Eric O. Feigl

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University of Washington
School of Medicine
Physiology and Biophysics
ProfessorAppointed: 1972

Mailing Address

Box 357290
University of Washington
Seattle, Washington 98195
United States

Contact Information

Phone: (206) 543-1496
Fax: (206) 685-0619
efeigl@u.washington.edu

Qualifications

M.D., University of Minnesota, Medical School, 1958.

Expertise and Research Interests

The blood vessels that perfuse the heart course over its surface like a crown; whence the term that applies to those vessels - coronary. The heart muscle depends on oxygen on a beat-to-beat basis, and even brief periods without blood flow are injurious. Since the heart supplies its own blood flow, compromising the coronary circulation lessens the pumping power of the heart, which further impairs coronary blood flow to further weaken the heart and so on in a vicious circle. This is why a coronary occlusion is a medical emergency.

Coronary blood flow is controlled by intrinsic local factors in the heart muscle, or myocardium, and extrinsic parasympathetic and sympathetic nerves. Both intrinsic and extrinsic coronary control mechanisms are being studied in my laboratory. The role of adenosine in local control of coronary blood flow is investigated with high pressure liquid chromatography (HPLC). The synergistic action of oxygen and carbon dioxide in the local control of coronary vasodilation and the recently discovered endothelium-derived relaxing factor that is nitric oxide (NO) is under investigation, and the role of sympathetic coronary vasoconstriction during exercise has been examined. Therefore, all aspects of coronary physiology are being investigated, from microvascular exchange and local metabolic factors to neural parasympathetic and sympathetic control.

Keywords

COS Keywords:

Cardiovascular Biology, Cardiovascular Diseases, Cardiovascular System, Ischemia, Vascular Biology.

Additional Terms:

Cardiac Biology, Cardiac Innervation, Cardiovascular Biology, Coronary Vessels & Hem, Ischemia, Vascular Biology, Vessel Wall Biology.

Publications

  • Richmond KN, Tune JD, Gorman MW, Feigl EO, Role of K+ATP channels in local metabolic coronary vasodilation., American Journal of Physiology, 277(6 Pt 2), H2115-23, December 1999 Abstract
  • Yada T, Richmond KN, Van Bibber R, Kroll K, Feigl EO, Role of adenosine in local metabolic coronary vasodilation., American Journal of Physiology, 276(5 Pt 2), H1425-33, May 1999 Abstract
  • Feigl E O, Neural control of coronary blood flow., Journal of Vascular Research, 35(2), 85-92, March 1998 Abstract
  • Stepp D W, Kroll K, Feigl E O, K+ATP channels and adenosine are not necessary for coronary autoregulation., American Journal of Physiology, 273(3 Pt 2), H1299-308, September 1997 Abstract
  • Van Bibber R, Stepp D W, Kroll K, Feigl E O, Role of adenosine in norepinephrine-induced coronary vasodilation., American Journal of Physiology, 273(2 Pt 2), H557-65, August 1997 Abstract
  • Stepp D W, Van Bibber R, Kroll K, Feigl E O, Quantitative relation between interstitial adenosine concentration and coronary blood flow., Circulation Research, 79(3), 601-10, September 1996 Abstract
  • Van Bibber R, Traub O, Kroll K, Feigl E O, EDRF and norepinephrine-induced vasodilation in the canine coronary circulation., American Journal of Physiology, 268(5 Pt 2), H1973-81, May 1995 Abstract
  • Miyashiro J K, Feigl E O, A model of combined feedforward and feedback control of coronary blood flow., American Journal of Physiology, 268(2 Pt 2), H895-908, February 1995 Abstract
  • Feigl E O, No adrenergic constriction in isolated coronary arterioles?, Basic Research In Cardiology, 90(1), 70-2, Winter 1995 Abstract
  • Miyashiro J K, Feigl E O, Feedforward control of coronary blood flow via coronary beta-receptor stimulation., Circulation Research, 73(2), 252-63, August 1993 Abstract
  • Feigl E O, Adenosine coronary vasodilation during hypoxia depends on adrenergic receptor activation., Advances In Experimental Medicine and Biology, 346, 199-205, 1993 Abstract
  • Herrmann S C, Feigl E O, Adrenergic blockade blunts adenosine concentration and coronary vasodilation during hypoxia., Circulation Research, 70(6), 1203-16, June 1992 Abstract
  • Broten T P, Miyashiro J K, Moncada S, Feigl E O, Role of endothelium-derived relaxing factor in parasympathetic coronary vasodilation., American Journal of Physiology, 262(5 Pt 2), H1579-84, May 1992 Abstract
  • Broten T P, Feigl E O, Role of myocardial oxygen and carbon dioxide in coronary autoregulation., American Journal of Physiology, 262(4 Pt 2), H1231-7, April 1992 Abstract
  • Herrmann S C, Feigl E O, Subtraction method for the high-performance liquid chromatographic measurement of plasma adenosine., Journal of Chromatography, 574(2), 247-53, 14 Feb 1992 Abstract
  • Broten T P, Romson J L, Fullerton D A, Van Winkle D M, Feigl E O, Synergistic action of myocardial oxygen and carbon dioxide in controlling coronary blood flow., Circulation Research, 68(2), 531-42, February 1991 Abstract
  • Trivella M G, Broten T P, Feigl E O, Beta-receptor subtypes in the canine coronary circulation., American Journal of Physiology, 259(5 Pt 2), H1575-85, November 1990 Abstract
  • Feigl E O, Neat G W, Huang A H, Interrelations between coronary artery pressure, myocardial metabolism and coronary blood flow., Journal of Molecular and Cellular Cardiology, 22(4), 375-90, April 1990 Abstract
  • Feigl E O, Van Winkle D M, Miyashiro J K, Cholinergic vasodilatation of coronary resistance vessels in dogs, baboons and goats., Blood Vessels, 27(2-5), 94-105, 1990 Abstract
  • Feigl E O, Adrenergic control of transmural coronary blood flow., Basic Research In Cardiology, 85 Suppl 1, 167-76, 1990 Abstract

Profile Details

Last Updated: 3/2/1999

COS Expertise ID #307470
Reference this profile directly: http://myprofile.cos.com/feigle70