Dr. Ferric C. Fang

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University of Washington
School of Medicine
Laboratory Medicine and Microbiology
Professor
Harborview Medical Center
Clinical Microbiology
Director
University of Washington
School of Medicine
Medicine
Allergy and Infectious Diseases
Adjunct Professor
Professional Headshot of Ferric C. Fang

Mailing Address

University of Washington
Box 357242
School of Medicine
Seattle, Washington 98195-7242
United States

Contact Information

Phone: (206) 221-6770
Fax: (206) 616-1575
fcfang@u.washington.edu
http://depts.washington.edu/fanglab/index.html

Qualifications

Re-certification, American Board of Internal Medicine, Infectious Diseases, 2000.
Certification, American Board of Internal Medicine, Infectious Diseases, 1990.
Certification, American Board of Internal Medicine, Internal Medicine, 1986.
M.D., Harvard University, 1983.
A.B., Harvard University, 1979.

Expertise and Research Interests

The Fang laboratory studies bacterial pathogenesis, in particular, the antimicrobial actions of phagocyte-derived reactive oxygen and nitrogen species and the strategies used by pathogenic microbes to resist these host defenses. Specific projects include the identification of novel nitric oxide targets in Salmonella enterica and Staphylococcus aureus, the role of iron metabolism in host-Salmonella interactions, the activation of Salmonella virulence gene expression by alternative sigma factors and other transcriptional regulators, and the mechanisms by which reactive nitrogen and oxygen species damage microbial DNA or impair DNA replication. Using a whole genome approach, the Fang laboratory recently discovered "xenogeneic silencing," a mechanism by which enteric gamma-proteobacteria can recognize and integrate foreign DNA into pre-existing regulatory networks.

Prof. Fang also oversees the Clinical Microbiology Laboratory of the 413-bed Harborview Medical Center where he is working on molecular methods for improved diagnosis of bacterial infections.

Keywords

COS Keywords:

Infectious Diseases Or Agents, Macrophage, Molecular Genetics, Pathogenesis.

Additional Terms:

Macrophage, Nitric Oxide, Oxidative, Pathogenesis, Salmonella.

Memberships

American College of Physicians
American Society for Clinical Investigation
American Society for Microbiology
Infectious Diseases Society of America
Nitric Oxide Society

Honors and Awards

2009, Visiting Lecturer, Alberta Heritage Foundation for Medical Research (AHFMR), University of Calgary
2009, Keynote Speaker, MIRL Symposium, National Health Research Institutes of Taiwan
2009, Co-Chair, ASM Conference on Salmonella, American Society for Microbiology
2007-2012, Editor-in-Chief, Infection and Immunity, American Society for Microbiology
2007, Elected to the American Academy of Microbiology, American Society for Microbiology
2006-2009, Advisory Board Member, Bill and Melinda Gates Foundation Global Health Program, Arizona State University
2005, Member, Committee on New Directions in the Study of Antimicrobial Therapeutics, National Academies of Sciences
2005, Keynote Speaker, Mid-Atlantic Microbial Pathogenesis Meeting
2005, Abraham I. Braude Visiting Professor, Division of Infectious Diseases, University of California, San Diego
2004-2007, Chair, General Meeting Program Committee, American Society for Microbiology
2003, Keynote Speaker, Bay Area Pathogenesis Symposium
2003, Harry F. Dowling Lecturer, Department of Medicine, University of Illinois at Chicago
2003-2008, Director, Interdisciplinary Training Program in Bacterial Pathogenesis, National Institutes of Health, University of Washington
2002-2006, Invited Contributor, Faculty of 1000, Biomednet Central
2002-2007, Advisory Editor, Journal of Experimental Medicine
2002-2007, Editor, Infection and Immunity, American Society for Microbiology
2001-2004, Vice-Chair, General Meeting Program Committee, American Society for Microbiology
2000, Division B Lecturer, American Society for Microbiology
2000-2002, Editorial Board Member, Infection and Immunity, American Society for Microbiology
1998, Elected to the American Society for Clinical Investigation, ASCI
1998, Keynote Speaker, MidWest Microbial Pathogenesis Meeting
1998-1999, Foundation Award, James Biundo Foundation
1997-2002, Program Committee, Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), American Society for Microbiology
1996-2001, Member, Bacteriology Mycology-1 Study Section, National Institutes of Health (NIH)
1995, Outstanding Infectious Diseases Educator, Division of Infectious Diseases, University of Colorado Health Sciences Center
1994, Young Investigator's Award, Baxter Diagnostics Microscan, American Society for Microbiology
1992, Senior Residents' Teaching Award, Department of Medicine, University of California, San Diego
1992, Chief Residents' Teaching Award, Department of Medicine, University of California, San Diego
1987, Kaiser-Permanente Teaching Award, Kaiser-Permanente, University of California, San Diego
1987-1992, Physician-Scientist Award, National Institutes of Health (NIH), University of California, San Diego
1985, Kaiser-Permanente Teaching Award, Kaiser-Permanente, University of California, San Diego

