Prof. Edward K. L. Chan

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University of Florida
College of Dentistry
Oral Biology
ProfessorAppointed: 2002
University of Florida
College of Medicine
Anatomy and Cell Biology Department
ProfessorAppointed: 2004
Professional Headshot of Edward K. L. Chan

Mailing Address

Department of Oral Biology
P.O. Box 100424
University of Florida
Gainesville, Florida 32610-0424
United States

Contact Information

Phone: (352) 273-8849
echan@ufl.edu
http://www.dental.ufl.edu/Faculty/EChan/

Qualifications

Ph.D., University of Calgary, Immunopathology, 1984.
M.Sc., University of Calgary, Clinical Chemistry, 1979.
B.Sc., University of British Columbia, Biochemistry, 1976.

Previous Positions

2001-2002, Head, Rheumatic Diseases Core Centers at San Diego, DNA Sequencing Service
1997-2002, Associate Professor, Scripps Research Institute, Molecular and Experimental Medicine
1995-2001, Head, Multipurpose Arthritis and Musculoskeletal Diseases Center at San Diego, DNA Sequencing Core
1991-2002, Head, Scripps Research Institute, Molecular and Experimental Medicine, DNA Core Lab
1990-1996, Assistant Professor, Scripps Research Institute, Molecular and Experimental Medicine

Honors and Awards

2010, Keynote Speaker, MBL
2009, Keynote Speaker, Autoantibody Network
2008-2010, University of Florida Research Foundation Professorship, University of Florida Research Foundation
2008, Keynote Speaker, Oral Immunology and Microbiology Research Group
2003, Keynote Speaker, Tokyo, Japan
1989-1992, Arthritis Foundation Investigator Award, Arthritis Foundation
1987, Senior Rheumatology Scholar Award, American College of Rheumatology
1986-1989, Fellowship Award, Arthritis Foundation
1986, Western Region Fellows Awards, American Rheumatism Association
1985, Western Region Fellows Awards, American Rheumatism Association
1983-1986, Fellowship Award, Alberta Heritage Foundation for Medical Research
1980-1983, Studentship Award, Alberta Heritage Foundation for Medical Research

Memberships

American Association for Cancer Research
American Association for Dental Research
American College of Rheumatology
American Society for Biochemistry and Molecular Biology
American Society for Cell Biology
Kunkel Society
RNA Society

Other Expertise

- Editorial boards:
Molecular Biology Reports
Electronic Journal of Biotechnology
Arthritis Research and Therapy
Autoantigens, Autoantibodies, and Autoimmunity
The Open Arthritis Journal
The Open Autoimmunity Journal
Journal of Dental Research
Autoimmune Diseases

- Member, NIH General Medicine A-1 Study Section (1995-1999)
- Member, Molecular Biology and Genetics Study Section, the Arthritis Foundation (1999-2001)
- Vice-Chair, Autoantibody Standardization Committee in Rheumatic and Related Disorders of the International Union of Immunological Societies, the World Health Organization, the Arthritis Foundation, and Centers for Disease Control and Prevention (Member: 1999 - 2005; Vice-Chair: 2005 -present)
- Ad Hoc member, Special Emphasis Panel, Dermatology and Rheumatoid Sciences, NIH, 2004
- Ad Hoc member, Immunology IRG Special Study Section for SLE, NIH, 2005
- Ad Hoc member, Immunology IRG Study Section, NIH, 2006

Expertise and Research Interests

Our laboratory is primarily interested in autoimmunity with the focus in autoantigens and autoantibodies associated with systemic autoimmune diseases and cancer. The two main directions are (1) to identify and characterize specific autoimmune target antigens and understand why autoantibodies are induced and continually produced in different disease states and (2) to use human autoantibodies as unique probes to reveal the molecular and cellular functions of interesting macromolecules and subcellular organelles that are autoimmune targets. The overall strategy is that by understanding the biology of autoantigens in health and disease states, we may be able to fully appreciate the functional and pathogenic potentials of autoantibodies.

Our laboratory is actively characterizing the RNA binding protein GW182 which is a macromolecule marker for cytoplasmic domains known as GW bodies (GWBs). The most common clinical diagnosis of patients with anti-GW182 antibodies was Sjogren's syndrome, followed by neurological disease (motor and sensory neuropathy and/or ataxia), and systemic lupus erythematosus. Several novel autoantigens have been identified in GWBs and we focus on their roles in the regulation of RNA interference and mRNA degradation.

