Dr. Lisa M. Frenkel

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University of Washington
School of Medicine
Pediatrics and Laboratory Medicine
Infectious Diseases and Virology
ProfessorAppointed: 2003

Mailing Address

Box 359300/C9S-8
University of Washington
Seattle, Washington 98101
United States

Contact Information

Phone: (206) 987-5140
Fax: (206) 884-7311
lfrenkel@u.washington.edu

Qualifications

Certificate, University of California, Los Angeles, Infectious Disease Fellowship, 1987.
Certificate, University of California, Los Angeles, Pediatric Residency, 1984.
M.D., University of Kansas, Medical Center, 1981.

Expertise and Research Interests

Our research focuses on practical questions related to the prevention of HIV-1 infection in infants, mechanisms leading to shedding of virus in adults and treatment of drug-resistant virus in children and adults. Several projects, detailed below, evaluate the selection and dynamics of drug-resistant HIV-1 mutants during antiretroviral therapy (ART) and as a result of peripartum chemoprophylaxis given to women and infants. Our group is also keenly interested in the implementation of interventions to prevent mother-to-child-transmission in resource-strapped communities, and understanding the mechanisms that cause some adults but not others to shed HIV-1 from their in their breast milk or from their genital tract. In addition, we aim to develop and transfer practical and economical assays for HIV-1 detection in infants, and for monitoring treatment and drug-resistant mutants in these communities. Our projects include collaborative studies with colleagues in India, Mozambique, Peru, Thailand, the USA and Zimbabwe.

Keywords

COS Keywords:

Pediatrics, Physical Medicine and Rehabilitation, Rehabilitation or Therapy.

Additional Terms:

Cytomegalovirus, HIV-1, Herpes Simplex Virus, Infectious Diseases.

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)
Spanish: (Functional, Functional, Functional)

Previous Positions

1994-2003, Associate Professor, University of Washington, School of Medicine, Departments of Pediatrics and Laboratory Medicine, Divisions of Infectious Diseases and Virology
1991-1994, Assistant Professor, University of Rochester, School of Medicine, Department of Pediatrics, Division of Infectious Diseases
1987-1991, Assistant Professor, University of California, Los Angeles, School of Medicine, Department of Pediatrics, Division of Infectious Diseases

Funding Received

  • NIAID-NIH: Reservoirs of Drug Resistant HIV-1 in India, 2007 to 2008.
  • NIAID-NIH: Mechanism/predictors of genital/rectal HIV shedding during ART with plasma <50c/mL, 2006 to 2011.
  • NIH: Reservoirs of drug-resistant HIV-1, 2005 to 2010.
  • NIH: Etiology of mastitis in HIV-1 infected women, 2005 to 2008.
  • NIH: Immunization by HIV Exposure during Chemoprophylaxis, 2003 to 2008.
  • NICHD - NIH: Pediatric HIV Clinical Trials Network, 2003 to 2014.
  • Fogarty International Center, NIH: Prevention of HIV resistance to nevirapine in pregnancy, 2001 to 2008.

