Dr. Frank E. Harrell

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Vanderbilt University
Medicine
Biostatistics
ChairAppointed: 2003
Health Services and Outcomes Research Methodology
Managing EditorAppointed: 1998

Mailing Address

S-2323 Medical Center North 2158
Nashville, Tennessee 37232
United States

Contact Information

Phone: (615) 322-2001
Fax: (615) 343-4924
f.harrell@vanderbilt.edu
http://biostat.mc.vanderbilt.edu

Qualifications

Ph.D., University of North Carolina at Chapel Hill, Biostatistics, 1979.
B.S., University of Alabama at Birmingham, Mathematics, 1973.

Expertise and Research Interests

Statistical analysis
Clinical prediction
Statistical models
Statistical computing
Statistical graphics
Statistical reporting
Cardiovascular disease
Medical applications of statistics
Clinical trials
Clinical safety assessment and analysis in pharmaceutical trials
Risk adjustment
Health services and outcomes research
Pharmaceutical research
Medical diagnosis and prognosis

Future Research

Bayesian statistics


Industrial Relevance

Statistical analysis and coordinating center for pharmaceutical trials Safety and Data Monitoring Boards
Experimental design
Study design
Statistical issues in drug development
Statistical models in outcomes research for pharmaceutical companies
Pharmacoeconomics
Cost-effectiveness analysis

Keywords

COS Keywords:

Biometry, Biostatistics, Cardiovascular Diseases, Clinical Trial, Computer Programming, Computer Software, Epidemiology, Experimental Design, Mathematics, Medical Diagnosis, Outcomes Research (Medical), Pharmaceuticals, Pharmacoeconomics, Research Methodology, Risk Factor Analysis, Statistics.

Additional Terms:

Clinical Epidemiology, Clinical Prediction Models, Clinical Safety, Computer Languages/Software: S, R, S-Plus, Experimental Design, Health Services Research, Outcomes Research, Pharmaceutical Research, Pharmacoeconomics.

Memberships

American Statistical Association
Biometric Society
Drug Information Association
International Society of Clinical Biostatistics
Society for Clinical Trials

Previous Positions

1996, Professor, University of Virginia, College and Graduate School of Arts and Sciences, Statistics
1996-2003, Professor, University of Virginia, School of Medicine, Health Evaluation Sciences, Biostatistics and Epidemiology
1987-1991, Cardiorenal Advisory Committee, United States Food and Drug Administration, Cardio-Renal Drug Products
1978-1996, Assistant, Associate Professor, Duke University, School of Medicine, Family Medicine, Biometry

