Dr. Gideon Steinbach

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University of Washington
School of Medicine
Medicine, Gastroenterology
Associate ProfessorAppointed: 2001
Fred Hutchinson Cancer Research Center
Clinical Research Division
Public Health Sciences Division
Associate MemberAppointed: 2001

Mailing Address

Fred Hutchinson Cancer Research Center
P.O. Box 19024
Seattle, Washington 98109-1024
United States

Contact Information

gst@u.washington.edu

Qualifications

M.D., Albert Einstein College of Medicine, Medicine, 1981.
Ph.D., Brooklyn College, The City University of New York, Literature.

Expertise and Research Interests

Dr. Steinbach's research is focused on gastrointestinal cancer prevention, including genetic and clinical predisposition, chemoprevention, and early detection. The work is based on multidisciplinary and inter-institutional collaborations. Recent collaborative studies investigated the role of aspirin in the prevention of colorectal adenomatous polyps in persons with previous colorectal tumors and the effect of cyclooxygenase-2 inhibition on colorectal adenomatous polyps in patients with FAP (an inherited predisposition to colorectal adenomas). The latter was the first clinical trial to investigate the effect of COX-2 inhibition on a human tumor. Demonstration of efficacy on adenomatous polyps in FAP provided support for initiating trials of COX-2 inhibition for the control of sporadic colon tumors and other tumors that express COX-2.

Keywords

COS Keywords:

Cancer Prevention, Clinical Research or Studies, Gastroenterology.

Additional Terms:

Cancer Prevention, Gastroenterology.