Previous Positions

1997-2001, Associate Professor, University of Colorado Health Sciences Center, School of Medicine, Medicine, Pathology and Microbiology
1992-1997, Assistant Professor, University of Colorado Health Sciences Center, School of Medicine, Medicine and Pathology
1990-1992, Adjunct Instructor, University of California, San Diego, School of Medicine, Medicine, Infectious Diseases

Publications

  • Nairz M, Fritsche G, Crouch ML, Barton HC, Fang FC, Weiss G (Jun 2009) Slc11a1 limits intracellular growth of Salmonella enterica sv. Typhimurium by promoting macrophage immune effector functions and impairing bacterial iron acquisition., Cellular microbiology Abstract
  • Richardson AR, Soliven KC, Castor ME, Barnes PD, Libby SJ, Fang FC (May 2009) The Base Excision Repair system of Salmonella enterica serovar typhimurium counteracts DNA damage by host nitric oxide., PLoS pathogens, 5 (5), e1000451 Abstract
  • Casadevall A, Fang FC (Apr 2009) Is peer review censorship?, Infection and immunity, 77 (4), 1273-4 Abstract
  • Muller C, Bang IS, Velayudhan J, Karlinsey J, Papenfort K, Vogel J, Fang FC (Mar 2009) Acid stress activation of the sigma(E) stress response in Salmonella enterica serovar Typhimurium., Molecular microbiology, 71 (5), 1228-38 Abstract
  • Fang FC, Casadevall A (Mar 2009) NIH peer review reform--change we need, or lipstick on a pig?, Infection and immunity, 77 (3), 929-32 Abstract
  • Stahlhut SG, Chattopadhyay S, Struve C, Weissman SJ, Aprikian P, Libby SJ, Fang FC, Krogfelt KA, Sokurenko EV (Mar 2009) Population variability of the FimH type 1 fimbrial adhesin in Klebsiella pneumoniae., Journal of bacteriology, 191 (6), 1941-50 Abstract
  • Wang W, Richardson AR, Martens-Habbena W, Stahl DA, Fang FC, Hansen EJ (Dec 2008) Identification of a repressor of a truncated denitrification pathway in Moraxella catarrhalis., Journal of bacteriology, 190 (23), 7762-72 Abstract
  • Papp-Wallace KM, Nartea M, Kehres DG, Porwollik S, McClelland M, Libby SJ, Fang FC, Maguire ME (Oct 2008) The CorA Mg2+ channel is required for the virulence of Salmonella enterica serovar typhimurium., Journal of bacteriology, 190 (19), 6517-23 Abstract
  • Casadevall A, Fang FC (Sep 2008) Descriptive science., Infection and immunity, 76 (9), 3835-6 Abstract
  • Ammendola S, Pasquali P, Pacello F, Rotilio G, Castor M, Libby SJ, Figueroa-Bossi N, Bossi L, Fang FC, Battistoni A (May 2008) Regulatory and structural differences in the Cu,Zn-superoxide dismutases of Salmonella enterica and their significance for virulence., The Journal of biological chemistry, 283 (20), 13688-99 Abstract
  • Fang FC (May 2008) On rejection., Infection and immunity, 76 (5), 1802-3 Abstract
  • Fang FC, Rimsky S (Apr 2008) New insights into transcriptional regulation by H-NS., Current opinion in microbiology, 11 (2), 113-20 Abstract
  • Richardson AR, Libby SJ, Fang FC (Mar 2008) A nitric oxide-inducible lactate dehydrogenase enables Staphylococcus aureus to resist innate immunity., Science (New York, N.Y.), 319 (5870), 1672-6 Abstract
  • Main-Hester KL, Colpitts KM, Thomas GA, Fang FC, Libby SJ (Mar 2008) Coordinate regulation of Salmonella pathogenicity island 1 (SPI1) and SPI4 in Salmonella enterica serovar Typhimurium., Infection and immunity, 76 (3), 1024-35 Abstract
