Gregory Dale Fink

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Michigan State University
College of Osteopathic Medicine
Pharmacology and Toxicology
Professor
Professional Headshot of Gregory Dale Fink

Mailing Address

B327 Life Sciences
Michigan State University
East Lansing, Michigan 48824
United States

Contact Information

Phone: (517) 353-4648
Fax: (517) 353-8915
finkg@msu.edu

Qualifications

Ph.D., Tulane University, Pharmacology, 1975.
B.Sc., Pennsylvania State University, 1971.

Expertise and Research Interests

My research interests are integrative cardiovascular and renal physiology and pharmacology, with a special emphasis on hypertension. My laboratory uses whole-animal models to investigate long-term blood pressure regulation. Most of my research concerns the role of blood vessels, the sympathetic nervous system and the kidney in blood pressure control. Other interests are the renin-angiotensin system, endothelin and oxidative stress. We use pharmacological tools (and more recently gene transfer) in conscious animals to answer most experimental questions. Techniques include chronic instumentation of rats and mice for repeated sampling of blood and other tissues; radiotelemetric recording of physiological data in conscious, unrestrained animals; chronic hemodynamic monitoring; and hormone assays. I also collaborate with other investigators at MSU to evaluate cardiovascular, kidney and brain function at the cellular and molecular levels. A special research interest in recent times is how control of vein function contributes to overall cardiovascular homeostasis in health and disease.

Other Expertise

Developmental programming of cardiovascular and metabolic disease. Obesity. Inflammation and cardiovascular disease.

Industrial Relevance

Participant in MSU Integrative Pharmacology Center.

Keywords

COS Keywords:

Cardiovascular Biology, Cardiovascular Physiology, Congestive Heart Failure, Human Physiology, Hypertension, Kidney (Renal) Functions, Oxidative Stress, Pharmacology, Pharmacotherapy, Toxicology, Vascular Diseases Or Injury.

Additional Terms:

Aldosterone, Angiotensin, Baroreflexes, Congestive Heart Failure, Endothelin, Hypertension, Oxidative Stress, Renin, Sympathetic, Vascular Function, Veins.

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)

Memberships

American Heart Association, Council on High Blood Pressure Research
American Physiological Society
American Society for Pharmacology and Experimental Therapeutics

