Raymond E. Galinsky

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Purdue University
School of Pharmacy and Pharmaceutical Sciences
Industrial and Physical Pharmacy
ProfessorAppointed: 1995
Indiana University Purdue University Indianapolis
School of Medicine
Medicine
Clinical Pharmacology
Adjunct ProfessorAppointed: 1995
Professional Headshot of Raymond E. Galinsky

Mailing Address

Division of Clinical Pharmacology, W-7123
Indiana University Department of Medicine
Wishard Memorial Hospital
1001 West 10th Street
Indianapolis, Indiana 46202
United States

Contact Information

Phone: (317) 630-8749
Fax: (317) 630-8185
rgalinsk@iupui.edu

Qualifications

Diplomate, American Board of Clinical Pharmacology, 1995.
Pharm.D., University of California, San Francisco, 1975.
B.A., University of California, Berkeley, Biological Sciences, 1970.

Expertise and Research Interests

Hepatic and Intestinal Oxidative and Conjugative Metabolism;
Effects of Parenteral Nutrition on Drug Metabolism and Drug Disposition; Hepatic Drug Metabolism in Adult Offspring Following Prenatal Drug Exposure;
Effect of Disease on Pharmacokinetics and Pharmacodynamics of Drugs; Pharmacogenomics

Other Expertise

Pharmacokinetics
Drug Metabolism
Therapeutic Drug Monitoring
Clinical Pharmacy

Industrial Relevance

Pharmaceutical Drug Development
Therapeutics

Keywords

COS Keywords:

AIDS, Bioavailability, Biopharmaceutics, Birth Or Congenital Defects, Blood - Brain Barrier, Clinical Research Or Studies, Clinical Trial, Disease Model, Dosage Forms, Drug Delivery Systems, Drug Metabolism, Drug Resistance, Drug Toxicity, Drugs Or Drug Abuse, Food Additives, Gastroenterology, Hepatitis, Liver Disorders, Liver Functions, Mechanism of Action (Medical), Metabolism, Neonatal Disorders, Nutrition Or Dietetics, Perinatal Disorders, Pharmaceuticals, Pharmacokinetics, Pharmacology, Pharmacy, Prenatal Factors, Xenobiotics.

Additional Terms:

Biopharmaceutics, Drug Interactions, Hepatic and Intestinal Drug Metabolism, Pharmacokinetics, Therapeutic Drug Monitoring.

Memberships

American Federation for Aging Research
American Society for Pharmacology and Experimental Therapeutics
International Society for the Study of Xenobiotics
New York Academy of Sciences
Society for Experimental Medicine and Biology

Honors and Awards

1992, Co-Author, Outstanding Paper, Controlled Release Society
1987-1992, R29 AG07135, National Institutes of Health (NIH), National Institute on Aging

Previous Positions

1997, Visiting Scientist, Mayo Foundation for Medical Education and Research, Mayo Medical School, Pharmacology
1995-1997, Associate Professor, Purdue University, Industrial & Physical Pharmacy
1990-1995, Associate Professor, University of Utah, Pharmaceutics and Pharmaceutical Chemistry
1983-1990, Assistant Professor, University of Utah, Pharmaceutics and Pharmaceutical Chemistry
1980-1983, Research Assistant Professor, University at Buffalo, School of Pharmacy and Pharmaceutical Sciences
1978-1980, Postdoctoral Fellow, University at Buffalo, School of Pharmacy and Pharmaceutical Sciences
1977-1978, Instructor, Philadelphia College of Pharmacy & Science, Clinical Pharmacy
1976-1976, Pharmacist, Committee for the Relief of Guatemala
1976-1977, Primary Care Pharmacist, Summit Pharmacy, Oakland
1975-1976, Resident, University of California, San Francisco, School of Pharmacy, Clinical Pharmacy

Patents

Histamine-N-methyltransferase variants associated with histaminergic disease, Patent Number: 6316188, 2001, Institution, United States of America.

