Paul Ernsberger

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Case Western Reserve University
School of Medicine
Nutrition
Associate ProfessorAppointed: 1989
Professional Headshot of Paul Ernsberger

Mailing Address

Case Western Reserve University
Department of Nutrition
10900 Euclid Ave.
Cleveland, Ohio 44106-4954
United States

Contact Information

Phone: (216) 368-4738
Fax: (216) 368-6644
pre@po.cwru.edu

Qualifications

Ph.D., Northwestern University, Neuroscience/Pharmacology, 1985.
B.A., Macalester College, 1978.

Expertise and Research Interests

I am a receptor pharmacologist with an interest in characterizing the interaction of drugs with their receptors and receptor subtypes and I discovered a receptor, which I term the I1 imidazoline receptor, which mediates antihypertensive effects within the brain while eliciting few side effects, this finding has been great interest to the pharmaceutical industry. I also use autoradiographic techniques to localize receptors in specific tissues and cell types and in brain regions with specialized functions.

A second area of interest is my work with animal models of obese hypertension. I have characterized a novel form of hypertension induced by repeated loss and repeated regain of weight, working most recently with a genetic, obese-hypertensive rat strain unique to this institution. This is potentially a very valuable model for testing antihypertensive drugs, antiobesity drugs and antihyperlipidemic drugs.

Other Expertise

Associate Editor for Endocrine Pharmacology, Journal of Pharmacology and Experimental Therapeutics
Fellow, High Blood Pressure Council of the AHA.
Member, Vascular Biology Blood Pressure/Regulation Study Section, AHA
Consultant:
Kali-Chemie/Solvay Pharma (Germany)
Luboratorie Therapeutique Moderne (France)
Abbott Laboratories
Neurogenetics
Upjohn
Servier Pharmaceuticals (France)
Sterling Drug Group
Merck, Sharp & Dohme
Dupont Pharma

Phi Betta Kappa, Macalester College, 1977
Predoctoral Fellowship, National Science Foundation, 1981
Young Investigator Award, Eastern Hypertension Society, 1987
FIRST Award, National Heart, Lung & Blood Institute, 1990

Future Research

We are currently examining the role of oxidative stress in the initiation of type 2 diabetes.

Industrial Relevance

We have characterized the leading animal model for metabolic syndrome and tested a number of different antihypertensive, lipid lowering and antidiabetic agents. Our interest is in the pharmacological treatment of nutriton-related chronic diseases.

Keywords

COS Keywords:

Animal Models, Apnea, Hypertension, Neuropharmacology, Nutrition Or Dietetics, Obesity, Pharmacology, Sleep Disorders, Specialties of Medical and Allied Fields.

Additional Terms:

Drug Development, Drug Screening, Hypertension, Neuropharmacology, Obesity, Pharmacology, Radioligand Binding, Receptor Autoradiography, Receptor Pharmacology, Sleep Apnea.

Memberships

American Society for Nutritional Sciences
American Society for Pharmacology and Experimental Therapeutics
American Society of Hypertension
Catecholamine Club
New York Academy of Sciences
North American Association for the Study of Obesity

Previous Positions

1988-1989, Assistant Professor, Cornell University, Weill Medical College
1987, Instructor, Cornell University, Weill Medical College
1987, Assistant Professor, Cornell University, Weill Medical College, Neurology, Neurobiology
1984-1986, Postdoctoral Fellow, Cornell University, Weill Medical College
1981-1984, National Science Foundation Fellow, Northwestern University

Funding Received

  • National Institutes of Health (NIH): Pre- and Postganglionic Vagal Mechanisms in Heart Failure, $24,400 available as, 7/95 to 6/98.