Publications

  • Steyerberg EW, Frankema SP, Harrell FE Jr, Statistical analyses of trauma outcome: when is more too much?, Journal of Trauma, 54(6), 1256-7; author reply, June 2003 Abstract
  • Moons KG, Harrell FE, Sensitivity and specificity should be de-emphasized in diagnostic accuracy studies, Academic Radiology, 10(6), 670-2, June 2003 Abstract
  • Griffin MP, O'Shea TM, Bissonette EA, Harrell FE Jr, Lake DE, Moorman JR, Abnormal heart rate characteristics preceding neonatal sepsis and sepsis-like illness, Pediatric Research, 53(6), 920-6, June 2003 Abstract
  • Taylor AG, Galper DI, Taylor P, Rice LW, Andersen W, Irvin W, Wang XQ, Harrell FE Jr, Effects of adjunctive Swedish massage and vibration therapy on short-term postoperative outcomes: a randomized, controlled trial, Journal of Alternative and Complementary Medicine (new York, N.y.), 9(1), 77-89, February 2003 Abstract
  • Moons KG, Harrell FE, Steyerberg EW, Should scoring rules be based on odds ratios or regression coefficients?, Journal of Clinical Epidemiology, 55(10), 1054-5, October 2002 Abstract
  • Wu AW, Young Y, Dawson NV, Brant L, Galanos AN, Broste S, Landefeld SC, Harrell FE, Lynn J, Estimates of future physical functioning by seriously ill hospitalized patients, their families, and their physicians, Journal of the American Geriatrics Society, 50(2), 230-7, February 2002 Abstract
  • Parkerson GR Jr, Harrell FE Jr, Hammond WE, Wang XQ, Characteristics of adult primary care patients as predictors of future health services charges, Medical Care, 39(11), 1170-81, November 2001 Abstract
  • Calnon DA, McGrath PD, Doss AL, Harrell FE Jr, Watson DD, Beller GA, Prognostic value of dobutamine stress technetium-99m-sestamibi single-photon emission computed tomography myocardial perfusion imaging: stratification of a high-risk population, Journal of the American College of Cardiology, 38(5), 1511-7, November 2001 Abstract
  • Steyerberg EW, Harrell FE Jr, Borsboom GJ, Eijkemans MJ, Vergouwe Y, Habbema JD, Internal validation of predictive models: efficiency of some procedures for logistic regression analysis, Journal of Clinical Epidemiology, 54(8), 774-81, August 2001 Abstract
  • McMahon RP, Harrell FE Jr, Joint testing of mortality and a non-fatal outcome in clinical trials, Statistics in Medicine, 20(8), 1165-72, April 2001 Abstract
  • Harrell FE Jr, Shih YC, Using full probability models to compute probabilities of actual interest to decision makers, International Journal of Technology Assessment in Health Care, 17(1), 17-26, Winter 2001 Abstract
  • Stare J, Harrell FE Jr, Heinzl H, BJ: an S-Plus program to fit linear regression models to censored data using the Buckley-James method, Computer Methods and Programs in Biomedicine, 64(1), 45-52, Jan 2001 Abstract
  • Steyerberg EW, Eijkemans MJ, Harrell FE Jr, Habbema JD, Prognostic modeling with logistic regression analysis: in search of a sensible strategy in small data sets, Medical Decision Making : an International Journal of the Society for Medical Decision Making, 21(1), 45-56, 2001 Abstract
  • McMahon RP, Harrell FE, Power calculation for clinical trials when the outcome is a composite ranking of survival and a nonfatal outcome, Controlled Clinical Trials, 21(4), 305-12, August 2000 Abstract
  • Teno JM, Harrell FE Jr, Knaus W, Phillips RS, Wu AW, Connors A Jr, Wenger NS, Wagner D, Galanos A, Desbiens NA, Lynn J, Prediction of survival for older hospitalized patients: the HELP survival model. Hospitalized Elderly Longitudinal Project, Journal of the American Geriatrics Society, 48(5 Suppl), S16-24, May 2000 Abstract
  • Wenger NS, Lynn J, Oye RK, Liu H, Teno JM, Phillips RS, Desbiens NA, Sehgal A, Kussin P, Taub H, Harrell F, Knaus W, Withholding versus withdrawing life-sustaining treatment: patient factors and documentation associated with dialysis decisions, Journal of the American Geriatrics Society, 48(5 Suppl), S75-83, May 2000 Abstract
  • Claessens MT, Lynn J, Zhong Z, Desbiens NA, Phillips RS, Wu AW, Harrell FE Jr, Connors AF Jr, Dying with lung cancer or chronic obstructive pulmonary disease: insights from SUPPORT. Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments, Journal of the American Geriatrics Society, 48(5 Suppl), S146-53, May 2000 Abstract
  • Teno JM, Fisher E, Hamel MB, Wu AW, Murphy DJ, Wenger NS, Lynn J, Harrell FE Jr, Decision-making and outcomes of prolonged ICU stays in seriously ill patients, Journal of the American Geriatrics Society, 48(5 Suppl), S70-4, May 2000 Abstract
  • Steyerberg EW, Eijkemans MJ, Harrell FE Jr, Habbema JD, Prognostic modelling with logistic regression analysis: a comparison of selection and estimation methods in small data sets, Statistics in Medicine, 19(8), 1059-79, April 2000 Abstract
  • Weiss JP, Gruver C, Kaul S, Harrell FE Jr, Sklenar J, Dent JM, Ordering an echocardiogram for evaluation of left ventricular function: level of expertise necessary for efficient use, Journal of the American Society of Echocardiography, 13(2), 124-30, February 2000 Abstract