Funding Received

  • National Institutes of Health (NIH), R.E. Galinsky, P.I.: R01 GM48433: TPN, The Aging Liver, and Drug Conjugation, $321,000, Oct 1, 1993 to Sep 30, 1996.
  • National Institutes of Health (NIH), S.D. Hall & R.E. Galinsky, P.I.: R01 AG13718: Effect of Aging on Drug Bioavailability, Apr 1, 1996 to Mar 31, 1999.
  • National Institutes of Health, Kinam Park, P.I.: R01 GM65284-01 Hydrotropic polymers for oral delivery of paclitaxel, $1,200,000, 2006 to 2009.
  • National Institutes of Health (NIH): R01 GM67044: Solvent Exchange Methods for Protein Microencapsulation, K. Park, P.I., $200,000 per annum, 2002 to 2008.
  • National Institutes of Health (NIH), J. Kopecek, P.I.: R01 GM50839: Degradable Hydrogels for Oral Delivery of Calcitonin, $496,166, 1995 to 1999.
  • National Institutes of Health (NIH), B.D. Anderson, P.I.: R01 AI34133: Enzyme-Based Strategies for CNS Delivery of AIDS Drugs, $842,086, 1993 to 1997.
  • National Institutes of Health (NIH), W.E. Samlowski & J.B. Hibbs, P.I.: U01 CA58248: Use of Sulfhydryl Compounds to Increase IL-2 Activity, $518,451, 1992 to 1996.
  • National Institutes of Health (NIH), B.D. Anderson & D.C. Baker, P.I.: N01 AI82680: Targeting Drugs to the Central Nervous System for AIDS Therapy, $1,110,708, 1988 to 1992.
  • National Institutes of Health (NIH), R.E. Galinsky, P.I.: R29 AG07135: Ethanol, the Aging Liver and Drug Sulfation, $339,665, 1987 to 1993.