Publications

  • Nozawa K, Fritzler MJ, Takasaki Y, Wood MR, Chan EKL (Nov 2008) Co-clustering of Golgi complex and other cytoplasmic organelles to crescentic region of half-moon nuclei during apoptosis., Cell biology international, 33 (2), 148-57 Abstract
  • Nahid MA, Pauley KM, Satoh M, Chan EKL (Oct 2009) MICRORNA-146A is critical for endotoxin-induced tolerance. Implication on innate immunity., The Journal of biological chemistry Abstract
  • Bulosan M, Pauley KM, Yo K, Chan EKL, Katz J, Peck AB, Cha S (Oct 2008) Inflammatory caspases are critical for enhanced cell death in the target tissue of Sjögren's syndrome before disease onset., Immunology and cell biology, 87 (1), 81-90 Abstract
  • Brucato A, Grava C, Bortolati M, Ikeda K, Milanesi O, Cimaz R, Ramoni V, Vignati G, Martinelli S, Sadou Y, Borghi A, Tincani A, Chan EKL, Ruffatti A (Aug 2009) Congenital heart block not associated with anti-Ro/La antibodies: comparison with anti-Ro/La-positive cases., The Journal of rheumatology, 36 (8), 1744-8 Abstract
  • Pereira DB, Sannes T, Dodd SM, Jensen SE, Morgan LS, Chan EKL (Aug 2009) Life stress, negative mood states, and antibodies to heat shock protein 70 in endometrial cancer., Brain, behavior, and immunity Abstract
  • Ostrov DA, Magis AT, Wronski TJ, Chan EKL, Toro EJ, Donatelli RE, Sajek K, Haroun IN, Nagib MI, Piedrahita A, Harris A, Holliday LS (Jul 2009) Identification of Enoxacin as an Inhibitor of Osteoclast Formation and Bone Resorption by Structure-Based Virtual Screening., Journal of medicinal chemistry Abstract
  • Lian SL, Li S, Abadal GX, Pauley BA, Fritzler MJ, Chan EKL (May 2009) The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing., RNA, 15 (5), 804-13 Abstract
  • Chan EKL, Satoh M, Pauley KM (Apr 2009) Contrast in aberrant microRNA expression in systemic lupus erythematosus and rheumatoid arthritis: is microRNA-146 all we need?, Arthritis and rheumatism, 60 (4), 912-5 Abstract
  • Llanos C, Chan EKL, Li S, Abadal GX, Izmirly P, Byrne C, Clancy RM, Buyon JP (Mar 2009) Antibody reactivity to alpha-enolase in mothers of children with congenital heart block., The Journal of rheumatology, 36 (3), 565-9 Abstract
  • Satoh M, Vázquez-Del Mercado M, Chan EKL (Mar 2009) Clinical interpretation of antinuclear antibody tests in systemic rheumatic diseases., Modern rheumatology / the Japan Rheumatism Association Abstract
  • Palafox Sánchez CA, Satoh M, Chan EKL, Carcamo WC, Muñoz Valle JF, Orozco Barocio G, Oregon Romero E, Navarro Hernández RE, Salazar Páramo M, Cabral Castañeda A, Vázquez Del Mercado M (Feb 2009) Reduced IgG anti-small nuclear ribonucleoprotein autoantibody production in systemic lupus erythematosus patients with positive IgM anti-cytomegalovirus antibodies., Arthritis research & therapy, 11 (1), R27 Abstract
  • Moser JJ, Chan EKL, Fritzler MJ (2009) Optimization of immunoprecipitation-western blot analysis in detecting GW182-associated components of GW/P bodies., Nature protocols, 4 (5), 674-85 Abstract
  • Pauley KM, Cha S, Chan EKL (2009) MicroRNA in autoimmunity and autoimmune diseases., Journal of autoimmunity, 32 (3-4), 189-94 Abstract
  • Nozawa K, Ikeda K, Satoh M, Reeves WH, Stewart CM, Li YC, Yen TJ, Rios RM, Takamori K, Ogawa H, Sekigawa I, Takasaki Y, Chan EKL (2009) Autoantibody to NA14 is an independent marker primarily for Sjogren's syndrome., Frontiers in bioscience, 14, 3733-9 Abstract
  • Koppang EO, Bjerkås I, Haugarvoll E, Chan EKL, Szabo NJ, Ono N, Akikusa B, Jirillo E, Poppe TT, Sveier H, Tørud B, Satoh M (Oct 2008) Vaccination-induced systemic autoimmunity in farmed atlantic salmon., Journal of immunology, 181 (7), 4807-14 Abstract
  • Pauley KM, Satoh M, Chan AL, Bubb MR, Reeves WH, Chan EKL (2008) Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients., Arthritis research & therapy, 10 (4), R101 Abstract
  • Kakumanu P, Yamagata H, Sobel ES, Reeves WH, Chan EKL, Satoh M (Jun 2008) Patients with pulmonary tuberculosis are frequently positive for anti-cyclic citrullinated peptide antibodies, but their sera also react with unmodified arginine-containing peptide., Arthritis and rheumatism, 58 (6), 1576-81 Abstract
  • Nozawa K, Fritzler MJ, Ikeda K, Takasaki Y, Satoh M, Chan EKL (2008) Differential anti-Golgi complex autoantibody production following murine lactate dehydrogenase-elevating virus infection., Immunopharmacology and immunotoxicology, 30 (1), 13-25 Abstract
  • Moser JJ, Eystathioy T, Chan EKL, Fritzler MJ (Dec 2007) Markers of mRNA stabilization and degradation, and RNAi within astrocytoma GW bodies., Journal of Neuroscience Research, 85 (16), 3619-31 Abstract
  • Bhanji RA, Eystathioy T, Chan EKL, Bloch DB, Fritzler MJ (Dec 2007) Clinical and serological features of patients with autoantibodies to GW/P bodies., Clinical Immunology, 125 (3), 247-56 Abstract
  • Lian S, Fritzler MJ, Katz J, Hamazaki T, Terada N, Satoh M, Chan EKL (Sep 2007) Small interfering RNA-mediated silencing induces target-dependent assembly of GW/P bodies., Molecular Biology of the Cell, 18 (9), 3375-87 Abstract
  • Chan EKL, Fritzler MJ, Wiik A, Andrade LE, Reeves WH, Tincani A, Meroni PL (Sep 2007) AutoAbSC.Org -- Autoantibody Standardization Committee in 2006., Autoimmunity Reviews, 6 (8), 577-80 Abstract
  • Junttila MR, Puustinen P, Niemelä M, Ahola R, Arnold H, Böttzauw T, Ala-aho R, Nielsen C, Ivaska J, Taya Y, Lu SL, Lin S, Chan EKL, Wang XJ, Grènman R, Kast J, Kallunki T, Sears R, Kähäri VM, Westermarck J (Jul 2007) CIP2A inhibits PP2A in human malignancies., Cell, 130 (1), 51-62 Abstract
  • Jakymiw A, Pauley KM, Li S, Ikeda K, Lian S, Eystathioy T, Satoh M, Fritzler MJ, Chan EKL (Apr 2007) The role of GW/P-bodies in RNA processing and silencing., Journal of cell science, 120 (Pt 8), 1317-23 Abstract
  • Yamasaki Y, Narain S, Yoshida H, Hernandez L, Barker T, Hahn PC, Sobel ES, Segal MS, Richards HB, Chan EKL, Reeves WH, Satoh M (Feb 2007) Autoantibodies to RNA helicase A: a new serologic marker of early lupus., Arthritis and rheumatism, 56 (2), 596-604 Abstract
  • Kopp K, Gasiorowski JZ, Chen D, Gilmore R, Norton JT, Wang C, Leary DJ, Chan EKL, Dean DA, Huang S (Feb 2007) Pol I transcription and pre-rRNA processing are coordinated in a transcription-dependent manner in mammalian cells., Molecular biology of the cell, 18 (2), 394-403 Abstract