Publications

  • Wilson CG, Akhter S, Mayer CA, Kc P, Balan KV, Ernsberger P, Haxhiu MA (Dec 2007) Allergic lung inflammation affects central noradrenergic control of cholinergic outflow to the airways in ferrets., Journal of applied physiology (Bethesda, Md. : 1985), 103 (6), 2095-104 Abstract
  • Wilson CG, Akhter S, Mayer CA, Kc P, Balan KV, Ernsberger P, Haxhiu MA (Dec 2007) Allergic lung inflammation affects central noradrenergic control of cholinergic outflow to the airways in ferrets., Journal of applied physiology (Bethesda, Md. : 1985), 103 (6), 2095-104 Abstract
  • Dallanoce C, De Amici M, Barocelli E, Bertoni S, Roth BL, Ernsberger P, De Micheli C (Dec 2007) Novel oxotremorine-related heterocyclic derivatives: Synthesis and in vitro pharmacology at the muscarinic receptor subtypes., Bioorganic & medicinal chemistry, 15 (24), 7626-37 Abstract
  • Wilson CG, Akhter S, Mayer CA, Kc P, Balan KV, Ernsberger P, Haxhiu MA (Dec 2007) Allergic lung inflammation affects central noradrenergic control of cholinergic outflow to the airways in ferrets., Journal of applied physiology (Bethesda, Md. : 1985), 103 (6), 2095-104 Abstract
  • Dallanoce C, De Amici M, Barocelli E, Bertoni S, Roth BL, Ernsberger P, De Micheli C (Dec 2007) Novel oxotremorine-related heterocyclic derivatives: Synthesis and in vitro pharmacology at the muscarinic receptor subtypes., Bioorganic & medicinal chemistry, 15 (24), 7626-37 Abstract
  • Ernsberger P, Johnson JL, Rosenthal T, Mirelman D, Koletsky RJ (Aug 2007) Therapeutic actions of allylmercaptocaptopril and captopril in a rat model of metabolic syndrome., American journal of hypertension : journal of the American Society of Hypertension, 20 (8), 866-74 Abstract
  • Ernsberger P, Johnson JL, Rosenthal T, Mirelman D, Koletsky RJ (Aug 2007) Therapeutic actions of allylmercaptocaptopril and captopril in a rat model of metabolic syndrome., American journal of hypertension : journal of the American Society of Hypertension, 20 (8), 866-74 Abstract
  • Xu C, Arinze IJ, Johnson J, Tuy TT, Bone F, Ernsberger P, Massillon D (Jul 2007) Metabolic dysregulation in the SHROB rat reflects abnormal expression of transcription factors and enzymes that regulate carbohydrate metabolism. Abstract
  • Sun Z, Chang CH, Ernsberger P (Apr 2007) Identification of IRAS/Nischarin as an I1-imidazoline receptor in PC12 rat pheochromocytoma cells., Journal of neurochemistry, 101 (1), 99-108 Abstract
  • Ernsberger P, Koletsky RJ (Apr 2007) Metabolic actions of angiotensin receptor antagonists: PPAR-gamma agonist actions or a class effect?, Current opinion in pharmacology, 7 (2), 140-5 Abstract
  • Sharma N, Okere IC, Duda MK, Johnson J, Yuan CL, Chandler MP, Ernsberger P, Hoit BD, Stanley WC (Apr 2007) High fructose diet increases mortality in hypertensive rats compared to a complex carbohydrate or high fat diet., American journal of hypertension : journal of the American Society of Hypertension, 20 (4), 403-9 Abstract
  • Sun Z, Chang CH, Ernsberger P (Apr 2007) Identification of IRAS/Nischarin as an I1-imidazoline receptor in PC12 rat pheochromocytoma cells., Journal of neurochemistry, 101 (1), 99-108 Abstract
  • Ernsberger P, Koletsky RJ (Apr 2007) Metabolic actions of angiotensin receptor antagonists: PPAR-gamma agonist actions or a class effect?, Current opinion in pharmacology, 7 (2), 140-5 Abstract
  • Sun Z, Ernsberger P (Feb 2007) Marked insulin resistance in obese spontaneously hypertensive rat adipocytes is ameliorated by in vivo but not in vitro treatment with moxonidine., The Journal of pharmacology and experimental therapeutics, 320 (2), 845-52 Abstract
  • Sun Z, Ernsberger P (Feb 2007) Marked insulin resistance in obese spontaneously hypertensive rat adipocytes is ameliorated by in vivo but not in vitro treatment with moxonidine., The Journal of pharmacology and experimental therapeutics, 320 (2), 845-52 Abstract
  • Keiser MJ, Roth BL, Armbruster BN, Ernsberger P, Irwin JJ, Shoichet BK (Feb 2007) Relating protein pharmacology by ligand chemistry., Nature biotechnology, 25 (2), 197-206 Abstract
