • Freedman M H, Grunberger T, Correa P, Axelrad A A, Dube I D, Cohen A, Autocrine and paracrine growth control by granulocyte-monocyte colony-stimulating factor of acute lymphoblastic leukemia cells., Blood, 81(11), 3068-75, 1 Jun 1993 Abstract
  • Abrams-Ogg A C, Kruth S A, Carter R F, Dick J E, Valli V E, Kamel-Reid S, Dube I D, Clinical and pathological findings in dogs following supralethal total body irradiation with and without infusion of autologous long-term marrow culture cells., Canadian Journal of Veterinary Research, 57(2), 79-88, April 1993 Abstract
  • Abrams-Ogg A C, Kruth S A, Carter R F, Valli V E, Kamel-Reid S, Dube I D, Preparation and transfusion of canine platelet concentrates., American Journal of Veterinary Research, 54(4), 635-42, April 1993 Abstract
  • Sanchez-Sweatman O H, de Harven E P, Dube I D, Human chromosomes: evaluation of processing techniques for scanning electron microscopy., Scanning Microscopy, 7(1), 97-104; discussion 1, March 1993 Abstract
  • Pinkerton P H, Reis M D, DeCoteau J, Srigley J R, Dube I D, London B, A lineage-specific t(1;14)(q21;q32) as an early event in development of B-cell clonal expansion., Cancer Genetics and Cytogenetics, 64(2), 166-9, December 1992 Abstract
  • Borrow J, Goddard A D, Gibbons B, Katz F, Swirsky D, Fioretos T, Dube I, Winfield D A, Kingston J, Hagemeijer A, et al, Diagnosis of acute promyelocytic leukaemia by RT-PCR: detection of PML-RARA and RARA-PML fusion transcripts., British Journal of Haematology, 82(3), 529-40, November 1992 Abstract
  • Abrams-Ogg A C, Kruth S A, Carter R F, Valli V E, Kamel-Reid S, Dube I D, The use of an implantable central venous (Hickman) catheter for long-term venous access in dogs undergoing bone marrow transplantation., Canadian Journal of Veterinary Research, 56(4), 382-6, October 1992 Abstract
  • Reis M D, Sher G D, Lakhani A, Dube I D, Senn J S, Pinkerton P H, Deletion of the long arm of chromosome 5 in essential thrombocythemia, Cancer Genetics and Cytogenetics, 61(1), 93-5, 1 Jul 1992 Abstract
  • Brandwein J M, Dube I D, Laraya P, Keating A, Maintenance of Philadelphia-chromosome-positive progenitors in long-term marrow cultures from patients with advanced chronic myeloid leukemia., Leukemia, 6(6), 556-61, June 1992 Abstract
  • Lorber BJ, Freeman SB, Hassold T, Ragab AH, Vega RA, Cockwell AE, Jacobs PA, Radford M, Doyle J, Dube ID, et al, Characterization and molecular analysis of nondisjunction in 18 cases of trisomy 21 and leukemia, Genes, Chromosomes and Cancer, 4(3), 222-7, April 1992 Abstract
  • Carter R F, Abrams-Ogg A C, Dick J E, Kruth S A, Valli V E, Kamel-Reid S, Dube I D, Autologous transplantation of canine long-term marrow culture cells genetically marked by retroviral vectors., Blood, 79(2), 356-64, 15 Jan 1992 Abstract
  • DeCoteau JF, Dube ID, Kamel-Reid S, Recent advances in the detection of minimal residual malignant hematological disease, Diagnostic Oncology, 2, 168-173, 1992
  • Dube I D, Kamel-Reid S, Yuan C C, Lu M, Wu X, Corpus G, Raimondi S C, Crist W M, Carroll A J, Minowada J, et al, A novel human homeobox gene lies at the chromosome 10 breakpoint in lymphoid neoplasias with chromosomal translocation t(10;14)., Blood, 78(11), 2996-3003, 1 Dec 1991 Abstract
  • Lewis M E, Solh H, Poon A, Dube I D, Secondary acute non-lymphocytic leukemia with monosomy 7 arising 9 years after acute lymphoblastic leukemia in childhood., Cancer Genetics and Cytogenetics, 55(1), 85-8, August 1991 Abstract
  • LeBrun D P, Pinkerton P H, Sheridan B L, Chen-Lai J, Dube I D, Poldre P A, Essential thrombocythemia with the Philadelphia chromosome and BCR-ABL gene rearrangement. An entity distinct from chronic myeloid leukemia and Philadelphia chromosome-negative essential thrombocythem, Cancer Genetics and Cytogenetics, 54(1), 21-5, 1 Jul 1991 Abstract