Publications

  • Quinney SK, Galinsky RE, Jiyamapa-Serna VA, Chen Y, Hamman MA, Hall SD, Kimura RE (Jun 2008) Hydroxyitraconazole, formed during intestinal first-pass metabolism of itraconazole, controls the time course of hepatic CYP3A inhibition and the bioavailability of itraconazole in rats., Drug metabolism and disposition: the biological fate of chemicals, 36 (6), 1097-101 Abstract
  • Abbo LA, Ko JC, Maxwell LK, Galinsky RE, Moody DE, Johnson BM, Fang WB (2008) Pharmacokinetics of buprenorphine following intravenous and oral transmucosal administration in dogs., Veterinary therapeutics : research in applied veterinary medicine, 9 (2), 83-93 Abstract
  • Lee SC, Huh KM, Lee J, Cho YW, Galinsky RE, Park K (Jan 2007) Hydrotropic polymeric micelles for enhanced paclitaxel solubility: in vitro and in vivo characterization., Biomacromolecules, 8 (1), 202-8 Abstract
  • Pu X, Lee LS, Galinsky RE, Carlson GP (Jan 2006) Bioavailability of 2,3',4,4',5-pentachlorobiphenyl (PCB118) and 2,2',5,5'-tetrachlorobiphenyl (PCB52) from soils using a rat model and a physiologically based extraction test., Toxicology, 217 (1), 14-21 Abstract
  • Morrow JD, Edeki TI, El Mouelhi M, Galinsky RE, Kovelesky R, Noveck RJ, Preuss C (Mar 2005) American Society for Clinical Pharmacology and Therapeutics position statement on dietary supplement safety and regulation., Clinical pharmacology and therapeutics, 77 (3), 113-22 Abstract
  • Uhing MR, Beno DW, Jiyamapa-Serna VA, Chen Y, Galinsky RE, Hall SD, Kimura RE (Nov 2004) The effect of anesthesia and surgery on CYP3A activity in rats., Drug metabolism and disposition: the biological fate of chemicals, 32 (11), 1325-30 Abstract
  • Ward BA, Morocho A, Kandil A, Galinsky RE, Flockhart DA, Desta Z (Sep 2004) Characterization of human cytochrome P450 enzymes catalyzing domperidone N-dealkylation and hydroxylation in vitro., British journal of clinical pharmacology, 58 (3), 277-87 Abstract
  • Pu X, Lee LS, Galinsky RE, Carlson GP (May 2004) Evaluation of a rat model versus a physiologically based extraction test for assessing phenanthrene bioavailability from soils., Toxicological sciences : an official journal of the Society of Toxicology, 79 (1), 10-7 Abstract
  • Shaw AA, Hall SD, Franklin MR, Galinsky RE, The influence of L-glutamine on the depression of hepatic cytochrome P450 activity in male rats caused by total parenteral nutrition, Drug Metabolism and Disposition: the Biological Fate of Chemicals, 30(2), 177-82, February 2002 Abstract
  • Chalasani N, Gorski JC, Patel NH, Hall SD, Galinsky RE, Hepatic and intestinal cytochrome P450 3A activity in cirrhosis: effects of transjugular intrahepatic portosystemic shunts, Hepatology (baltimore, Md.), 34(6), 1103-8, December 2001 Abstract
  • Yan L, Galinsky RE, Bernstein JA, Liggett SB, Weinshilboum RM, Histamine N-methyltransferase pharmacogenetics: association of a common functional polymorphism with asthma, Pharmacogenetics, 10(3), 261-6, April 2000 Abstract
  • Raftogianis RB, Franklin MR, Galinsky RE, Effect of total parenteral nutrition containing lipid calories on hepatic drug metabolism in rats, Drug Metabolism and Disposition: the Biological Fate of Chemicals, 24(4), 502-5, April 1996 Abstract
  • Gygi SP, Colon F, Raftogianis RB, Galinsky RE, Wilkins DG, Rollins DE, Dose-related distribution of codeine and its metabolites into rat hair, Drug Metabolism and Disposition: the Biological Fate of Chemicals, 24(3), 282-7, March 1996 Abstract
  • Raftogianis RB, Franklin MR, Galinsky RE, Effect of lipid-free total parenteral nutrition on hepatic drug conjugation in rats, Journal of Pharmacology and Experimental Therapeutics, 276(2), 602-8, February 1996 Abstract
  • Raftogianis RB, Franklin MR, Galinsky RE, The depression of hepatic drug conjugation reactions in rats after lipid-free total parenteral nutrition administered via the portal vein, Jpen. Journal of Parenteral and Enteral Nutrition, 19(4), 303-9, 1995 Abstract
  • Yim CY, Hibbs JB Jr, McGregor JR, Galinsky RE, Samlowski WE, Use of N-acetyl cysteine to increase intracellular glutathione during the induction of antitumor responses by IL-2, Journal of Immunology, 152(12), 5796-805, June 1994 Abstract
  • Bonkovsky HL, Kane RE, Jones DP, Galinsky RE, Banner B, Acute hepatic and renal toxicity from low doses of acetaminophen in the absence of alcohol abuse or malnutrition: evidence for increased susceptibility to drug toxicity due to cardiopulmonary and rena, Hepatology, 19(5), 1141-8, May 1994 Abstract
