Dr. Andrew G. Farr

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University of Washington
School of Medicine
Biological Structure
ProfessorAppointed: 1997
University of Washington
School of Medicine
Institute for Stem Cell and Regenerative Medicine
MemberAppointed: 2007
University of Washington
School of Medicine
Immunology
ProfessorAppointed: 2005

Mailing Address

Box 357420
University of Washington
Seattle, Washington 98195
United States

Contact Information

Phone: (206) 685-1584
Fax: (206) 543-1524
farr@u.washington.edu

Qualifications

Ph.D., University of Chicago, Anatomy, 1975.
B.A., University of Colorado at Boulder, Biology, 1972.

Expertise and Research Interests

The efforts of this laboratory are directed at defining the non-lymphoid elements comprising the thymic environment, and gaining a better understanding of their contributions to the production and differentiation of T lymphocytes. A number of approaches are taken, including monoclonal antibody technology to define the phenotypic heterogeneity of the stromal cells comprising the thymic environment and to identify stromal cell surface molecules involved in T-lymphopoiesis. Molecular biological approaches are used to clone genes encoding stromal cell surface molecules and to generate soluble forms of these cell surface molecules as a means to assess their functional significance in vitro and in vivo. Tissue culture approaches are utilized to generate stromal cell lines representative of the different stromal cell populations and to assess their ability to support various aspects of T-lymphopoiesis in vitro. Finally, ultrastructural immunohistochemistry is used to precisely define the expression of cell interaction molecules within the thymic environment.

Other Expertise

Affiliated with the University of Washington Diabetes Research Center

Industrial Relevance

The following monoclonal antibodies and corresponding hybridomas have been deposited with, and are available from the Developmental Studies Hybridoma Bank (www.uiowa.edu/~dshbwww/)
G8.8 (anti-murine Ep-cam)
8.1.1 (anti-murine GP38; T1alpha;podoplanin)
Two anti-murine Thymic Stroma Lymphopoietin[TSLP]
28F12, which blocks TSLP activity
65B12, which does not block TSLP activity
These two anti-TSLP reagents can be used to create a sensitive TSLP elisa assay

Keywords

COS Keywords:

Bone Marrow, Cell Biology, Cell Culture, Cell Differentiation, Cytokines, Genetics, Gerontology, Growth Factor Receptors, Growth Factors, Immunochemistry, Immunology, Lymphocytes, Mitosis, Molecular Biology, Stem Cells.

Additional Terms:

Aging, Blood, Blood Cells, Bone Marrow, Cell Biology, Cell Differentiation, Cell Growth, Cell Kinetics, Cell-cell Interactions, Cytokines, Gerontology, Growth Factor Receptors, Growth Factors, Hematopoiesis, Immunology, Lymphocytes, Lymphoid Organs, Lymphopoie, Mitosis, Roles in Normal Process, Specific Cell Types, Stem Cells, Tissue and Organ, White Cells.

Honors and Awards

2009, Charlie Garcia Distinguished Service Award, University of Washington
2007, Basic Science Distinguished Teaching Award, School of Medicine, University of Washington

Previous Positions

1997-2005, Adjunct Professor, University of Washington, School of Medicine, Immunology
1990-1997, Adjunct Associate Professor, University of Washington, School of Medicine, Immunology
1987-1997, Associate Professor, University of Washington, School of Medicine, Biological Structure
1982-1987, Assistant Professor, University of Washington, School of Medicine, Biological Structure
1981-1982, Member, Basel Institute for Immunology

Patents

Thymic Stromal Lymphopoietin Receptor Molecules and Uses Thereof, Patent Number: 6955895, 2005, Institution, United States of America.

