Dr. Sean Ekins

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Collaborations in Chemistry
computational chemistry
Senior ConsultantAppointed: 2007
University of Medicine and Dentistry of New Jersey
Pharmacology
Adjunct ProfessorAppointed: 2007
ACT LLC
Computational Biology
Senior Vice PresidentAppointed: 2006
University of Maryland at Baltimore
Pharmaceutical Sciences
Adjunct Associate ProfessorAppointed: 2005
Professional Headshot of Sean Ekins

Mailing Address

601 Runnymede Ave.
Jenkintown, Pennsylvania 19046
United States

Contact Information

Phone: (215) 687-1320
ekinssean@yahoo.com

Qualifications

D.Sc., University of Aberdeen, Science, 2005.
Ph.D., University of Aberdeen, Medicine and Therapeutics (Clinical Pharmacology), 1996.
M.Sc., University of Aberdeen, Clinical Pharmacology, 1993.
HND, Nottingham Trent University, Science (Applied Biology), 1991.

Expertise and Research Interests

A versatile research scientist with applied pharmaceutical company experience in computational drug discovery, systems biology applied to pathway and biomarker discovery, in vitro and computational ADME/TOX. I also have start-up company experience in successfully obtaining NIH grant funding, leading teams of international scientists and directing technology development, marketing and application development.

Other Expertise

Book editing
Wiley.com link
http://www.wiley.com/WileyCDA/WileyTitle/productCd-0471737798.html

Book on Amazon
http://www.amazon.com/Computer-Applications-Pharmaceutical-Research-Development-Wiley-Drug-Discovery-/dp/0471737798/sr=1-2/qid=1158779632/ref=sr_1_2/102-3419621-0534527?ie=UTF8&s=books

Book on Barnes and Noble
http://search.barnesandnoble.com/booksearch/isbnInquiry.asp?z=y&endeca=1&isbn=0471737798&itm=4

Future Research

The integration of in vitro and computational approaches for drug discovery.

Industrial Relevance

I have broad experience of in vitro and computational methods relevant to ADME, Toxicity and drug discovery.

Scientific Advisory Board Membership
Emiliem, Inc. (Aug 2006-present) http://biospace.com/news_story.aspx?StoryId=30196

Invited editorial for Drug Discovery Today, Editors Choice - Drug Metabolism, July 2006. http://ionmx.com/apps/display.aspx?t=d3e-1-1-1-1ff4b9

Keywords

COS Keywords:

Biomarkers, Computational Biology, Drug Metabolism, Pharmaceuticals, Toxicology.

Additional Terms:

ADME, Computational Drug Discovery, Drug Discovery, In Silico, In Silico ADME/Tox, In Vitro ADME/Tox, Metabolism, Toxicology.

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)

Memberships

American Chemical Society
American Society for Pharmacology and Experimental Therapeutics
International Society for the Study of Xenobiotics

Honors and Awards

1997, Postdoctoral fellow in vitro studies presentation, ISSX
1995, Graduate student in vitro studies presentation, ISSX

Previous Positions

2004-2006, Vice President, GeneGo, Inc., Computational Biology
2001-2004, Associate Director, Concurrent Pharmaceuticals, Inc., Computational Drug Discovery
1999-2001, Senior Computational Chemist, Lilly Research Laboratories
1998-1999, Research Scientist, Pfizer, Inc., Central Research
1996-1998, Postdoctoral Fellow,, Lilly Research Laboratories, Drug Disposition
1989-1990, Industrial internship, Servier Research & Development, Drug Disposition

Funding Received

  • National Institutes of Health (NIH): In Silico Assessment of Drug Metabolism and Toxicity, SBIR phase II, ~$750,000, 2005 to 2007.

Publications

  • Sean Ekins (2007) Computational Toxicology: Risk Assessment For Pharmaceutical and Environmental Chemicals, John Wiley and Sons, ISBN=978-0-470-049
  • Sean Ekins (2006) Computer Applications in Pharmaceutical Research and Development, Hoboken, NJ, John Wiley and Sons
  • Swaan PW, Ekins S (Sep 2005) Reengineering the pharmaceutical industry by crash-testing molecules, Drug Discovery Today, 10 (17), 1191-200
  • Chang C, Pang KS, Swaan PW, Ekins S (Aug 2005) Comparative pharmacophore modeling of organic anion transporting polypeptides: a meta-analysis of rat Oatp1a1 and human OATP1B1, The Journal of Pharmacology and Experimental Therapeutics, 314 (2), 533-41
  • Suhre WM, Ekins S, Chang C, Swaan PW, Wright SH (Apr 2005) Molecular determinants of substrate/inhibitor binding to the human and rabbit renal organic cation transporters hOCT2 and rbOCT2, Molecular Pharmacology, 67 (4), 1067-77
  • Ekins S, Kirillov E, Rakhmatulin EA, Nikolskaya T (Mar 2005) A novel method for visualizing nuclear hormone receptor networks relevant to drug metabolism, Drug Metabolism and Disposition: the Biological Fate of Chemicals, 33 (3), 474-81
  • Ekins S, Kim RB, Leake BF, Dantzig AH, Schuetz EG, Lan LB, Yasuda K, Shepard RL, Winter MA, Schuetz JD, Wikel JH, Wrighton SA (May 2002) Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein, Molecular Pharmacology, 61 (5), 964-73
  • Sean Ekins, Jim J Xu, Drug Efficacy, Safety, and Biologics Discovery: Emerging Technologies and Tools, John Wiley and Sons, In Press

Profile Details

Last Updated: 9/22/2008

COS Expertise ID #1243079
Reference this profile directly: http://myprofile.cos.com/ekinssean