Publications

  • Park J, Galligan JJ, Fink GD, Swain GM (Nov 2007) Differences in sympathetic neuroeffector transmission to rat mesenteric arteries and veins as probed by in vitro continuous amperometry and video imaging., The Journal of physiology, 584 (Pt 3), 819-34 Abstract
  • King AJ, Osborn JW, Fink GD (Sep 2007) Splanchnic circulation is a critical neural target in angiotensin II salt hypertension in rats., Hypertension, 50 (3), 547-56 Abstract
  • Fink G, Li M, Lau Y, Osborn J, Watts S (Sep 2007) Chronic activation of endothelin B receptors: new model of experimental hypertension., Hypertension, 50 (3), 512-8 Abstract
  • Xu H, Fink GD, Galligan JJ (Jul 2007) Increased sympathetic venoconstriction and reactivity to norepinephrine in mesenteric veins in anesthetized DOCA-salt hypertensive rats., American journal of physiology. Heart and circulatory physiology, 293 (1), H160-8 Abstract
  • King AJ, Olivier NB, Mohankumar PS, Lee JS, Padmanabhan V, Fink GD (Jun 2007) Hypertension caused by prenatal testosterone excess in female sheep., American journal of physiology. Endocrinology and metabolism, 292 (6), E1837-41 Abstract
  • MohanKumar SM, King A, Shin AC, Sirivelu MP, MohanKumar PS, Fink GD (Jun 2007) Developmental programming of cardiovascular disorders: focus on hypertension., Reviews in endocrine & metabolic disorders, 8 (2), 115-25 Abstract
  • Watts SW, Rondelli C, Thakali K, Li X, Uhal B, Pervaiz MH, Watson RE, Fink GD (May 2007) Morphological and biochemical characterization of remodeling in aorta and vena cava of DOCA-salt hypertensive rats., American journal of physiology. Heart and circulatory physiology, 292 (5), H2438-48 Abstract
  • Pérez-Rivera AA, Hlavacova A, Rosario-Colón LA, Fink GD, Galligan JJ (May 2007) Differential contributions of alpha-1 and alpha-2 adrenoceptors to vasoconstriction in mesenteric arteries and veins of normal and hypertensive mice., Vascular pharmacology, 46 (5), 373-82 Abstract
  • Rondelli CM, Szasz IT, Kayal A, Thakali K, Watson RE, Rovner AS, Eddinger TJ, Fink GD, Watts SW (2007) Preferential myosin heavy chain isoform B Expression may contribute to the faster velocity of contraction in veins versus arteries., Journal of vascular research, 44 (4), 264-72 Abstract
  • Xu H, Jackson WF, Fink GD, Galligan JJ (Dec 2006) Activation of potassium channels by tempol in arterial smooth muscle cells from normotensive and deoxycorticosterone acetate-salt hypertensive rats., Hypertension, 48 (6), 1080-7 Abstract
  • King AJ, Fink GD (Nov 2006) Chronic low-dose angiotensin II infusion increases venomotor tone by neurogenic mechanisms., Hypertension, 48 (5), 927-33 Abstract
  • King AJ, Fink GD (Nov 2006) Chronic low-dose angiotensin II infusion increases venomotor tone by neurogenic mechanisms., Hypertension, 48 (5), 927-33 Abstract
  • Thakali KM, Lau Y, Fink GD, Galligan JJ, Chen AF, Watts SW (Jun 2006) Mechanisms of hypertension induced by nitric oxide (NO) deficiency: focus on venous function., Journal of cardiovascular pharmacology, 47 (6), 742-50 Abstract
  • Thakali K, Davenport L, Fink GD, Watts SW (Mar 2006) Pleiotropic effects of hydrogen peroxide in arteries and veins from normotensive and hypertensive rats., Hypertension, 47 (3), 482-7 Abstract
  • Wang H, Chen AF, Watts SW, Galligan JJ, Fink GD (Feb 2005) Endothelin in the splanchnic vascular bed of DOCA-salt hypertensive rats., 288 (2), H729-36 Abstract
  • Dai X, Galligan JJ, Watts SW, Fink GD, Kreulen DL (May 2004) Increased O2*- production and upregulation of ETB receptors by sympathetic neurons in DOCA-salt hypertensive rats., 43 (5), 1048-54 Abstract
  • Luo M, Fink GD, Lookingland KJ, Morris JA, Galligan JJ (Apr 2004) Impaired function of alpha2-adrenergic autoreceptors on sympathetic nerves associated with mesenteric arteries and veins in DOCA-salt hypertension., 286 (4), H1558-64 Abstract
  • Thakali K, Fink GD, Watts SW (Mar 2004) Arteries and veins desensitize differently to endothelin., 43 (3), 387-93 Abstract
  • Xu H, Fink GD, Galligan JJ (Feb 2004) Tempol lowers blood pressure and sympathetic nerve activity but not vascular O2- in DOCA-salt rats., 43 (2), 329-34 Abstract