  • Salinas C, Muzic RF, Ernsberger P, Saidel GM (Jan 2007) Robust experiment design for estimating myocardial beta adrenergic receptor concentration using PET., Medical physics, 34 (1), 151-65 Abstract
  • Okere IC, Young ME, McElfresh TA, Chess DJ, Sharov VG, Sabbah HN, Hoit BD, Ernsberger P, Chandler MP, Stanley WC (Dec 2006) Low carbohydrate/high-fat diet attenuates cardiac hypertrophy, remodeling, and altered gene expression in hypertension., Hypertension, 48 (6), 1116-23 Abstract
  • Okere IC, Young ME, McElfresh TA, Chess DJ, Sharov VG, Sabbah HN, Hoit BD, Ernsberger P, Chandler MP, Stanley WC (Dec 2006) Low carbohydrate/high-fat diet attenuates cardiac hypertrophy, remodeling, and altered gene expression in hypertension., Hypertension, 48 (6), 1116-23 Abstract
  • Okere IC, Chandler MP, McElfresh TA, Rennison JH, Sharov V, Sabbah HN, Tserng KY, Hoit BD, Ernsberger P, Young ME, Stanley WC (Jul 2006) Differential effects of saturated and unsaturated fatty acid diets on cardiomyocyte apoptosis, adipose distribution, and serum leptin., American journal of physiology. Heart and circulatory physiology, 291 (1), H38-44 Abstract
  • Ernsberger P, Koletsky RJ (Jul 2006) Metabolic effects of antihypertensive agents: role of sympathoadrenal and renin-angiotensin systems., Naunyn-Schmiedeberg's archives of pharmacology, 373 (4), 245-58 Abstract
  • Campos P, Saguy A, Ernsberger P, Oliver E, Gaesser G (Feb 2006) The epidemiology of overweight and obesity: public health crisis or moral panic?, International journal of epidemiology, 35 (1), 55-60 Abstract
  • Velliquette RA, Kossover R, Previs SF, Ernsberger P (Jan 2006) Lipid-lowering actions of imidazoline antihypertensive agents in metabolic syndrome X., Naunyn-Schmiedeberg's archives of pharmacology, 372 (4), 300-12 Abstract
  • Okere IC, Chess DJ, McElfresh TA, Johnson J, Rennison J, Ernsberger P, Hoit BD, Chandler MP, Stanley WC (Oct 2005) High-fat diet prevents cardiac hypertrophy and improves contractile function in the hypertensive dahl salt-sensitive rat., Clinical and experimental pharmacology & physiology, 32 (10), 825-31 Abstract
  • Salinas C, Muzic RF Jr, Berridge M, Ernsberger P (Aug 2005) PET imaging of myocardial beta-adrenergic receptors with fluorocarazolol: lack of interference by endogenous catecholamines, Journal of Cardiovascular Pharmacology, 46 (2), 222-31
  • Velliquette RA, Friedman JE, Shao J, Zhang BB, Ernsberger P (Jul 2005) Therapeutic actions of an insulin receptor activator and a novel peroxisome proliferator-activated receptor gamma agonist in the spontaneously hypertensive obese rat model of metabolic syndrome X., The Journal of pharmacology and experimental therapeutics, 314 (1), 422-30 Abstract
  • Faulx MD, Ernsberger P, Vatner D, Hoffman RD, Lewis W, Strachan R, Hoit BD (Jul 2005) Strain-dependent beta-adrenergic receptor function influences myocardial responses to isoproterenol stimulation in mice, American Journal of Physiology. Heart and Circulatory Physiology, 289 (1), H30-6
  • Velliquette RA, Friedman JE, Shao J, Zhang BB, Ernsberger P (Jul 2005) Therapeutic actions of an insulin receptor activator and a novel peroxisome proliferator-activated receptor gamma agonist in the spontaneously hypertensive obese rat model of metabolic syndrome X, The Journal of Pharmacology and Experimental Therapeutics, 314 (1), 422-30
  • Ernsberger P (2005) Readers' responses to the webcast video editorial entitled "how to take useful drugs without hurting yourself"., MedGenMed : Medscape general medicine, 7 (2), 38 Abstract
  • Ikeda J, Amy NK, Ernsberger P, Gaesser GA, Berg FM, Clark CA, Parham ES, Peters P (Jul-Aug 2005) The National Weight Control Registry: a critique, Journal of Nutrition Education and Behavior, 37 (4), 203-5
  • Prell GD, Martinelli GP, Holstein GR, Matulic-Adamic J, Watanabe KA, Chan SL, Morgan NG, Haxhiu MA, Ernsberger P, Imidazoleacetic acid-ribotide: an endogenous ligand that stimulates imidazol(in)e receptors, Proceedings of the National Academy of Sciences of the United States of America., 101(37), 13677-82, September 2004 Abstract
