Dr. Susan L. Ewart

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Michigan State University
College of Veterinary Medicine
Large Animal Clinical Sciences
ProfessorAppointed: 2006
Michigan State University
College of Veterinary Medicine
Large Animal Clinical Sciences
Research and Graduate Studies
Associate DeanAppointed: 2006
Professional Headshot of Susan L. Ewart

Mailing Address

G-100 Veterinary Medical Center
Office of the Dean
College of Veterinary Medicine
Michigan State University
East Lansing, Michigan 48824
United States

Contact Information

Phone: (517) 432-2388
Fax: (517) 432-7141
ewarts@msu.edu

Qualifications

Ph.D., Johns Hopkins University, Environmental Physiology, 1995.
D.V.M., Michigan State University, Veterinary Medicine, 1987.
B.S., Michigan State University, Veterinary Medicine, 1985.

Expertise and Research Interests

Dr. Ewart investigates the genetic origins and mechanisms of asthma and allergy. Studies are conducted in longitudinal cohort populations as well as animal models of asthma and allergy. Genome-wide association studies have indicated unique genes underlying important clinical phenotypes related to asthma and allergy.

Other Expertise

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Keywords

COS Keywords:

Animal Genome, Animal Science, Food Safety, Gene Regulation, Veterinary Medicine.

Additional Terms:

GWAS.

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)

Memberships

American College of Veterinary Internal Medicine
American Thoracic Society
American Veterinary Medical Association

Honors and Awards

2003, Pfizer Animal Health Award for Research Excellence, Pfizer Animal Health
1986, Phi Zeta Honor Society, Zeta Chapter, College of Veterinary Medicine

Previous Positions

1999-2008, Associate Professor, Michigan State University, College of Veterinary Medicine, Large Animal Clinical Sciences
1995-1999, Assistant Professor, Michigan State University, College of Veterinary Medicine, Large Animal Clinical Sciences
1994-1995, Instructor, Johns Hopkins University, School of Medicine, Anesthesiology and Critical Care Medicine
1991-1994, Postdoctoral Fellow, Johns Hopkins University, Bloomberg School of Public Health, Environmental Health Sciences
1989-1991, Resident, Michigan State University, College of Veterinary Medicine, Internal Medicine
1987-1989, Veterinarian, Equine Veterinary Clinic

Funding Received

  • National Institutes of Health (NIH): Asthma positional candidate gene in mice and humans, Sep 1, 2000 to Aug 30, 2005.
  • National Institutes of Health (NIH): Positional candidate genes for airway responsiveness, Aug 1, 2000 to Jul 31, 2005.
  • National Institutes of Health (NIH): Epidemiology of asthma: risk and prognosis in a cohort from birth to adolescence, 2007 to 2011.
  • National Institutes of Health (NIH): Genetic & epidemiologic cohort study of asthma & allergy, 2005 to 2010.