Publications

  • Cohen J, Guidi C, Tewalt E, Qiao H, Rouhani S, Ruddell A, Farr A, Tung K, Engelhard V (2010) Lymph node resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation, Journal of Experimental Medicine, In Press
  • Dooley J, Erickson M, Farr AG (Oct 2009) Lessons from thymic epithelial heterogeneity: FoxN1 and tissue-restricted gene expression by extrathymic, endodermally derived epithelium., Journal of immunology (Baltimore, Md. : 1950), 183 (8), 5042-9 Abstract
  • Mazzucchelli RI, Warming S, Lawrence SM, Ishii M, Abshari M, Washington AV, Feigenbaum L, Warner AC, Sims DJ, Li WQ, Hixon JA, Gray DH, Rich BE, Morrow M, Anver MR, Cherry J, Naf D, Sternberg LR, McVicar DW, Farr AG, Germain RN, Rogers K, Jenkins NA, Copeland NG, Durum SK (2009) Visualization and identification of IL-7 producing cells in reporter mice., PloS one, 4 (11), e7637 Abstract
  • Dooley J, Erickson M, Farr AG (Oct 2008) Alterations of the medullary epithelial compartment in the Aire-deficient thymus: implications for programs of thymic epithelial differentiation., Journal of immunology (Baltimore, Md. : 1950), 181 (8), 5225-32 Abstract
  • Liston A, Nutsch KM, Farr AG, Lund JM, Rasmussen JP, Koni PA, Rudensky AY (Aug 2008) Differentiation of regulatory Foxp3+ T cells in the thymic cortex., Proceedings of the National Academy of Sciences of the United States of America, 105 (33), 11903-8 Abstract
  • Demehri S, Liu Z, Lee J, Lin MH, Crosby SD, Roberts CJ, Grigsby PW, Miner JH, Farr AG, Kopan R (May 2008) Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity., PLoS biology, 6 (5), e123 Abstract
  • Sokol CL, Barton GM, Farr AG, Medzhitov R (Dec 2007) A mechanism for the initiation of allergen-induced T helper type 2 responses., Nature immunology, 9, 310-8 Abstract
  • Chappaz S, Flueck L, Farr AG, Rolink AG, Finke D (Dec 2007) Increased TSLP availability restores T- and B-cell compartments in adult IL-7 deficient mice., Blood, 110 (12), 3862-70 Abstract
  • Dooley J, Erickson M, Larochelle WJ, Gillard GO, Farr AG (Dec 2007) FGFR2IIIb signaling regulates thymic epithelial differentiation., Developmental dynamics : an official publication of the American Association of Anatomists, 236 (12), 3459-71 Abstract
  • Astrakhan A, Omori M, Nguyen T, Becker-Herman S, Iseki M, Aye T, Hudkins K, Dooley J, Farr A, Alpers CE, Ziegler SF, Rawlings DJ (May 2007) Local increase in thymic stromal lymphopoietin induces systemic alterations in B cell development., Nature immunology, 8 (5), 522-31 Abstract
  • Liston A, Farr AG, Chen Z, Benoist C, Mathis D, Manley NR, Rudensky AY (Mar 2007) Lack of Foxp3 function and expression in the thymic epithelium., The Journal of experimental medicine, 204 (3), 475-80 Abstract
  • Gillard GO, Dooley J, Erickson M, Peltonen L, Farr AG (Mar 2007) Aire-dependent alterations in medullary thymic epithelium indicate a role for Aire in thymic epithelial differentiation., Journal of immunology (Baltimore, Md. : 1950), 178 (5), 3007-15 Abstract
  • Kowalewska J, Mühlfeld AS, Hudkins KL, Yeh MM, Farr AG, Ravetch JV, Alpers CE (Mar 2007) Thymic stromal lymphopoietin transgenic mice develop cryoglobulinemia and hepatitis with similarities to human hepatitis C liver disease., The American journal of pathology, 170 (3), 981-9 Abstract
  • Gillard, G.O., Farr, A.G. (2006) The thymus: a house dividing, Blood, 108, 3629-3630
  • Parsons-Wingerter P, Chandrasekharan UM, McKay TL, Radhakrishnan K, DiCorleto PE, Albarran B, Farr AG (Nov 2006) A VEGF165-induced phenotypic switch from increased vessel density to increased vessel diameter and increased endothelial NOS activity., Microvascular research, 72 (3), 91-100 Abstract
  • Dooley J, Erickson M, Gillard GO, Farr AG (Jun 2006) Cervical thymus in the mouse., Journal of immunology (Baltimore, Md. : 1950), 176 (11), 6484-90 Abstract
  • Gillard GO, Farr AG (May 2006) Features of medullary thymic epithelium implicate postnatal development in maintaining epithelial heterogeneity and tissue-restricted antigen expression., Journal of immunology (Baltimore, Md. : 1950), 176 (10), 5815-24 Abstract
  • Fontenot JD, Dooley JL, Farr AG, Rudensky AY (Oct 2005) Developmental regulation of Foxp3 expression during ontogeny., The Journal of experimental medicine, 202 (7), 901-6 Abstract
  • Dooley J, Erickson M, Farr AG (Oct 2005) An organized medullary epithelial structure in the normal thymus expresses molecules of respiratory epithelium and resembles the epithelial thymic rudiment of nude mice., Journal of immunology (Baltimore, Md. : 1950), 175 (7), 4331-7 Abstract
