Dr. Jeremy B. A. Green

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King's College London
Department of Craniofacial Development
ReaderAppointed: 2005
Professional Headshot of Jeremy B. A. Green

Mailing Address

Department of Craniofacial Development
King's College London
Guys Tower
Floor 27
London, SE1 9RT
United Kingdom

Contact Information

Phone: +44 (20) 7188 1794
Fax: +44 (20) 7188 1674
jeremy.green@kcl.ac.uk

Qualifications

Ph.D., Imperial College of Science, Technology and Medicine, University of London, Biotechnology/Biochemistry, 1987.
B.A., University of Cambridge, Biochemistry, 1983.

Expertise and Research Interests

My lab uses Xenopus frog embryos and sometimes zebrafish and cultured mammalian cells to investigate basic mechanisms in development. This includes the molecular mechanisms governing

- Embryo and cell polarity,
- Morphogen growth factor action (activin, Wnts)
- Tissue morphogenesis
- Signal transduction (GSK3, Wnts)
- Differentiation of mesoderm and
- Specification of neurons (neurogenesis) and ciliated cells

Molecules of interest include the canonical and non-canonical Wnt pathways, the PAR polarity proteins, especially the kinases PAR1 and PAR4, atypical PKC and glycogen synthase kinase (GSK3). My group works within a lively Developmental Biology Department at the Guy's Hospital campus of King's College London with fabulous views over the heart of central London. We are beginning to apply our morphogen expertise to directed differentiation of embryonic stem cells.

Other Expertise

Cell polarity in development and cancer
Relationship of cancer to developmental biology

Industrial Relevance

Stem cell manipulation
Ethics of cloning. stem cells, etc.

Keywords

COS Keywords:

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)
French: (Basic, Basic, Functional)
German: (Basic, Basic, Functional)

Memberships

American Association for the Advancement of Science
American Society for Cell Biology
British Society for Developmental Biology
Ethics Advisory Board, Advanced Cell Technology Inc.
Society for Developmental Biology

Previous Positions

1995-2005, Assistant Professor, Harvard University, Medical School, Genetics
1995-2005, Assistant Professor, Dana-Farber Cancer Institute, Clinical and Basic Science Research, Cancer Biology
1992-1994, Miller Fellow, University of California, Berkeley, Miller Institute for Basic Research in Science, Molecular & Cell Biology
1988-1992, Postdoctoral Fellow, National Institute for Medical Research (MRC), Jim Smith Laboratory
1987-1988, Postdoctoral Fellow, EMBL, Heidelberg & Technische Hochschule, Darmstadt

