Dr. Ruth Etzioni

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Fred Hutchinson Cancer Research Center
Public Health Sciences Division
Biostatistics Program
Translational & Outcomes Research Group
Full MemberAppointed: 2002
University of Washington
Affilitate ProfessorAppointed: 1997
Professional Headshot of Ruth Etzioni

Mailing Address

Fred Hutchinson Cancer Research Center
1100 Fairview Avenue North
M2-B230
P.O. Box 19024
Seattle, Washington 98109-1024
United States

Contact Information

Phone: (206) 667-6561
Fax: (206) 667-7264
retzioni@fhcrc.org

Qualifications

Ph.D., Carnegie Mellon University, Statistics, 1990.
M.S., Carnegie Mellon University, Statistics, 1987.
B.S., University of Cape Town, Statistics, 1985.

Expertise and Research Interests

Cancer screening
Methods for evaluating diagnostic tests
Modeling and outcomes research in prostate cancer
Modeling impact of PSA screening and other interventions on prostate cancer incidence and mortality
Costs and benefits of prostate cancer screening
Trends in prostate cancer screening and related behaviors

Dr. Ruth (Douglas) Etzioni is a Full Member in Biostatistics of the Division of Public Health Sciences at the Fred Hutchinson Cancer Research Center. Her work focuses on the development and implementation of statistical methods for prostate cancer studies. In the past, she has worked on assessing the efficacy of PSA screening from population studies, estimating the frequency of overdiagnosis associated with PSA, evaluating novel prostate cancer biomarkers, and tracking patterns and outcomes of prostate cancer care. Her work in prostate cancer surveillance is conducted as part of the Cancer Intervention and Surveillance Modeling Network (CISNET).

As leader of the biostatistics core for the Northwest Prostate Cancer SPORE, Dr. Etzioni has developed methods for analyzing immunohistochemical studies, and combining results from microarray experiments, while working with SPORE investigators to select the most appropriate design and analysis approaches for a broad array of studies. She is an affiliate investigator on the Data Management Coordination Center for the Early Detection Research Network (EDRN) and continues to work with EDRN statisticians on methods for biomarker development. In addition to these projects, her current interests include modeling the development of resistance to androgen ablation therapy.

Keywords

COS Keywords:

Biometry, Biostatistics, Cancer Or Carcinogenesis, Cancer Prevention, Health Behavior, Medical Diagnosis, Outcomes Research (Medical), Prostate Cancer, Public Health, Statistics.

Memberships

American Statistical Association
Institute of Mathematical Statistics
International Biometric Society
Society for Medical Decision Making

Funding Received

  • NIH/NCI: Pacific Northwest Prostate Cancer SPORE, Core C: Biostatistics Core (PI), $88,234 (direct), May 1, 2002 to 2012.
  • NIH/NCI: Outcomes Based Guidelines Development for Prostate Cancer Screening and Treatment, $172,221, 2008 to 2012.
  • NIH/NCI: Primary Prevention versus Screening for Prostate Cancer (PI), $178,000 (annual dir, 2003 to 2009.
  • NCI: Modeling US prostate cancer trends: PSA, treatment and risk: Cancer Intervention Surveillance Modeling Network (PI), $153,065 (annual dir, 2000 to 2010.