  • Tang J, Kozaki K, Farr AG, Martin PJ, Lindahl P, Betsholtz C, Raines EW (Sep 2005) The absence of platelet-derived growth factor-B in circulating cells promotes immune and inflammatory responses in atherosclerosis-prone ApoE-/- mice., The American Journal of Pathology, 167 (3), 901-12 Abstract
  • Dooley J, Erickson M, Roelink H, Farr AG (Aug 2005) Nude thymic rudiment lacking functional foxn1 resembles respiratory epithelium., Developmental dynamics : an official publication of the American Association of Anatomists, 233 (4), 1605-12 Abstract
  • Gillard GO, Farr AG (Jul 2005) Contrasting models of promiscuous gene expression by thymic epithelium., The Journal of Experimental Medicine, 202 (1), 15-9 Abstract
  • Lei LW, Winn W, Scott C, Farr A (May 2005) Evaluation of computer-assisted instruction in histology: effect of interaction on learning outcome., Anatomical Record. Part B, New Anatomist, 284 (1), 28-34 Abstract
  • Fontenot JD, Rasmussen JP, Williams LM, Dooley JL, Farr AG, Rudensky AY (Mar 2005) Regulatory T cell lineage specification by the forkhead transcription factor foxp3., Immunity, 22 (3), 329-41 Abstract
  • Rodriguez-Galan MC, Bream JH, Farr A, Young HA (Mar 2005) Synergistic effect of IL-2, IL-12, and IL-18 on thymocyte apoptosis and, Journal of Immunology, 174, 2796-804 Abstract
  • Lehar SM, Dooley J, Farr AG, Bevan MJ (Feb 2005) Notch ligands Delta 1 and Jagged1 transmit distinct signals to T-cell precursors., Blood, 105 (4), 1440-7 Abstract
  • Cooper CJ, Turk GL, Sun M, Farr AG, Fink PJ (2004) Cutting edge: TCR revision occurs in germinal centers., Journal of Immunology, 173, 6532-6 Abstract
  • Muhlfeld AS, Segerer S, Hudkins K, Farr AG, Bao L, Kraus D, Holers VM, Quigg RJ, Alpers CE (Apr 2004) Overexpression of complement inhibitor Crry does not prevent cryoglobulin-associated membranoproliferative glomerulonephritis., Kidney International, 65 (4), 1214-23 Abstract
  • Ruddell A, Mezquita P, Brandvold KA, Farr A, Iritani BM (Dec 2003) B lymphocyte-specific c-Myc expression stimulates early and functional expansion of the vasculature and lymphatics during lymphomagenesis., The American Journal of Pathology, 163 (6), 2233-45 Abstract
  • Muhlfeld AS, Segerer S, Hudkins K, Carling MD, Wen M, Farr AG, Ravetch JV, Alpers CE (Sep 2003) Deletion of the fcgamma receptor IIb in thymic stromal lymphopoietin transgenic mice aggravates membranoproliferative glomerulonephritis., The American Journal of Pathology, 163 (3), 1127-36 Abstract
  • Taneda S, Hudkins KL, Cui Y, Farr AG, Alpers CE, Segerer S (Feb 2003) Growth factor expression in a murine model of cryoglobulinemia., Kidney International, 63 (2), 576-90 Abstract
  • Erickson M, Morkowski S, Lehar S, Gillard G, Beers C, Dooley J, Rubin JS, Rudensky A, Farr AG (Nov 2002) Regulation of thymic epithelium by keratinocyte growth factor., Blood, 100 (9), 3269-78 Abstract
  • Farr AG, Dooley JL, Erickson M (Nov 2002) Organization of thymic medullary epithelial heterogeneity: implications for mechanisms of epithelial differentiation., Immunological Reviews, 189, 20-7 Abstract
  • Segerer S, Hudkins KL, Taneda S, Wen M, Cui Y, Segerer M, Farr AG, Alpers CE (Apr 2002) Oral interferon-alpha treatment of mice with cryoglobulinemic glomerulonephritis., American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation., 39 (4), 876-88 Abstract
  • Isaksen DE, Baumann H, Zhou B, Nivollet S, Farr AG, Levin SD, Ziegler SF (Apr 2002) Uncoupling of proliferation and Stat5 activation in thymic stromal lymphopoietin-mediated signal transduction., Journal of Immunology (baltimore, Md. : 1950), 168 (7), 3288-94 Abstract
  • Taneda S, Segerer S, Hudkins KL, Cui Y, Wen M, Segerer M, Wener MH, Khairallah CG, Farr AG, Alpers CE (Dec 2001) Cryoglobulinemic glomerulonephritis in thymic stromal lymphopoietin transgenic mice., The American Journal of Pathology, 159 (6), 2355-69 Abstract
  • Gebe JA, Novak EJ, Kwok WW, Farr AG, Nepom GT, Buckner JH (Sep 2001) T cell selection and differential activation on structurally related HLA-DR4 ligands., Journal of Immunology (baltimore, Md. : 1950), 167 (6), 3250-6 Abstract
  • Luther SA, Tang HL, Hyman PL, Farr AG, Cyster JG (Nov 2000) Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse., Proceedings of the National Academy of Sciences of the United States of America., 97 (23), 12694-9 Abstract
