Dr. William M. Grady

(Reading, Writing, Speaking)

• Kaz A, Kim Y-H, Dzieciatkowski S, Lynch H, Watson P, Washington MK, Lin L, Grady WM (2007) Evidence for the Role of Aberrant DNA Methylation in the Pathogenesis of Lynch Syndrome Adenomas., International Journal of Cancer, 120, 1922-1929
• Izeradjene K, Combs C, Best M, Gopinathan A, Wagner A, Grady WM, Deng C-X, Hruban RH, Adsay NV, Tuveson DA, Hingorani SR (2007) KrasG12D and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas., Cancer Cell, 11, 229-243
• Ochs-Balcom HM, Falk G, Grady WM, Kinnard M, Willis J, Elston R, Eng C, Chak A (2007) Consortium approach to identifying genes for Barrett's esophagus and esophageal adenocarcinoma, Translational Research, 150 (1), 3-17
• Veiseh M, Gabikian P, Bahrami SB, Veiseh O, Zhang M, Hackman RC, Ravanpay AC, Stroud MR, Kusuma Y, Hansen SJ, Kwok D, Munoz NM, Sze RW, Grady WM, Greenberg NM, Ellenbogen RG, Olson JM (2007) Tumor paint: a chlorotoxin:cy5.5 bioconjugate for intraoperative visualization of cancer foci., Cancer Research, 67 (14), 6882-8
• Grady WM, Willis JE, Trobridge P, Romero-Gallo J, Munoz N, Olechnowicz J, Ferguson K, Guatam S, Markowitz SD (2006) Proliferation and cdk4 expression in microsatellite unstable colon cancers with TGFBR2 mutations., Int. Journal of Cancer, 118, 600-8
• Gray KD, Ballard BR, Washington MK, Belue,R, Grady WM, Chapman WC, Stain SC (2006) Do adverse findings in colorectal cancer patients explain disparate outcomes?, Journal of the National Medical Association, 98, 348-351
• Kim YH, Petko Z, Dzieciatkowski S, Lin L, Ghiassi M, Stain S, Chapman WC, Washington MK, Willis J, Markowitz SD, Grady WM (2006) CpG island methylation of genes accumulates during the adenoma progression step of the multi-step pathogenesis of colorectal cancer., Genes, Chromosomes, and Cancer, 14, 781-789
• Ye C (2006) Promoter methylation status of the MGMT, hMLH1, and CDKN2A/p16 genes in non-neoplastic mucosa of patients with and without colorectal adenomas., Oncology Reports, 2, 429-435
• Muñoz NM, Upton MP, Rojas A, Washington MK, Lin L, Chytil A, Sozmen EG, Madison BB, Pozzi A, Moon RT, Moses HL, Grady WM (2006) Transforming growth factor B receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation., Cancer Research, 66, 9837-44
• Chak A, Ochs-Balcom H, Falk G, Grady WM, Kinnard M, Willis JE, Elston R, Eng C (2006) Familiality in Barrett's esophagus, adenocarcinoma of the esophagus, and adenocarcinoma of the gastroesophageal junction., Cancer Epidemiology Biomarkers and Prevention, 15, 1668-73
• Chak A, Faulx A, Eng C, Grady W, Kinard M, Ochs-Balcom H, Falk G (2006) Gastroesophageal reflux symptoms in patients with adenocarcinoma of the esophagus or cardia., Cancer, 107, 2160-2166
• Petko P, Ghiassi M, Shuber A, Gorham J, Smalley W, Washington MK, Schultenover S, Gautam S, Markowitz SD, Grady WM (2005) Aberrantly methylated CDKN2A, MGMT and MLH1 in colon polyps and in fecal DNA from patients with colorectal polyps., Clinical Cancer Research, 11, 1203-1209
• Means AL, Chytil A, Moses HL, Coffey RJ, Wright CVE, Taketo MM, Grady WM, (2005) The Keratin 19 gene drives Cre recombinase expression throughout the early post-implantation mouse embryo., Genesis, 42, 23-27
• Romero-Gallo J, Sozman E, Chytil A, Russell WE, Whitehead RW, Parks T, Holdren MS, Her MF, Gautam S, Magnuson M, Moses HL, Grady WM (2005) Inactivation of TGF-ß signaling in hepatocytes results in an increased proliferative response after partial hepatectomy., Oncogene, 24, 3028-41
• Biswas S, Chytil A, Washington MK, Romero-Gallo J, Gorska AE, Gautam S, Moses HL, Grady WM (2004) TGFBR2 inactivation promotes the establishment and progression of colon cancer., Cancer Research, 34, 651-656
• Traicoff JL, Periyasamy S, Brattain MG, Grady W, Casey G (2003) Reconstitution of TGF-ß sensitivity in the VACO-411 human colon carcinoma line by somatic cell fusion with MCF-7., Journal of Biomedical Science, 10, 253-259
• Grady WM (2003) Genetic testing for high-risk colon cancer., Gastroenterology, 124 (6), 1579-1597
• Drovdlic DM, Goddard KAB, Chak A, Brock W, Chessler L, King JF, Richter J, Falk GW, Johnston DK, Fisher JL, Grady WM, Lemeshow S, Eng C (2003) Demographic and Phenotypic Features of 70 Families Segregating Barrett Oesophagus and Oesophageal Adenocarcinoma., American Journal of Genetics, 40, 651-656
• Lynch HT, Grady WM, Lynch JF, Tsuchiya KD, Weisner G, Markowitz SD (2000) E-cadherin mutation-based genetic counseling and hereditary diffuse gastric carcinoma., Cancer Genetics and Cytogenetics, 122, 1-6
• Grady WM, Willis J, Guilford PJ, Dunbier AK, Toro TT, Lynch H, Weisner G, Ferguson K, Markowitz S (2000) Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer., Nature Genetics, 26, 16-17
• Grady WM, Myeroff LL, Swinler SE, Rajput A, Thiagalingam S, Lutterbaugh JD, Neumann A, Brattain MG, Chang J, Kim S-J, Kinzler KW, Vogelstein B, Willson JKV, Markowitz S (1999) Mutational inactivation of transforming growth factor ß receptor type II in microsatellite stable colon cancers., Cancer Research, 59, 320-324
• Guilford PJ, Hopkins JB, Grady WM, Markowitz SD, Willis J, Lynch H, Rajput A, Weisner GL, Lindor NM, Burgart LJ, Toto TT, Lee D, Limacher J-M, Shaw DW, Findlay MPN, Reeve AE (1999) E-cadherin germline mutations define an inherited cancer syndrome dominated by diffuse gastric cancer., Human Mutation, 14, 249-255
• Liu DF, Ferguson K, Cooper G, Grady WM, Willis J (1999) p27 cell cycle inhibitor is inversely correlated with lymph node metastases in right-sided colon cancer., Journal of Clinical Laboratory Analysis, 13, 291-295
• Grady WM, Rajput A, Myeroff L, Liu D, Kwon K, Willis J, Markowitz S (1998) Mutation of the type II TGF-ß receptor is coincident with the transformation of human colon adenomas to malignant carcinomas., Cancer Research, 58, 3101-3104