  • Hamel MB, Davis RB, Teno JM, Knaus WA, Lynn J, Harrell F Jr, Galanos AN, Wu AW, Phillips RS, Older age, aggressiveness of care, and survival for seriously ill, hospitalized adults. SUPPORT Investigators. Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments, Annals of Internal Medicine, 131(10), 721-8, November 1999 Abstract
  • Senn S, Harrell FE Jr, On subgroups and groping for significance, Journal of Clinical Epidemiology, 51(12), 1367-8, December 1998 Abstract
  • Shaw LJ, Peterson ED, Shaw LK, Kesler KL, DeLong ER, Harrell FE Jr, Muhlbaier LH, Mark DB, Use of a prognostic treadmill score in identifying diagnostic coronary disease subgroups, Circulation, 98(16), 1622-30, October 1998 Abstract
  • Steyerberg EW, Harrell FE Jr, Goodman PH, Neural networks, logistic regression, and calibration [letter, Medical Decision Making, 18(3), 349-50, 1998 Abstract
  • Weeks JC, Cook EF, O'Day SJ, Peterson LM, Wenger N, Reding D, Harrell FE, Kussin P, Dawson NV, Connors AF Jr, Lynn J, Phillips RS, Relationship between cancer patients' predictions of prognosis and their treatment preferences, Jama, 279(21), 1709-14, June 1998 Abstract
  • Harrell FE Jr, The inappropriate use of hypothesis testing to infer safety of calcium channel blockers [editorial; comment], Cardiovascular Drugs and Therapy, 12(2), 151-3; discussion 15, May 1998 Abstract
  • Harrell FE Jr, Margolis PA, Gove S, Mason KE, Mulholland EK, Lehmann D, Muhe L, Gatchalian S, Eichenwald HF, Development of a clinical prediction model for an ordinal outcome: the World Health Organization Multicentre Study of Clinical Signs and Etiological agents of Pneumonia, Sepsis and Meningitis in Young, Statistics in Medicine, 17(8), 909-44, April 1998 Abstract
  • Galanos AN, Pieper CF, Kussin PS, Winchell MT, Fulkerson WJ, Harrell FE Jr, Teno JM, Layde P, Connors AF Jr, Phillips RS, Wenger NS, Relationship of body mass index to subsequent mortality among seriously ill hospitalized patients. SUPPORT Investigators. The Study to Understand Prognoses and Preferences for Outcome and Risks of Tre, Critical Care Medicine, 25(12), 1962-8, December 1997 Abstract
  • Chapman IM, Hartman ML, Pezzoli SS, Harrell FE Jr, Hintz RL, Alberti KG, Thorner MO, Effect of aging on the sensitivity of growth hormone secretion to insulin-like growth factor-I negative feedback, Journal of Clinical Endocrinology and Metabolism, 82(9), 2996-3004, September 1997 Abstract
  • Califf RM, Adams KF, McKenna WJ, Gheorghiade M, Uretsky BF, McNulty SE, Darius H, Schulman K, Zannad F, Handberg-Thurmond E, Harrell FE Jr, Wheeler W, Soler-Soler J, Swedberg K, A randomized controlled trial of epoprostenol therapy for severe congestive heart failure: The Flolan International Randomized Survival Trial (FIRST), American Heart Journal, 134(1), 44-54, July 1997 Abstract
  • Senn S, Harrell F, On wisdom after the event [comment] [see comments], Journal of Clinical Epidemiology, 50(7), 749-51, July 1997 Abstract
  • Califf RM, Woodlief LH, Harrell FE Jr, Lee KL, White HD, Guerci A, Barbash GI, Simes RJ, Weaver WD, Simoons ML, Topol EJ, Selection of thrombolytic therapy for individual patients: development of a clinical model. GUSTO-I Investigators, American Heart Journal, 133(6), 630-9, June 1997 Abstract
  • Lynn J, Harrell F Jr, Cohn F, Wagner D, Connors AF Jr, Prognoses of seriously ill hospitalized patients on the days before death: implications for patient care and public policy, New Horizons, 5(1), 56-61, February 1997 Abstract
  • Burke HB, Goodman PH, Rosen DB, Henson DE, Weinstein JN, Harrell FE Jr, Marks JR, Winchester DP, Bostwick DG, Artificial neural networks improve the accuracy of cancer survival prediction, Cancer, 79(4), 857-62, February 1997 Abstract
  • Scully KW, Pates RD, Desper GS, Connors AF, Harrell FE Jr, Pieper KS, Hannan RL, Reynolds RE, Development of an enterprise-wide clinical data repository: merging multiple legacy databases, Proceedings of the AMIA Annual Fall Symposium, 32-6, 1997 Abstract
  • Ohman EM, Armstrong PW, Christenson RH, Granger CB, Katus HA, Hamm CW, O'Hanesian MA, Wagner GS, Kleiman NS, Harrell FE Jr, Califf RM, Topol EJ, Cardiac troponin T levels for risk stratification in acute myocardial ischemia. GUSTO IIA Investigators, New England Journal of Medicine, 335(18), 1333-41, October 1996 Abstract
  • Lynn J, Harrell FE, Cohn F, Hamel M, Dawson N, Wu AW, Defining the 'terminally ill': insights from SUPPORT, Duquesne Law Review, 35(1), 311-36, 1996 Abstract
  • Connors AF Jr, Speroff T, Dawson NV, Thomas C, Harrell FE Jr, Wagner D, Desbiens N, Goldman L, Wu AW, Califf RM, Fulkerson WJ Jr, Vidaillet H, Broste S, Bellamy P, Lynn J, Knaus WA, The effectiveness of right heart catheterization in the initial care of critically ill patients. SUPPORT Investigators, Jama, 276(11), 889-97, September 1996 Abstract