  • Park LS, Martin U, Garka K, Gliniak B, Di Santo JP, Muller W, Largaespada DA, Copeland NG, Jenkins NA, Farr AG, Ziegler SF, Morrissey PJ, Paxton R, Sims JE (Sep 2000) Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: Formation of a functional heteromeric complex requires interleukin 7 receptor., The Journal of Experimental Medicine, 192 (5), 659-70 Abstract
  • Sims JE, Williams DE, Morrissey PJ, Garka K, Foxworthe D, Price V, Friend SL, Farr A, Bedell MA, Jenkins NA, Copeland NG, Grabstein K, Paxton RJ (Sep 2000) Molecular cloning and biological characterization of a novel murine lymphoid growth factor., The Journal of Experimental Medicine, 192 (5), 671-80 Abstract
  • Pandey A, Ozaki K, Baumann H, Levin SD, Puel A, Farr AG, Ziegler SF, Leonard WJ, Lodish HF (Jul 2000) Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin., Nature Immunology, 1 (1), 59-64 Abstract
  • Anderson M, Anderson SK, Farr AG (Jul 2000) Thymic vasculature: organizer of the medullary epithelial compartment?, International Immunology, 12 (7), 1105-10 Abstract
  • Parsons-Wingerter P, Elliott KE, Clark JI, Farr AG (May 2000) Fibroblast growth factor-2 selectively stimulates angiogenesis of small vessels in arterial tree., Arteriosclerosis, Thrombosis, and Vascular Biology, 20 (5), 1250-6 Abstract
  • Parsons-Wingerter P, Elliott KE, Farr AG, Radhakrishnan K, Clark JI, Sage EH (Mar 2000) Generational analysis reveals that TGF-beta1 inhibits the rate of angiogenesis in vivo by selective decrease in the number of new vessels., Microvascular Research, 59 (2), 221-32 Abstract
  • Kaneta M, Osawa M, Sudo K, Nakauchi H, Farr AG, Takahama Y (Jan 2000) A role for pref-1 and HES-1 in thymocyte development., Journal of Immunology (baltimore, Md. : 1950), 164 (1), 256-64 Abstract
  • Blish CA, Dillon SR, Farr AG, Fink PJ, Anergic CD8+ T cells can persist and function in vivo., Journal of Immunology, 163(1), 155-64, 1 Jul 1999 Abstract
  • Clegg CH, Haugen HS, Rulffes JT, Friend SL, Farr AG, Oncostatin M transforms lymphoid tissue function in transgenic mice by stimulating lymph node T-cell development and thymus autoantibody production., Experimental Hematology, 27(4), 712-25, April 1999 Abstract
  • Alaniz RC, Thomas SA, Perez-Melgosa M, Mueller K, Farr AG, Palmiter RD, Wilson CB, Dopamine beta-hydroxylase deficiency impairs cellular immunity., Proceedings of the National Academy of Sciences (USA), 96(5), 2274-8, 2 Mar 1999 Abstract
  • Levin SD, Koelling RM, Friend SL, Isaksen DE, Ziegler SF, Perlmutter RM, Farr AG, Thymic stromal lymphopoietin: a cytokine that promotes the development of IgM+ B cells in vitro and signals via a novel mechanism., Journal of Immunology, 162(2), 677-83, 15 Jan 1999 Abstract
  • Nelson AJ, Clegg CH, Farr AG, In vitro positive selection and anergy induction of class II-restricted TCR transgenic thymocytes by a cortical thymic epithelial cell line., Int Immunol, 10(9), 1335-46, September 1998 Abstract
  • Farr AG, Rudensky A, Medullary thymic epithelium: a mosaic of epithelial self?, Journal of Experimental Medicine, 188(1), 1-4, July 1998 Abstract
  • Mackall CL, Punt JA, Morgan P, Farr AG, Gress RE, Thymic function in young/old chimeras: substantial thymic T cell regenerative capacity despite irreversible age-associated thymic involution, European Journal of Immunology, 28(6), 1886-93, June 1998 Abstract
  • Martinez A, Farr A, Vos MD, Cuttitta F, Treston AM, Peptide-amidating enzymes are expressed in the stellate epithelial cells of the thymic medulla, Journal of Histochemistry and Cytochemistry, 46(5), 661-8, May 1998 Abstract
  • Nakagawa T, Roth W, Wong P, Nelson A, Farr A, Deussing J, Villadangos JA, Ploegh H, Peters C, Rudensky AY, Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus, Science, 280(5362), 450-3, April 1998 Abstract
  • Wang R, Nelson A, Kimachi K, Grey HM, Farr AG, The role of peptides in thymic positive selection of class II major histocompatibility complex-restricted T cells., Proceedings of the National Academy of Sciences (USA), 95(7), 3804-9, 31 1998 Abstract
  • Wang R, Nelson A, Kimachi K, Grey HM, Farr AG, The role of peptides in thymic positive selection of class II major histocompatibility complex-restricted T cells, Proceedings of the National Academy of Sciences (USA), 95(7), 3804-9, March 1998 Abstract
  • Nelson, AJ, Clegg, CH, Farr, AG, In vitro positive selection and anergy induction of class II-restricted transgenic thymocytes by a cortical thymic epithleial cell line, International Immunology, 10, 1335-1346, 1998