  • Bakhtian S, Kimura RE, Galinsky RE, Age-related changes in homeostasis of inorganic sulfate in male F-344 rats, Mechanisms of Ageing and Development, 66(3), 257-67, January 1993 Abstract
  • Samlowski WE, Park KJ, Galinsky RE, Ward JH, Schumann GB, Intrathecal administration of interleukin-2 for meningeal carcinomatosis due to malignant melanoma: Sequential evaluation of intracranial pressure, cerebrospinal fluid cytology, and cytokine induction, Journal of Immunotherapy, 13(1), 49-54, January 1993
  • Galinsky RE, Manning BW, Kimura RE, Franklin MR, Changes in conjugative enzyme activity and acetaminophen metabolism in young and senescent male F-344 rats following prolonged exposure to buthionine sulfoximine, Experimental Gerontology, 27(2), 221-32, 1992 Abstract
  • Hoesterey BL, Galinsky RE, Anderson BD, Dose dependence in the plasma pharmacokinetics and uptake kinetics of 2',3'-dideoxyinosine into brain and cerebrospinal fluid of rats, Drug Metabolism and Disposition: The Biological Fate of Chemicals, 19(5), 907-12, 1991
  • Galinsky RE, Flaharty KK, Hoesterey BL, Anderson BD, Probenecid enhances central nervous system uptake of 2',3'-dideoxyinosine by inhibiting cerebrospinal fluid efflux, Journal of Pharmacology and Experimental Therapeutics, 257(3), 972-8, June 1991 Abstract
  • Manning BW, Franklin MR, Galinsky RE, Drug metabolizing enzyme changes after chronic buthionine sulfoximine exposure modify acetaminophen disposition in rats, Drug Metabolism and Disposition: The Biological Fate of Chemicals, 19(2), 498-502, 1991
  • Galinsky RE, Eshima D, Hansen L, Greene J, Dillehay D, Taylor A Jr, Effect of advanced age on p-aminohippurate-induced inhibition of renal tubular secretion in male Fischer 344 rats, Mechanisms of Ageing and Development, 56(3), 209-22, December 1990 Abstract
  • Galinsky RE, Johnson DH, Kane RE, Franklin MR, Effect of aging on hepatic biotransformation in female Fischer 344 rats: Changes in sulfotransferase activities are consistent with known gender-related changes in pituitary growth hormone secretion i, Journal of Pharmacology and Experimental Therapeutics, 255(2), 577-83, November 1990
  • Johnson DH, Kimura RE, Galinsky RE, New chronic gastric cannula for feeding ethanol liquid diet to young and old rats, Journal of Pharmacological Methods, 24(1), 37-42, August 1990 Abstract
  • Anderson BD, Hoesterey BL, Baker DC, Galinsky RE, Uptake kinetics of 2',3'-dideoxyinosine into brain and cerebrospinal fluid of rats: intravenous infusion studies, Journal of Pharmacology and Experimental Therapeutics, 253(1), 113-8, April 1990 Abstract
  • Galinsky RE, Hoesterey BL, Anderson BD, Brain and cerebrospinal fluid uptake of zidovudine (AZT) in rats after intravenous injection, Life Sciences, 47(9), 781-8, 1990 Abstract
  • Galinsky RE, Corcoran GB, Suppression of acetaminophen conjugation and of conjugate elimination in the rat by metyrapone, a classical P-450 inhibitor, Drug Metabolism and Disposition: The Biological Fate of Chemicals, 16(3), 348-54, 1988
  • Galinsky RE, Alexander DP, Franklin MR, Effect of cyclosporine on hepatic oxidative and conjugative metabolism in rats, Drug Metabolism and Disposition: The Biological Fate of Chemicals, 15(5), 731-3, 1987
  • Lau RJ, Emery MG, Galinsky RE, Unexpected accumulation of acyclovir in breast milk with estimation of infant exposure, Obstetrics and Gynecology, 69(3 Pt 2), 468-71, March 1987 Abstract
  • Galinsky RE, Kane RE, Franklin MR, Effect of aging on drug-metabolizing enzymes important in acetaminophen elimination, Journal of Pharmacology and Experimental Therapeutics, 237(1), 107-13, April 1986 Abstract
  • Galinsky RE, Role of glutathione turnover in drug sulfation: Differential effects of diethylmaleate and buthionine sulfoximine on the pharmacokinetics of acetaminophen in the rat, Journal of Pharmacology and Experimental Therapeutics, 236(1), 133-9, January 1986
  • Levy G, Galinsky RE, Lin JH, Pharmacokinetic consequences and toxicologic implications of endogenous cosubstrate depletion, Drug Metabolism Reviews, 13(6), 1009-20, 1982 Abstract
  • Galinsky RE, Levy G, Dose- and time-dependent elimination of acetaminophen in rats: Pharmacokinetic implications of cosubstrate depletion, Journal of Pharmacology and Experimental Therapeutics, 219(1), 14-20, October 1981

Profile Details

Last Updated: 3/18/2009

COS Expertise ID #114115
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