  • Zhang JY, Megliorino R, Peng XX, Tan EM, Chen Y, Chan EKL (Jan 2007) Antibody detection using tumor-associated antigen mini-array in immunodiagnosing human hepatocellular carcinoma., Journal of hepatology, 46 (1), 107-14 Abstract
  • Chan,E.K.L., Peebles,C., Fritzler,M.J., Satoh,M. (2007) Anti-spliceosomal autoantibodies, Systemic Lupus Erythematosus: A Companion to Rheumatology, Chapter 22G Edition, San Diego, CA, Elsevier Science (bookchapter)
  • Ikeda K, Satoh M, Pauley KM, Fritzler MJ, Reeves WH, Chan EK (Dec 2006) Detection of the argonaute protein Ago2 and microRNAs in the RNA induced silencing complex (RISC) using a monoclonal antibody., Journal of immunological methods, 317 (1-2), 38-44 Abstract
  • Fritzler, M.J., Chan, E.K.L. (2006) Golgi complex and endosome antibodies, Autoantibodies, 2nd edition, Chapter 35, Elsevier Science, 263-270 pages (bookchapter)
  • Fritzler, M.J., Chan, E.K.L. (2006) Autoantibodies to GW Bodies and components of the microRNA pathway, Autoantibodies, 2nd edition, Chapter 34, Elsevier Science, 257-262 pages (bookchapter)
  • Pauley KM, Eystathioy T, Jakymiw A, Hamel JC, Fritzler MJ, Chan EKL (Sep 2006) Formation of GW bodies is a consequence of microRNA genesis., EMBO reports, 7 (9), 904-10 Abstract
  • Yamasaki Y, Honkanen-Scott M, Hernandez L, Ikeda K, Barker T, Bubb MR, Narain S, Richards HB, Chan EKL, Reeves WH, Satoh M (Sep 2006) Nucleolar staining cannot be used as a screening test for the scleroderma marker anti-RNA polymerase I/III antibodies., Arthritis and rheumatism, 54 (9), 3051-6 Abstract
  • Yamasaki Y, Yamada H, Nozaki T, Akaogi J, Nichols C, Lyons R, Loy AC, Chan EKL, Reeves WH, Satoh M (Jun 2006) Unusually high frequency of autoantibodies to PL-7 associated with milder muscle disease in Japanese patients with polymyositis/dermatomyositis., Arthritis and rheumatism, 54 (6), 2004-9 Abstract
  • Lian S, Jakymiw A, Eystathioy T, Hamel JC, Fritzler MJ, Chan EKL (Feb 2006) GW bodies, microRNAs and the cell cycle., Cell cycle (Georgetown, Tex.), 5 (3), 242-5 Abstract
  • Jakymiw A, Ikeda K, Fritzler MJ, Reeves WH, Satoh M, Chan EKL (2006) Autoimmune targeting of key components of RNA interference., Arthritis research & therapy, 8 (4), R87 Abstract
  • Yamasaki Y, Narain S, Hernandez L, Barker T, Ikeda K, Segal MS, Richards HB, Chan EKL, Reeves WH, Satoh M (2006) Autoantibodies against the replication protein A complex in systemic lupus erythematosus and other autoimmune diseases., Arthritis research & therapy, 8 (4), R111 Abstract
  • Chan EKL (2006) Ninth international workshop on autoantibodies and autoimmunity, Autoimmun Rev., 5 (6), 365-6
  • Chan,E.K., Burlingame,R.W., Fritzler,M.J. (2006) Detection of autoantibodies using immobilized natural and recombinant autoantigens, Manual of Molecular and Clinical Laboratory Immunology, 7th Edition, Washington, D.C., American Society for Microbiology Press, 1019-26 pages (bookchapter)
  • Chan, E.K.L. (2006) Autoantibodies and the cloning and characterization of cellular constituents, Autoantibodies and Autoimmunity: Molecular Mechanisms in Health and Disease, Weinheim, Germany, Wiley-VCH Verlag GmbH & Co, 419-446 pages, ISBN=3-527-31141-6 (bookchapter)
  • Jakymiw A, Lian S, Eystathioy T, Li S, Satoh M, Hamel JC, Fritzler MJ, Chan EKL (Dec 2005) Disruption of GW bodies impairs mammalian RNA interference., Nature cell biology, 7 (12), 1267-74 Abstract
  • Himoto T, Kuriyama S, Zhang JY, Chan EKL, Kimura Y, Masaki T, Uchida N, Nishioka M, Tan EM (Oct 2005) Analyses of autoantibodies against tumor-associated antigens in patients with hepatocellular carcinoma., International journal of oncology, 27 (4), 1079-85 Abstract
  • Clancy RM, Buyon JP, Ikeda K, Nozawa K, Argyle DA, Friedman DM, Chan EKL (Oct 2005) Maternal antibody responses to the 52-kd SSA/RO p200 peptide and the development of fetal conduction defects., Arthritis and rheumatism, 52 (10), 3079-86 Abstract
  • Zhang, J.Y., Chan, E.K.L. (2005) Tumor specific autoimmune responses - Why and when do they develop?, Methods, Possibilities and Perspectives of Pre-symptomatic Tumor Diagnostics, Lengerich, Germany, Pabst Scientific Publishers, 35-42 pages (bookchapter)
  • Shi FD, Zhang JY, Liu D, Rearden A, Elliot M, Nachtsheim D, Daniels T, Casiano CA, Heeb MJ, Chan EK, Tan EM, Preferential Humoral Immune Response in Prostate Cancer to Cellular Proteins P90 and P62 in a Panel of Tumor-associated Antigens., The Prostate, 63(3), 252-8, May 2005 Abstract
  • Himoto T, Kuriyama S, Zhang JY, Chan EK, Nishioka M, Tan EM, Significance of Autoantibodies Against Insulin-like Growth Factor II MRNA-binding Proteins in Patients With Hepatocellular Carcinoma., International Journal of Oncology, 26(2), 311-7, Feb 2005 Abstract
  • Nozawa K, Fritzler MJ, Chan EK, Unique and Shared Features of Golgi Complex Autoantigens., Autoimmunity Reviews, 4(1), 35-41, Jan 2005 Abstract
  • Megliorino R, Shi FD, Peng XX, Wang X, Chan EK, Tan EM, Zhang JY, Autoimmune Response to Anti-apoptotic Protein Survivin and Its Association With Antibodies to P53 and C-myc in Cancer Detection., Cancer Detection and Prevention, 29(3), 241-8, 2005 Abstract
  • Lu Y, Ye P, Chen SL, Tan EM, Chan EKL (2005) Identification of kinectin as a novel Behçet's disease autoantigen., Arthritis research & therapy, 7 (5), R1133-9 Abstract
  • Yang Z, Jakymiw A, Wood MR, Eystathioy T, Rubin RL, Fritzler MJ, Chan EKL (Nov 2004) GW182 Is Critical for the Stability of GW Bodies Expressed During the Cell Cycle and Cell Proliferation., Journal of Cell Science, 117, 5567-78 Abstract
  • Eronen M, Miettinen A, Walle TK, Chan EK, Julkunen H, Relationship of maternal autoimmune response to clinical manifestations in children with congenital complete heart block, Acta Paediatrica, 93(6), 803-9, 01 Jun 2004 Abstract
  • Stinton LM, Eystathioy T, Selak S, Chan EK, Fritzler MJ, Autoantibodies to protein transport and messenger RNA processing pathways: endosomes, lysosomes, Golgi complex, proteasomes, assemblyosomes, exosomes, and GW bodies, Clinical Immunology, 110(1), 30-44, 01 Jan 2004 Abstract