  • Clegg C H, Rulffes J T, Haugen H S, Hoggatt I H, Aruffo A, Durham S K, Farr A G, Hollenbaugh D, Thymus dysfunction and chronic inflammatory disease in gp39 transgenic mice., International Immunology, 9(8), 1111-22, August 1997 Abstract
  • Goverman J, Brabb T, Huseby E S, Farr A G, TCR signaling regulates thymic organization: lessons from TCR-transgenic mice., Immunology Today, 18(5), 204-8, May 1997 Abstract
  • Muller K M, Luedecker C J, Udey M C, Farr A G, Involvement of E-cadherin in thymus organogenesis and thymocyte maturation., Immunity, 6(3), 257-64, March 1997 Abstract
  • Brabb T, Huseby E S, Morgan T M, Sant'Angelo D B, Kirchner J, Farr A G, Goverman J, Thymic stromal organization is regulated by the specificity of T cell receptor/major histocompatibility complex interactions., European Journal of Immunology, 27(1), 136-46, January 1997 Abstract
  • Dunn R J, Luedecker C J, Haugen H S, Clegg C H, Farr A G, Thymic overexpression of CD40 ligand disrupts normal thymic epithelial organization., Journal of Histochemistry and Cytochemistry, 45(1), 129-41, January 1997 Abstract
  • Borkowski T A, Letterio J J, Mackall C L, Saitoh A, Farr A G, Wang X J, Roop D R, Gress R E, Udey M C, Langerhans cells in the TGF beta 1 null mouse., Advances In Experimental Medicine and Biology, 417, 307-10, 1997 Abstract
  • Otipoby K L, Andersson K B, Draves K E, Klaus S J, Farr A G, Kerner J D, Perlmutter R M, Law C L, Clark E A, CD22 regulates thymus-independent responses and the lifespan of B cells., Nature, 384(6610), 634-7, 19-26 Dec 1996 Abstract
  • Farr A, DeRoos P C, Eastman S, Rudensky A Y, Differential expression of CLIP:MHC class II and conventional endogenous peptide:MHC class II complexes by thymic epithelial cells and peripheral antigen-presenting cells., European Journal of Immunology, 26(12), 3185-93, December 1996 Abstract
  • Borkowski T A, Letterio J J, Farr A G, Udey M C, A role for endogenous transforming growth factor beta 1 in Langerhans cell biology: the skin of transforming growth factor beta 1 null mice is devoid of epidermal Langerhans cells., Journal of Experimental Medicine, 184(6), 2417-22, 1 Dec 1996 Abstract
  • Kahn S J, Wleklinski M, Ezekowitz R A, Coder D, Aruffo A, Farr A, The major surface glycoprotein of Trypanosoma cruzi amastigotes are ligands of the human serum mannose-binding protein., Infection and Immunity, 64(7), 2649-56, July 1996 Abstract
  • Starling G C, Whitney G S, Siadak A W, Llewellyn M B, Bowen M A, Farr A G, Aruffo A A, Characterization of mouse CD6 with novel monoclonal antibodies which enhance the allogeneic mixed leukocyte reaction., European Journal of Immunology, 26(4), 738-46, April 1996 Abstract
  • Nelson A J, Dunn R J, Peach R, Aruffo A, Farr A G, The murine homolog of human Ep-CAM, a homotypic adhesion molecule, is expressed by thymocytes and thymic epithelial cells., European Journal of Immunology, 26(2), 401-8, February 1996 Abstract
  • Borkowski T A, Nelson A J, Farr A G, Udey M C, Expression of gp40, the murine homologue of human epithelial cell adhesion molecule (Ep-CAM), by murine dendritic cells., European Journal of Immunology, 26(1), 110-4, January 1996 Abstract
  • Kahn S, Wleklinski M, Aruffo A, Farr A, Coder D, Kahn M, Trypanosoma cruzi amastigote adhesion to macrophages is facilitated by the mannose receptor., Journal of Experimental Medicine, 182(5), 1243-58, 1 Nov 1995 Abstract
  • Edwards C P, Farr A G, Marken J S, Nelson A, Bajorath J, Hellstrom K E, Hellstrom I, Aruffo A, Cloning of the murine counterpart of the tumor-associated antigen H-L6: epitope mapping of the human and murine L6 antigens., Biochemistry, 34(39), 12653-60, 3 Oct 1995 Abstract
  • Zheng Z, Katoh S, He Q, Oritani K, Miyake K, Lesley J, Hyman R, Hamik A, Parkhouse RM, Farr AG, et al, Monoclonal antibodies to CD44 and their influence on hyaluronan recognition, Journal of Cell Biology, 130(2), 485-95, July 1995 Abstract
  • Borkowski T A, Farr A G, Nelson A J, Udey M C, Identification of a novel cell surface protein expressed by murine epidermal Langerhans cells and some lymphoid dendritic cells., Advances In Experimental Medicine and Biology, 378, 93-5, 1995 Abstract
  • Morishima C, Norby-Slycord C, McConnell K R, Finch R J, Nelson A J, Farr A G, Pullen A M, Expression of two structurally identical viral superantigens results in thymic elimination at distinct developmental stages., Journal of Immunology, 153(11), 5091-103, 1 Dec 1994 Abstract