  • Prell GD, Martinelli GP, Holstein GR, Matulić-Adamić J, Watanabe KA, Chan SL, Morgan NG, Haxhiu MA, Ernsberger P (Sep 2004) Imidazoleacetic acid-ribotide: an endogenous ligand that stimulates imidazol(in)e receptors., Proceedings of the National Academy of Sciences of the United States of America, 101 (37), 13677-82 Abstract
  • Prell GD, Martinelli GP, Holstein GR, Matulic-Adamic J, Watanabe KA, Chan SL, Morgan NG, Haxhiu MA, Ernsberger P (Sep 2004) Imidazoleacetic acid-ribotide: an endogenous ligand that stimulates imidazol(in)e receptors, Proceedings of the National Academy of Sciences of the United States of America, 101 (37), 13677-82
  • Velliquette RA, Ernsberger P, Contrasting metabolic effects of antihypertensive agents, The Journal of Pharmacology and Experimental Therapeutics, 307(3), 1104-11, December 2003 Abstract
  • Koletsky RJ, Velliquette RA, Ernsberger P, The role of I(1)-imidazoline receptors and alpha(2)-adrenergic receptors in the modulation of glucose and lipid metabolism in the SHROB model of metabolic syndrome X, Annals of the New York Academy of Sciences, 1009, 251-61, December 2003 Abstract
  • Piletz JE, Deleersnijder W, Roth BL, Ernsberger P, Zhu H, Ziegler D, IRAS splice variants, Annals of the New York Academy of Sciences, 1009, 419-26, December 2003 Abstract
  • Mukaddam-Daher S, Menaouar A, El-Ayoubi R, Gutkowska J, Jankowski M, Velliquette RA, Ernsberger P, Cardiac effects of moxonidine in spontaneously hypertensive obese rats, Annals of the New York Academy of Sciences, 1009, 244-50, December 2003 Abstract
  • Velliquette RA, Ernsberger P (Dec 2003) Contrasting metabolic effects of antihypertensive agents., The Journal of pharmacology and experimental therapeutics, 307 (3), 1104-11 Abstract
  • Mukaddam-Daher S, Menaouar A, El-Ayoubi R, Gutkowska J, Jankowski M, Velliquette RA, Ernsberger P (Dec 2003) Cardiac effects of moxonidine in spontaneously hypertensive obese rats., Annals of the New York Academy of Sciences, 1009, 244-50 Abstract
  • Koletsky RJ, Velliquette RA, Ernsberger P (Dec 2003) The role of I(1)-imidazoline receptors and alpha(2)-adrenergic receptors in the modulation of glucose and lipid metabolism in the SHROB model of metabolic syndrome X., Annals of the New York Academy of Sciences, 1009, 251-61 Abstract
  • Piletz JE, Deleersnijder W, Roth BL, Ernsberger P, Zhu H, Ziegler D (Dec 2003) IRAS splice variants., Annals of the New York Academy of Sciences, 1009, 419-26 Abstract
  • Mukaddam-Daher S, Menaouar A, El-Ayoubi R, Gutkowska J, Jankowski M, Velliquette RA, Ernsberger P (Dec 2003) Cardiac effects of moxonidine in spontaneously hypertensive obese rats, Annals of the New York Academy of Sciences, 1009, 244-50
  • Velliquette RA, Ernsberger P (Dec 2003) Contrasting metabolic effects of antihypertensive agents, The Journal of Pharmacology and Experimental Therapeutics, 307 (3), 1104-11
  • Dunlap ME, Bibevski S, Rosenberry TL, Ernsberger P, Mechanisms of altered vagal control in heart failure: influence of muscarinic receptors and acetylcholinesterase activity, American Journal of Physiology. Heart and Circulatory Physiology, 285(4), H1632-40, October 2003 Abstract
  • De Amici M, Conti P, Fasoli E, Barocelli E, Ballabeni V, Bertoni S, Impicciatore M, Roth BL, Ernsberger P, De Micheli C, Synthesis and in vitro pharmacology of novel heterocyclic muscarinic ligands, Farmaco (societa Chimica Italiana : 1989), 58(9), 739-48, September 2003 Abstract
  • De Amici M, Conti P, Fasoli E, Barocelli E, Ballabeni V, Bertoni S, Impicciatore M, Roth BL, Ernsberger P, De Micheli C (Sep 2003) Synthesis and in vitro pharmacology of novel heterocyclic muscarinic ligands, Farmaco (societa Chimica Italiana : 1989), 58 (9), 739-48