  • Julkunen H, Miettinen A, Walle TK, Chan EK, Eronen M, Autoimmune response in mothers of children with congenital and postnatally diagnosed isolated heart block: a population based study, The Journal of Rheumatology, 31(1), 183-9, January 2004 Abstract
  • Nozawa K, Fritzler MJ, von Muhlen CA, Chan EK, Giantin Is the Major Golgi Autoantigen in Human Anti-Golgi Complex Sera., Arthritis Research & Therapy, 6(2), R95-102, 2004
  • Luft LM, Barr SG, Martin LO, Chan EK, Fritzler MJ, Autoantibodies to tissue transglutaminase in Sjogren's syndrome and related rheumatic diseases, The Journal of Rheumatology, 30(12), 2613-9, December 2003 Abstract
  • Eystathioy T, Chan EK, Takeuchi K, Mahler M, Luft LM, Zochodne DW, Fritzler MJ, Clinical and serological associations of autoantibodies to GW bodies and a novel cytoplasmic autoantigen GW182, Journal of Molecular Medicine, 81(12), 811-8, 01 Dec 2003 Abstract
  • Koziol JA, Zhang JY, Casiano CA, Peng XX, Shi FD, Feng AC, Chan EK, Tan EM, Recursive partitioning as an approach to selection of immune markers for tumor diagnosis, Clinical Cancer Research, 9(14), 5120-6, November 2003
  • Fritzler MJ, Wiik A, Tan EM, Smolen JS, McDougal JS, Chan EK, Gordon TP, Hardin JA, Kalden JR, Lahita RG, Maini RN, Reeves WH, Rothfield NF, Takasaki Y, Wilson M, Byrd MG, Slivka L, Koziol JA, A critical evaluation of enzyme immunoassay kits for detection of antinuclear autoantibodies of defined specificities. III. Comparative performance characteristics of academic and manufact, The Journal of Rheumatology, 30(11), 2374-81, November 2003 Abstract
  • Eystathioy T, Jakymiw A, Chan EK, Seraphin B, Cougot N, Fritzler MJ, The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies, RNA, 9(10), 1171-3, October 2003
  • Clancy RM, Chan EK, Chandrashekhar S, Buyon JP, Does the cellular localization of antigens in or on apoptotic blebs influence the pathogenicity or benefit of cognate antibodies? Comment on the article by Dieude et al, Arthritis and Rheumatism, 48(7), 2080-2; author reply, July 2003 Abstract
  • Eystathioy T, Chan EK, Mahler M, Luft LM, Fritzler ML, Fritzler MJ, A Panel of Monoclonal Antibodies to Cytoplasmic GW Bodies and the mRNA Binding Protein GW182, Hybridoma and Hybridomics, 22(2), 79-86, April 2003
  • Staub HL, Souza F, Chan EK, von Muhlen CA, Anti-Golgi antibodies in adult Still's disease, Clinical and Experimental Rheumatology, 21(2), 275-6, 2003
  • Zhang JY, Casiano CA, Peng XX, Koziol JA, Chan EK, Tan EM, Enhancement of Antibody Detection in Cancer Using Panel of Recombinant Tumor-associated Antigens, Cancer Epidemiology, Biomarkers and Prevention, 12(2), 136-43, February 2003
  • Roti EC, Myers CD, Ayers RA, Boatman DE, Delfosse SA, Chan EK, Ackerman MJ, January CT, Robertson GA, Interaction with GM130 during HERG ion channel trafficking. Disruption by type 2 congenital long QT syndrome mutations. Human Ether-a-go-go-Related Gene, Journal of Biological Chemistry, 277(49), 47779-85, December 2002 Abstract
  • Kickhoefer VA, Poderycki MJ, Chan EK, Rome LH, The La RNA-binding protein interacts with the vault RNA and is a vault-associated protein, Journal of Biological Chemistry, 277(43), 41282-6, October 2002 Abstract
  • Buyon JP, Clancy R, Di Donato F, Miranda-Carus ME, Askanase AD, Garcia J, Qu Y, Hu K, Yue Y, Chan EK, Boutjdir M, Cardiac 5-HT(4) serotoninergic receptors, 52kD SSA/Ro and autoimmune-associated congenital heart block, Journal of Autoimmunity, 19(1-2), 79-86, 2002 Abstract
  • Soo Hoo L, Zhang JY, Chan EK, Cloning and characterization of a novel 90 kDa 'companion' auto-antigen of p62 overexpressed in cancer, Oncogene, 21(32), 5006-15, July 2002
  • Zhang J, Chan EK, Autoantibodies to IGF-II mRNA binding protein p62 and overexpression of p62 in human hepatocellular carcinoma, Autoimmun Rev, 1(3), 146-53, May 2002 Abstract
  • Eystathioy T, Chan EK, Tenenbaum SA, Keene JD, Griffith K, Fritzler MJ, A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles, Molecular Biology of the Cell, 13(4), 1338-51, April 2002 Abstract
  • Eystathioy T, Peebles CL, Hamel JC, Vaughn JH, Chan EK, Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera, Arthritis and Rheumatism, 46(3), 726-34, March 2002 Abstract
  • Nozawa K, Casiano CA, Hamel JC, Molinaro C, Fritzler MJ, Chan EK, Fragmentation of Golgi complex and Golgi autoantigens during apoptosis and necrosis, Arthritis Research, 4(4), R3, 2002 Abstract
  • Chan EKL, Himoto T, Zhang, JY, Autoantibodies in liver diseases and hepatocellular carcinoma, Liver Immunology, edited by M. Eric Gershwin, John M. Vierling, and Michael P. Manns, 12, 151-169, 2002
  • Wang D, Buyon JP, Yang Z, Di Donato F, Miranda-Carus ME, Chan EK, Leucine zipper domain of 52 kDa SS-A/Ro promotes protein dimer formation and inhibits in vitro transcription activity, Biochimica Et Biophysica Acta, 1568(2), 155-61, December 2001 Abstract
  • Marra P, Maffucci T, Daniele T, Tullio GD, Ikehara Y, Chan EK, Luini A, Beznoussenko G, Mironov A, De Matteis MA, The GM130 and GRASP65 Golgi proteins cycle through and define a subdomain of the intermediate compartment, Nature Cell Biology, 3(12), 1101-13, December 2001 Abstract
  • Zhu W, Chan EK, Li J, Hemmerich P, Tan EM, Transcription activating property of autoantigen SG2NA and modulating effect of WD-40 repeats, Experimental Cell Research, 269(2), 312-21, October 2001 Abstract
  • Hales CM, Griner R, Hobdy-Henderson KC, Dorn MC, Hardy D, Kumar R, Navarre J, Chan EK, Lapierre LA, Goldenring JR, Identification and characterization of a family of Rab11-interacting proteins, Journal of Biological Chemistry, 276(42), 39067-75, October 2001 Abstract
  • Di Donato F, Chan EK, Askanase AD, Miranda-Carus M, Buyon JP, Interaction between 52 kDa SSA/Ro and deubiquitinating enzyme UnpEL: a clue to function, The International Journal of Biochemistry & Cell Biology, 33(9), 924-34, September 2001 Abstract
  • Lu M, Nakamura RM, Dent ED, Zhang JY, Nielsen FC, Christiansen J, Chan EK, Tan EM, Aberrant expression of fetal RNA-binding protein p62 in liver cancer and liver cirrhosis, American Journal of Pathology, 159(3), 945-53, September 2001 Abstract
  • Billaut-Mulot O, Cocude C, Kolesnitchenko V, Truong MJ, Chan EK, Hachula E, de la Tribonniere X, Capron A, Bahr GM, SS-56, a novel cellular target of autoantibody responses in Sjogren syndrome and systemic lupus erythematosus, Journal of Clinical Investigation, 108(6), 861-9, September 2001 Abstract