  • Borkowski T A, Van Dyke B J, Schwarzenberger K, McFarland V W, Farr A G, Udey M C, Expression of E-cadherin by murine dendritic cells: E-cadherin as a dendritic cell differentiation antigen characteristic of epidermal Langerhans cells and related cells., European Journal of Immunology, 24(11), 2767-74, November 1994 Abstract
  • Wee S, Wang W C, Farr A G, Nelson A J, Patel D D, Haynes B F, Linsley P S, Aruffo A, Characterization of a CD6 ligand(s) expressed on human- and murine-derived cell lines and murine lymphoid tissues., Cellular Immunology, 158(2), 353-64, 15 Oct 1994 Abstract
  • Heyborne K, Fu Y X, Nelson A, Farr A, O'Brien R, Born W, Recognition of trophoblasts by gamma delta T cells., Journal of Immunology, 153(7), 2918-26, 1 Oct 1994 Abstract
  • Lee M G, Sharrow S O, Farr A G, Singer A, Udey M C, Expression of the homotypic adhesion molecule E-cadherin by immature murine thymocytes and thymic epithelial cells., Journal of Immunology, 152(12), 5653-9, 15 Jun 1994 Abstract
  • Takahama Y, Letterio J J, Suzuki H, Farr A G, Singer A, Early progression of thymocytes along the CD4/CD8 developmental pathway is regulated by a subset of thymic epithelial cells expressing transforming growth factor beta., Journal of Experimental Medicine, 179(5), 1495-506, 1 May 1994 Abstract
  • Marken J S, Bajorath J, Edwards C P, Farr A G, Schieven G L, Hellstrom I, Hellstrom K E, Aruffo A, Membrane topology of the L6 antigen and identification of the protein epitope recognized by the L6 monoclonal antibody., Journal of Biological Chemistry, 269(10), 7397-401, 11 Mar 1994 Abstract
  • Friend S L, Hosier S, Nelson A, Foxworthe D, Williams D E, Farr A, A thymic stromal cell line supports in vitro development of surface IgM+ B cells and produces a novel growth factor affecting B and T lineage cells., Experimental Hematology, 22(3), 321-8, March 1994 Abstract
  • Nelson A J, Hosier S, Brady W, Linsley P S, Farr A G, Medullary thymic epithelium expresses a ligand for CTLA4 in situ and in vitro., Journal of Immunology, 151(5), 2453-61, 1 Sep 1993 Abstract
  • Nelson AJ, Hosier S, Brady W, Linsley PS, Farr AG (Sep 1993) Medullary thymic epithelium expresses a ligand for CTLA4 in situ and in vitro., Journal of Immunology (baltimore, Md. : 1950), 151 (5), 2453-61 Abstract
  • Van Voorhis W C, Barrett L, Koelling R, Farr A G, FL-160 proteins of Trypanosoma cruzi are expressed from a multigene family and contain two distinct epitopes that mimic nervous tissues., Journal of Experimental Medicine, 178(2), 681-94, 1 Aug 1993 Abstract
  • Van Voorhis WC, Barrett L, Koelling R, Farr AG (Aug 1993) FL-160 proteins of Trypanosoma cruzi are expressed from a multigene family and contain two distinct epitopes that mimic nervous tissues., The Journal of Experimental Medicine, 178 (2), 681-94 Abstract
  • Farr A, Nelson A, Hosier S, Kim A, A novel cytokine-responsive cell surface glycoprotein defines a subset of medullary thymic epithelium in situ., Journal of Immunology, 150(4), 1160-71, 15 Feb 1993 Abstract
  • Itohara S, Mombaerts P, Lafaille J, Iacomini J, Nelson A, Clarke A R, Hooper M L, Farr A, Tonegawa S, T cell receptor delta gene mutant mice: independent generation of alpha beta T cells and programmed rearrangements of gamma delta TCR genes., Cell, 72(3), 337-48, 12 Feb 1993 Abstract
  • Itohara S, Mombaerts P, Lafaille J, Iacomini J, Nelson A, Clarke AR, Hooper ML, Farr A, Tonegawa S (Feb 1993) T cell receptor delta gene mutant mice: independent generation of alpha beta T cells and programmed rearrangements of gamma delta TCR genes., Cell, 72 (3), 337-48 Abstract
  • Farr A, Nelson A, Hosier S, Kim A (Feb 1993) A novel cytokine-responsive cell surface glycoprotein defines a subset of medullary thymic epithelium in situ., Journal of Immunology (baltimore, Md. : 1950), 150 (4), 1160-71 Abstract
  • Farr A G, Berry M L, Kim A, Nelson A J, Welch M P, Aruffo A, Characterization and cloning of a novel glycoprotein expressed by stromal cells in T-dependent areas of peripheral lymphoid tissues., Journal of Experimental Medicine, 176(5), 1477-82, 1 Nov 1992 Abstract
  • Chalupny N J, Peach R, Hollenbaugh D, Ledbetter J A, Farr A G, Aruffo A, T-cell activation molecule 4-1BB binds to extracellular matrix proteins., Proceedings of the National Academy of Sciences (USA), 89(21), 10360-4, 1 Nov 1992 Abstract