Publications

  • Melvin AJ, Rodrigo AG, Mohan KM, Lewis PA, Manns-Arcuino L, Coombs RW, Mullins JI, Frenkel LM, HIV-1 dynamics in children., Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 20(5), 468-73, 15 Apr 1999 Abstract
  • Zerr DM, Frenkel LM, Advances in antiviral therapy., Curr Opin Pediatr, 11(1), 21-7, February 1999 Abstract
  • Frenkel LM, Mullins JI, Learn GH, Manns-Arcuino L, Herring BL, Kalish ML, Steketee RW, Thea DM, Nichols JE, Liu SL, Harmache A, He X, Muthui D, Madan A, Hood L, Haase AT, Zupancic M, Staskus K, Wolinsky S, Krogstad P, Zhao J, Chen I, Koup R, Ho D, Roberts, Genetic evaluation of suspected cases of transient HIV-1 infection of infants., Science, 280(5366), 1073-7, 15 1998 Abstract
  • Eastman P S, Shapiro D E, Coombs R W, Frenkel L M, McSherry G D, Britto P, Herman S A, Sperling R S, Maternal viral genotypic zidovudine resistance and infrequent failure of zidovudine therapy to prevent perinatal transmission of human immunodeficiency virus type 1 in pediatric AIDS Clinical Trials G, Journal of Infectious Diseases, 177(3), 557-64, March 1998 Abstract
  • Edelstein R E, Nickerson D A, Tobe V O, Manns-Arcuino L A, Frenkel L M, Oligonucleotide ligation assay for detecting mutations in the human immunodeficiency virus type 1 pol gene that are associated with resistance to zidovudine, didanosine, and lamivudine., Journal of Clinical Microbiology, 36(2), 569-72, February 1998 Abstract
  • Wald A, Frenkel L M, Benjamin D L, Christie D L, Cytomegalovirus gastropathy in a child: resolution after ganciclovir therapy., Clinical Infectious Diseases, 26(1), 199-200, Jan 1998 Abstract
  • Melvin A J, Frenkel L M, Pediatric HIV-1 infection., Obstetrics and Gynecology Clinics of North America, 24(4), 911-24, December 1997 Abstract
  • Edelstein R E, Arcuino L A, Hughes J P, Melvin A J, Mohan K M, King P D, McLellan C L, Murante B L, Kassman B P, Frenkel L M, Risk of mother-to-infant transmission of HIV-1 is not reduced in CCR5/delta32ccr5 heterozygotes., Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 16(4), 243-6, 1 Dec 1997 Abstract
  • Frenkel L M, Melvin A J, Issues regarding antiretroviral treatment for patients with HIV-1 infection [letter], Jama, 278(15), 1234; discussion 123, 15 Oct 1997 Abstract
  • Melvin A J, Mohan K M, Arcuino L A, Edelstein R E, Frenkel L M, Clinical, virologic and immunologic responses of children with advanced human immunodeficiency virus type 1 disease treated with protease inhibitors., Pediatric Infectious Disease Journal, 16(10), 968-74, October 1997 Abstract
  • Melvin A J, Frenkel L M, Prevention of mother-to-infant transmission of HIV-1., Molecular Medicine Today, 3(6), 242-5, June 1997 Abstract
  • Frenkel L M, Cowles M K, Shapiro D E, Melvin A J, Watts D H, McLellan C, Mohan K, Murante B, Burchett S, Bryson Y J, O'Sullivan M J, Mitchell C, Landers D, Analysis of the maternal components of the AIDS clinical trial group 076 zidovudine regimen in the prevention of mother-to-infant transmission of human immunodeficiency virus type 1., Journal of Infectious Diseases, 175(4), 971-4, April 1997 Abstract
  • Melvin A J, Burchett S K, Watts D H, Hitti J, Hughes J P, McLellan C L, King P D, Johnson E J, Williams B L, Frenkel L M, Coombs R W, Effect of pregnancy and zidovudine therapy on viral load in HIV-1-infected women., Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 14(3), 232-6, 1 Mar 1997 Abstract
  • Melvin A J, Tamura G S, House J K, Hobson A C, Cone R W, Frenkel L M, Burchett S, Lack of detection of human immunodeficiency virus type 1 in the saliva of infected children and adolescents., Archives of Pediatrics and Adolescent Medicine, 151(3), 228-32, March 1997 Abstract
  • Melvin A J, Frenkel L M, Pediatric HIV disease: new developments in treatment and prevention., AIDS Clinical Review, 109-27, 1997- Abstract
  • Shafer R W, Winters M A, Mayers D L, Japour A J, Kuritzkes D R, Weislow O S, White F, Erice A, Sannerud K J, Iversen A, Pena F, Dimitrov D, Frenkel L M, Reichelderfer P S, Interlaboratory comparison of sequence-specific PCR and ligase detection reaction to detect a human immunodeficiency virus type 1 drug resistance mutation. The AIDS Clinical Trials Group Virology Comm, Journal of Clinical Microbiology, 34(7), 1849-53, July 1996 Abstract