  • Zhang JY, Chan EK, Peng XX, Lu M, Wang X, Mueller F, Tan EM, Autoimmune responses to mRNA binding proteins p62 and Koc in diverse malignancies, Clinical Immunology (orlando, Fla.), 100(2), 149-56, August 2001 Abstract
  • Zhang JY, Zhu W, Imai H, Kiyosawa K, Chan EK, Tan EM, De-novo humoral immune responses to cancer-associated autoantigens during transition from chronic liver disease to hepatocellular carcinoma, Clinical and Experimental Immunology, 125(1), 3-9, July 2001 Abstract
  • Tucker KE, Berciano MT, Jacobs EY, LePage DF, Shpargel KB, Rossire JJ, Chan EK, Lafarga M, Conlon RA, Matera AG, Residual Cajal bodies in coilin knockout mice fail to recruit Sm snRNPs and SMN, the spinal muscular atrophy gene product, Journal of Cell Biology, 154(2), 293-307, July 2001 Abstract
  • Miranda-Carus ME, Askanase AD, Clancy RM, Di Donato F, Chou TM, Libera MR, Chan EK, Buyon JP, Anti-SSA/Ro and anti-SSB/La autoantibodies bind the surface of apoptotic fetal cardiocytes and promote secretion of TNF-alpha by macrophages, Journal of Immunology (baltimore, Md. : 1950), 165(9), 5345-51, November 2000 Abstract
  • Moreno RD, Ramalho-Santos J, Sutovsky P, Chan EK, Schatten G, Vesicular traffic and golgi apparatus dynamics during mammalian spermatogenesis: implications for acrosome architecture, Biology of Reproduction, 63(1), 89-98, July 2000 Abstract
  • Ochs RL, Muro Y, Si Y, Ge H, Chan EK, Tan EM, Autoantibodies to DFS 70 kd/transcription coactivator p75 in atopic dermatitis and other conditions, Journal of Allergy and Clinical Immunology, 105(6 Pt 1), 1211-20, June 2000 Abstract
  • Tucker KE, Massello LK, Gao L, Barber TJ, Hebert MD, Chan EK, Matera AG, Structure and characterization of the murine p80 coilin gene, Coil, Journal of Structural Biology, 129(2-3), 269-77, April 2000 Abstract
  • Eystathioy T, Jakymiw A, Fujita DJ, Fritzler MJ, Chan EK, Human autoantibodies to a novel Golgi protein golgin-67: high similarity with golgin-95/gm 130 autoantigen., Journal of Autoimmunity, 14(2), 179-87, 2000 Abstract
  • Moreno RD, Ramalho-Santos J, Chan EK, Wessel GM, Schatten G, The Golgi apparatus segregates from the lysosomal/acrosomal vesicle during rhesus spermiogenesis: structural alterations, Developmental Biology, 219(2), 334-49, March 2000 Abstract
  • Jakymiw A, Raharjo E, Rattner JB, Eystathioy T, Chan EK, Fujita DJ, Identification and characterization of a novel Golgi protein, golgin-67, Journal of Biological Chemistry, 275(6), 4137-44, February 2000 Abstract
  • Fritzler MJ, Kerfoot SM, Feasby TE, Zochodne DW, Westendorf JM, Dalmau JO, Chan EK, Autoantibodies from patients with idiopathic ataxia bind to M-phase phosphoprotein-1 (MPP1), Journal of Investigative Medicine, 48(1), 28-39, Jan 2000
  • Smirnova I, Poltorak A, Chan EK, McBride C, Beutler B, Phylogenetic variation and polymorphism at the toll-like receptor 4 locus (TLR4), Genome Biology, 1(1), 2, 2000
  • Wang D, Buyon JP, Zhu W, Chan EK, Defining a novel 75-kDa phosphoprotein associated with SS-A/Ro and identification of distinct human autoantibodies, Journal of Clinical Investigation, 104(9), 1265-75, November 1999 Abstract
  • Selak S, Chan EK, Schoenroth L, Senecal JL, Fritzler MJ, Early endosome antigen. 1: An autoantigen associated with neurological diseases, Journal of Investigative Medicine, 47(6), 311-8, July 1999
  • Zhang JY, Chan EK, Peng XX, Tan EM, A novel cytoplasmic protein with RNA-binding motifs is an autoantigen in human hepatocellular carcinoma, Journal of Experimental Medicine, 189(7), 1101-10, April 1999 Abstract
  • Tseng CE, Miranda E, Di Donato F, Boutjdir M, Rashbaum W, Chan EK, Buyon JP, mRNA and protein expression of SSA/Ro and SSB/La in human fetal cardiac myocytes cultured using a novel application of the Langendorff procedure, Pediatric Research, 45(2), 260-9, February 1999 Abstract
  • Miranda-Carus ME, Boutjdir M, Tseng CE, DiDonato F, Chan EK, Buyon JP, Induction of antibodies reactive with SSA/Ro-SSB/La and development of congenital heart block in a murine model, Journal of Immunology (baltimore, Md. : 1950), 161(11), 5886-92, December 1998 Abstract
  • Miranda ME, Tseng CE, Rashbaum W, Ochs RL, Casiano CA, Di Donato F, Chan EK, Buyon JP, Accessibility of SSA/Ro and SSB/La antigens to maternal autoantibodies in apoptotic human fetal cardiac myocytes, Journal of Immunology (baltimore, Md. : 1950), 161(9), 5061-9, November 1998 Abstract
  • Poltorak A, Smirnova I, He X, Liu MY, Van Huffel C, McNally O, Birdwell D, Alejos E, Silva M, Du X, Thompson P, Chan EK, Ledesma J, Roe B, Clifton S, Vogel SN, Beutler B, Genetic and physical mapping of the Lps locus: identification of the toll-4 receptor as a candidate gene in the critical region, Blood Cells, Molecules, and Diseases, 24(3), 340-55, September 1998 Abstract
  • Seo BB, Kitajima-Ihara T, Chan EK, Scheffler IE, Matsuno-Yagi A, Yagi T, Molecular remedy of complex I defects: rotenone-insensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae mitochondria restores the NADH oxidase activity of complex I-de, Proceedings of the National Academy of Sciences (USA), 95(16), 9167-71, August 1998 Abstract
  • Furuta K, Hildebrandt B, Matsuoka S, Kiyosawa K, Reimer G, Luderschmidt C, Chan EK, Tan EM, Immunological characterization of heterochromatin protein p25beta autoantibodies and relationship with centromere autoantibodies and pulmonary fibrosis in systemic scleroderma, Journal of Molecular Medicine, 76(1), 54-60, Jan 1998
  • Hassfeld W, Chan EK, Mathison DA, Portman D, Dreyfuss G, Steiner G, Tan EM, Molecular definition of heterogeneous nuclear ribonucleoprotein R (hnRNP R) using autoimmune antibody: immunological relationship with hnRNP P, Nucleic Acids Research, 26(2), 439-45, Jan 1998 Abstract
  • Griffith KJ, Chan EK, Lung CC, Hamel JC, Guo X, Miyachi K, Fritzler MJ, Molecular cloning of a novel 97-kd Golgi complex autoantigen associated with Sjogren's syndrome, Arthritis and Rheumatism, 40(9), 1693-702, September 1997 Abstract
  • Furuta K, Chan EK, Kiyosawa K, Reimer G, Luderschmidt C, Tan EM, Heterochromatin protein HP1Hsbeta (p25beta) and its localization with centromeres in mitosis, Chromosoma, 106(1), 11-9, June 1997 Abstract