Publications

  • Sandler, R. S., Halabi, S., Baron, J. A., Budinger, S., Paskett, E., Keresztes, R., Petrelli, N., Pipas, J. M., Karp, D. D., Loprinzi, C. L., Steinbach, G., and Schilsky, R, A Randomized Trial of Aspirin to Prevent Colorectal Adenomas in Patients with Previous Colorectal Cancer, New England Journal of Medicine, 348(10), 883-890, March 2003
  • Phillips RK, Wallace MH, Lynch PM, Hawk E, Gordon GB, Saunders BP, Wakabayashi N, Shen Y, Zimmerman S, Godio L, Rodrigues-Bigas M, Su LK, Sherman J, Kelloff G, Levin B, Steinbach G, FAP Study Group, A randomised, double blind, placebo controlled study of celecoxib, a selective cyclooxygenase 2 inhibitor, on duodenal polyposis in familial adenomatous polyposis, Gut, 50(6), 857-60, June 2002 Abstract
  • Su LK, Barnes CJ, Yao W, Qi Y, Lynch PM, Steinbach G, Inactivation of germline mutant APC alleles by attenuated somatic mutations: a molecular genetic mechanism for attenuated familial adenomatous polyposis, American Journal of Human Genetics, 67(3), 582-90, September 2000 Abstract
  • Steinbach G, Lynch PM, Phillips RK, Wallace MH, Hawk E, Gordon GB, Wakabayashi N, Saunders B, Shen Y, Fujimura T, Su LK, Levin B, Godio L, Rodriguez-Bigas MA, DuBois RN, Hittelman WN, Zimmerman S, Sherman JW, Kelloff G., The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis, The New England Journal of Medicine, 342(26), 1946-52, June 2000
  • Su LK, Steinbach G, Sawyer JC, Hindi M, Ward PA, Lynch PM, Genomic rearrangements of the APC tumor-suppressor gene in familial adenomatous polyposis, Human Genetics, 106(1), 101-7, Jan 2000 Abstract
  • Steinbach G, Ford R, Glober G, Sample D, Hagemeister FB, Lynch PM, McLaughlin PW, Rodriguez MA, Romaguera JE, Sarris AH, Younes A, Luthra R, Manning JT, Johnson CM, Lahoti S, Shen Y, Lee JE, Winn RJ, Genta RM, Graham DY, Cabanillas FF, Antibiotic treatment of gastric lymphoma of mucosa-associated lymphoid tissue. An uncontrolled trial, Annals of Internal Medicine, 131(2), 88-95, 1999 Abstract
  • Vadlamudi R, Mandal M, Adam L, Steinbach G, Mendelsohn J, Kumar R, Regulation of cyclooxygenase-2 pathway by HER2 receptor, Oncogene, 18(2), 305-14, 1999 Abstract
  • Osato MS, Gutierrez O, Kim JG, Steinbach G, Graham DY, Microflora of gastric biopsies from patients with duodenal ulcer and gastric cancer: a comparative study of patients from Korea, Colombia, and the United States, Digestive Diseases and Sciences, 43(10), 2291-5, October 1998 Abstract
  • Konishi H, Steinbach G, Terry NH, Fujita K, Lee JJ, Ruifrok A, Spaulding D, Lynch PM, Dubin JA, Andreeff M, Goodacre AM, Hattori T, Hittelman WN, S phase determination in intact colonic crypts by histone H3 messenger RNA in situ hybridization and confocal microscopy, Cancer Epidemiology, Biomarkers and Prevention, 6(7), 531-6, July 1997 Abstract
  • Hudmon KS, Stoltzfus C, Chamberlain RM, Lorimor RJ, Steinbach G, Winn RJ, Participants' perceptions of a phase I colon cancer chemoprevention trial, Controlled Clinical Trials, 17(6), 494-508, December 1996 Abstract
  • Steinbach G, Lupton J, Reddy BS, Lee JJ, Kral JG, Holt PR, Calcium carbonate treatment of diarrhoea in intestinal bypass patients, European Journal of Gastroenterology and Hepatology, 8(6), 559-62, June 1996 Abstract
  • Lupton JR, Steinbach G, Chang WC, O'Brien BC, Wiese S, Stoltzfus CL, Glober GA, Wargovich MJ, McPherson RS, Winn RJ, Calcium supplementation modifies the relative amounts of bile acids in bile and affects key aspects of human colon physiology, Journal of Nutrition, 126(5), 1421-8, May 1996 Abstract
  • Konishi H, Steinbach G, Terry NH, Lee JJ, Dubin JA, Glober GA, Fujita K, Spaulding D, Cass L, Hittelman WN, Histone H3 messenger RNA in situ hybridization correlates with in vivo bromodeoxyuridine labeling of S-phase cells in rat colonic epithelium, Cancer Research, 56(3), 434-7, 1996 Abstract
  • Steinbach G, Hong WK, Early detection of esophageal cancer by chromoendoscopy, Cancer, 76(6), 919-21, 1995 Abstract
  • Weber DM, Dimopoulos MA, Anandu DP, Pugh WC, Steinbach G, Regression of gastric lymphoma of mucosa-associated lymphoid tissue with antibiotic therapy for Helicobacter pylori, Gastroenterology, 107(6), 1835-8, December 1994 Abstract
  • Steinbach G, Lupton J, Reddy BS, Kral JG, Holt PR, Effect of calcium supplementation on rectal epithelial hyperproliferation in intestinal bypass subjects, Gastroenterology, 106(5), 1162-7, May 1994 Abstract
  • Steinbach G, Heymsfield S, Olansen NE, Tighe A, Holt PR, Effect of caloric restriction on colonic proliferation in obese persons: implications for colon cancer prevention, Cancer Research, 54(5), 1194-7, 1994 Abstract
  • Steinbach G, Morotomi M, Nomoto K, Lupton J, Weinstein IB, Holt PR, Calcium reduces the increased fecal 1,2-sn-diacylglycerol content in intestinal bypass patients: a possible mechanism for altering colonic hyperproliferation, Cancer Research, 54(5), 1216-9, 1994 Abstract
  • Steinbach G, Kumar SP, Reddy BS, Lipkin M, Holt PR, Effects of caloric restriction and dietary fat on epithelial cell proliferation in rat colon, Cancer Research, 53(12), 2745-9, 1993 Abstract

Profile Details

Last Updated: 3/7/2003

COS Expertise ID #345997
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