  • Crouch ML, Castor M, Karlinsey JE, Kalhorn T, Fang FC (Mar 2008) Biosynthesis and IroC-dependent export of the siderophore salmochelin are essential for virulence of Salmonella enterica serovar Typhimurium., Molecular microbiology, 67 (5), 971-83 Abstract
  • Vazquez-Torres A, Stevanin T, Jones-Carson J, Castor M, Read RC, Fang FC (2008) Analysis of nitric oxide-dependent antimicrobial actions in macrophages and mice., Methods in enzymology, 437, 521-38 Abstract
  • Walthers D, Carroll RK, Navarre WW, Libby SJ, Fang FC, Kenney LJ (Jul 2007) The response regulator SsrB activates expression of diverse Salmonella pathogenicity island 2 promoters and counters silencing by the nucleoid-associated protein H-NS., Molecular microbiology, 65 (2), 477-93 Abstract
  • Navarre WW, McClelland M, Libby SJ, Fang FC (Jun 2007) Silencing of xenogeneic DNA by H-NS-facilitation of lateral gene transfer in bacteria by a defense system that recognizes foreign DNA., Genes & development, 21 (12), 1456-71 Abstract
  • Velayudhan J, Castor M, Richardson A, Main-Hester KL, Fang FC (Mar 2007) The role of ferritins in the physiology of Salmonella enterica sv. Typhimurium: a unique role for ferritin B in iron-sulphur cluster repair and virulence., Molecular microbiology, 63 (5), 1495-507 Abstract
  • Fang FC, Nathan CF (Mar 2007) Man is not a mouse: reply., Journal of leukocyte biology, 81 (3), 580 Abstract
  • Bang IS, Liu L, Vazquez-Torres A, Crouch ML, Stamler JS, Fang FC (Sep 2006) Maintenance of nitric oxide and redox homeostasis by the salmonella flavohemoglobin hmp., The Journal of biological chemistry, 281 (38), 28039-47 Abstract
  • Richardson AR, Dunman PM, Fang FC (Aug 2006) The nitrosative stress response of Staphylococcus aureus is required for resistance to innate immunity., Molecular microbiology, 61 (4), 927-39 Abstract
  • Navarre WW, Porwollik S, Wang Y, McClelland M, Rosen H, Libby SJ, Fang FC (Jul 2006) Selective silencing of foreign DNA with low GC content by the H-NS protein in Salmonella., Science (New York, N.Y.), 313 (5784), 236-8 Abstract
  • Jones-Carson J, Fantuzzi G, Siegmund B, Dinarello C, Tracey KJ, Wang H, Fang FC, Vazquez-Torres A (Sep 2005) Suppressor alphabeta T lymphocytes control innate resistance to endotoxic shock., The Journal of infectious diseases, 192 (6), 1039-46 Abstract
  • Onufryk C, Crouch ML, Fang FC, Gross CA (Jul 2005) Characterization of six lipoproteins in the sigmaE regulon., Journal of Bacteriology, 187 (13), 4552-61 Abstract
  • Bang IS, Frye JG, McClelland M, Velayudhan J, Fang FC (May 2005) Alternative sigma factor interactions in Salmonella: sigma and sigma promote antioxidant defences by enhancing sigma levels., Molecular Microbiology, 56 (3), 811-23 Abstract
  • Becker LA, Bang IS, Crouch ML, Fang FC (May 2005) Compensatory role of PspA, a member of the phage shock protein operon, in rpoE mutant Salmonella enterica serovar Typhimurium., Molecular Microbiology, 56 (4), 1004-16 Abstract
  • Crouch ML, Becker LA, Bang IS, Tanabe H, Ouellette AJ, Fang FC (May 2005) The alternative sigma factor sigma is required for resistance of Salmonella enterica serovar Typhimurium to anti-microbial peptides., Molecular Microbiology, 56 (3), 789-99 Abstract
  • Monsieurs P, De Keersmaecker S, Navarre WW, Bader MW, De Smet F, McClelland M, Fang FC, De Moor B, Vanderleyden J, Marchal K (Apr 2005) Comparison of the PhoPQ regulon in Escherichia coli and Salmonella typhimurium., Journal of Molecular Evolution, 60 (4), 462-74 Abstract