  • Velliquette RA, Ernsberger P, The role of I(1)-imidazoline and alpha(2)-adrenergic receptors in the modulation of glucose metabolism in the spontaneously hypertensive obese rat model of metabolic syndrome X, The Journal of Pharmacology and Experimental Therapeutics, 306(2), 646-57, August 2003 Abstract
  • Edwards L, Ernsberger P, The I(1)-imidazoline receptor in PC12 pheochromocytoma cells reverses NGF-induced ERK activation and induces MKP-2 phosphatase, Brain Research, 980(1), 71-9, August 2003 Abstract
  • Shi Q, Savage JE, Hufeisen SJ, Rauser L, Grajkowska E, Ernsberger P, Wroblewski JT, Nadeau JH, Roth BL, L-homocysteine sulfinic acid and other acidic homocysteine derivatives are potent and selective metabotropic glutamate receptor agonists, The Journal of Pharmacology and Experimental Therapeutics, 305(1), 131-42, April 2003 Abstract
  • Shi Q, Savage JE, Hufeisen SJ, Rauser L, Grajkowska E, Ernsberger P, Wroblewski JT, Nadeau JH, Roth BL (Apr 2003) L-homocysteine sulfinic acid and other acidic homocysteine derivatives are potent and selective metabotropic glutamate receptor agonists, The Journal of Pharmacology and Experimental Therapeutics, 305 (1), 131-42
  • Kroeze WK, Hufeisen SJ, Popadak BA, Renock SM, Steinberg S, Ernsberger P, Jayathilake K, Meltzer HY, Roth BL, H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs, Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology., 28(3), 519-26, March 2003 Abstract
  • Kroeze WK, Hufeisen SJ, Popadak BA, Renock SM, Steinberg S, Ernsberger P, Jayathilake K, Meltzer HY, Roth BL (Mar 2003) H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs, Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 28 (3), 519-26
  • Roth BL, Baner K, Westkaemper R, Siebert D, Rice KC, Steinberg S, Ernsberger P, Rothman RB, Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist, Proceedings of the National Academy of Sciences of the United States of America., 99(18), 11934-9, September 2002 Abstract
  • Butterweck V, Nahrstedt A, Evans J, Hufeisen S, Rauser L, Savage J, Popadak B, Ernsberger P, Roth BL, In vitro receptor screening of pure constituents of St. John's wort reveals novel interactions with a number of GPCRs, Psychopharmacology, 162(2), 193-202, July 2002 Abstract
  • Velliquette RA, Koletsky RJ, Ernsberger P, Plasma glucagon and free fatty acid responses to a glucose load in the obese spontaneous hypertensive rat (SHROB) model of metabolic syndrome X, Experimental Biology and Medicine (maywood, N.j.), 227(3), 164-70, March 2002 Abstract
  • Edwards L, Fishman D, Horowitz P, Bourbon N, Kester M, Ernsberger P, The I1-imidazoline receptor in PC12 pheochromocytoma cells activates protein kinases C, extracellular signal-regulated kinase (ERK) and c-jun N-terminal kinase (JNK), Journal of Neurochemistry, 79(5), 931-40, December 2001 Abstract
  • Roth BL, Ernsberger P, Steinberg SA, Rao S, Rauser L, Savage J, Hufeisen S, Berridge MS, Muzic RF Jr, The in vitro pharmacology of the beta-adrenergic receptor pet ligand (s)-fluorocarazolol reveals high affinity for cloned beta-adrenergic receptors and moderate affinity for the human 5-HT, Psychopharmacology, 157(1), 111-4, August 2001 Abstract
  • Tolentino-Silva FP, Haxhiu MA, Ernsberger P, Waldbaum S, Dreshaj IA, Differential cardiorespiratory control elicited by activation of ventral medullary sites in mice, Journal of Applied Physiology (bethesda, Md. : 1985), 89(2), 437-44, August 2000 Abstract
  • Piletz JE, Ivanov TR, Sharp JD, Ernsberger P, Chang CH, Pickard RT, Gold G, Roth B, Zhu H, Jones JC, Baldwin J, Reis DJ, Imidazoline receptor antisera-selected (IRAS) cDNA: cloning and characterization, Dna and Cell Biology, 19(6), 319-29, June 2000 Abstract
  • Tolentino-Silva FP, Haxhiu MA, Waldbaum S, Dreshaj IA, Ernsberger P, alpha(2)-adrenergic receptors are not required for central anti-hypertensive action of moxonidine in mice, Brain Research, 862(1-2), 26-35, April 2000 Abstract
  • Thomas AJ, Erokwu BO, Yamamoto BK, Ernsberger P, Bishara O, Strohl KP, Alterations in respiratory behavior, brain neurochemistry and receptor density induced by pharmacologic suppression of sleep in the neonatal period, Brain Research. Developmental Brain Research, 120(2), 181-9, April 2000 Abstract