Publications

  • Ogbuanu IU, Karmaus W, Arshad SH, Kurukulaaratchy RJ, Ewart S (Jan 2009) Effect of breastfeeding duration on lung function at age 10 years: a prospective birth cohort study., Thorax, 64 (1), 62-6 Abstract
  • Andersson LS, Juras R, Ramsey DT, Eason-Butler J, Ewart S, Cothran G, Lindgren G (Dec 2008) Equine Multiple Congenital Ocular Anomalies maps to a 4.9 megabase interval on horse chromosome 6., BMC genetics, 9 (1), 88 Abstract
  • Karmaus W, Dobai AL, Ogbuanu I, Arshard SH, Matthews S, Ewart S (Oct 2008) Long-term effects of breastfeeding, maternal smoking during pregnancy, and recurrent lower respiratory tract infections on asthma in children., The Journal of asthma : official journal of the Association for the Care of Asthma, 45 (8), 688-95 Abstract
  • Arshad SH, Karmaus W, Kurukulaaratchy R, Sadeghnejad A, Huebner M, Ewart S (Jun 2008) Polymorphisms in the interleukin 13 and GATA binding protein 3 genes and the development of eczema during childhood., The British journal of dermatology, 158 (6), 1315-22 Abstract
  • Huebner M, Kim DY, Ewart S, Karmaus W, Sadeghnejad A, Arshad SH (Feb 2008) Patterns of GATA3 and IL13 gene polymorphisms associated with childhood rhinitis and atopy in a birth cohort., The Journal of allergy and clinical immunology, 121 (2), 408-14 Abstract
  • Sadeghnejad A, Karmaus W, Arshad SH, Kurukulaaratchy R, Huebner M, Ewart S (2008) IL13 gene polymorphisms modify the effect of exposure to tobacco smoke on persistent wheeze and asthma in childhood, a longitudinal study., Respiratory research, 9, 2 Abstract
  • Sadeghnejad A, Karmaus W, Hasan Arshad S, Ewart S (Jun 2007) IL13 gene polymorphism association with cord serum immunoglobulin E., Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 18 (4), 288-92 Abstract
  • Li X, Fleis RI, Shubitowski DM, Ramadas RA, Ewart SL (Jun 2007) Fine mapping of murine asthma quantitative trait loci and analyses of Ptgs1 and Mrc1 as positional candidate genes., DNA sequence : the journal of DNA sequencing and mapping, 18 (3), 190-5 Abstract
  • Ewart SL, Robinson NE (May 2007) Genes and respiratory disease: a first step on a long journey., Equine veterinary journal, 39 (3), 270-4 Abstract
  • Berndt A, Derksen FJ, Venta PJ, Ewart S, Yuzbasiyan-Gurkan V, Robinson NE (Apr 2007) Elevated amount of Toll-like receptor 4 mRNA in bronchial epithelial cells is associated with airway inflammation in horses with recurrent airway obstruction., American journal of physiology. Lung cellular and molecular physiology, 292 (4), L936-43 Abstract
  • Ramadas RA, Sadeghnejad A, Karmaus W, Arshad SH, Matthews S, Huebner M, Kim DY, Ewart SL (Mar 2007) Interleukin-1R antagonist gene and pre-natal smoke exposure are associated with childhood asthma., The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology, 29 (3), 502-8 Abstract
  • Li X, Wills-Karp M, Ewart S (Oct 2006) Investigating Gata3 as a positional candidate gene for allergic asthma in a murine model., International journal of immunogenetics, 33 (5), 333-7 Abstract
  • Ramadas RA, Li X, Shubitowski DM, Samineni S, Wills-Karp M, Ewart SL (Oct 2006) IL-1 Receptor antagonist as a positional candidate gene in a murine model of allergic asthma., Immunogenetics, 58 (10), 851-5 Abstract
  • Ewart SL (2006) Genetics of Asthma and Allergy, The Year in Allergy, Volume 3 Edition, Oxford, Clinical Publishing, Atlas Medical Publishing Ltd (bookchapter)
  • Ewart SL, Ramadas R (2005) Genetics of Disease Resistance, The Mouse in Animal Genetics and Breeding Research, London, Imperial College Press, 205-236 pages (bookchapter)
  • Wills-Karp M, Ewart SL (May 2004) Time to draw breath: asthma-susceptibility genes are identified., Nature reviews. Genetics, 5 (5), 376-87 Abstract
  • Shubitowski DM, Wills-Karp M, Ewart SL, The complement factor 5a receptor gene maps to murine chromosome 7, Cytogenetic and Genome Research, 97(1-2), 133-5, 2002 Abstract
  • Shubitowski DM, Wills-Karp M, Ewart SL (2002) The complement factor 5a receptor gene maps to murine chromosome 7., Cytogenetic and genome research, 97 (1-2), 133-5 Abstract