  • Hakim RB, Teno JM, Harrell FE Jr, Knaus WA, Wenger N, Phillips RS, Layde P, Califf R, Connors AF Jr, Lynn J, Factors associated with do-not-resuscitate orders: patients' preferences, prognoses, and physicians' judgments. SUPPORT Investigators. Study to Understand Prognoses and Preferences for Outcomes and Ri, Annals of Internal Medicine, 125(4), 284-93, August 1996 Abstract
  • Harrell FE Jr, Lee KL, Mark DB, Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors, Statistics in Medicine, 15(4), 361-87, February 1996 Abstract
  • Knaus WA, Harrell FE Jr, LaBrecque JF, Wagner DP, Pribble JP, Draper EA, Fisher CJ Jr, Soll L, Use of predicted risk of mortality to evaluate the efficacy of anticytokine therapy in sepsis. The rhIL-1ra Phase III Sepsis Syndrome Study Group, Critical Care Medicine, 24(1), 46-56, January 1996 Abstract
  • Connors AF, Dawson NV, Thomas C, Harrell FE, Desbiens N, Fulkerson WJ, Kussin P, Bellamy P, Goldman L, Knaus WA, Outcomes following acute exacerbation of severe chronic obstructive lung disease, American Journal of Respiratory and Critical Care Medicine, 154, 959-67, 1996
  • Herndon JE 2nd, Harrell FE Jr, The restricted cubic spline as baseline hazard in the proportional hazards model with step function time-dependent covariables, Statistics in Medicine, 14(19), 2119-29, October 1995 Abstract
  • Lynn J, Teno JM, Harrell FE Jr, Accurate prognostications of death. Opportunities and challenges for clinicians, Western Journal of Medicine, 163(3), 250-7, September 1995 Abstract
  • Smith SR, Minda SA, Samsa GP, Harrell FE Jr, Gunnells JC, Coffman TM, Butterly DW, Late withdrawal of cyclosporine in stable renal transplant recipients, American Journal of Kidney Diseases, 26(3), 487-94, September 1995 Abstract
  • Hamel MB, Goldman L, Teno J, Lynn J, Davis RB, Harrell FE Jr, Connors AF Jr, Califf R, Kussin P, Bellamy P, et al, Identification of comatose patients at high risk for death or severe disability. SUPPORT Investigators. Understand Prognoses and Preferences for Outcomes and Risks of Treatments, Jama, 273(23), 1842-8, June 1995 Abstract
  • Wu AW, Damiano AM, Lynn J, Alzola C, Teno J, Landefeld CS, Desbiens N, Tsevat J, Mayer-Oakes A, Harrell FE Jr, et al, Predicting future functional status for seriously ill hospitalized adults. The SUPPORT prognostic model, Annals of Internal Medicine, 122(5), 342-50, March 1995 Abstract
  • Knaus WA, Harrell FE Jr, Lynn J, Goldman L, Phillips RS, Connors AF Jr, Dawson NV, Fulkerson WJ Jr, Califf RM, Desbiens N, et al, The SUPPORT prognostic model. Objective estimates of survival for seriously ill hospitalized adults. Study to understand prognoses and preferences for outcomes and risks of treatments, Annals of Internal Medicine, 122(3), 191-203, February 1995 Abstract
  • Arkes HR, Dawson NV, Speroff T, Harrell FE Jr, Alzola C, Phillips R, Desbiens N, Oye RK, Knaus W, Connors AF Jr, The covariance decomposition of the probability score and its use in evaluating prognostic estimates. SUPPORT Investigators, Medical Decision Making, 15(2), 120-31, 1995 Abstract
  • Wagner DP, Knaus WA, Harrell FE, Zimmerman JE, Watts C, Daily prognostic estimates for critically ill adults in intensive care units: results from a prospective, multicenter, inception cohort analysis, Critical Care Medicine, 22(9), 1359-72, September 1994 Abstract
  • Mark DB, Nelson CL, Califf RM, Harrell FE Jr, Lee KL, Jones RH, Fortin DF, Stack RS, Glower DD, Smith LR, et al, Continuing evolution of therapy for coronary artery disease. Initial results from the era of coronary angioplasty, Circulation, 89(5), 2015-25, May 1994 Abstract
  • Margolis PA, Ferkol TW, Marsocci S, Super DM, Keyes LL, McNutt R, Harrell FE Jr, Accuracy of the clinical examination in detecting hypoxemia in infants with respiratory illness, Journal of Pediatrics, 124(4), 552-60, April 1994 Abstract
  • Krucoff MW, Green CL, Harrell FE, Simoons ML, Wilderman NM, Trollinger KM, Sawchak ST, Pope JE, Shah A, Granger CB, et al, From signal/noise to information content/noise. Reconsidering the statistical analysis of continuous ST-segment data streams with gaps: potential optimization of application-specific information conte, Journal of Electrocardiology, 27 Suppl, 233-7, 1994 Abstract
  • Knaus WA, Harrell FE, Fisher CJ Jr, Wagner DP, Opal SM, Sadoff JC, Draper EA, Walawander CA, Conboy K, Grasela TH, The clinical evaluation of new drugs for sepsis. A prospective study design based on survival analysis, Jama, 270(10), 1233-41, September 1993 Abstract
  • Dudley RA, Harrell FE Jr, Smith LR, Mark DB, Califf RM, Pryor DB, Glower D, Lipscomb J, Hlatky M, Comparison of analytic models for estimating the effect of clinical factors on the cost of coronary artery bypass graft surgery, Journal of Clinical Epidemiology, 46(3), 261-71, March 1993 Abstract
  • Pryor DB, Shaw L, McCants CB, Lee KL, Mark DB, Harrell FE Jr, Muhlbaier LH, Califf RM, Value of the history and physical in identifying patients at increased risk for coronary artery disease, Annals of Internal Medicine, 118(2), 81-90, January 1993 Abstract