  • Cohen A, Grunberger T, Vanek W, Dube I D, Doherty P J, Letarte M, Roifman C, Freedman M H, Constitutive expression and role in growth regulation of interleukin-1 and multiple cytokine receptors in a biphenotypic leukemic cell line., Blood, 78(1), 94-102, 1 Jul 1991 Abstract
  • Kapelushnik J, Dube I, Wilson P, Greenberg M, Acute lymphoblastic leukemia with t(4;11) translocation after osteogenic sarcoma., Cancer, 67(11), 2887-9, 1 Jun 1991 Abstract
  • Carter R, Dube I, McKeithan T, Carstairs K, DeHarven E, Bailey D, Scott J G, Translocation (14;19) in acute biphenotypic leukemia., Cancer Genetics and Cytogenetics, 53(1), 67-73, May 1991 Abstract
  • Reis M D, Dube I D, Pinkerton P H, Chen-Lai J, Robinson J B, Klock R J, Senn J S, "Jumping" translocations involving band 3q13.3 in a case of acute monocytic leukemia., Cancer Genetics and Cytogenetics, 51(2), 189-94, February 1991 Abstract
  • Lishner M, Amato D, Chalvardjian P, Baker M A, Fernandes B, Pantalony D, Dube I D, Unusual findings in two patients with acquired deletions of the long arm of chromosome 5 (5q-)., Clinical and Laboratory Haematology, 13(1), 87-92, 1991 Abstract
  • Reis MD, Dube ID, Gene rearrangement studies in the assessment of lymphoid neoplasias, Leukemia and Lymphoma, 4, 313-316, 1991
  • Pinkerton PH, Dube ID, Chronic myeloid leukemia as a paradign for oncogenesis, Diagnostic Oncology, 1, 288-297, 1991
  • Carter R F, Kruth S A, Valli V E, Dube I D, Long-term culture of canine marrow: cytogenetic evaluation of purging of lymphoma and leukemia., Experimental Hematology, 18(9), 995-1001, October 1990 Abstract
  • Pinkerton P H, London B, Dube I D, Senn J S, Trisomy 14q in myelodysplastic syndromes., Cancer Genetics and Cytogenetics, 49(1), 113-6, 1 Oct 1990 Abstract
  • Lu M, Dube I, Raimondi S, Carroll A, Zhao Y, Minden M, Sutherland P, Molecular characterization of the t(10;14) translocation breakpoints in T-cell acute lymphoblastic leukemia: further evidence for illegitimate physiological recombination., Genes, Chromosomes and Cancer, 2(3), 217-22, September 1990 Abstract
  • Schuh A C, Sutherland D R, Horsfall W, Mills G B, Dube I, Baker M A, Siminovitch K, Bailey D, Keating A, Chronic myeloid leukemia arising in a progenitor common to T cells and myeloid cells., Leukemia, 4(9), 631-6, September 1990 Abstract
  • Stewart K, Carstairs K C, Dube I D, Keating A, Neutrophilic myelofibrosis presenting as Philadelphia chromosome negative BCR non-rearranged chronic myeloid leukemia., American Journal of Hematology, 34(1), 59-63, May 1990 Abstract
  • Dube I D, Carter R F, Pinkerton P H, Chromosome abnormalities in chronic myeloid leukaemia. A model for acquired chromosome changes in haematological malignancy., Tumour Biology, 11 Suppl 1, 3-24, 1990 Abstract
  • Colwill R, Dube I, Scott J G, Bailey D, Deharven E, Carstairs K, Pantalony D, Isochromosome 7q as the sole abnormality in an unusual case of T-cell lineage malignancy., Hematologic Pathology, 4(1), 53-8, 1990 Abstract
  • Al-Jaouni S, Pinkerton PH, Sheridan BL, Dube ID, Normal C, Breakpoints on the long arm of chromosome 5 in relation to morphological diagnosis in 34 patients with myelodysplasia and acute non-lymphocytic leukemia, Leukemia and Lymphoma, 3, 195-200, 1990
  • Korneluk RG, MacKenzie AE, Nakamura Y, Dube I, Jacob P, Hunter AG, A reordering of human chromosome 19 long-arm DNA markers and identification of markers flanking the myotonic dystrophy locus, Genomics, 5(3), 596-604, October 1989 Abstract
  • Dube I, Dixon J, Beckett T, Grossman A, Weinstein M, Benn P, McKeithan T, Norman C, Pinkerton P, Location of breakpoints within the major breakpoint cluster region (bcr) in 33 patients with bcr rearrangement-positive chronic myeloid leukemia (CML) with complex or absent Philadelphia chromosomes, Genes, Chromosomes and Cancer, 1(1), 106-11, September 1989 Abstract
  • Battaglia D, Dube I, Pinkerton P, Senn J, Acquisition of additional primary chromosome abnormalities in the course of karyotype evolution in a case of FAB-M2 acute leukemia, Cancer Genetics and Cytogenetics, 40(1), 105-10, July 1989 Abstract
