Dr. Patricia Elaine Ganey

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Michigan State University
College of Human Medicine
Pharmacology and Toxicology
Associate ProfessorAppointed: 1998
Michigan State University
College of Veterinary Medicine

Mailing Address

214 Food Safety and Toxicology Building
National Food Safety and Toxicology Center
Michigan State University
East Lansing, Michigan 48824-1302
United States

Contact Information

Phone: (517) 432-1761
Fax: (517) 432-2310
ganey@msu.edu

Qualifications

Ph.D., Michigan State University, Pharmacology and Toxicolgy-Environmental Toxicology, 1986.
B.S., University of Maryland, Biological Sciences, 1979.

Expertise and Research Interests

Neutrophils and Hepatotoxicity
Endotoxins and Hepatotoxicity
Signal Transduction and Inflammatory Cells

Other Expertise

Cell culture

Keywords

COS Keywords:

Adhesives, Food Safety, Pharmacology, Signal Transduction, Toxicology.

Additional Terms:

Abl Kinase, Adhesion Molecules, Cyclooxygenase 2, Endotoxins, Food Safety, Hepatotoxicity, NF Kappa B, Pharmacology, Polychlorinated Biphenyls, Toxicology, Xenobiotic Agents.

Memberships

American Society for Pharmacology and Experimental Therapeutics
International Endotoxin Society
Michigan Regional Chapter of the Society of Toxicology
Society of Leukocyte Biology
Society of Toxicology

Honors and Awards

2002-2002, Pfizer Award for Research Excellence, Pfizer Animal Health, Michigan State University
2002-2004, Secretary-Treasurer, Toxicology Division, American Society for Pharmacology and Experimental Therapeutics
2001-2004, Member and Chair, Membership Committee, Society of Toxicology, Elected Office
1999-2000, President, Michigan Regional Chapter, Society of Toxicology

Previous Positions

1996-1998, Assistant Professor, Michigan State University, Jointly with Human/Osteopathic/Veterinary Medicine, Pharmacology and Toxicology
1990-1996, Michigan State University, Jointly with Human/Osteopathic/Veterinary Medicine, Medicine and Pharmacology and Toxicology

Funding Received

  • NIH/NIDDK: Endotoxin Enhancement of Hepatotoxicity, 1998 to 2002.
  • NIEHS 04911 (Program Project): Health Hazards from Groundwater Contamination, 1995 to 2003.