  • Covini G, von Muhlen CA, Pacchetti S, Colombo M, Chan EK, Tan EM, Diversity of antinuclear antibody responses in hepatocellular carcinoma, Journal of Hepatology, 26(6), 1255-65, June 1997 Abstract
  • Tseng CE, Chan EK, Miranda E, Gross M, Di Donato F, Buyon JP, The 52-kd protein as a target of intermolecular spreading of the immune response to components of the SS-A/Ro-SS-B/La complex, Arthritis and Rheumatism, 40(5), 936-44, May 1997 Abstract
  • Matera AG, Wu W, Imai H, O'Keefe CL, Chan EK, Molecular cloning of the RNA polymerase I transcription factor hUBF/NOR-90 (UBTF) gene and localization to 17q21.3 by fluorescence in situ hybridization and radiation hybrid mapping, Genomics, 41(1), 135-8, April 1997 Abstract
  • Buyon JP, Tseng CE, Di Donato F, Rashbaum W, Morris A, Chan EK, Cardiac expression of 52beta, an alternative transcript of the congenital heart block-associated 52-kd SS-A/Ro autoantigen, is maximal during fetal development, Arthritis and Rheumatism, 40(4), 655-60, April 1997 Abstract
  • Covini G, Chan EK, Nishioka M, Morshed SA, Reed SI, Tan EM, Immune response to cyclin B1 in hepatocellular carcinoma., Hepatology, 25(1), 75-80, 1997 Abstract
  • Lung CC, Chan EK, Zuraw BL, Analysis of an exon 1 polymorphism of the B2 bradykinin receptor gene and its transcript in normal subjects and patients with C1 inhibitor deficiency., Journal of Allergy and Clinical Immunology, 99(1 (Pt. 1)), 134-46, 1997 Abstract
  • Lung CC, Chan EK, Simplifying 5'RACE in the hunt for full-length cDNAs, Trends in Genetics : Tig, 12(10), 389-91, October 1996 Abstract
  • Wang D, Chan EK, 17-beta-estradiol increases expression of 52-kDa and 60-kDa SS-A/Ro autoantigens in human keratinocytes and breast cancer cell line MCF-7, Journal of Investigative Dermatology, 107(4), 610-4, October 1996 Abstract
  • Andrade LE, Chan EK, Peebles CL, Tan EM, Two major autoantigen-antibody systems of the mitotic spindle apparatus, Arthritis and Rheumatism, 39(10), 1643-53, October 1996 Abstract
  • Ochs RL, Stein TW Jr, Chan EK, Ruutu M, Tan EM, cDNA cloning and characterization of a novel nucleolar protein, Molecular Biology of the Cell, 7(7), 1015-24, July 1996 Abstract
  • Tseng CE, Caldwell K, Feit S, Chan EK, Buyon JP, Subclass distribution of maternal and neonatal anti-Ro(SSA) and La(SSB) antibodies in congenital heart block, Journal of Rheumatology, 23(5), 925-32, May 1996 Abstract
  • Covini G, Chan EK, Colombo M, Tan EM, Tan EM, Comparison of protocols for depleting anti-E. coli antibody in immunoblotting of recombinant antigens., Journal of Immunological Methods, 190(1), 143-5, 28 1996 Abstract
  • Wang D, Buyon JP, Chan EK, Cloning and expression of mouse 60 kDa ribonucleoprotein SS-A/Ro, Molecular Biology Reports, 23(3-4), 205-10, 1996 Abstract
  • Fritzler MJ, Lung CC, Hamel JC, Griffith KJ, Chan EK, Molecular characterization of Golgin-245, a novel Golgi complex protein containing a granin signature, Journal of Biological Chemistry, 270(52), 31262-8, December 1995 Abstract
  • Chan EK, Di Donato F, Hamel JC, Tseng CE, Buyon JP, 52-kD SS-A/Ro: genomic structure and identification of an alternatively spliced transcript encoding a novel leucine zipper-minus autoantigen expressed in fetal and adult heart., Journal of Experimental Medicine, 182(4), 983-92, 1 Oct 1995 Abstract
  • von Muhlen CA, Chan EK, Peebles CL, Imai H, Kiyosawa K, Tan EM, Non-muscle myosin as target antigen for human autoantibodies in patients with hepatitis C virus-associated chronic liver diseases., Clinical and Experimental Immunology, 100(1), 67-74, 1995 Abstract
  • Puvion-Dutilleul F, Besse S, Chan EK, Tan EM, Puvion E, p80-coilin: a component of coiled bodies and interchromatin granule-associated zones, Journal of Cell Science, 108 ( Pt 3), 1143-53, March 1995 Abstract
  • Ochs RL, Stein TW Jr, Andrade LE, Gallo D, Chan EK, Tan EM, Brasch K, Formation of nuclear bodies in hepatocytes of estrogen-treated roosters, Molecular Biology of the Cell, 6(3), 345-56, March 1995 Abstract
  • Muro Y, Chan EK, Landberg G, Tan EM, A cell-cycle nuclear autoantigen containing WD-40 motifs expressed mainly in S and G2 phase cells, Biochemical and Biophysical Research Communications, 207(3), 1029-37, February 1995 Abstract
  • Chan EK, Takano S, von Muhlen CA, A microscale method for depleting cross-reactive anti-antibodies used in indirect immunofluorescence microscopy, Journal of Immunological Methods, 176(2), 271-3, December 1994 Abstract
  • Chan EK, Takano S, Andrade LE, Hamel JC, Matera AG, Structure, expression and chromosomal localization of human p80-coilin gene, Nucleic Acids Research, 22(21), 4462-9, October 1994 Abstract
  • Buyon JP, Waltuck J, Caldwell K, Crawford B, Slade SG, Copel J, Chan EK, Relationship between maternal and neonatal levels of antibodies to 48 kDa SSB(La), 52 kDa SSA(Ro), and 60 kDa SSA(Ro) in pregnancies complicated by congenital heart block, Journal of Rheumatology, 21(10), 1943-50, October 1994 Abstract
  • Malatesta M, Zancanaro C, Martin TE, Chan EK, Amalric F, Luhrmann R, Vogel P, Fakan S, Cytochemical and immunocytochemical characterization of nuclear bodies during hibernation, European Journal of Cell Biology, 65(1), 82-93, October 1994 Abstract
  • Chan EK, Tan EM, Ward DC, Matera AG, Human 60-kDa SS-A/Ro ribonucleoprotein autoantigen gene \(SSA2\) localized to 1q31 by fluorescence in situ hybridization., Genomics, 23(1), 298-300, 1 1994 Abstract
  • Buyon JP, Slade SG, Reveille JD, Hamel JC, Chan EK, Autoantibody responses to the 'native' 52-kDa SS-A/Ro protein in neonatal lupus syndromes, systemic lupus erythematosus, and Sjogren's syndrome, Journal of Immunology (baltimore, Md. : 1950), 152(7), 3675-84, April 1994 Abstract
  • Malatesta M, Zancanaro C, Martin TE, Chan EK, Amalric F, Luhrmann R, Vogel P, Fakan S, Is the coiled body involved in nucleolar functions?, Experimental Cell Research, 211(2), 415-9, April 1994 Abstract
  • Imai H, Fritzler MJ, Neri R, Bombardieri S, Tan EM, Chan EK, Immunocytochemical characterization of human NOR-90 \(upstream binding factor\) and associated antigens reactive with autoimmune sera. Two MR forms of NOR-90/hUBF autoantigens., Molecular Biol Rep, 19(2), 115-24, 1994 Abstract