  • Navarre WW, Halsey TA, Walthers D, Frye J, McClelland M, Potter JL, Kenney LJ, Gunn JS, Fang FC, Libby SJ (Apr 2005) Co-regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ., Molecular Microbiology, 56 (2), 492-508 Abstract
  • Fang FC, Libby SJ, Castor ME, Fung AM (Apr 2005) Isocitrate lyase (AceA) is required for Salmonella persistence but not for acute lethal infection in mice., Infection and Immunity, 73 (4), 2547-9 Abstract
  • Fang FC (Apr 2005) Sigma cascades in prokaryotic regulatory networks., Proceedings of the National Academy of Sciences of the United States of America., 102 (14), 4933-4 Abstract
  • Fang FC, Sandler N, Libby SJ (Feb 2005) Liver abscess caused by magA+ Klebsiella pneumoniae in North America., Journal of Clinical Microbiology, 43 (2), 991-2 Abstract
  • Pottumarthy S, Schapiro JM, Prentice JL, Houze YB, Swanzy SR, Fang FC, Cookson BT (Dec 2004) Clinical isolates of Staphylococcus intermedius masquerading as methicillin-resistant Staphylococcus aureus., Journal of Clinical Microbiology, 42 (12), 5881-4 Abstract
  • Fang FC, Antimicrobial reactive oxygen and nitrogen species: concepts and controversies, Nat Rev Microbiol, 2(10), 820-32, Oct 2004 Abstract
  • Schapiro JM, Gupta R, Stefansson E, Fang FC, Limaye AP, Isolation of Metronidazole-Resistant Bacteroides fragilis Carrying the nimA Nitroreductase Gene from a Patient in Washington State, Journal of Clinical Microbiology, 42(9), 4127-9, Sep 2004 Abstract
  • Zaharik ML, Cullen VL, Fung AM, Libby SJ, Kujat Choy SL, Coburn B, Kehres DG, Maguire ME, Fang FC, Finlay BB, The Salmonella enterica serovar typhimurium divalent cation transport systems MntH and SitABCD are essential for virulence in an Nramp1G169 murine typhoid model, Infection and Immunity, 72(9), 5522-5, Sep 2004 Abstract
  • Vazquez-Torres A, Vallance BA, Bergman MA, Finlay BB, Cookson BT, Jones-Carson J, Fang FC, Toll-like receptor 4 dependence of innate and adaptive immunity to Salmonella: importance of the Kupffer cell network, Journal of Immunology (baltimore, Md. : 1950), 172(10), 6202-8, May 2004 Abstract
  • Halsey TA, Vazquez-Torres A, Gravdahl DJ, Fang FC, Libby SJ, The ferritin-like Dps protein is required for Salmonella enterica serovar Typhimurium oxidative stress resistance and virulence, Infection and Immunity, 72(2), 1155-8, Feb 2004 Abstract
  • Bader MW, Navarre WW, Shiau W, Nikaido H, Frye JG, McClelland M, Fang FC, Miller SI, Regulation of Salmonella typhimurium virulence gene expression by cationic antimicrobial peptides, Molecular Microbiology, 50(1), 219-30, Oct 2003 Abstract
  • Schapiro JM, Libby SJ, Fang FC, Inhibition of bacterial DNA replication by zinc mobilization during nitrosative stress, Proceedings of the National Academy of Sciences of the United States of America., 100(14), 8496-501, Jul 2003 Abstract
  • Fang F, Vazquez-Torres A (Sep 2002) Salmonella selectively stops traffic., Trends in microbiology, 10 (9), 391-2 Abstract
  • Fang FC, Vazquez-Torres A, Nitric oxide production by human macrophages: there's NO doubt about it, American Journal of Physiology. Lung Cellular and Molecular Physiology, 282(5), L941-3, May 2002 Abstract