  • Del Toro A, Berkowitz R, Meyerowitz C, Frenkel L M, Oral findings in asymptomatic (P-1) and symptomatic (P-2) HIV infected children., Pediatric Dentistry, 18(2), 114-6, Spring 1996 Abstract
  • Berkowitz R, Frenkel L M, Cancer in the HIV-infected child., Pediatric Dentistry, 18(2), 127-8, Spring 1996 Abstract
  • Frenkel L M, Nielsen K, Garakian A, Jin R, Wolinsky J S, Cherry J D, A search for persistent rubella virus infection in persons with chronic symptoms after rubella and rubella immunization and in patients with juvenile rheumatoid arthritis., Clinical Infectious Diseases, 22(2), 287-94, February 1996 Abstract
  • Nielsen K, Wei L S, Sim M S, Deveikis A, Keller M, Stiehm E R, Frenkel L M, Bryson Y J, Correlation of clinical progression in human immunodeficiency virus-infected children with in vitro zidovudine resistance measured by a direct quantitative peripheral blood lymphocyte assay., Journal of Infectious Diseases, 172(2), 359-64, August 1995 Abstract
  • Nielsen K, Garakian A, Frenkel L M, Cherry J D, The in vitro growth and serial passage of RA 27/3 rubella vaccine virus in cord blood mononuclear leukocytes from normal babies., Pediatric Research, 37(5), 623-5, May 1995 Abstract
  • Frenkel L M, Wagner L E 2nd, Demeter L M, Dewhurst S, Coombs R W, Murante B L, Reichman R C, Effects of zidovudine use during pregnancy on resistance and vertical transmission of human immunodeficiency virus type 1., Clinical Infectious Diseases, 20(5), 1321-6, May 1995 Abstract
  • Frenkel L M, Wagner L E 2nd, Atwood S M, Cummins T J, Dewhurst S, Specific, sensitive, and rapid assay for human immunodeficiency virus type 1 pol mutations associated with resistance to zidovudine and didanosine., Journal of Clinical Microbiology, 33(2), 342-7, February 1995 Abstract
  • Frenkel L M, Nielsen K, Garakian A, Cherry J D, A search for persistent measles, mumps, and rubella vaccine virus in children with human immunodeficiency virus type 1 infection., Archives of Pediatrics and Adolescent Medicine, 148(1), 57-60, January 1994 Abstract
  • Annunziato P W, Frenkel L M, The epidemiology of pediatric HIV-1 infection., Pediatric Annals, 22(7), 401-5, July 1993 Abstract
  • Cvetkovich T A, Frenkel L M, Current management of HIV infection in children., Pediatric Annals, 22(7), 428-35, July 1993 Abstract
  • Frenkel L M, Garratty E M, Shen J P, Wheeler N, Clark O, Bryson Y J, Clinical reactivation of herpes simplex virus type 2 infection in seropositive pregnant women with no history of genital herpes., Annals of Internal Medicine, 118(6), 414-8, 15 Mar 1993 Abstract
  • Prober C G, Corey L, Brown Z A, Hensleigh P A, Frenkel L M, Bryson Y J, Whitley R J, Arvin A M, The management of pregnancies complicated by genital infections with herpes simplex virus., Clinical Infectious Diseases, 15(6), 1031-8, December 1992 Abstract
  • Hill D A, Thomas J C, Frenkel L M, Settlage R H, Lee M, Yonekura M L, Human immunodeficiency virus-1 seroprevalence among parturients in Los Angeles County public hospitals., Obstetrics and Gynecology, 79(5 ( Pt 1)), 657-60, May 1992 Abstract
  • Stiehm E R, Bryson Y J, Frenkel L M, Szelc C M, Gillespie S, Williams M E, Watkins J M, Prednisone improves human immunodeficiency virus encephalopathy in children., Pediatric Infectious Disease Journal, 11(1), 49-50, January 1992 Abstract
  • Frenkel L M, Brown Z A, Bryson Y J, Corey L, Unadkat J D, Hensleigh P A, Arvin A M, Prober C G, Connor J D, Pharmacokinetics of acyclovir in the term human pregnancy and neonate., American Journal of Obstetrics and Gynecology, 164(2), 569-76, February 1991 Abstract
  • Frenkel L, Pineda E, Garratty E, Fall H, Dillon M, Bryson Y, A prospective study of the effects of acyclovir treatment on the HSV-2 lymphoproliferative response of persons with frequently recurring HSV-2 genital infections., Journal of Infectious Diseases, 159(5), 845-50, May 1989 Abstract

Profile Details

Last Updated: 1/14/2008

COS Expertise ID #307483
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