Publications

  • Kinser S, Sneed R, Roth R, Ganey P, Neutrophils contribute to endotoxin enhancement of allyl alcohol hepatotoxicity, Journal of Toxicology and Environmental Health. Part A, 67(12), 911-28, June 2004
  • Harrigan GG, LaPlante RH, Cosma GN, Cockerell G, Goodacre R, Maddox JF, Luyendyk JP, Ganey PE, Roth RA, Application of high-throughput Fourier-transform infrared spectroscopy in toxicology studies: Contribution to a study on the development of an animal model for idiosyncratic toxicity, Toxicology Letters, 146(3), 197-205, February 2004
  • Maddox JF, Domzalski AC, Roth RA Ganey PE, 15-Deoxy Prostaglandin J2 enhances allyl alcohol-induced toxicity in rat hepatocytes, Toxicological Sciences, 77, 290-298, 2004
  • Luyendyk JP, Mattes WB, Burgoon LD, Zacharewski TR, Maddox JF, Cosma GN, Ganey PE, Roth RA, Gene expression analysis points to hemostasis in livers of rats cotreated with lipopolysaccharide and ranitidine, Toxicological Sciences, 80, 203-213, 2004
  • Copple BL, Rondelli CM, Maddox JF, Hoglen NC, Ganey PE, Roth RA, Modes of cell death in rat liver after monocrotaline exposure, Toxicological Sciences, 77, 172-182, 2004
  • Hanumegowda UM, Copple BL, Shibuya M, Malle E, Ganey PE, Roth RA, Basement membrane and matrix metalloproteinases in monocrotaline-induced liver injury, Toxicological Sciences: An Official Journal of the Society of Toxicology, 76(1), 237-46, November 2003
  • Roth RA, Luyendyk JP, Maddox JF, Ganey PE, Inflammation and drug idiosyncrasy--is there a connection?, The Journal of Pharmacology and Experimental Therapeutics, 307(1), 1-8, October 2003 Abstract
  • Luyendyk JP, Maddox JF, Cosma GN, Ganey PE, Cockerell GL, Roth RA, Ranitidine treatment during a modest inflammatory response precipitates idiosyncrasy-like liver injury in rats, The Journal of Pharmacology and Experimental Therapeutics, 307(1), 9-16, October 2003 Abstract
  • Copple BL, Ganey PE, Roth RA, Liver inflammation during monocrotaline hepatotoxicity, Toxicology, 190(3), 155-69, August 2003 Abstract
  • Yee SB, Harkema JR, Ganey PE, Roth RA, The coagulation system contributes to synergistic liver injury from exposure to monocrotaline and bacterial lipopolysaccharide, Toxicological Sciences: An Official Journal of the Society of Toxicology, 74(2), 457-69, August 2003
  • Yee SB, Hanumegowda UM, Copple BL, Shibuya M, Ganey PE, Roth RA, Endothelial cell injury and coagulation system activation during synergistic hepatotoxicity from monocrotaline and bacterial lipopolysaccharide coexposure, Toxicological Sciences: An Official Journal of the Society of Toxicology, 74(1), 203-14, July 2003
  • Maddox JF, Roth RA, Ganey PE, Allyl alcohol activation of protein kinase C delta leads to cytotoxicity of rat hepatocytes, Chemical Research in Toxicology, 16(5), 609-15, May 2003 Abstract
  • Copple BL, Moulin F, Hanumegowda UM, Ganey PE, Roth RA, Thrombin and protease-activated receptor-1 agonists promote lipopolysaccharide-induced hepatocellular injury in perfused livers, The Journal of Pharmacology and Experimental Therapeutics, 305(2), 417-25, May 2003 Abstract
  • Luyendyk JP, Copple BL, Barton CC, Ganey PE, Roth RA, Augmentation of aflatoxin B1 hepatotoxicity by endotoxin: involvement of endothelium and the coagulation system, Toxicological Sciences: An Official Journal of the Society of Toxicology, 72(1), 171-81, March 2003
  • Yee SB, Hanumegowda UM, Hotchkiss JA, Ganey PE, Roth RA, Role of neutrophils in the synergistic liver injury from monocrotaline and bacterial lipopolysaccharide exposure, Toxicological Sciences: An Official Journal of the Society of Toxicology, 72(1), 43-56, March 2003
  • Yee SB, Ganey PE, Roth RA, The role of Kupffer cells and TNF-alpha in monocrotaline and bacterial lipopolysaccharide-induced liver injury, Toxicological Sciences: An Official Journal of the Society of Toxicology, 71(1), 124-32, January 2003
  • Kinser S, Copple BL, Roth RA, Ganey PE, Enhancement of allyl alcohol hepatotoxicity by endotoxin requires extrahepatic factors, Toxicological Sciences: An Official Journal of the Society of Toxicology, 69(2), 470-81, October 2002