  • Ernsberger P, Pharmacology of moxonidine: an I1-imidazoline receptor agonist, Journal of Cardiovascular Pharmacology, 35(7 Suppl 4), S27-41, 2000 Abstract
  • Edwards L, Ernsberger P, Assay of arachidonic acid release coupled to alpha 1- and alpha 2-adrenergic receptors, Methods in Molecular Biology (clifton, N.j.), 126, 375-90, 2000 Abstract
  • Kastin AJ, Pan W, Maness LM, Koletsky RJ, Ernsberger P, Decreased transport of leptin across the blood-brain barrier in rats lacking the short form of the leptin receptor, Peptides, 20(12), 1449-53, December 1999 Abstract
  • Ernsberger P, Koletsky RJ, Friedman JE, Molecular pathology in the obese spontaneous hypertensive Koletsky rat: a model of syndrome X, Annals of the New York Academy of Sciences, 892, 272-88, November 1999 Abstract
  • Yohannan MD, Marti RJ, Dreshaj I, Haxhiu MA, Ernsberger P, Ontogeny of neurokinin-1 receptors in the porcine respiratory system, Peptides, 20(11), 1353-60, November 1999 Abstract
  • Ernsberger P, Koletsky RJ, Kline DD, Bedol DM, Friedman JE, The SHROB model of syndrome X: effects of excess dietary sucrose, Annals of the New York Academy of Sciences, 892, 315-8, November 1999 Abstract
  • Ernsberger P, The I1-imidazoline receptor and its cellular signaling pathways., Annals of the New York Academy of Sciences, 881, 35-53, 21 Jun 1999 Abstract
  • Haxhiu MA, Dreshaj IA, McFadden CB, Erokwu BO, Ernsberger P, Moxonidine acting centrally inhibits airway reflex responses, Annals of the New York Academy of Sciences, 881, 372-82, June 1999 Abstract
  • Piletz JE, Jones JC, Zhu H, Bishara O, Ernsberger P, Imidazoline receptor antisera-selected cDNA clone and mRNA distribution, Annals of the New York Academy of Sciences, 881, 1-7, June 1999 Abstract
  • Ernsberger P, Ishizuka T, Liu S, Farrell CJ, Bedol D, Koletsky RJ, Friedman JE, Mechanisms of antihyperglycemic effects of moxonidine in the obese spontaneously hypertensive Koletsky rat (SHROB), The Journal of Pharmacology and Experimental Therapeutics, 288(1), 139-47, Jan 1999 Abstract
  • Ernsberger P, Koletsky RJ, Kilani A, Viswan G, Bedol D, Effects of weight cycling on urinary catecholamines: sympathoadrenal role in refeeding hypertension., Journal of Human Hypertension, 16(12 Pt 2), 2001-5, December 1998 Abstract
  • Ishizuka T, Ernsberger P, Liu S, Bedol D, Lehman TM, Koletsky RJ, Friedman JE, Phenotypic consequences of a nonsense mutation in the leptin receptor gene (fak) in obese spontaneously hypertensive Koletsky rats (SHROB), The Journal of Nutrition, 128(12), 2299-306, December 1998 Abstract
  • Chelala JL, Kilani A, Miller MJ, Martin RJ, Ernsberger P, Muscarinic receptor binding sites of the M4 subtype in porcine lung parenchyma, Pharmacology & Toxicology, 83(5), 200-7, November 1998 Abstract
  • Ernsberger P, Arachidonic acid release from PC12 pheochromocytoma cells is regulated by I1-imidazoline receptors., Journal of the Autonomic Nervous System, 72(2-3), 147-54, 15 Oct 1998 Abstract
  • Haxhiu MA, Dreshaj IA, McFadden CB, Erokwu BO, Ernsberger P, I1-imidazoline receptors and cholinergic outflow to the airways, Journal of the Autonomic Nervous System, 71(2-3), 167-74, July 1998 Abstract
  • Coles SK, Ernsberger P, Dick TE, A role for NMDA receptors in posthypoxic frequency decline in the rat, The American Journal of Physiology, 274(6 Pt 2), R1546-55, June 1998 Abstract
  • Coles SK, Ernsberger P, Dick TE, Post-hypoxic frequency decline does not depend on alpha2-adrenergic receptors in the adult rat, Brain Research, 794(2), 267-73, June 1998 Abstract
  • Ernsberger P, Kou YR, Prabhakar NR, Carotid body I1-imidazoline receptors: binding, visualization and modulatory function, Respiration Physiology, 112(3), 239-51, June 1998 Abstract
  • Friedman JE, Ishizuka T, Liu S, Farrell CJ, Koletsky RJ, Bedol D, Ernsberger P, Anti-hyperglycemic activity of moxonidine: metabolic and molecular effects in obese spontaneously hypertensive rats, Blood Pressure, Suppl 3, 32-9, 1998 Abstract