Publications

  • Telesca D, Inoue LY, Neira M, Etzioni R, Gleave M, Nelson C (Nov 2008) Differential Expression and Network Inferences through Functional Data Modeling., Biometrics Abstract
  • Thompson IM, Ankerst DP, Etzioni R, Wang T (Oct 2008) It's time to abandon an upper limit of normal for prostate specific antigen: assessing the risk of prostate cancer., The Journal of urology, 180 (4), 1219-22 Abstract
  • Etzioni R (2008) Statistical issues in the evaluation of screening and early detection modalities., Urologic oncology, 26 (3), 308-15 Abstract
  • Etzioni R, Feuer E (May 2008) Studies of prostate-cancer mortality: caution advised., The lancet oncology, 9 (5), 407-9 Abstract
  • Telesca D, Etzioni R, Gulati R (Mar 2008) Estimating lead time and overdiagnosis associated with PSA screening from prostate cancer incidence trends., Biometrics, 64 (1), 10-9 Abstract
  • Etzioni R, Gulati R, Falcon S, Penson DF (Mar 2008) Impact of PSA Screening on the Incidence of Advanced Stage Prostate Cancer in the United States: A Surveillance Modeling Approach., Medical decision making : an international journal of the Society for Medical Decision Making Abstract
  • Etzioni R, Tsodikov A, Mariotto A, Szabo A, Falcon S, Wegelin J, Ditommaso D, Karnofski K, Gulati R, Penson DF, Feuer E (Mar 2008) Quantifying the role of PSA screening in the US prostate cancer mortality decline., Cancer causes & control : CCC, 19 (2), 175-81 Abstract
  • Inoue LYT, Etzioni R, Morrell C, Muller P (2008) Modeling Disease Progression with Longitudinal Markers, Journal of the American Statistical Association, 103 (481), 259-270
  • Kawachi MH, Bahnson RR, Barry M, Carroll PR, Carter HB, Catalona WJ, Epstein JI, Etzioni RB, Hemstreet GP, Howe RJ, Kopin JD, Lange PH, Lilja H, Mohler J, Moul J, Nadler RB, Patterson S, Pollack A, Presti JC, Stroup AM, Urban DA, Wake R, Wei JT (Aug 2007) Prostate cancer early detection. Clinical practice guidelines in oncology., Journal of the National Comprehensive Cancer Network : JNCCN, 5 (7), 714-36 Abstract
  • Inoue LY, Neira M, Nelson C, Gleave M, Etzioni R (Jul 2007) Cluster-based network model for time-course gene expression data., Biostatistics (Oxford, England), 8 (3), 507-25 Abstract
  • Mariotto AB, Etzioni R, Krapcho M, Feuer EJ (May 2007) Reconstructing PSA testing patterns between black and white men in the US from Medicare claims and the National Health Interview Survey., Cancer, 109 (9), 1877-86 Abstract
  • Etzioni RD, Ankerst DP, Thompson IM (Mar 2007) Re: Detection of life-threatening prostate cancer with prostate-specific antigen velocity during a window of curability., Journal of the National Cancer Institute, 99 (6), 489-90; author reply Abstract
  • Zeliadt SB, Etzioni R, Ramsey SD, Penson DF, Potosky AL (Feb 2007) Trends in treatment costs for localized prostate cancer: the healthy screenee effect., Medical care, 45 (2), 154-9 Abstract
  • Zeliadt SB, Potosky AL, Penson DF, Etzioni R (Oct 2006) Survival benefit associated with adjuvant androgen deprivation therapy combined with radiotherapy for high- and low-risk patients with nonmetastatic prostate cancer., International journal of radiation oncology, biology, physics, 66 (2), 395-402 Abstract
  • Etzioni D, Howlader N, Etzioni R (2006) Basic Statistical Methods In Penson DF, Wei J (eds), Clinical Research Methods for Surgeons, Totowa, New Jersey, Humana press, 123-40 pages, ISBN=1-59745-230-0 (bookchapter)
  • Kristal AR, Chi C, Tangen CM, Goodman PJ, Etzioni R, Thompson IM (Jan 2006) Associations of demographic and lifestyle characteristics with prostate-specific antigen (PSA) concentration and rate of PSA increase., Cancer, 106 (2), 320-8 Abstract
  • DeConde RP, Hawley S, Falcon S, Clegg N, Knudsen B, Etzioni R (2006) Combining results of microarray experiments: a rank aggregation approach., Statistical applications in genetics and molecular biology, 5, Article15 Abstract
  • Pinsky P, Etzioni R, Howlader N, Goodman PJ, Thompson I (2006) Modeling the Effect of a Preventative Intervention on the Natural History of Prostate Cancer, International Journal of Biostatistics, 2 (1), Article 12
  • Zeliadt SB, Etzioni RD, Kristal AR (2005) Estimated impact of the prostate cancer prevention trial on population mortality, Cancer, 104 (7), 1556-7