  • Narod S A, Dube I D, Occupational history and involvement of chromosomes 5 and 7 in acute nonlymphocytic leukemia., Cancer Genetics and Cytogenetics, 38(2), 261-9, April 1989 Abstract
  • Raimondi S C, Dube I D, Valentine M B, Mirro J Jr, Watt H J, Larson R A, Bitter M A, Le Beau M M, Rowley J D, Clinicopathologic manifestations and breakpoints of the t(3;5) in patients with acute nonlymphocytic leukemia., Leukemia, 3(1), 42-7, January 1989 Abstract
  • Kalousek DK, Dube ID, Eaves CJ, Eaves AC, Cytogenetic studies of haemopoietic colonies from patients with an initial diagnosis of acute lymphoblastic leukaemia, British Journal of Haematology, 70(1), 5-11, September 1988 Abstract
  • Worton RG, Sutherland J, Sylvester JE, Willard HF, Bodrug S, Dube I, Duff C, Kean V, Ray PN, Schmickel RD, Human ribosomal RNA genes: orientation of the tandem array and conservation of the 5' end, Science, 239(4835), 64-8, January 1988 Abstract
  • Estrov Z, Dube ID, Chan HS, Freedman MH, Residual juvenile chronic myelogenous leukemia cells detected in peripheral blood during clinical remission, Blood, 70(5), 1466-9, November 1987 Abstract
  • Estrov Z, Tawa A, Wang XH, Dube ID, Sulh H, Cohen A, Gelfand EW, Freedman MH, In vitro and in vivo effects of deferoxamine in neonatal acute leukemia, Blood, 69(3), 757-61, March 1987 Abstract
  • Dube ID, el-Solh H, An apparent tandem quadruplication of chromosome 21 in a case of childhood acute lymphoblastic leukemia, Cancer Genetics and Cytogenetics, 23(3), 253-6, November 1986 Abstract
  • Estrov Z, Grunberger T, Dube ID, Wang YP, Freedman MH, Detection of residual acute lymphoblastic leukemia cells in cultures of bone marrow obtained during remission, New England Journal of Medicine, 315(9), 538-42, August 1986 Abstract
  • Dube ID, Raimondi SC, Pi D, Kalousek DK, A new translocation, t(10;14)(q24;q11), in T cell neoplasia, Blood, 67(4), 1181-4, April 1986 Abstract
  • Dube ID, Greenberg ML, Phenotypic heterogeneity in three cases of lymphoid malignancy with chromosomal translocations in 14q11, Cytogenetics and Cell Genetics, 41(4), 215-8, 1986 Abstract
  • Eaves C, Coulombel L, Dube I, Kalousek D, Cashman J, Eaves A, Behavior of human leukemic progenitor populations in long-term marrow culture, Hamatologie Und Bluttransfusion, 29, 163-7, 1985 Abstract
  • Eaves C, Coulombel L, Dube I, Kalousek D, Cashman J, Eaves A, Maintenance of normal and abnormal hemopoietic cell populations in long-term cultures of CML and AML marrow cells, Progress in Clinical and Biological Research, 184, 403-13, 1985 Abstract
  • Dube ID, Arlin ZA, Kalousek DK, Eaves CJ, Eaves AC, Nonclonal hemopoietic progenitor cells detected in long-term marrow cultures from a Turner syndrome mosaic with chronic myeloid leukemia, Blood, 64(6), 1284-7, December 1984 Abstract
  • Dube ID, Kalousek DK, Coulombel L, Gupta CM, Eaves CJ, Eaves AC, Cytogenetic studies of early myeloid progenitor compartments in Ph1-positive chronic myeloid leukemia. II. Long-term culture reveals the persistence of Ph1-negative progenitors in treated as well as n, Blood, 63(5), 1172-7, May 1984 Abstract
  • Dube ID, Gupta CM, Kalousek DK, Eaves CJ, Eaves AC, Cytogenetic studies of early myeloid progenitor compartments in Ph1-positive chronic myeloid leukaemia (CML). I. Persistence of Ph1-negative committed progenitors that are suppressed from differentiat, British Journal of Haematology, 56(4), 633-44, April 1984 Abstract
  • Coulombel L, Eaves CJ, Dube ID, Kalousek DK, Eaves AC, Variable persistence of leukemic progenitor cells in long-term CML and AML marrow cultures, Kroc Foundation Series, 18, 243-54, 1984 Abstract
  • Dube ID, Eaves CJ, Kalousek DK, Eaves AC, A method for obtaining high quality chromosome preparations from single hemopoietic colonies on a routine basis, Cancer Genetics and Cytogenetics, 4(2), 157-68, October 1981 Abstract

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