  • Perez-Rivera AA, Fink GD, Galligan JJ (Jan 2004) Increased reactivity of murine mesenteric veins to adrenergic agonists: functional evidence supporting increased alpha1-adrenoceptor reserve in veins compared with arteries., 308 (1), 350-7 Abstract
  • Zheng JS, Yang XQ, Lookingland KJ, Fink GD, Hesslinger C, Kapatos G, Kovesdi I, Chen AF, Gene transfer of human guanosine 5'-triphosphate cyclohydrolase I restores vascular tetrahydrobiopterin level and endothelial function in low renin hypertension, Circulation, 108(10), 1238-45, September 2003 Abstract
  • Luo M, Hess MC, Fink GD, Olson LK, Rogers J, Kreulen DL, Dai X, Galligan JJ, Differential alterations in sympathetic neurotransmission in mesenteric arteries and veins in DOCA-salt hypertensive rats, Autonomic Neuroscience : Basic & Clinical, 104(1), 47-57, February 2003 Abstract
  • Xu H, Fink GD, Galligan JJ, Nitric oxide-independent effects of tempol on sympathetic nerve activity and blood pressure in DOCA-salt rats, American Journal of Physiology. Heart and Circulatory Physiology, 283(3), H885-92, September 2002 Abstract
  • Watts SW, Fink GD, Northcott CA, Galligan JJ, Endothelin-1-induced venous contraction is maintained in DOCA-salt hypertension; studies with receptor agonists, British Journal of Pharmacology, 137(1), 69-79, September 2002 Abstract
  • Johnson RJ, Fink GD, Watts SW, Galligan JJ, Endothelin receptor function in mesenteric veins from deoxycorticosterone acetate salt-hypertensive rats, Journal of Hypertension, 20(4), 665-76, April 2002 Abstract
  • Li L, Crockett E, Wang DH, Galligan JJ, Fink GD, Chen AF, Gene transfer of endothelial NO synthase and manganese superoxide dismutase on arterial vascular cell adhesion molecule-1 expression and superoxide production in deoxycorticosterone acetat, Arteriosclerosis, Thrombosis, and Vascular Biology, 22(2), 249-55, February 2002 Abstract
  • Ballew JR, Fink GD, Role of endothelin ETB receptor activation in angiotensin II-induced hypertension: effects of salt intake, American Journal of Physiology. Heart and Circulatory Physiology, 281(5), H2218-25, November 2001 Abstract
  • Xu H, Fink GD, Galligan JJ, Endothelin-1-induced elevation in blood pressure is independent of increases in sympathetic nerve activity in normotensive rats, Journal of Cardiovascular Pharmacology, 38(5), 784-95, November 2001 Abstract
  • Ballew JR, Fink GD, Characterization of the antihypertensive effect of a thiazide diuretic in angiotensin II-induced hypertension, Journal of Hypertension, 19(9), 1601-6, September 2001 Abstract
  • Xu H, Fink GD, Chen A, Watts S, Galligan JJ, Nitric oxide-independent effects of tempol on sympathetic nerve activity and blood pressure in normotensive rats, American Journal of Physiology. Heart and Circulatory Physiology, 281(2), H975-80, August 2001 Abstract
  • Johnson RJ, Galligan JJ, Fink GD, Effect of an ET(B)-selective and a mixed ET(A/B) endothelin receptor antagonist on venomotor tone in deoxycorticosterone-salt hypertension, Journal of Hypertension, 19(3), 431-40, March 2001 Abstract
  • Johnson RJ, Galligan JJ, Fink GD, Factors affecting endothelin-induced venous tone in conscious rats, Journal of Cardiovascular Pharmacology, 37(2), 187-95, February 2001 Abstract
  • Galligan JJ, Hess MC, Miller SB, Fink GD, Differential localization of P2 receptor subtypes in mesenteric arteries and veins of normotensive and hypertensive rats, Journal of Pharmacology and Experimental Therapeutics, 296(2), 478-85, February 2001 Abstract
  • Fink GD, Johnson RJ, Galligan JJ, Mechanisms of increased venous smooth muscle tone in desoxycorticosterone acetate-salt hypertension., Hypertension, 35(1 Pt 2), 464-9, 2000 Abstract
  • Johnson RJ, Fink GD, Galligan JJ, Mechanisms of endothelin-induced venoconstriction in isolated guinea pig mesentery., Journal of Pharmacology and Experimental Therapeutics, 289(2), 762-7, May 1999 Abstract

Profile Details

Last Updated: 1/29/2008

COS Expertise ID #411089
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