  • Imai H, Chan EK, Kiyosawa K, Fu XD, Tan EM, Novel nuclear autoantigen with splicing factor motifs identified with antibody from hepatocellular carcinoma, Journal of Clinical Investigation, 92(5), 2419-26, November 1993 Abstract
  • Julkunen H, Kurki P, Kaaja R, Heikkila R, Immonen I, Chan EK, Wallgren E, Friman C, Isolated congenital heart block. Long-term outcome of mothers and characterization of the immune response to SS-A/Ro and to SS-B/La, Arthritis and Rheumatism, 36(11), 1588-98, November 1993 Abstract
  • Humphreys-Beher MG, Brinkley L, Purushotham KR, Wang PL, Nakagawa Y, Dusek D, Kerr M, Chegini N, Chan EK, Characterization of antinuclear autoantibodies present in the serum from nonobese diabetic (NOD) mice, Clinical Immunology and Immunopathology, 68(3), 350-6, September 1993 Abstract
  • Fritzler MJ, Hamel JC, Ochs RL, Chan EK, Molecular characterization of two human autoantigens: unique cDNAs encoding 95- and 160-kD proteins of a putative family in the Golgi complex, Journal of Experimental Medicine, 178(1), 49-62, July 1993 Abstract
  • Meerovitch K, Svitkin YV, Lee HS, Lejbkowicz F, Kenan DJ, Chan EK, Agol VI, Keene JD, Sonenberg N, La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate, Journal of Virology, 67(7), 3798-807, July 1993 Abstract
  • Andrade LE, Tan EM, Chan EK, Immunocytochemical analysis of the coiled body in the cell cycle and during cell proliferation, Proceedings of the National Academy of Sciences (USA), 90(5), 1947-51, March 1993 Abstract
  • Chan EK, Andrade LE, Antinuclear antibodies in Sjogren's syndrome, Rheumatic Diseases Clinics of North America, 18(3), 551-70, August 1992 Abstract
  • Chan EK, Imai H, Hamel JC, Tan EM, Human autoantibody to RNA polymerase I transcription factor hUBF. Molecular identity of nucleolus organizer region autoantigen NOR-90 and ribosomal RNA transcription upstream binding facto, Journal of Experimental Medicine, 174(5), 1239-44, November 1991 Abstract
  • Raska I, Andrade LE, Ochs RL, Chan EK, Chang CM, Roos G, Tan EM, Immunological and ultrastructural studies of the nuclear coiled body with autoimmune antibodies, Experimental Cell Research, 195(1), 27-37, July 1991 Abstract
  • Andrade LE, Chan EK, Raska I, Peebles CL, Roos G, Tan EM, Human autoantibody to a novel protein of the nuclear coiled body: immunological characterization and cDNA cloning of p80-coilin, Journal of Experimental Medicine, 173(6), 1407-19, June 1991 Abstract
  • Alderuccio F, Chan EK, Tan EM, Molecular characterization of an autoantigen of PM-Scl in the polymyositis/scleroderma overlap syndrome: a unique and complete human cDNA encoding an apparent 75-kD acidic protein of the n, Journal of Experimental Medicine, 173(4), 941-52, April 1991 Abstract
  • Chan EK, Hamel JC, Buyon JP, Tan EM, Molecular definition and sequence motifs of the 52-kD component of human SS-A/Ro autoantigen, Journal of Clinical Investigation, 87(1), 68-76, January 1991 Abstract
  • Raska I, Ochs RL, Andrade LE, Chan EK, Burlingame R, Peebles C, Gruol D, Tan EM, Association between the nucleolus and the coiled body, Journal of Structural Biology, 104(1-3), 120-7, 1990 Abstract
  • Buyon JP, Slade SG, Chan EK, Tan EM, Winchester R, Effective separation of the 52 kDa SSA/Ro polypeptide from the 48 kDa SSB/La polypeptide by altering conditions of polyacrylamide gel electrophoresis, Journal of Immunological Methods, 129(2), 207-10, May 1990 Abstract
  • Pollard KM, Chan EK, Grant BJ, Sullivan KF, Tan EM, Glass CA, In vitro posttranslational modification of lamin B cloned from a human T-cell line, Molecular and Cellular Biology, 10(5), 2164-75, May 1990 Abstract
  • Chan EK, Tan EM, Epitopic targets for autoantibodies in systemic lupus erythematosus and Sjogren's syndrome, Current Opinion in Rheumatology, 1(3), 376-81, October 1989 Abstract
  • Chan EK, Sullivan KF, Tan EM, Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding, Nucleic Acids Research, 17(6), 2233-44, March 1989 Abstract
  • Tan EM, Chan EK, Sullivan KF, Rubin RL, Antinuclear antibodies (ANAs): diagnostically specific immune markers and clues toward the understanding of systemic autoimmunity, Clinical Immunology and Immunopathology, 47(2), 121-41, May 1988 Abstract
  • Ben-Chetrit E, Chan EK, Sullivan KF, Tan EM, A 52-kD protein is a novel component of the SS-A/Ro antigenic particle, Journal of Experimental Medicine, 167(5), 1560-71, May 1988 Abstract
  • Chan EK, Tan EM, Human autoantibody-reactive epitopes of SS-B/La are highly conserved in comparison with epitopes recognized by murine monoclonal antibodies, Journal of Experimental Medicine, 166(6), 1627-40, December 1987 Abstract
  • Chan EK, Tan EM, The small nuclear ribonucleoprotein SS-B/La binds RNA with a conserved protease-resistant domain of 28 kilodaltons, Molecular and Cellular Biology, 7(7), 2588-91, July 1987 Abstract
  • Pollard KM, Chan EK, Rubin RL, Tan EM, Monoclonal autoantibodies to nuclear antigens from murine graft-versus-host disease, Clinical Immunology and Immunopathology, 44(1), 31-40, July 1987 Abstract
  • Tsay GJ, Chan EK, Peebles CL, Pollard KM, Tan EM, An immunoassay differentiating sera with antibodies to Sm alone, antibodies to Sm/RNP complex, and antibodies to RNP alone, Arthritis and Rheumatism, 30(4), 389-96, April 1987 Abstract
  • Hamelin R, Chan EK, Tan EM, Arlinghaus RB, Antibodies against small nuclear ribonucleoproteins immunoprecipitate complexes containing ts110 Moloney murine sarcoma virus genomic and messenger RNAs, Virology, 152(1), 87-99, July 1986 Abstract
  • Chan EK, Francoeur AM, Tan EM, Epitopes, structural domains, and asymmetry of amino acid residues in SS-B/La nuclear protein, Journal of Immunology, 136(10), 3744-9, May 1986
  • Chan EK, Boyd ND, Alexander F, Barabas AZ, Lannigan R, Effect of cationic proteins on the glomerular deposition of anionic proteins and immune complexes, Nephron, 43(2), 93-104, 1986 Abstract
  • Francoeur AM, Chan EK, Garrels JI, Mathews MB, Characterization and purification of lupus antigen La, and RNA-binding protein, Molecular and Cellular Biology, 5(3), 586-90, March 1985 Abstract
  • Chan EK, Boyd ND, Preparation of covalently linked immune complexes of specific composition, Journal of Immunological Methods, 33(1), 55-61, 1980 Abstract