  • Ernsberger P, Haxhiu MA, The I1-imidazoline-binding site is a functional receptor mediating vasodepression via the ventral medulla, The American Journal of Physiology, 273(5 Pt 2), R1572-9, November 1997 Abstract
  • Friedman JE, Ishizuka T, Liu S, Farrell CJ, Bedol D, Koletsky RJ, Kaung HL, Ernsberger P, Reduced insulin receptor signaling in the obese spontaneously hypertensive Koletsky rat, The American Journal of Physiology, 273(5 Pt 1), E1014-23, November 1997 Abstract
  • Jakupaj M, Martin RJ, Dreshaj IA, Potter CF, Haxhiu MA, Ernsberger P, Role of endogenous NO in modulating airway contraction mediated by muscarinic receptors during development, The American Journal of Physiology, 273(3 Pt 1), L531-6, September 1997 Abstract
  • Mandal A, Wang Y, Ernsberger P, Kester M, Interleukin-1-induced ether-linked diglycerides inhibit calcium-insensitive protein kinase C isotypes. Implications for growth senescence, Journal of Bioligical Chemistry, 272(32), 20306-11, August 1997 Abstract
  • Agani FH, Kuo NT, Chang CH, Dreshaj IA, Farver CF, Krause JE, Ernsberger P, Haxhiu MA, Martin RJ, Effect of hyperoxia on substance P expression and airway reactivity in the developing lung, The American Journal of Physiology, 273(1 Pt 1), L40-5, July 1997 Abstract
  • Separovic D, Kester M, Haxhiu MA, Ernsberger P, Activation of phosphatidylcholine-selective phospholipase C by I1-imidazoline receptors in PC12 cells and rostral ventrolateral medulla, Brain Research, 749(2), 335-9, February 1997 Abstract
  • Ernsberger P, Shen IH, Membrane localization and guanine nucleotide sensitivity of medullary I1-imidazoline binding sites, Neurochemistry International, 30(1), 17-23, January 1997 Abstract
  • Ernsberger P, Friedman JE, Koletsky RJ, The I1-imidazoline receptor: from binding site to therapeutic target in cardiovascular disease, Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension., 15(1), S9-23, January 1997 Abstract
  • Ernsberger P, Koletsky RJ, Collins LA, Bedol D, Sympathetic nervous system in salt-sensitive and obese hypertension: amelioration of multiple abnormalities by a central sympatholytic agent, Cardiovascular Drugs and Therapy / Sponsored by the International Society of Cardiovascular Pharmacotherapy., 10 Suppl 1, 275-82, June 1996 Abstract
  • Separovic D, Kester M, Ernsberger P, Coupling of I1-imidazoline receptors to diacylglyceride accumulation in PC12 rat pheochromocytoma cells, Molecular Pharmacology, 49(4), 668-75, April 1996 Abstract
  • Ernsberger P, Koletsky RJ, Baskin JS, Collins LA, Consequences of weight cycling in obese spontaneously hypertensive rats, The American Journal of Physiology, 270(4 Pt 2), R864-72, April 1996 Abstract
  • Ziegler D, Haxhiu MA, Kaan EC, Papp JG, Ernsberger P, Pharmacology of moxonidine, an I1-imidazoline receptor agonist, Journal of Cardiovascular Pharmacology, 27 Suppl 3, S26-37, 1996 Abstract
  • Koletsky RJ, Boccia J, Ernsberger P, Acceleration of renal disease in obese SHR by exacerbation of hypertension, Clinical and Experimental Pharmacology & Physiology. Supplement, 22(1), S254-6, December 1995 Abstract
  • Huang SS, Khosrof SA, Koletsky RJ, Benetz BA, Ernsberger P, Characterization of retinal vascular abnormalities in lean and obese spontaneously hypertensive rats, Clinical and Experimental Pharmacology & Physiology. Supplement, 22(1), S129-31, December 1995 Abstract
  • Evinger MJ, Ernsberger P, Regunathan S, Reis DJ, Regulation of phenylethanolamine N-methyltransferase gene expression by imidazoline receptors in adrenal chromaffin cells, Journal of Neurochemistry, 65(3), 988-97, September 1995 Abstract
  • Dreshaj IA, Miller MJ, Ernsberger P, Haxhiu-Poskurica B, Martin RJ, Haxhiu MA, Central effects of endothelin on respiratory output during development, Journal of Applied Physiology (bethesda, Md. : 1985), 79(2), 420-7, August 1995 Abstract