  • Muhlbaier LH, Pryor DB, Rankin JS, Smith LR, Mark DB, Jones RH, Glower DD, Harrell FE Jr, Lee KL, Califf RM, et al, Observational comparison of event-free survival with medical and surgical therapy in patients with coronary artery disease. 20 years of follow-up, Circulation, 86(5 Suppl), II198-204, November 1992 Abstract
  • McClelland JH, Daubert JP, Kavanagh KM, Harrell FE Jr, Ideker RE, High and low strength nonsynchronized shocks given during canine ventricular tachycardia, Pacing and Clinical Electrophysiology, 15(7), 986-92, July 1992 Abstract
  • Smith LR, Harrell FE Jr, Rankin JS, Califf RM, Pryor DB, Muhlbaier LH, Lee KL, Mark DB, Jones RH, Oldham HN, et al, Determinants of early versus late cardiac death in patients undergoing coronary artery bypass graft surgery, Circulation, 84(5 Suppl), III245-53, November 1991 Abstract
  • Mark DB, Shaw L, Harrell FE Jr, Hlatky MA, Lee KL, Bengtson JR, McCants CB, Califf RM, Pryor DB, Prognostic value of a treadmill exercise score in outpatients with suspected coronary artery disease, New England Journal of Medicine, 325(12), 849-53, September 1991 Abstract
  • Pryor DB, Shaw L, Harrell FE Jr, Lee KL, Hlatky MA, Mark DB, Muhlbaier LH, Califf RM, Estimating the likelihood of severe coronary artery disease, American Journal of Medicine, 90(5), 553-62, May 1991 Abstract
  • Linzer M, Prystowsky EN, Divine GW, Matchar DB, Samsa G, Harrell F Jr, Pressley JC, Pryor DB, Predicting the outcomes of electrophysiologic studies of patients with unexplained syncope: preliminary validation of a derived model, Journal of General Internal Medicine, 6(2), 113-20, 1991 Abstract
  • Brazer SR, Pancotto FS, Long TT 3d, Harrell FE Jr, Lee KL, Tyor MP, Pryor DB, Using ordinal logistic regression to estimate the likelihood of colorectal neoplasia, Journal of Clinical Epidemiology, 44(11), 1263-70, 1991 Abstract
  • Lee KL, Pryor DB, Pieper KS, Harrell FE Jr, Califf RM, Mark DB, Hlatky MA, Coleman RE, Cobb FR, Jones RH, Prognostic value of radionuclide angiography in medically treated patients with coronary artery disease. A comparison with clinical and catheterization variables, Circulation, 82(5), 1705-17, November 1990 Abstract
  • Honan MB, Harrell FE Jr, Reimer KA, Califf RM, Mark DB, Pryor DB, Hlatky MA, Cardiac rupture, mortality and the timing of thrombolytic therapy: a meta-analysis, Journal of the American College of Cardiology, 16(2), 359-67, August 1990 Abstract
  • Brazer SR, Tyor MP, Pancotto FS, Nickl NJ, Wildermann NM, Harrell FE Jr, Pryor DB, Studies of gastric ulcer disease by community-based gastroenterologists, American Journal of Gastroenterology, 85(7), 824-8, July 1990 Abstract
  • Siegel WC, Hlatky MA, Mark DB, Barefoot JC, Harrell FE Jr, Pryor DB, Williams RB Jr, Effect of Type A behavior on exercise test outcome in coronary artery disease, American Journal of Cardiology, 66(2), 179-82, July 1990 Abstract
  • Hlatky MA, Califf RM, Harrell FE Jr, Lee KL, Mark DB, Muhlbaier LH, Pryor DB, Clinical judgment and therapeutic decision making, Journal of the American College of Cardiology, 15(1), 1-14, January 1990 Abstract
  • Harrell FE Jr, Marcus SE, Layde PM, Broste SK, Cook EF, Wagner DP, Muhlbaier LH, Peck SL, Statistical methods in SUPPORT, Journal of Clinical Epidemiology, 43 Suppl, 89S-98S, 1990 Abstract
  • Pratt CM, Brater DC, Harrell FE Jr, Kowey PR, Leier CV, Lowenthal DT, Messerli F, Packer M, Pritchett EL, Ruskin JN, Clinical and regulatory implications of the Cardiac Arrhythmia Suppression Trial, American Journal of Cardiology, 65(1), 103-5, January 1990 Abstract
  • Siegel WC, Mark DB, Hlatky MA, Harrell FE Jr, Pryor DB, Barefoot JC, Williams RB Jr, Clinical correlates and prognostic significance of type A behavior and silent myocardial ischemia on the treadmill, American Journal of Cardiology, 64(19), 1280-3, December 1989 Abstract
  • Spanos A, Harrell FE Jr, Durack DT, Differential diagnosis of acute meningitis. An analysis of the predictive value of initial observations, Jama, 262(19), 2700-7, November 1989 Abstract
  • Mark DB, Hlatky MA, Califf RM, Morris JJ Jr, Sisson SD, McCants CB, Lee KL, Harrell FE Jr, Pryor DB, Painless exercise ST deviation on the treadmill: long-term prognosis, Journal of the American College of Cardiology, 14(4), 885-92, October 1989 Abstract
  • Barefoot JC, Peterson BL, Harrell FE Jr, Hlatky MA, Pryor DB, Haney TL, Blumenthal JA, Siegler IC, Williams RB Jr, Type A behavior and survival: a follow-up study of 1,467 patients with coronary artery disease, American Journal of Cardiology, 64(8), 427-32, September 1989 Abstract
  • Brazer SR, Tyor MP, Pancotto FS, Brice RS, Garbutt JT Jr, Wildermann NM, Harrell FE, Pryor DB, Liss CL, Root JK, et al, Randomized, double-blind comparison of famotidine with ranitidine in treatment of acute, benign gastric ulcer disease. Community-based study coupled with a patient registry, Digestive Diseases and Sciences, 34(7), 1047-52, July 1989 Abstract
  • Kong DF, Lee KL, Harrell FE Jr, Boswick JM, Mark DB, Hlatky MA, Califf RM, Pryor DB, Clinical experience and predicting survival in coronary disease, Archives of Internal Medicine, 149(5), 1177-81, May 1989 Abstract
