Myron Genel

powered by
COS Expertise®
Yale University
School of Medicine
Pediatrics

Mailing Address

333 Cedar Street, P.O. Box 208019
Yale University
New Haven, Connecticut 06520-8047
United States

Contact Information

myron.genel@yale.edu

Expertise and Research Interests

This is a long standing study of 30 years duration of a large kindredwith 131 members, some of whom have the hereditary form of thyroid andadrenal cancer. Screening of family members with a calciumpentagastrininfusion and linkage mapping using restriction fragment lengthpolymorphism in this study has linked the gene to the centromere ofchromosome #10. This data is now being correlated with definitive PcRanalysis for mutating in the RET gene.

Keywords

COS Keywords:

Biomedical Research Resources, Biomedical Research Resources, Other, Polymerase Chain Reaction.

Additional Terms:

Adrenal Neoplasm, Calcium, Centromere, Chromosome, Family Genetics, Gene Mutation, Human Genetic Material Tag, Human Subject, Linkage Mapping, Mass Screening, Medullary Thyroid Carcinoma, Neoplasm Cancer Diagnosis, Neoplasm Cancer Epidemiology, Neoplasm Cancer Genetics, Polymerase Chain Reaction, Restriction Fragment Length Polymorphism.

Funding Received

  • National Institutes of Health (NIH), 5 M01 RR06022-07 SUB: 0345, GENERAL CLINICAL RESEARCH CENTER: MONITORING MEDULLARY CARCINOMA OF THE THYROID IN A LARGE KINDRED, $18896, 1996-1998

Publications

  • Heptulla RA, Schwartz RP, Bale AE, Flynn S, Genel M, Familial medullary thyroid carcinoma: presymptomatic diagnosis and management in children., Journal of Pediatrics, 135(3), 327-31, September 1999 Abstract
  • Gill J R, Reyes-Mugica M, Iyengar S, Kidd K K, Touloukian R J, Smith C, Keller M S, Genel M, Early presentation of metastatic medullary carcinoma in multiple endocrine neoplasia, type IIA: implications for therapy., Journal of Pediatrics, 129(3), 459-64, September 1996 Abstract
  • Lichter J B, Wu J S, Genel M, Flynn S D, Pakstis A J, Kidd J R, Kidd K K, Presymptomatic testing using DNA markers for individuals at risk for familial multiple endocrine neoplasia 2A., Journal of Clinical Endocrinology and Metabolism, 74(2), 368-73, February 1992 Abstract
  • Wu J S, Carson N L, Myers S, Pakstis A J, Kidd J R, Castiglione C M, Anderson L, Hoyle L S, Genel M, Verdy M, et al, The genetic defect in multiple endocrine neoplasia type 2A maps next to the centromere of chromosome 10., American Journal of Human Genetics, 46(3), 624-30, March 1990 Abstract

Profile Details

Last Updated: 6/19/1997

COS Expertise ID #535122
Reference this profile directly: http://myprofile.cos.com/genelm22