  • Lu S, Killoran PB, Fang FC, Riley LW, The global regulator ArcA controls resistance to reactive nitrogen and oxygen intermediates in Salmonella enterica serovar Enteritidis, Infection and Immunity, 70(2), 451-61, Feb 2002 Abstract
  • Testerman TL, Vazquez-Torres A, Xu Y, Jones-Carson J, Libby SJ, Fang FC, The alternative sigma factor sigmaE controls antioxidant defences required for Salmonella virulence and stationary-phase survival, Molecular Microbiology, 43(3), 771-82, Feb 2002 Abstract
  • Vazquez-Torres A, Fang FC, Salmonella evasion of the NADPH phagocyte oxidase, Microbes and Infection / Institut Pasteur, 3(14-15), 1313-20, Nov-D 2001 Abstract
  • Hickman-Davis JM, Fang FC, Nathan C, Shepherd VL, Voelker DR, Wright JR, Lung surfactant and reactive oxygen-nitrogen species: antimicrobial activity and host-pathogen interactions, American Journal of Physiology. Lung Cellular and Molecular Physiology, 281(3), L517-23, Sep 2001 Abstract
  • Stamler JS, Lamas S, Fang FC (Sep 2001) Nitrosylation. the prototypic redox-based signaling mechanism., Cell, 106 (6), 675-83 Abstract
  • Méresse S, Unsworth KE, Habermann A, Griffiths G, Fang F, Martínez-Lorenzo MJ, Waterman SR, Gorvel JP, Holden DW (Aug 2001) Remodelling of the actin cytoskeleton is essential for replication of intravacuolar Salmonella., Cellular microbiology, 3 (8), 567-77 Abstract
  • Piddington DL, Fang FC, Laessig T, Cooper AM, Orme IM, Buchmeier NA (Aug 2001) Cu,Zn superoxide dismutase of Mycobacterium tuberculosis contributes to survival in activated macrophages that are generating an oxidative burst., Infection and immunity, 69 (8), 4980-7 Abstract
  • Allen CA, Fedorka-Cray PJ, Vazquez-Torres A, Suyemoto M, Altier C, Ryder LR, Fang FC, Libby SJ, In vitro and in vivo assessment of Salmonella enterica serovar Typhimurium DT104 virulence, Infection and Immunity, 69(7), 4673-7, July 2001 Abstract
  • Vázquez-Torres A, Fantuzzi G, Edwards CK, Dinarello CA, Fang FC (Feb 2001) Defective localization of the NADPH phagocyte oxidase to Salmonella-containing phagosomes in tumor necrosis factor p55 receptor-deficient macrophages., Proceedings of the National Academy of Sciences of the United States of America, 98 (5), 2561-5 Abstract
  • Vazquez-Torres A, Fang FC, Oxygen-dependent anti-Salmonella activity of macrophages, Trends in Microbiology, 9(1), 29-33, Jan 2001 Abstract
  • Vazquez-Torres A, Jones-Carson J, Mastroeni P, Ischiropoulos H, Fang FC, Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. I. Effects on microbial killing by activated peritoneal macrophages in vitro, Journal of Experimental Medicine, 192(2), 227-36, 2000 Abstract
  • Mastroeni P, Vazquez-Torres A, Fang FC, Xu Y, Khan S, Hormaeche CE, Dougan G, Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. II. Effects on microbial proliferation and host survival in vivo, Journal of Experimental Medicine, 192(2), 237-48, 2000 Abstract
  • Vazquez-Torres A, Xu Y, Jones-Carson J, Holden DW, Lucia SM, Dinauer MC, Mastroeni P, Fang FC, Salmonella pathogenicity island 2-dependent evasion of the phagocyte NADPH oxidase, Science, 287(5458), 1655-8, 2000 Abstract
  • Vazquez-Torres A, Fang FC, Cellular routes of invasion by enteropathogens, Current Opinion in Microbiology, 3(1), 54-9, February 2000 Abstract