  • Califf RM, Harrell FE Jr, Lee KL, Rankin JS, Hlatky MA, Mark DB, Jones RH, Muhlbaier LH, Oldham HN Jr, Pryor DB, The evolution of medical and surgical therapy for coronary artery disease. A 15-year perspective, Jama, 261(14), 2077-86, April 1989 Abstract
  • Harrell FE Jr, Lee KL, Pollock BG, Regression models in clinical studies: determining relationships between predictors and response, Journal of the National Cancer Institute, 80(15), 1198-202, October 1988 Abstract
  • Hickey MS, Smith LR, Muhlbaier LH, Harrell FE Jr, Reves JG, Hinohara T, Califf RM, Pryor DB, Rankin JS, Current prognosis of ischemic mitral regurgitation. Implications for future management, Circulation, 78(3 Pt 2), I51-9, September 1988 Abstract
  • Bounous EP, Mark DB, Pollock BG, Hlatky MA, Harrell FE Jr, Lee KL, Rankin JS, Wechsler AS, Pryor DB, Califf RM, Surgical survival benefits for coronary disease patients with left ventricular dysfunction, Circulation, 78(3 Pt 2), I151-7, September 1988 Abstract
  • Califf RM, Harrell FE Jr, Lee KL, Rankin JS, Mark DB, Hlatky MA, Muhlbaier LH, Wechsler AS, Jones RH, Oldham HN Jr, et al, Changing efficacy of coronary revascularization. Implications for patient selection, Circulation, 78(3 Pt 2), I185-91, September 1988 Abstract
  • Williams RB Jr, Barefoot JC, Haney TL, Harrell FE Jr, Blumenthal JA, Pryor DB, Peterson B, Type A behavior and angiographically documented coronary atherosclerosis in a sample of 2,289 patients, Psychosomatic Medicine, 50(2), 139-52, 1988 Abstract
  • Hlatky MA, Califf RM, Harrell FE Jr, Lee KL, Mark DB, Pryor DB, Comparison of predictions based on observational data with the results of randomized controlled clinical trials of coronary artery bypass surgery, Journal of the American College of Cardiology, 11(2), 237-45, February 1988 Abstract
  • Califf RM, Mark DB, Harrell FE Jr, Hlatky MA, Lee KL, Rosati RA, Pryor DB, Importance of clinical measures of ischemia in the prognosis of patients with documented coronary artery disease, Journal of the American College of Cardiology, 11(1), 20-6, January 1988 Abstract
  • Bounous EP Jr, Califf RM, Harrell FE Jr, Hinohara T, Mark DB, Ideker RE, Selvester RH, Wagner GS, Prognostic value of the simplified Selvester QRS score in patients with coronary artery disease, Journal of the American College of Cardiology, 11(1), 35-41, January 1988 Abstract
  • Pryor DB, Harrell FE Jr, Rankin JS, Lee KL, Muhlbaier LH, Oldham HN, Hlatky MA, Mark DB, Reves JG, Califf RM, The changing survival benefits of coronary revascularization over time, Circulation, 76(5 Pt 2), V13-21, November 1987 Abstract
  • Slater DK, Hlatky MA, Mark DB, Harrell FE Jr, Pryor DB, Califf RM, Outcome in suspected acute myocardial infarction with normal or minimally abnormal admission electrocardiographic findings, American Journal of Cardiology, 60(10), 766-70, October 1987 Abstract
  • Vidaillet HJ Jr, Pressley JC, Henke E, Harrell FE Jr, German LD, Familial occurrence of accessory atrioventricular pathways (preexcitation syndrome), New England Journal of Medicine, 317(2), 65-9, July 1987 Abstract
  • Lederman SN, Wenger TL, Harrell FE Jr, Strauss HC, Effects of different paced heart rates on canine coronary occlusion and reperfusion arrhythmias, American Heart Journal, 113(6), 1365-9, June 1987 Abstract
  • Mark DB, Hlatky MA, Harrell FE Jr, Lee KL, Califf RM, Pryor DB, Exercise treadmill score for predicting prognosis in coronary artery disease, Annals of Internal Medicine, 106(6), 793-800, June 1987 Abstract
  • Hlatky MA, Mark DB, Harrell FE Jr, Lee KL, Califf RM, Pryor DB, Rethinking sensitivity and specificity, American Journal of Cardiology, 59(12), 1195-8, May 1987 Abstract
  • Kay GN, Pryor DB, Lee KL, Harrell FE Jr, Pressley JC, Gilbert MR, German LD, Comparison of survival of amiodarone-treated patients with coronary artery disease and malignant ventricular arrhythmias with that of a control group with coronary artery disease, Journal of the American College of Cardiology, 9(4), 877-81, April 1987 Abstract
  • Chu A, Califf RM, Pryor DB, McKinnis RA, Harrell FE Jr, Lee KL, Curtis SE, Oldham HN Jr, Wagner GS, Prognostic effect of bundle branch block related to coronary artery bypass grafting, American Journal of Cardiology, 59(8), 798-803, April 1987 Abstract
  • Harris RE, Harrell FE Jr, Patil KD, Al-Rashid R, The seasonal risk of pediatric/juvenile acute lymphocytic leukemia in the United States, Journal of Chronic Diseases, 40(10), 915-23, 1987 Abstract
  • Mark DB, Hlatky MA, Lee KL, Harrell FE Jr, Califf RM, Pryor DB, Localizing coronary artery obstructions with the exercise treadmill test, Annals of Internal Medicine, 106(1), 53-5, January 1987 Abstract
  • Papanicolaou MN, Califf RM, Hlatky MA, McKinnis RA, Harrell FE Jr, Mark DB, McCants B, Rosati RA, Lee KL, Pryor DB, Prognostic implications of angiographically normal and insignificantly narrowed coronary arteries, American Journal of Cardiology, 58(13), 1181-7, December 1986 Abstract