  • Chalupny NJ, Peach R, Hollenbaugh D, Ledbetter JA, Farr AG, Aruffo A (Nov 1992) T-cell activation molecule 4-1BB binds to extracellular matrix proteins., Proceedings of the National Academy of Sciences of the United States of America., 89 (21), 10360-4 Abstract
  • Farr AG, Berry ML, Kim A, Nelson AJ, Welch MP, Aruffo A (Nov 1992) Characterization and cloning of a novel glycoprotein expressed by stromal cells in T-dependent areas of peripheral lymphoid tissues., The Journal of Experimental Medicine, 176 (5), 1477-82 Abstract
  • Farr A, Nelson A, Hosier S, Characterization of an antigenic determinant preferentially expressed by type I epithelial cells in the murine thymus., Journal of Histochemistry and Cytochemistry, 40(5), 651-64, May 1992 Abstract
  • Farr A, Nelson A, Hosier S (May 1992) Characterization of an antigenic determinant preferentially expressed by type I epithelial cells in the murine thymus., The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 40 (5), 651-64 Abstract
  • Farr A, Nelson A, Truex J, Hosier S, Epithelial heterogeneity in the murine thymus: a cell surface glycoprotein expressed by subcapsular and medullary epithelium., Journal of Histochemistry and Cytochemistry, 39(5), 645-53, May 1991 Abstract
  • Tonegawa S, Berns A, Bonneville M, Farr A G, Ishida I, Ito K, Itohara S, Janeway C A Jr, Kanagawa O, Kubo R, et al, Diversity, development, ligands, and probable functions of gamma delta T cells., Advances In Experimental Medicine and Biology, 292, 53-61, 1991 Abstract
  • Reardon C, Lefrancois L, Farr A, Kubo R, O'Brien R, Born W, Expression of gamma/delta T cell receptors on lymphocytes from the lactating mammary gland., Journal of Experimental Medicine, 172(4), 1263-6, 1 Oct 1990 Abstract
  • Bonneville M, Itohara S, Krecko E G, Mombaerts P, Ishida I, Katsuki M, Berns A, Farr A G, Janeway C A Jr, Tonegawa S, Transgenic mice demonstrate that epithelial homing of gamma/delta T cells is determined by cell lineages independent of T cell receptor specificity., Journal of Experimental Medicine, 171(4), 1015-26, 1 Apr 1990 Abstract
  • Itohara S, Farr A G, Lafaille J J, Bonneville M, Takagaki Y, Haas W, Tonegawa S, Homing of a gamma delta thymocyte subset with homogeneous T-cell receptors to mucosal epithelia., Nature, 343(6260), 754-7, 22 Feb 1990 Abstract
  • Farr A, Hosier S, Nelson A, Itohara S, Tonegawa S, Distribution of thymocytes expressing gamma delta receptors in the murine thymus during development., Journal of Immunology, 144(2), 492-8, 15 Jan 1990 Abstract
  • Garvin A M, Abraham K M, Forbush K A, Farr A G, Davison B L, Perlmutter R M, Disruption of thymocyte development and lymphomagenesis induced by SV40 T-antigen., International Immunology, 2(2), 173-80, 1990 Abstract
  • Press OW, Farr AG, Borroz KI, Anderson SK, Martin PJ (Sep 1989) Endocytosis and degradation of monoclonal antibodies targeting human B-cell malignancies., Cancer Research, 49 (17), 4906-12 Abstract
  • Farr AG, Braddy SC (Jul 1989) Patterns of keratin expression in the murine thymus., The Anatomical Record, 224 (3), 374-8 Abstract
  • Farr AG, Hosier S, Braddy SC, Anderson SK, Eisenhardt DJ, Yan ZJ, Robles CP (Apr 1989) Medullary epithelial cell lines from murine thymus constitutively secrete IL-1 and hematopoietic growth factors and express class II antigens in response to recombinant interferon-gamma., Cellular Immunology, 119 (2), 427-44 Abstract
  • Scofield K, Yan ZJ, Farr AG (Apr 1989) Characterization of murine thymocyte subpopulations reacting with Dolichos bifloris agglutinin., Cellular Immunology, 120 (1), 114-25 Abstract
  • Tonegawa S, Berns A, Bonneville M, Farr A, Ishida I, Ito K, Itohara S, Janeway CA Jr, Kanagawa O, Katsuki M, Et Al. (1989) Diversity, development, ligands, and probable functions of gamma delta T cells., Cold Spring Harbor Symposia On Quantitative Biology, 54 Pt 1, 31-44 Abstract
  • Farr AG, Mannschreck JW, Anderson SK (Oct 1988) Expression of class II MHC antigens in murine pancreas after streptozocin-induced insulitis., Diabetes, 37 (10), 1373-9 Abstract
  • Tombes RM, Farr A, Shapiro BM (Oct 1988) Sea urchin sperm creatine kinase: the flagellar isozyme is a microtubule-associated protein., Experimental Cell Research, 178 (2), 307-17 Abstract
  • Farr AG, Anderson SK (Oct 1988) In situ localization of T cell receptor beta chain in the murine thymus: changes in the intrathymic distribution of thymocytes expressing beta chain during fetal development., Cellular Immunology, 116 (1), 135-48 Abstract