  • Cotton MF, Wasserman E, Pieper CH, Theron DC, van Tubbergh D, Campbell G, Fang FC, Barnes aJ, Invasive disease due to extended spectrum beta-lactamase-producing Klebsiella pneumoniae in a neonatal unit: the possible role of cockroaches, Journal of Hospital Infection, 44(1), 13-7, Jan 2000 Abstract
  • Lu S, Manges AR, Xu Y, Fang FC, Riley LW, Analysis of virulence of clinical isolates of Salmonella enteritidis in vivo and in vitro, Infection and Immunity, 67(11), 5651-7, November 1999 Abstract
  • Vazquez-Torres A, Jones-Carson J, Baumler AJ, Falkow S, Valdivia R, Brown W, Le M, Berggren R, Parks WT, Fang FC, Extraintestinal dissemination of Salmonella by CD18-expressing phagocytes, Nature, 401(6755), 804-8, October 1999 Abstract
  • Fang FC, DeGroote MA, Foster JW, Baumler AJ, Ochsner U, Testerman T, Bearson S, Giard JC, Xu Y, Campbell G, Laessig T, Virulent Salmonella typhimurium has two periplasmic Cu, Zn-superoxide dismutases., Proceedings of the National Academy of Sciences (USA), 96(13), 7502-7, 22 Jun 1999 Abstract
  • Lundberg BE, Wolf RE Jr, Dinauer MC, Xu Y, Fang FC, Glucose 6-phosphate dehydrogenase is required for Salmonella typhimurium virulence and resistance to reactive oxygen and nitrogen intermediates., Infection and Immunity, 67(1), 436-8, Jan 1999 Abstract
  • Shiloh MU, MacMicking JD, Nicholson S, Brause JE, Potter S, Marino M, Fang F, Dinauer M, Nathan C, Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase, Immunity, 10(1), 29-38, Jan 1999 Abstract
  • Hensel M, Shea JE, Waterman SR, Mundy R, Nikolaus T, Banks G, Vazquez-Torres A, Gleeson C, Fang FC, Holden DW, Genes encoding putative effector proteins of the type III secretion system of Salmonella pathogenicity island 2 are required for bacterial virulence and proliferation in macrophages, Molecular Microbiology, 30(1), 163-74, October 1998 Abstract
  • De Groote MA, Ochsner UA, Shiloh MU, Nathan C, McCord JM, Dinauer MC, Libby SJ, Vazquez-Torres A, Xu Y, Fang FC, Periplasmic superoxide dismutase protects Salmonella from products of phagocyte NADPH-oxidase and nitric oxide synthase., Proceedings of the National Academy of Sciences (USA), 94(25), 13997-4001, 9 Dec 1997 Abstract
  • Fang FC, Vazquez-Torres A, Xu Y, The transcriptional regulator SoxS is required for resistance of Salmonella typhimurium to paraquat but not for virulence in mice, Infection and Immunity, 65(12), 5371-5, December 1997 Abstract
  • Bisognano JD, Young B, Brown JM, Gill EA, Fang FC, Zisman LS, Diverse presentation of aberrant origin of the right subclavian artery: two case reports., Chest, 112(6), 1693-7, December 1997 Abstract
  • Fang FC, Vazquez-Torres A, Xu Y, The transcriptional regulator SoxS is required for resistance of Salmonella typhimurium to paraquat but not for virulence in mice., Infection and Immunity, 65(12), 5371-5, December 1997 Abstract
  • Buchmeier N, Bossie S, Chen CY, Fang FC, Guiney DG, Libby SJ, SlyA, a transcriptional regulator of Salmonella typhimurium, is required for resistance to oxidative stress and is expressed in the intracellular environment of macrophages, Infection and Immunity, 65(9), 3725-30, September 1997 Abstract
  • Fang FC, Perspectives series: host/pathogen interactions. Mechanisms of nitric oxide-related antimicrobial activity, Journal of Clinical Investigation, 99(12), 2818-25, June 1997 Abstract