  • Shubitowski DM, Venta PJ, Douglass CL, Zhou RX, Ewart SL, Polymorphism identification within 50 equine gene-specific sequence tagged sites, Animal Genetics, 32(2), 78-88, April 2001 Abstract
  • Ewart SL, Schott HC 2nd, Robison RL, Dwyer RM, Eberhart SW, Walker RD, Identification of sources of Salmonella organisms in a veterinary teaching hospital and evaluation of the effects of disinfectants on detection of Salmonella organisms on surface materials, Journal of the American Veterinary Medical Association, 218(7), 1145-51, April 2001 Abstract
  • Schott HC 2nd, Ewart SL, Walker RD, Dwyer RM, Dietrich S, Eberhart SW, Kusey J, Stick JA, Derksen FJ, An outbreak of salmonellosis among horses at a veterinary teaching hospital, Journal of the American Veterinary Medical Association, 218(7), 1152-9, 1100, April 2001 Abstract
  • Ewart SL, Schott HC, Robison RL, Dwyer RM, Eberhart SW, Walker RD (Apr 2001) Identification of sources of Salmonella organisms in a veterinary teaching hospital and evaluation of the effects of disinfectants on detection of Salmonella organisms on surface materials., Journal of the American Veterinary Medical Association, 218 (7), 1145-51 Abstract
  • Schott HC, Ewart SL, Walker RD, Dwyer RM, Dietrich S, Eberhart SW, Kusey J, Stick JA, Derksen FJ (Apr 2001) An outbreak of salmonellosis among horses at a veterinary teaching hospital., Journal of the American Veterinary Medical Association, 218 (7), 1152-9, 1100 Abstract
  • Mansfield LS, Schott HC 2nd, Murphy AJ, Rossano MG, Tanhauser SM, Patterson JS, Nelson K, Ewart SL, Marteniuk JV, Bowman DD, Kaneene JB, Comparison of Sarcocystis neurona isolates derived from horse neural tissue, Veterinary Parasitology, 95(2-4), 167-78, February 2001 Abstract
  • Mansfield LS, Schott HC, Murphy AJ, Rossano MG, Tanhauser SM, Patterson JS, Nelson K, Ewart SL, Marteniuk JV, Bowman DD, Kaneene JB (Feb 2001) Comparison of Sarcocystis neurona isolates derived from horse neural tissue., Veterinary parasitology, 95 (2-4), 167-78 Abstract
  • Ewart SL, Jones RL (2001) Disinfectants and Control of Environmental Contamination, Large Animal Internal Medicine, St. Louis, MO, Mosby,, 1371-1380 pages (bookchapter)
  • Ewart SL, Kuperman D, Schadt E, Tankersley C, Grupe A, Shubitowski DM, Peltz G, Wills-Karp M, Quantitative trait loci controlling allergen-induced airway hyperresponsiveness in inbred mice, American Journal of Respiratory Cell and Molecular Biology, 23(4), 537-45, October 2000 Abstract
  • Ewart SL, Kuperman D, Schadt E, Tankersley C, Grupe A, Shubitowski DM, Peltz G, Wills-Karp M (Oct 2000) Quantitative trait loci controlling allergen-induced airway hyperresponsiveness in inbred mice., American journal of respiratory cell and molecular biology, 23 (4), 537-45 Abstract
  • Karp CL, Grupe A, Schadt E, Ewart SL, Keane-Moore M, Cuomo PJ, Kohl J, Wahl L, Kuperman D, Germer S, Aud D, Peltz G, Wills-Karp M, Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma, Nature Immunology, 1(3), 221-6, September 2000 Abstract
  • Karp CL, Grupe A, Schadt E, Ewart SL, Keane-Moore M, Cuomo PJ, Köhl J, Wahl L, Kuperman D, Germer S, Aud D, Peltz G, Wills-Karp M (Sep 2000) Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma., Nature immunology, 1 (3), 221-6 Abstract
  • Ewart SL, Ramsey DT, Xu J, Meyers D, The horse homolog of congenital aniridia conforms to codominant inheritance, Journal of Heredity, 91(2), 93-8, 2000 Abstract
  • Nicolaides NC, Holroyd KJ, Ewart SL, Eleff SM, Kiser MB, Dragwa CR, Sullivan CD, Grasso L, Zhang LY, Messler CJ, Zhou T, Kleeberger SR, Buetow KH, Levitt RC, Interleukin 9: a candidate gene for asthma, Proceedings of the National Academy of Sciences (USA), 94(24), 13175-80, November 1997 Abstract
  • Nicolaides NC, Holroyd KJ, Ewart SL, Eleff SM, Kiser MB, Dragwa CR, Sullivan CD, Grasso L, Zhang LY, Messler CJ, Zhou T, Kleeberger SR, Buetow KH, Levitt RC (Nov 1997) Interleukin 9: a candidate gene for asthma., Proceedings of the National Academy of Sciences of the United States of America, 94 (24), 13175-80 Abstract