  • Liedtke CM, Ernsberger P, Regulation of electrolyte transport in rabbit tracheal epithelial cells by the I1-imidazoline agonist moxonidine, Annals of the New York Academy of Sciences, 763, 401-4, July 1995 Abstract
  • Ernsberger P, Li P, Smyth DD, 2,6-Dimethyl clonidine: alpha 2-adrenoceptor or I1-imidazoline receptor agonist?, Annals of the New York Academy of Sciences, 763, 96-9, July 1995 Abstract
  • Ernsberger P, Piletz JE, Graff LM, Graves ME, Optimization of radioligand binding assays for I1-imidazoline sites, Annals of the New York Academy of Sciences, 763, 163-8, July 1995 Abstract
  • Haxhiu MA, Dreshaj IA, Erokwu B, Collins LA, Ernsberger P, Effect of I1-imidazoline receptor activation on responses of hypoglossal and phrenic nerve to chemical stimulation, Annals of the New York Academy of Sciences, 763, 445-62, July 1995 Abstract
  • Lei L, Slavica M, Ernsberger P, Graves ME, Patil P, Miller D, Feller D, Calcium channel-dependent and I1-imidazoline receptor binding properties of 2-(4'-isothiocyanatobenzyl) imidazoline analogs in vascular and brain tissues, Annals of the New York Academy of Sciences, 763, 283-6, July 1995 Abstract
  • Ernsberger P, Graves ME, Graff LM, Zakieh N, Nguyen P, Collins LA, Westbrooks KL, Johnson GG, I1-imidazoline receptors. Definition, characterization, distribution, and transmembrane signaling, Annals of the New York Academy of Sciences, 763, 22-42, July 1995 Abstract
  • Buccafusco JJ, Lapp CA, Westbrooks KL, Ernsberger P, Role of medullary I1-imidazoline and alpha 2-adrenergic receptors in the antihypertensive responses evoked by central administration of clonidine analogs in conscious spontaneously hyperte, The Journal of Pharmacology and Experimental Therapeutics, 273(3), 1162-71, June 1995 Abstract
  • Ernsberger P, Koletsky RJ, Weight cycling, Jama : the Journal of the American Medical Association, 273(13), 998-9, April 1995 Abstract
  • Piletz JE, Chikkala DN, Ernsberger P, Comparison of the properties of agmatine and endogenous clonidine-displacing substance at imidazoline and alpha-2 adrenergic receptors, The Journal of Pharmacology and Experimental Therapeutics, 272(2), 581-7, February 1995 Abstract
  • Yohannan MD, Ernsberger P, Heterogeneity of neurokinin1 binding sites in porcine respiratory tract, Peptides, 16(5), 873-82, 1995 Abstract
  • Arango, V, Ernsberger, P, Reis, D.J, Mann, J.J., Demonstration of high-and low-affinity B- adrenergic receptors in slide-mounted sections of rat and human brain, Brain Research, 516, 113-21, 1990
  • Ernsberger, P, Giuliano, R, Willette, R.N, Reis, D.J., Role of imidazole receptors in the vasodepressor response to clonidine analogs in the rostral ventrolateral medulla, Journal of Pharmacology and Experimental Therapeutics, 253, 408-18, 1990
  • Arneric, S.P, Giuliano, R, Ernsberger, P, Underwood, M.D, Reis, D.J., Synthesis, release and receptor binding of acetylcholine in the C1 area of the rostral ventrolateral medulla: contributions in regulating arterial pressure, Brain Research, 511, 98-112, 1990
  • Ernsberger, P, Feinland, G, Meeley, M.P, Reis, D.J., Characterization and visualization of clonidine-sensitive imidazole sites in rat kidney which recognize clonidine-displacing substance, American Journal of Hypertension, 3, 90-7, 1990
  • Ernsberger, P, Nelson, D.O., Refeeding hypertension in dietary obesity, American Journal of Physiology, 254, R47-R55, 1988
  • Okere IC, Chandler MP, McElfresh TA, Rennison JH, Kung TA, Hoit BD, Ernsberger P, Young ME, Stanley WC, Carnitine palmitoyl transferase-I inhibition is not associated with cardiac hypertrophy in rats fed a high-fat diet., Clinical and experimental pharmacology & physiology, 34 (1-2), 113-9 Abstract
  • Ikeda J, Amy NK, Ernsberger P, Gaesser GA, Berg FM, Clark CA, Parham ES, Peters P, The National Weight Control Registry: a critique., Journal of nutrition education and behavior, 37 (4), 203-5 Abstract

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Last Updated: 3/6/2008

COS Expertise ID #246513
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