  • Chen CY, Eckmann L, Libby SJ, Fang FC, Okamoto S, Kagnoff MF, Fierer J, Guiney DG, Expression of Salmonella typhimurium rpoS and rpoS-dependent genes in the intracellular environment of eukaryotic cells, Infection and Immunity, 64(11), 4739-43, November 1996 Abstract
  • Fang FC, Chen CY, Guiney DG, Xu Y, Identification of sigma S-regulated genes in Salmonella typhimurium: complementary regulatory interactions between sigma S and cyclic AMP receptor protein, Journal of Bacteriology, 178(17), 5112-20, September 1996 Abstract
  • De Groote MA, Testerman T, Xu Y, Stauffer G, Fang FC, Homocysteine antagonism of nitric oxide-related cytostasis in Salmonella typhimurium, Science, 272(5260), 414-7, April 1996 Abstract
  • Gass R, Fisher J, Badesch D, Zamora M, Weinberg A, Melsness H, Grover F, Tully J G, Fang F C, Donor-to-host transmission of Mycoplasma hominis in lung allograft recipients., Clinical Infectious Diseases, 22(3), 567-8, March 1996 Abstract
  • Fang F C, Madinger N E, Resistant nosocomial gram-negative bacillary pathogens: Acinetobacter baumannii, Xanthomonas maltophilia, and Pseudomonas cepacia., Current Clinical Topics In Infectious Diseases, 16, 52-83, 1996 Abstract
  • Berggren RE, Wunderlich A, Ziegler E, Schleicher M, Duke RC, Looney D, Fang FC, HIV gp120-specific cell-mediated immune responses in mice after oral immunization with recombinant Salmonella, Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 10(5), 489-95, December 1995 Abstract
  • De Groote M A, Fang F C, NO inhibitions: antimicrobial properties of nitric oxide., Clinical Infectious Diseases, 21 Suppl 2, S162-5, October 1995 Abstract
  • Guiney D G, Fang F C, Krause M, Libby S, Buchmeier N A, Fierer J, Biology and clinical significance of virulence plasmids in Salmonella serovars., Clinical Infectious Diseases, 21 Suppl 2, S146-51, October 1995 Abstract
  • Chen CY, Buchmeier NA, Libby S, Fang FC, Krause M, Guiney DG, Central regulatory role for the RpoS sigma factor in expression of Salmonella dublin plasmid virulence genes, Journal of Bacteriology, 177(18), 5303-9, September 1995 Abstract
  • Krause M, Fang FC, el-Gedaily A, Libby S, Guiney DG, Mutational analysis of SpvR binding to DNA in the regulation of the Salmonella plasmid virulence operon, Plasmid, 34(1), 37-47, July 1995 Abstract
  • De Groote MA, Granger D, Xu Y, Campbell G, Prince R, Fang FC, Genetic and redox determinants of nitric oxide cytotoxicity in a Salmonella typhimurium model, Proceedings of the National Academy of Sciences (USA), 92(14), 6399-403, July 1995 Abstract
  • Guiney D G, Libby S, Fang F C, Krause M, Fierer J, Growth-phase regulation of plasmid virulence genes in Salmonella., Trends In Microbiology, 3(7), 275-9, July 1995 Abstract
  • Buchmeier NA, Libby SJ, Xu Y, Loewen PC, Switala J, Guiney DG, Fang FC, DNA repair is more important than catalase for Salmonella virulence in mice, Journal of Clinical Investigation, 95(3), 1047-53, March 1995 Abstract
  • Volkert M R, Hajec L I, Matijasevic Z, Fang F C, Prince R, Induction of the Escherichia coli aidB gene under oxygen-limiting conditions requires a functional rpoS (katF) gene., Journal of Bacteriology, 176(24), 7638-45, December 1994 Abstract
  • Guiney DG, Fang FC, Krause M, Libby S, Plasmid-mediated virulence genes in non-typhoid Salmonella serovars, Fems Microbiology Letters, 124(1), 1-9, November 1994 Abstract
