Dr. Frederic Geissmann

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Universite Rene Descartes Paris V
Faculte de Medecine Necker
IFR Necker-Enfants Malades
Cell Biology and Pathology
Associate ProfessorAppointed: 2003
Professional Headshot of Frederic Geissmann

Mailing Address

Hopital Necker-Enfants Malades
149 Rue de Sevres
Paris, 75015
France

Contact Information

Phone: 33 (1) 44 49 49 98
Fax: 33 (1) 44 49 49 99
geissman@necker.fr

Qualifications

Ph.D., University of Paris V, Immunology, 1999.
M.D., University Paris VI, Hematology, 1996.

Expertise and Research Interests

The laboratory is supported by INSERM, the University Paris V and Necker Medical School. The focus of my research is on the differentiation and functions of cells of the mononuclear phagocyte system in vivo, in immune responses, inflammation and tumor biology, and the pathophysiology of histiocytoses.

To address these interests we use and develop mouse models utilizing GFP knock-in and knock-out mice and in vivo microscopy. We also study the biology of human monocytes and dendritic cells witn the aim to identify with the collaboration of clinicians the molecular basis of diseases of mononuclear phagocytes.

Keywords

COS Keywords:

Animal Models, Cell Biology, Cell Differentiation, Hematology, Immunology, Microscopy, Pathogenesis, Pathology, Proteomics, Tumors.

Additional Terms:

Phagocytes.

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)
French: (Fluent, Fluent, Fluent)

Honors and Awards

2003-2006, Equipe Avenir, INSERM
2000-2003, Long term fellowship, Human Frontier Science Program, Skirball Institute, New York University, Immunology
1997-1999, INSERM fellowship, INSERM, CNRS UMR8603, pathology and biology of dendritic cells
1996-1997, Medaille de l'internat des hopitaux de Paris, Assistance Publique-Hopitaux de Paris, Universite Rene Descartes Paris V, Pathology and Immunology of dendritic cells

Previous Positions

2000-2003, Postdoctoral Fellow, New York University, School of Medicine, Skirball Institute for Biomolecular Medicine, Molecular Pathogenesis
1999-2000, Assistant, Universite Paris V, Faculte de Medecine Necker, Pathology
1996-1999, Ph.D. Student, Universite Paris V
1992-1996, Resident, Paris University Hospitals, Medicine