  • Wills-Karp M, Ewart SL, The genetics of allergen-induced airway hyperresponsiveness in mice, American Journal of Respiratory and Critical Care Medicine, 156(4 Pt 2), S89-96, October 1997 Abstract
  • Wills-Karp M, Ewart SL (Oct 1997) The genetics of allergen-induced airway hyperresponsiveness in mice., American journal of respiratory and critical care medicine, 156 (4 Pt 2), S89-96 Abstract
  • Tankersley CG, Fitzgerald RS, Levitt RC, Mitzner WA, Ewart SL, Kleeberger SR, Genetic control of differential baseline breathing pattern, Journal of Applied Physiology, 82(3), 874-81, March 1997 Abstract
  • Tankersley CG, Fitzgerald RS, Levitt RC, Mitzner WA, Ewart SL, Kleeberger SR (Mar 1997) Genetic control of differential baseline breathing pattern., Journal of applied physiology (Bethesda, Md. : 1985), 82 (3), 874-81 Abstract
  • Ewart SL, Gavett SH, Margolick J, Wills-Karp M, Cyclosporin A attenuates genetic airway hyperresponsiveness in mice but not through inhibition of CD4 or CD8 T cells, American Journal of Respiratory Cell and Molecular Biology, 14(6), 627-34, June 1996 Abstract
  • Ewart SL, Gavett SH, Margolick J, Wills-Karp M (Jun 1996) Cyclosporin A attenuates genetic airway hyperresponsiveness in mice but not through inhibition of CD4+ or CD8+ T cells., American journal of respiratory cell and molecular biology, 14 (6), 627-34 Abstract
  • Ewart SL, Mitzner W, DiSilvestre DA, Meyers DA, Levitt RC (May 1996) Airway hyperresponsiveness to acetylcholine: segregation analysis and evidence for linkage to murine chromosome 6., American journal of respiratory cell and molecular biology, 14 (5), 487-95 Abstract
  • Ewart SL, Levitt RC (1996) Inbred animal models of genetic susceptibility to bronchial hyperresponsiveness, The Genetics of Asthma, New York, Marcel Dekker, 259-278 pages (bookchapter)
  • Levitt RC, Eleff SM, Zhang LY, Kleeberger SR, Ewart SL, Linkage homology for bronchial hyperresponsiveness between DNA markers on human chromosome 5q31-q33 and mouse chromosome 13, Clinical and Experimental Allergy, 25 Suppl 2, 61-3, November 1995 Abstract
  • Levitt RC, Eleff SM, Zhang LY, Kleeberger SR, Ewart SL (Nov 1995) Linkage homology for bronchial hyperresponsiveness between DNA markers on human chromosome 5q31-q33 and mouse chromosome 13., Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 25 Suppl 2, 61-3 Abstract
  • Ewart S, Levitt R, Mitzner W (Aug 1995) Respiratory system mechanics in mice measured by end-inflation occlusion., Journal of applied physiology (Bethesda, Md. : 1985), 79 (2), 560-6 Abstract
  • Levitt RC, Ewart SL, Genetic susceptibility to atracurium-induced bronchoconstriction, American Journal of Respiratory and Critical Care Medicine, 151(5), 1537-42, May 1995 Abstract
  • Levitt RC, Ewart SL (May 1995) Genetic susceptibility to atracurium-induced bronchoconstriction., American journal of respiratory and critical care medicine, 151 (5), 1537-42 Abstract
  • Ewart S, Williams A, Stickle R (Aug 1992) What is your diagnosis? Diaphragmatic hernia in a horse., Journal of the American Veterinary Medical Association, 201 (3), 493-4 Abstract
  • Ewart S, Brown C, Derksen F, Kufuor-Mensa E (Apr 1992) Serratia marcescens endocarditis in a horse., Journal of the American Veterinary Medical Association, 200 (7), 961-3 Abstract
  • Padrid P, Ewart S, Production of granulocyte colony stimulating factor and granulocyte macrophage colony stimulating factor by carcinomas in a dog and a cat with paraneoplastic leukocytosis., Journal of veterinary internal medicine / American College of Veterinary Internal Medicine, 11 (2), 95 Abstract
  • Ewart SL, Ramsey DT, Xu J, Meyers D, The horse homolog of congenital aniridia conforms to codominant inheritance., The Journal of heredity, 91 (2), 93-8 Abstract

Profile Details

Last Verified: 1/18/2009

COS Expertise ID #453073
Reference this profile directly: http://myprofile.cos.com/ewart