  • Hindman N, Grande P, Harrell FE Jr, Anderson C, Harrison D, Ideker RE, Selvester RH, Wagner GS, Relation between electrocardiographic and enzymatic methods of estimating acute myocardial infarct size, American Journal of Cardiology, 58(1), 31-5, July 1986 Abstract
  • Lee KL, Pryor DB, Harrell FE Jr, Califf RM, Behar VS, Floyd WL, Morris JJ, Waugh RA, Whalen RE, Rosati RA, Predicting outcome in coronary disease. Statistical models versus expert clinicians, American Journal of Medicine, 80(4), 553-60, April 1986 Abstract
  • Williams RB Jr, Haney TL, McKinnis RA, Harrell FE Jr, Lee KL, Pryor DB, Califf R, Kong YH, Rosati RA, Blumenthal JA, Psychosocial and physical predictors of anginal pain relief with medical management, Psychosomatic Medicine, 48(3-4), 200-10, 1986 Abstract
  • Califf RM, Hlatky MA, Mark DB, Lee KL, Harrell FE Jr, Rosati RA, Pryor DB, Randomized trials of coronary artery bypass surgery: impact on clinical practice at Duke University Medical Center, Circulation, 72(6 Pt 2), V136-44, December 1985 Abstract
  • Harrell FE Jr, Lee KL, Matchar DB, Reichert TA, Regression models for prognostic prediction: advantages, problems, and suggested solutions, Cancer Treatment Reports, 69(10), 1071-77, October 1985 Abstract
  • Pryor DB, Califf RM, Harrell FE Jr, Hlatky MA, Lee KL, Mark DB, Rosati RA, Clinical data bases. Accomplishments and unrealized potential, Medical Care, 23(5), 623-47, May 1985 Abstract
  • Hlatky MA, Lee KL, Harrell FE Jr, Califf RM, Pryor DB, Mark DB, Rosati RA, Tying clinical research to patient care by use of an observational database, Statistics in Medicine, 3(4), 375-87, 1984 Abstract
  • Hlatky MA, Pryor DB, Harrell FE Jr, Califf RM, Mark DB, Rosati RA, Factors affecting sensitivity and specificity of exercise electrocardiography. Multivariable analysis, American Journal of Medicine, 77(1), 64-71, July 1984 Abstract
  • Califf RM, Conley MJ, Behar VS, Harrell FE Jr, Lee KL, Pryor DB, McKinnis RA, Rosati RA, 'Left main equivalent' coronary artery disease: its clinical presentation and prognostic significance with nonsurgical therapy, American Journal of Cardiology, 53(11), 1489-95, June 1984 Abstract
  • Mark DB, Califf RM, Morris KG, Harrell FE Jr, Pryor DB, Hlatky MA, Lee KL, Rosati RA, Clinical characteristics and long-term survival of patients with variant angina, Circulation, 69(5), 880-8, May 1984 Abstract
  • Harrell FE Jr, Lee KL, Califf RM, Pryor DB, Rosati RA, Regression modelling strategies for improved prognostic prediction, Statistics in Medicine, 3(2), 143-52, 1984 Abstract
  • Wenger TL, Harrell FE Jr, Brown KK, Lederman S, Strauss HC, Ventricular fibrillation following canine coronary artery reperfusion: different outcomes with pentobarbital and alpha-chloralose, Canadian Journal of Physiology and Pharmacology, 62(2), 224-8, February 1984 Abstract
  • Pryor DB, Lee KL, Harris PJ, Harrell FE Jr, Rosati RA, The effect of crossovers on estimates of survival in medically treated patients with coronary artery disease, Journal of Chronic Diseases, 37(7), 521-9, 1984 Abstract
  • Pryor DB, Harrell FE Jr, Lee KL, Rosati RA, Coleman RE, Cobb FR, Califf RM, Jones RH, Prognostic indicators from radionuclide angiography in medically treated patients with coronary artery disease, American Journal of Cardiology, 53(1), 18-22, January 1984 Abstract
  • Califf RM, McKinnis RA, McNeer JF, Harrell FE Jr, Lee KL, Pryor DB, Waugh RA, Harris PJ, Rosati RA, Wagner GS, Prognostic value of ventricular arrhythmias associated with treadmill exercise testing in patients studied with cardiac catheterization for suspected ischemic heart disease, Journal of the American College of Cardiology, 2(6), 1060-7, December 1983 Abstract
  • Pryor DB, Harrell FE Jr, Lee KL, Califf RM, Rosati RA, Estimating the likelihood of significant coronary artery disease, American Journal of Medicine, 75(5), 771-80, November 1983 Abstract
  • Roberts KB, Califf RM, Harrell FE Jr, Lee KL, Pryor DB, Rosati RA, The prognosis for patients with new-onset angina who have undergone cardiac catheterization, Circulation, 68(5), 970-8, November 1983 Abstract
  • Gibbons RJ, Lee KL, Pryor D, Harrell FE Jr, Coleman RE, Cobb FR, Rosati RA, Jones RH, The use of radionuclide angiography in the diagnosis of coronary artery disease--a logistic regression analysis, Circulation, 68(4), 740-6, October 1983 Abstract
  • Pryor DB, Harrell FE Jr, Lee KL, Califf RM, Rosati RA, An improving prognosis over time in medically treated patients with coronary artery disease, American Journal of Cardiology, 52(5), 444-8, September 1983 Abstract
  • Kinney HC, Burger PC, Harrell FE Jr, Hudson RP Jr, 'Reactive gliosis' in the medulla oblongata of victims of the sudden infant death syndrome, Pediatrics, 72(2), 181-7, August 1983 Abstract
  • Hlatky MA, Califf RM, Kong Y, Harrell FE Jr, Rosati RA, Natural history of patients with single-vessel disease suitable for percutaneous transluminal coronary angioplasty, American Journal of Cardiology, 52(3), 225-9, August 1983 Abstract