Publications

  • Idbaih A, Donadieu J, Barthez MA, Geissmann F, Bertrand Y, Hermine O, Brugieres L, Genereau T, Thomas C, Hoang-Xuan K, Retinoic acid therapy in 'degenerative-like' neuro-langerhans cell histiocytosis: a prospective pilot study, Pediatr Blood Cancer, 43(1), 55-8, July 2004
  • Geissmann F, Revy P, Brousse N, Lepelletier Y, Folli C, Durandy A, Chambon P, Dy M, Retinoids regulate survival and antigen presentation by immature dendritic cells, Journal of Experimental Medicine, 198(4), 623-34, August 2003 Abstract
  • Geissmann F, Jung S, Littman DR, Blood monocytes consist of two principal subsets with distinct migratory properties, Immunity, 19(1), 71-82, July 2003 Abstract
  • Slacmeulder M, Geissmann F, Lepelletier Y, Fournet JC, Brousse N, Thomas C, Donadieu J, Gessain A, No association between Langerhans cell histiocytosis and human herpes virus 8, Medical and Pediatric Oncology, 39(3), 187-9, September 2002 Abstract
  • Geissmann F, Dieu-Nosjean MC, Dezutter C, Valladeau J, Kayal S, Leborgne M, Brousse N, Saeland S, Davoust J, Accumulation of immature Langerhans cells in human lymph nodes draining chronically inflamed skin, Journal of Experimental Medicine, 196(4), 417-30, Aug 2002 Abstract
  • Aucouturier P, Geissmann F, Damotte D, Saborio GP, Meeker HC, Kascsak R, Kascsak R, Carp RI, Wisniewski T, Infected splenic dendritic cells are sufficient for prion transmission to the CNS in mouse scrapie, Journal of Clinical Investigation, 108(5), 703-8, September 2001 Abstract
  • Pron B, Boumaila C, Jaubert F, Berche P, Milon G, Geissmann F, Gaillard JL, Dendritic cells are early cellular targets of Listeria monocytogenes after intestinal delivery and are involved in bacterial spread in the host, Cellular Microbiology, 3(5), 331-40, May 2001 Abstract
  • Doffinger R, Smahi A, Bessia C, Geissmann F, Feinberg J, Durandy A, Bodemer C, Kenwrick S, Dupuis-Girod S, Blanche S, Wood P, Rabia SH, Headon DJ, Overbeek PA, Le Deist F, Holland SM, Belani K, Kumararatne DS, Fischer A, Shapiro R, Conley ME, et al., X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kappaB signaling, Nature Genetics, 27(3), 277-85, March 2001
  • Geissmann F, Lepelletier Y, Fraitag S, Valladeau J, Bodemer C, Debre M, Leborgne M, Saeland S, Brousse N, Differentiation of Langerhans cells in Langerhans cell histiocytosis, Blood, 97(5), 1241-8, March 2001 Abstract
  • Geissmann F, Launay P, Pasquier B, Lepelletier Y, Leborgne M, Lehuen A, Brousse N, Monteiro RC, A subset of human dendritic cells expresses IgA Fc receptor (CD89), which mediates internalization and activation upon cross-linking by IgA complexes, Journal of Immunology (baltimore, Md. : 1950), 166(1), 346-52, Jan 2001 Abstract
  • Revy P, Muto T, Levy Y, Geissmann F, Plebani A, Sanal O, Catalan N, Forveille M, Dufourcq-Labelouse R, Gennery A, Tezcan I, Ersoy F, Kayserili H, Ugazio AG, Brousse N, Muramatsu M, Notarangelo LD, Kinoshita K, Honjo T, Fischer A, Durandy A, Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2), Cell, 102(5), 565-75, September 2000 Abstract
  • Emile JF, Geissmann F, Martin OC, Radford-Weiss I, Lepelletier Y, Heymer B, Espanol T, de Santes KB, Bertrand Y, Brousse N, Casanova JL, Fischer A, Langerhans cell deficiency in reticular dysgenesis, Blood, 96(1), 58-62, July 2000 Abstract
  • Bouloc A, Boulland ML, Geissmann F, Fraitag S, Andry P, Teillac D, Bensussan A, Revuz J, Boumsell L, Wechsler J, Bagot M, CD101 expression by Langerhans cell histiocytosis cells, Histopathology, 36(3), 229-32, March 2000 Abstract
  • Geissmann F, [Current knowledge of the physiology and physiopathology of dendritic cells], La Revue De Medecine Interne / Fondee ... Par La Societe Nationale Francaise De Medecine Interne., 20(5), 441-4, May 1999 Abstract
  • Geissmann F, Revy P, Regnault A, Lepelletier Y, Dy M, Brousse N, Amigorena S, Hermine O, Durandy A, TGF-beta 1 prevents the noncognate maturation of human dendritic Langerhans cells, Journal of Immunology (baltimore, Md. : 1950), 162(8), 4567-75, April 1999 Abstract
  • Geissmann F, Thomas C, [Current status of clinical knowledge, physiopathology, and treatment of Langerhans histiocytosis (histiocytosis X)], Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie., 6 Suppl 2, 414s-416s, 1999 Abstract
  • Geissmann F, Ruskone-Fourmestraux A, Hermine O, Bourquelot P, Belanger C, Audouin J, Delmer A, Macintyre EA, Varet B, Brousse N, Homing receptor alpha4beta7 integrin expression predicts digestive tract involvement in mantle cell lymphoma, American Journal of Pathology, 153(6), 1701-5, December 1998 Abstract
  • Revy P, Geissmann F, Debre M, Fischer A, Durandy A, Normal CD40-mediated activation of monocytes and dendritic cells from patients with hyper-IgM syndrome due to a CD40 pathway defect in B cells, European Journal of Immunology, 28(11), 3648-54, November 1998 Abstract
  • Geissmann F, Patey-Mariaud de Serre N, Brousse N, [Cellular adhesion molecules in hematologic disease], Annales De Pathologie, 18(4), 253-60, October 1998 Abstract
  • Geissmann F, Prost C, Monnet JP, Dy M, Brousse N, Hermine O, Transforming growth factor beta1, in the presence of granulocyte/macrophage colony-stimulating factor and interleukin 4, induces differentiation of human peripheral blood monocytes into de, Journal of Experimental Medicine, 187(6), 961-6, March 1998 Abstract
  • Geissmann F, Emile JF, Andry P, Thomas C, Fraitag S, De Prost Y, Brousse N, Lack of expression of E-cadherin is associated with dissemination of Langerhans' cell histiocytosis and poor outcome, Journal of Pathology, 181(3), 301-4, March 1997 Abstract
  • Geissmann F, Thomas C, Emile JF, Micheau M, Canioni D, Cerf-Bensussan N, Lazarovits AI, Brousse N, Digestive tract involvement in Langerhans cell histiocytosis. The French Langerhans Cell Histiocytosis Study Group, Journal of Pediatrics, 129(6), 836-45, December 1996 Abstract
  • Sibilia J, Geissmann F, Brice P, [Peroperative anaphylactoid reaction in systemic mastocytosis], Revue Du Rhumatisme (ed. Francaise : 1993), 61(9), 650-1, October 1994 Abstract
  • Geissmann F, Derouin F, Marolleau JP, Gisselbrecht C, Brice P, Disseminated toxoplasmosis following autologous bone marrow transplantation, Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America., 19(4), 800-1, October 1994 Abstract
  • Welker Y, Geissmann F, Benali A, Bron J, Molina JM, Decazes JM, Toxoplasma-induced cystitis in a patient with AIDS, Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America., 18(3), 453-4, March 1994 Abstract
  • Geissmann F, Hennequin C, Maarek H, Viard JP, [Aspergillus fumigatus sinusitis in AIDS], Presse Medicale (paris, France : 1983), 22(35), 1792, November 1993 Abstract

Profile Details

Last Verified: 9/26/2004

COS Expertise ID #1102268
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