Funding Received

  • Lupus Research Institute: miRNA biomarkers affecting the interferon pathway in SLE, 2009 to 2012.
  • Andrew J. Semesco Foundation: Development of MicroRNA Biomarkers for Human Oral Cancer, 2009 to 2010.
  • NIEHS: Detailed Autoantibody Determinations in a NHANES Cohort, 2009 to 2010.
  • NIAID: Antigens of the RNA-induced silencing complex in autoimmunity, 2006 to 2011.

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Keywords

COS Keywords:

Anatomy, Antibodies, Autoimmunity, Biomedical Research Resources, Biomedical Research Resources, Other, Cancer or Carcinogenesis, Cell Biology, Clinical Research or Studies, Dentistry, Electroblotting, Gene Expression, Immunofluorescence, Immunopathology, Immunoprecipitation, Molecular Biology, Molecular Cloning, Monoclonal Antibodies, Neonatal Disorders, Oral Diseases, Proteins and Macromolecules, Rheumatic Diseases, Rheumatology, RNA.

Additional Terms:

Antibody Formation, Autoantibody, Autoantigen, Autoimmunity, Expression Cloning, GW Body, Immunofluorescence Technique, Monoclonal Antibody, RNA Interference.

Profile Details

Last Updated: 10/25/2009

COS Expertise ID #532344
Reference this profile directly: http://myprofile.cos.com/eklchan