  • Luyendyk JP, Shores KC, Ganey PE, Roth RA, Bacterial lipopolysaccharide exposure alters aflatoxin B(1) hepatotoxicity: benchmark dose analysis for markers of liver injury, Toxicological Sciences: An Official Journal of the Society of Toxicology, 68(1), 220-5, July 2002
  • Yee SB, Copple BL, Ganey PE, Roth RA, The temporal relationship between bacterial lipopolysaccharide and monocrotaline exposures influences toxicity: shift in response from hepatotoxicity to nitric oxide-dependent lethality, Journal of Toxicology and Environmental Health. Part A, 65(14), 961-76, July 2002
  • Copple BL, Woolley B, Banes A, Ganey PE, Roth RA, Anticoagulants prevent monocrotaline-induced hepatic parenchymal cell injury but not endothelial cell injury in the rat, Toxicology and Applied Pharmacology, 180(3), 186-96, May 2002 Abstract
  • Olivero J, Bezdecny SA, Ganey PE, A molecular motif required for the activation of rat neutrophil phospholipase A(2) by organochlorine compounds, Chemical Research in Toxicology, 15(2), 153-9, February 2002 Abstract
  • Copple BL, Banes A, Ganey PE, Roth RA, Endothelial cell injury and fibrin deposition in rat liver after monocrotaline exposure, Toxicological Sciences: An Official Journal of the Society of Toxicology, 65(2), 309-18, February 2002
  • Buchweitz JP, Ganey PE, Bursian SJ, Roth RA, Underlying endotoxemia augments toxic responses to chlorpromazine: is there a relationship to drug idiosyncrasy?, The Journal of Pharmacology and Experimental Therapeutics, 300(2), 460-7, February 2002 Abstract
  • Ganey PE, Roth RA, Concurrent inflammation as a determinant of susceptibility to toxicity from xenobiotic agents, Toxicology, 169(3), 195-208, December 2001 Abstract
  • Moulin F, Copple BL, Ganey PE, Roth RA, Hepatic and extrahepatic factors critical for liver injury during lipopolysaccharide exposure, American Journal of Physiology. Gastrointestinal and Liver Physiology, 281(6), G1423-31, December 2001 Abstract
  • Olivero J, Ganey PE, Participation of Ca2+/calmodulin during activation of rat neutrophils by polychlorinated biphenyls, Biochemical Pharmacology, 62(8), 1125-32, October 2001 Abstract
  • Barton CC, Barton EX, Ganey PE, Kunkel SL, Roth RA, Bacterial lipopolysaccharide enhances aflatoxin B1 hepatotoxicity in rats by a mechanism that depends on tumor necrosis factor alpha, Hepatology (Baltimore, MD), 33(1), 66-73, Jan 2001
  • Barton CC, Ganey PE, Roth RA, Lipopolysaccharide augments aflatoxin B(1)-induced liver injury through neutrophil-dependent and -independent mechanisms, Toxicological Sciences: An Official Journal of the Society of Toxicology, 58(1), 208-15, November 2000
  • Yee SB, Kinser S, Hill DA, Barton CC, Hotchkiss JA, Harkema JR, Ganey PE, Roth RA, Synergistic hepatotoxicity from coexposure to bacterial endotoxin and the pyrrolizidine alkaloid monocrotaline, Toxicology and Applied Pharmacology, 166(3), 173-85, August 2000 Abstract
  • Sneed RA, Buchweitz JP, Jean PA, Ganey PE, Pentoxifylline attenuates bacterial lipopolysaccharide-induced enhancement of allyl alcohol hepatotoxicity, Toxicological Sciences: An Official Journal of the Society of Toxicology, 56(1), 203-10, July 2000
  • Barton CC, Hill DA, Yee SB, Barton EX, Ganey PE, Roth RA, Bacterial lipopolysaccharide exposure augments aflatoxin B(1)-induced liver injury, Toxicological Sciences: An Official Journal of the Society of Toxicology, 55(2), 444-52, June 2000
  • Olivero J, Ganey PE, Role of protein phosphorylation in activation of phospholipase A2 by the polychlorinated biphenyl mixture Aroclor 1242, Toxicology and Applied Pharmacology, 163(1), 9-16, February 2000 Abstract
  • Tithof PK, Olivero J, Ruehle K, Ganey PE, Activation of neutrophil calcium-dependent and -independent phospholipases A2 by organochlorine compounds, Toxicological Sciences, 53(1), 40-7, Jan 2000