  • Prince RW, Xu Y, Libby SJ, Fang FC, Cloning and sequencing of the gene encoding the RpoS (KatF) sigma factor from Salmonella typhimurium 14028s, Biochimica Et Biophysica Acta, 1219(1), 198-200, September 1994 Abstract
  • O'Neal CR, Gabriel WM, Turk AK, Libby SJ, Fang FC, Spector MP, RpoS is necessary for both the positive and negative regulation of starvation survival genes during phosphate, carbon, and nitrogen starvation in Salmonella typhimurium, Journal of Bacteriology, 176(15), 4610-6, August 1994 Abstract
  • Libby SJ, Goebel W, Ludwig A, Buchmeier N, Bowe F, Fang FC, Guiney DG, Songer JG, Heffron F, A cytolysin encoded by Salmonella is required for survival within macrophages, Proceedings of the National Academy of Sciences (USA), 91(2), 489-93, January 1994 Abstract
  • Fierer J, Eckmann L, Fang F, Pfeifer C, Finlay B B, Guiney D, Expression of the Salmonella virulence plasmid gene spvB in cultured macrophages and nonphagocytic cells., Infection and Immunity, 61(12), 5231-6, December 1993 Abstract
  • Fang FC, Durland RH, Helinski DR, Mutations in the gene encoding the replication-initiation protein of plasmid RK2 produce elevated copy numbers of RK2 derivatives in Escherichia coli and distantly related bacteria, Gene, 133(1), 1-8, October 1993 Abstract
  • Fang FC, McClelland M, Guiney DG, Jackson MM, Hartstein AI, Morthland VH, Davis CE, McPherson DC, Welsh J, Value of molecular epidemiologic analysis in a nosocomial methicillin-resistant Staphylococcus aureus outbreak, Jama, 270(11), 1323-8, September 1993 Abstract
  • Miyamoto MI, Fang FC (Feb 1993) Pyogenic liver abscess involving Actinomyces: case report and review., Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America., 16 (2), 303-9 Abstract
  • Fang FC, Libby SJ, Buchmeier NA, Loewen PC, Switala J, Harwood J, Guiney DG, The alternative sigma factor katF (rpoS) regulates Salmonella virulence, Proceedings of the National Academy of Sciences (USA), 89(24), 11978-82, December 1992 Abstract
  • Krause M, Fang FC, Guiney DG, Regulation of plasmid virulence gene expression in Salmonella dublin involves an unusual operon structure, Journal of Bacteriology, 174(13), 4482-9, July 1992 Abstract
  • Fang FC, Krause M, Roudier C, Fierer J, Guiney DG, Growth regulation of a Salmonella plasmid gene essential for virulence, Journal of Bacteriology, 173(21), 6783-9, November 1991 Abstract
  • Fang FC, Helinski DR, Broad-host-range properties of plasmid RK2: importance of overlapping genes encoding the plasmid replication initiation protein TrfA, Journal of Bacteriology, 173(18), 5861-8, September 1991 Abstract
  • Fang FC, Fierer J, Human infection with Salmonella dublin, Medicine, 70(3), 198-207, May 1991 Abstract
  • Krekorian TD, Radner AB, Alcorn JM, Haghighi P, Fang FC, Biliary obstruction caused by epithelioid angiomatosis in a patient with AIDS., The American Journal of Medicine, 89(6), 820-2, Dec 1990 Abstract
  • Durland R H, Toukdarian A, Fang F, Helinski D R, Mutations in the trfA replication gene of the broad-host-range plasmid RK2 result in elevated plasmid copy numbers., Journal of Bacteriology, 172(7), 3859-67, July 1990 Abstract
  • Benson RF, Thacker WL, Fang FC, Kanter B, Mayberry WR, Brenner DJ (May 1990) Legionella sainthelensi serogroup 2 isolated from patients with pneumonia., Research in Microbiology, 141 (4), 453-63 Abstract

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