  • Etzioni RD, Howlader N, Shaw PA, Ankerst DP, Penson DF, Goodman PJ, Thompson IM (Sep 2005) Long-term effects of finasteride on prostate specific antigen levels: results from the prostate cancer prevention trial., The Journal of Urology, 174 (3), 877-81 Abstract
  • Zeliadt SB, Etzioni RD, Penson DF, Thompson IM, Ramsey SD (Aug 2005) Lifetime implications and cost-effectiveness of using finasteride to prevent prostate cancer., The American Journal of Medicine, 118 (8), 850-7 Abstract
  • Etzioni R, Hawley S, Billheimer D, True LD, Knudsen B (May 2005) Analyzing patterns of staining in immunohistochemical studies: application to a study of prostate cancer recurrence., Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 14 (5), 1040-6 Abstract
  • Moore S, Knudsen B, True LD, Hawley S, Etzioni R, Wade C, Gifford D, Coleman I, Nelson PS (Apr 2005) Loss of stearoyl-CoA desaturase expression is a frequent event in prostate carcinoma., International Journal of Cancer. Journal International Du Cancer, 114 (4), 563-71 Abstract
  • Zeliadt SB, Potosky AL, Etzioni R, Ramsey SD, Penson DF (Dec 2004) Racial disparity in primary and adjuvant treatment for nonmetastatic prostate cancer: SEER-Medicare trends 1991 to 1999., Urology, 64 (6), 1171-6 Abstract
  • Feuer EJ, Etzioni R, Cronin KA, Mariotto A (Dec 2004) The use of modeling to understand the impact of screening on U.S. mortality: examples from mammography and PSA testing., Statistical Methods in Medical Research, 13 (6), 421-42 Abstract
  • Shaw PA, Etzioni R, Zeliadt SB, Mariotto A, Karnofski K, Penson DF, Weiss NS, Feuer EJ (Dec 2004) An ecologic study of prostate-specific antigen screening and prostate cancer mortality in nine geographic areas of the United States., American Journal of Epidemiology, 160 (11), 1059-69 Abstract
  • Etzioni R, Falcon S, Gann PH, Kooperberg CL, Penson DF, Stampfer MJ (Oct 2004) Prostate-specific antigen and free prostate-specific antigen in the early detection of prostate cancer: do combination tests improve detection?, Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology., 13 (10), 1640-5 Abstract
  • Lai JS, Brown LG, True LD, Hawley SJ, Etzioni RB, Higano CS, Ho SM, Vessella RL, Corey E (Oct 2004) Metastases of prostate cancer express estrogen receptor-beta., Urology, 64 (4), 814-20 Abstract
  • Weiss NS, Dhillon PK, Etzioni R (Jul 2004) Case-control studies of the efficacy of cancer screening: overcoming bias from nonrandom patterns of screening., Epidemiology (cambridge, Mass.), 15 (4), 409-13 Abstract
  • Etzioni R, Thomas DB (Jul 2004) Modelling the effect of screening for cervical cancer on the population., Lancet, 364 (9430), 224-6 Abstract
  • Ramsey SD, Mandelson MT, Berry K, Etzioni R, Harrison R (Dec 2003) Cancer-attributable costs of diagnosis and care for persons with screen-detected versus symptom-detected colorectal cancer., Gastroenterology, 125 (6), 1645-50 Abstract
  • Chen C, Weiss NS, Stanczyk FZ, Lewis SK, DiTommaso D, Etzioni R, Barnett MJ, Goodman GE (Dec 2003) Endogenous sex hormones and prostate cancer risk: a case-control study nested within the Carotene and Retinol Efficacy Trial., Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology., 12 (12), 1410-6 Abstract
  • Etzioni R, Kooperberg C, Pepe M, Smith R, Gann PH (Oct 2003) Combining biomarkers to detect disease with application to prostate cancer., Biostatistics (oxford, England), 4 (4), 523-38 Abstract
  • Zeliadt SB, Penson DF, Albertsen PC, Concato J, Etzioni RD (Aug 2003) Race independently predicts prostate specific antigen testing frequency following a prostate carcinoma diagnosis., Cancer, 98 (3), 496-503 Abstract
  • Lamharzi N, Johnson MM, Goodman G, Etzioni R, Weiss NS, Dightman DA, Barnett M, DiTommaso D, Chen C (Jul 2003) Polymorphic markers in the 5alpha-reductase type II gene and the incidence of prostate cancer., International Journal of Cancer. Journal International Du Cancer, 105 (4), 480-3 Abstract
  • Ramsey SD, Berry K, Etzioni R, Kaplan RM, Sullivan SD, Wood DE, National Emphysema Treatment Trial Research Group (May 2003) Cost effectiveness of lung-volume-reduction surgery for patients with severe emphysema., The New England Journal of Medicine, 348 (21), 2092-102 Abstract