  • Press OW, Hansen JA, Farr A, Martin PJ (Apr 1988) Endocytosis and degradation of murine anti-human CD3 monoclonal antibodies by normal and malignant T-lymphocytes., Cancer Research, 48 (8), 2249-57 Abstract
  • Farr AG, Anderson SK, Braddy SC, Mejino JL Jr (Feb 1988) Selective binding of Dolichos biflorus agglutinin to L3T4-, Lyt-2- thymocytes. Expression of terminal alpha-linked N-acetyl-D-galactosamine residues defines a subpopulation of fetal and adult murine thymocytes., Journal of Immunology (baltimore, Md. : 1950), 140 (4), 1014-21 Abstract
  • Farr AG, Mannschreck JW, Anderson SK (Mar 1987) Expression of Ia antigens by murine kidney epithelium after exposure to streptozotocin., The American Journal of Pathology, 126 (3), 561-8 Abstract
  • Press OW, Vitetta ES, Farr AG, Hansen JA, Martin PJ (Oct 1986) Evaluation of ricin A-chain immunotoxins directed against human T cells., Cellular Immunology, 102 (1), 10-20 Abstract
  • Farr AG, Eisenhardt DJ, Anderson SK (Sep 1986) Isolation of murine thymic epithelium and an improved method for its propagation in vitro., The Anatomical Record, 216 (1), 85-94 Abstract
  • Foster CA, Holbrook KA, Farr AG (Mar 1986) Ontogeny of Langerhans cells in human embryonic and fetal skin: expression of HLA-DR and OKT-6 determinants., The Journal of Investigative Dermatology, 86 (3), 240-3 Abstract
  • Marrack P, Born W, Roehm N, Farr A, Kappler J (1986) T cell receptors in the thymus., Biochemical Society Symposium, 51, 197-204 Abstract
  • Farr AG, Anderson SK, Marrack P, Kappler J (Dec 1985) Expression of antigen-specific, major histocompatibility complex-restricted receptors by cortical and medullary thymocytes in situ., Cell, 43 (2 Pt 1), 543-50 Abstract
  • Farr AG, Anderson SK (Oct 1985) In situ ultrastructural demonstration of cells bearing Ia antigens in the murine pancreas., Diabetes, 34 (10), 987-90 Abstract
  • David GF, Koehler JK, Brown JA, Petra PH, Farr AG (Sep 1985) Light and electron microscopic studies on the localization of steroid-binding protein (SBP) in rabbit spermatozoa., Biology of Reproduction, 33 (2), 503-14 Abstract
  • Farr AG, Anderson SK (May 1985) Epithelial heterogeneity in the murine thymus: fucose-specific lectins bind medullary epithelial cells., Journal of Immunology (baltimore, Md. : 1950), 134 (5), 2971-7 Abstract
  • Farr AG, Sidman CL (Jul 1984) Reduced expression of Ia antigens by thymic epithelial cells of aged mice., Journal of Immunology (baltimore, Md. : 1950), 133 (1), 98-103 Abstract
  • Farr AG, Nakane PK (Apr 1983) Cells bearing Ia antigens in the murine thymus. An ultrastructural study., The American Journal of Pathology, 111 (1), 88-97 Abstract
  • Farr AG, Nakane PK (1981) Immunohistochemistry with enzyme labeled antibodies: a brief review., Journal of Immunological Methods, 47 (2), 129-44 Abstract
  • Farr AG, Cho Y, De Bruyn PP (Mar 1980) The structure of the sinus wall of the lymph node relative to its endocytic properties and transmural cell passage., The American Journal of Anatomy, 157 (3), 265-84 Abstract
  • Farr AG, Wechter WJ, Kiely JM, Unanue ER (Jun 1979) Induction of cytocidal macrophages after in vitro interactions between Listeria-immune T cells and macrophages--role of H-2., Journal of immunology (Baltimore, Md. : 1950), 122 (6), 2405-12 Abstract
  • Farr AG, Kiely JM, Unanue ER (Jun 1979) Macrophage-T cell interactions involving Listeria monocytogenes--role of the H-2 gene complex., Journal of Immunology (baltimore, Md. : 1950), 122 (6), 2395-404 Abstract
  • Beller DI, Farr AG, Unanue ER (Jan 1978) Regulation of lymphocyte proliferation and differentiation by macrophages., Federation Proceedings, 37 (1), 91-6 Abstract
  • Farr AG, Dorf ME, Unanue ER (Aug 1977) Secretion of mediators following T lymphocyte-macrophage interaction is regulated by the major histocompatibility complex., Proceedings of the National Academy of Sciences of the United States of America, 74 (8), 3542-6 Abstract
  • Farr AG, De Bruyn PP (Oct 1975) Macrophage-lymphocyte clusters in lymph nodes: a possible substrate for cellular interactions in the immune response., The American Journal of Anatomy, 144 (2), 209-31 Abstract
  • Farr AG, De Bruyn PP (May 1975) The mode of lymphocyte migration through postcapillary venule endothelium in lymph node., The American Journal of Anatomy, 143 (1), 59-92 Abstract

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