  • Lee KL, Harrell FE Jr, Tolley HD, Rosati RA, A comparison of test statistics for assessing the effects of concomitant variables in survival analysis, Biometrics, 39(2), 341-50, June 1983 Abstract
  • Califf RM, Tomabechi Y, Lee KL, Phillips H, Pryor DB, Harrell FE Jr, Harris PJ, Peter RH, Behar VS, Kong Y, Rosati RA, Outcome in one-vessel coronary artery disease, Circulation, 67(2), 283-90, February 1983 Abstract
  • Califf RM, Lee KL, Harrell FE Jr, Kimm SY, Grufferman S, Rosati RA, Assessment of the use of the age- and sex-specific United States population as a control group for analysis of survival in coronary artery disease, American Journal of Cardiology, 50(6), 1279-82, December 1982 Abstract
  • Hammill SC, Shand DG, Harrell FE Jr, Zimmerman JM, Reiter MJ, Verghese C, Pritchett EL, Pirmenol kinetics and effective oral dose, Clinical Pharmacology and Therapeutics, 32(6), 686-91, December 1982 Abstract
  • Goldman L, Cook EF, Mitchell N, Flatley M, Sherman H, Rosati R, Harrell F, Lee K, Cohn PF, Incremental value of the exercise test for diagnosing the presence or absence of coronary artery disease, Circulation, 66(5), 945-53, November 1982 Abstract
  • Austin M, Wenger TL, Harrell FE Jr, Luzzi FA, Strauss HC, Effect of myocardium at risk on outcome after coronary artery occlusion and release, American Journal of Physiology, 243(2), H340-5, August 1982 Abstract
  • Califf RM, McKinnis RA, Burks J, Lee KL, Harrell FE Jr, Behar VS, Pryor DB, Wagner GS, Rosati RA, Prognostic implications of ventricular arrhythmias during 24 hour ambulatory monitoring in patients undergoing cardiac catheterization for coronary artery disease, American Journal of Cardiology, 50(1), 23-31, July 1982 Abstract
  • Whalen RE, Harrell FE Jr, Lee KL, Rosati RA, Survival of coronary artery disease patients with stable pain and normal left ventricular function treated medically or surgically at Duke University, Circulation, 65(7 Pt 2), 49-52, June 1982 Abstract
  • Rosati RA, Lee KL, Califf RM, Pryor DB, Harrell FE Jr, Problems and advantages of an observational data base approach to evaluating the effect of therapy on outcome, Circulation, 65(7 Pt 2), 27-32, June 1982 Abstract
  • Harrell FE Jr, Califf RM, Pryor DB, Lee KL, Rosati RA, Evaluating the yield of medical tests, Jama, 247(18), 2543-6, May 1982 Abstract
  • Wagner GS, Freye CJ, Palmeri ST, Roark SF, Stack NC, Ideker RE, Harrell FE Jr, Selvester RH, Evaluation of a QRS scoring system for estimating myocardial infarct size. I. Specificity and observer agreement, Circulation, 65(2), 342-7, February 1982 Abstract
  • Palmeri ST, Harrison DG, Cobb FR, Morris KG, Harrell FE, Ideker RE, Selvester RH, Wagner GS, A QRS scoring system for assessing left ventricular function after myocardial infarction, New England Journal of Medicine, 306(1), 4-9, January 1982 Abstract
  • Dohrmann ML, Harrell FE Jr, Strauss HC, The effects of disobutamide on electrophysiologic properties of canine cardiac Purkinje fibers and papillary muscle, Journal of Pharmacology and Experimental Therapeutics, 217(3), 549-54, June 1981 Abstract
  • Harris PJ, Harrell FE Jr, Lee KL, Rosati RA, Nonfatal myocardial infarction in medically treated patients with coronary artery disease, American Journal of Cardiology, 46(6), 937-42, December 1980 Abstract
  • Harris PJ, Lee KL, Harrell FE Jr, Behar VS, Rosati RA, Outcome in medically treated coronary artery disease. Ischemic events: nonfatal infarction and death, Circulation, 62(4), 718-26, October 1980 Abstract
  • Harris PJ, Behar VS, Conley MJ, Harrell FE Jr, Lee KL, Peter RH, Kong Y, Rosati RA, The prognostic significance of 50% coronary stenosis in medically treated patients with coronary artery disease, Circulation, 62(2), 240-8, August 1980 Abstract
  • Starmer CF, Lee KL, Harrell FE, Rosati RA, On the complexity of investigating chronic illness, Biometrics, 36(2), 333-5, June 1980 Abstract
  • Wenger TL, Browning DJ, Masterton CE, Abou-Donia MB, Harrell FE Jr, Bache RJ, Strauss HC, Procainamide delivery to ischemic canine myocardium following rapid intravenous administration, Circulation Research, 46(6), 789-95, June 1980 Abstract
  • Fraker TD Jr, Wise NK, Harrell FE Jr, Behar VS, Comparison of biplane and single plane left ventricular volumes in atrial septal defect, Catheterization and Cardiovascular Diagnosis, 6(1), 39-48, 1980 Abstract
  • Harris PJ, Harrell FE Jr, Lee KL, Behar VS, Rosati RA, Survival in medically treated coronary artery disease, Circulation, 60(6), 1259-69, December 1979 Abstract
  • Smith M, Ratshin RA, Harrell FE Jr, Russell RO Jr, Rackley CE, Early sequential changes in left ventricular dimensions and filling pressure in patients after myocardial infarction, American Journal of Cardiology, 33(3), 363-9, March 1974 Abstract

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Last Updated: 3/21/2004

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