  • Etzioni R, Urban N, Ramsey S, McIntosh M, Schwartz S, Reid B, Radich J, Anderson G, Hartwell L (Apr 2003) The case for early detection., Nature Reviews. Cancer, 3 (4), 243-52 Abstract
  • Etzioni RD, Di Tommaso D, Kessler LG (2003) Using public health data to evaluate screening programs: application to prostate cancer In Brookmeyer R, Stroup DF (eds), Monitoring the Health of Populations - Statistical Principles and Methods for Public Health Surveillance, Oxford, England, Oxford University Press (bookchapter)
  • Etzioni R, Penson DF, Legler JM, di Tommaso D, Boer R, Gann PH, Feuer EJ (Jul 2002) Overdiagnosis due to prostate-specific antigen screening: lessons from U.S. prostate cancer incidence trends., Journal of the National Cancer Institute, 94 (13), 981-90 Abstract
  • Etzioni R, Riley GF, Ramsey SD, Brown M, Measuring costs: administrative claims data, clinical trials, and beyond, Medical Care, 40(6 Suppl), III63-72, June 2002 Abstract
  • Ramsey SD, Berry K, Etzioni R, Lifetime cancer-attributable cost of care for long term survivors of colorectal cancer, The American Journal of Gastroenterology, 97(2), 440-5, February 2002 Abstract
  • Etzioni R, Berry KM, Legler JM, Shaw P, Prostate-specific antigen testing in black and white men: an analysis of medicare claims from 1991-1998, Urology, 59(2), 251-5, February 2002 Abstract
  • Sullivan Pepe M, Etzioni R, Feng Z, Potter JD, Thompson ML, Thornquist M, Winget M, Yasui Y, Phases of biomarker development for early detection of cancer, Journal of the National Cancer Institute, 93(14), 1054-61, July 2001 Abstract
  • Etzioni R, Ramsey SD, Berry K, Brown M, The impact of including future medical care costs when estimating the costs attributable to a disease: a colorectal cancer case study, Health Economics, 10(3), 245-56, April 2001 Abstract
  • Brown ML, Riley GF, Potosky AL, Etzioni RD, Obtaining long-term disease specific costs of care: application to Medicare enrollees diagnosed with colorectal cancer, Medical Care, 37(12), 1249-59, December 1999 Abstract
  • Etzioni R, Cha R, Cowen ME, Serial prostate specific antigen screening for prostate cancer: a computer model evaluates competing strategies, Journal of Urology, 162(3 Pt 1), 741-8, September 1999 Abstract
  • Etzioni R, Pepe M, Longton G, Hu C, Goodman G, Incorporating the time dimension in receiver operating characteristic curves: a case study of prostate cancer, Medical Decision Making, 19(3), 242-51, 1999 Abstract
  • Etzioni R, Legler JM, Feuer EJ, Merrill RM, Cronin KA, Hankey BF, Cancer surveillance series: interpreting trends in prostate cancer--part III: Quantifying the link between population prostate-specific antigen testing and recent declines in prostate cancer mortality, Journal of the National Cancer Institute, 91(12), 1033-9, 16 Jun 1999 Abstract
  • Cronin KA, Legler JM, Etzioni RD, Assessing uncertainty in microsimulation modelling with application to cancer screening interventions, Statistics in Medicine, 17(21), 2509-23, 1998 Abstract
  • Etzioni R, Cha R, Feuer EJ, Davidov O, Asymptomatic incidence and duration of prostate cancer, American Journal of Epidemiology, 148(8), 775-85, 1998 Abstract
  • Etzioni RD, Weiss NS, Analysis of case-control studies of screening: impact of misspecifying the duration of detectable preclinical pathologic changes, American Journal of Epidemiology, 148(3), 292-7, 1998 Abstract
  • Draisma G, Etzioni R, Tsodikov A, Mariotto A, Wever E, Gulati R, Feuer E, de Koning H, Reconciling differing estimates of lead time and overdiagnosis due to PSA screening: Results from the Cancer Intervention and Surveillance Modeling Network, Journal of the National Cancer Institute, In Press
  • Fesinmeyer MD, Gulati R, Zeliadt S, Weiss N, Kristal A, Etzioni R, Impact of population trends in BMI on prostate cancer incidence and mortality in the US, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, In Press
  • Shaw PA, Pepe MS, Todd A, Etzioni R, Methods for Assessing Improvement in Specificity when a Biomarker in Combination with a Standard Screening Test, Statistics in Pharmaceutical Research, In Press

Profile Details

Last Verified: 12/31/2008

COS Expertise ID #676454
Reference this profile directly: http://myprofile.cos.com/etzionia1