  • Ganey PE, Quensen JF, Mousa MA, Boyd ST, Wagner MA, and Fischer LJ, Biological activity associated with noncoplanar polychlorinated biphenyls after microbial dechlorination of Aroclor 1242 and Acroclor 1254, Environmental Toxicology and Chemistry, 19, 1311-1316, 2000
  • Brown AP, Olivero-Verbel J, Holdan WL, Ganey PE, Neutrophil activation by polychlorinated biphenyls: structure-activity relationship, Toxicological Sciences, 46(2), 308-16, December 1998 Abstract
  • Olivero-Verbel J, Ganey PE, Effect of three polychlorinated biphenyls on f-met-leu-phe-induced degranulation in rat neutrophils, Toxicology Letters, 98(3), 195-202, September 1998 Abstract
  • Tithof PK, Peters-Golden M, Ganey PE, Distinct phospholipases A2 regulate the release of arachidonic acid for eicosanoid production and superoxide anion generation in neutrophils, Journal of Immunology, 160(2), 953-60, Jan 1998 Abstract
  • Fischer LJ, Seegal RF, Ganey PE, Pessah IN, Kodavanti PR, Symposium overview: toxicity of non-coplanar PCBs, Toxicological Sciences, 41(1), 49-61, Jan 1998 Abstract
  • Molnar RG, Wang P, Ayala A, Ganey PE, Roth RA, Chaudry IH, The role of neutrophils in producing hepatocellular dysfunction during the hyperdynamic stage of sepsis in rats, Journal of Surgical Research, 73(2), 117-22, December 1997 Abstract
  • Tithof PK, Watts S, Ganey PE, Protein tyrosine kinase involvement in the production of superoxide anion by neutrophils exposed to Aroclor 1242, a mixture of polychlorinated biphenyls, Biochemical Pharmacology, 53(12), 1833-42, June 1997 Abstract
  • Srinivasan R, Buchweitz JP, Ganey PE, Alteration by flutamide of neutrophil response to stimulation. Implications for tissue injury, Biochemical Pharmacology, 53(8), 1179-85, April 1997 Abstract
  • Brown AP, Harkema JR, Schultze AE, Roth RA, Ganey PE, Gadolinium chloride pretreatment protects against hepatic injury but predisposes the lungs to alveolitis after lipopolysaccharide administration, Shock, 7(3), 186-92, March 1997 Abstract
  • Moulin F, Pearson JM, Schultze AE, Scott MA, Schwartz KA, Davis JM, Ganey PE, Roth RA, Thrombin is a distal mediator of lipopolysaccharide-induced liver injury in the rat, Journal of Surgical Research, 65(2), 149-58, October 1996 Abstract
  • Jaeschke H, Smith CW, Clemens MG, Ganey PE, Roth RA, Mechanisms of inflammatory liver injury: adhesion molecules and cytotoxicity of neutrophils, Toxicology and Applied Pharmacology, 139(2), 213-26, August 1996 Abstract
  • Brown AP, Schultze AE, Holdan WL, Buchweitz JP, Roth RA, Ganey PE, Lipopolysaccharide-induced hepatic injury is enhanced by polychlorinated biphenyls, Environmental Health Perspectives, 104(6), 634-40, June 1996 Abstract
  • Wagner JG, Ganey PE, Roth RA, Nitric oxide is not involved in hepatocyte killing by neutrophils activated by N-formyl-methionyl-leucylphenylalanine or phorbol myristate acetate in vitro, Hepatology, 23(4), 803-10, April 1996 Abstract
  • Ganey PE, Schultze AE, Depletion of neutrophils and modulation of Kupffer cell function in allyl alcohol-induced hepatotoxicity, Toxicology, 99(1-2), 99-106, May 1995 Abstract
  • Brown AP, Ganey PE, Neutrophil degranulation and superoxide production induced by polychlorinated biphenyls are calcium dependent., Toxicology and Applied Pharmacology, 131(2), 198-205, 1995 Abstract
  • Tithof PK, Contreras ML, Ganey PE, Aroclor 1242 stimulates the production of inositol phosphates in polymorphonuclear neutrophils., Toxicology and Applied Pharmacology, 131(1), 136-43, 1995 Abstract
  • Ganey PE, Bailie MB, VanCise S, Colligan ME, Madhukar BV, Robinson JP, Roth RA, Activated neutrophils from rat injured isolated hepatocytes, Laboratory Investigation, 70(1), 53-60, January 1994 Abstract
  • Ganey PE, Sirois JE, Denison M, Robinson JP, Roth RA, Neutrophil function after exposure to polychlorinated biphenyls in vitro, Environmental Health Perspectives, 101(5), 430-4, October 1993 Abstract

Profile Details

Last Updated: 8/23/2004

COS Expertise ID #698974
Reference this profile directly: http://myprofile.cos.com/ganey