Publications

  • Green JB (Apr 2008) Sophistications of cell sorting., Nature cell biology, 10 (4), 375-7 Abstract
  • Lengerke C, Schmitt S, Bowman TV, Jang IH, Maouche-Chretien L, McKinney-Freeman S, Davidson AJ, Hammerschmidt M, Rentzsch F, Green JB, Zon LI, Daley GQ (Jan 2008) BMP and Wnt specify hematopoietic fate by activation of the Cdx-Hox pathway., Cell stem cell, 2 (1), 72-82 Abstract
  • Ossipova O, Tabler J, Green JB, Sokol SY (Dec 2007) PAR1 specifies ciliated cells in vertebrate ectoderm downstream of aPKC., Development (Cambridge, England), 134 (23), 4297-306 Abstract
  • Green JB, Davidson LA (Sep 2007) Convergent extension and the hexahedral cell., Nature cell biology, 9 (9), 1010-5 Abstract
  • Gurvich N, Berman MG, Wittner BS, Gentleman RC, Klein PS, Green JB ( Jul 2005) Association of valproate-induced teratogenesis with histone deacetylase, FASEB Journal, 19 (9), 1166-8 Abstract
  • Ossipova O, Dhawan S, Sokol S, Green JB (Jun 2005) Distinct PAR-1 proteins function in different branches of Wnt signaling during vertebrate development., Developmental cell, 8 (6), 829-41 Abstract
  • Ossipova O, Dhawan S, Sokol S, Green JB (Jun 2005) Distinct PAR-1 proteins function in different branches of Wnt signaling during vertebrate development., Developmental Cell, 8 (6), 829-41 Abstract
  • Green JB, Dominguez I, Davidson LA ( Nov 2004) Self-organization of vertebrate mesoderm based on simple boundary, Developmental Dynamics, 231 (3), 576-81 Abstract
  • Green JB ( Jan 2004) Lkb1 and GSK3-beta: kinases at the center and poles of the action., Cell Cycle, 3 (1), 12-4 Abstract
  • Ossipova O., Bardeesy N., DePinho R.A., Green J.B., LKB1 (XEEK1) regulates Wnt signalling in vertebrate development, Nature Cell Biology, 5(10), 889-94, Oct 2003 Abstract
  • Green JBA (Dec 2002) Morphogen gradients, positional information and Xenopus: The interplay of theory and experiment, Developmental Dynamics, 225 (4), 392-408
  • Ossipova O., He X., Green J., Molecular cloning and developmental expression of Par-1/MARK homologues XPar-1A and XPar-1B from Xenopus laevis, Gene Expression Patterns : Gep, 2(1-2), 145-50, Nov 2002 Abstract
  • Joukov V, Chen J, Fox EA, Green JB, Livingston DM ( Oct 2001) Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development., 98 (21), 12078-83 Abstract
  • Dominguez I, Green JB (Jul 2001) Missing links in GSK3 regulation., Developmental Biology, 235 (2), 303-13 Abstract
  • Kavka AI, Green JB, Evidence for dual mechanisms of mesoderm establishment in Xenopus embryos, Developmental Dynamics : an Official Publication of the American Association of Anatomists., 219(1), 77-83, Sep 2000 Abstract
  • Dominguez I, Green JB, Dorsal downregulation of GSK3beta by a non-Wnt-like mechanism is an early molecular consequence of cortical rotation in early Xenopus embryos, Development (cambridge, England), 127(4), 861-8, Feb 2000 Abstract
  • Green JBA., The animal cap assay, In: Guille M, ed. Methods in Molecular Biology. Newark: Humana Press,, 50-61, 1999
  • Kavka A I, Green J B, Tales of tails: Brachyury and the T-box genes, Biochimica Et Biophysica Acta, 1333(2), F73-F84, 24 Oct 1997
  • Green JB, Cook TL, Smith JC, Grainger RM ( Aug 1997) Anteroposterior neural tissue specification by activin-induced mesoderm., Proc. Acad. Natl. Sci. (USA), 94 (16), 8596-601 Abstract
  • New HV, Kavka AI, Smith JC, Green JB ( Jan 1997) Differential effects on Xenopus development of interference with type IIA, Mechanisms of Development, 61 (1-2), 175-86 Abstract
  • Green J.B., Borrowing thy neighbour's genetics: neural induction and a Brachyury mutant in Xenopus, Bioessays, 16(8), 539-540, 01 Aug 1994
  • Green JB, Smith JC, Gerhart JC ( Aug 1994) Slow emergence of a multithreshold response to activin requires, Development, 120 (8), 2271-8 Abstract
  • Green JB (May 1994) Roads to neuralness: embryonic neural induction as derepression of a default state., Cell, 77 (3), 317-20 Abstract
  • Smith J C, Cunliffe V, Green J B, New H V, Intercellular signalling in mesoderm formation during amphibian development, Philosophical Transactions of The Royal Society of london. Series B: Biological Sciences, 340(1293), 287-296, 29 Jun 1993
  • Green JB (Feb 1993) Mesodermal growth factor candidates elected!, Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology., 15 (2), 129-30 Abstract
  • Green JB, New HV, Smith JC ( Nov 1992) Responses of embryonic Xenopus cells to activin and FGF are separated by, Cell, 71 (5), 731-9 Abstract
  • Green JBA., The role of thresholds and mesoderm inducing factors in axis patterning in Xenopus, In Bellairs R, et al., eds. Formation and Differentiation of Early Embryonic Mesoderm. New York: Plenum Press, 241-249, 1992
  • Smith J C, Price B M, Green J B, Weigel D, Herrmann B G, Expression of a Xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction., Cell, 67(1), 79-87, 4 Oct 1991 Abstract
  • Green J B, Smith J C, Growth factors as morphogens: do gradients and thresholds establish body plan?, Trends In Genetics, 7(8), 245-250, 01 Aug 1991
  • Smith JC, Green JBA, Activation of muscle genes in Xenopus laevis by mesoderm-inducing factors, In: Ozawa E, et al., eds. Frontiers of Muscle Research. Amsterdam: Elsevier Science Publishers., 29-45, 1991
  • Green JBA, Cooke J., Induction, gradient models and the role of negative feedback in body pattern formation in the amphibian embryo, In: Meinhardt, H ed. Models of Pattern Formation, Seminars in Developmental Biology, 4, 95-106, 1991
  • Green JB (Sep 1990) Retinoic acid: the morphogen of the main body axis?, Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology., 12 (9), 437-9 Abstract
  • Green JB, Smith JC ( Sep 1990) Graded changes in dose of a Xenopus activin A homologue elicit stepwise, Nature, 347 (6291), 391-4 Abstract
  • Green JB, Howes G, Symes K, Cooke J, Smith JC (Jan 1990) The biological effects of XTC-MIF: quantitative comparison with Xenopus bFGF., Development (cambridge, England), 108 (1), 173-83 Abstract
  • Green JB (Mar 1989) Pyruvate decarboxylase is like acetolactate synthase (ILV2) and not like the pyruvate dehydrogenase E1 subunit., Febs Letters, 246 (1-2), 1-5 Abstract
  • Schaaff I, Green JB, Gozalbo D, Hohmann S (Feb 1989) A deletion of the PDC1 gene for pyruvate decarboxylase of yeast causes a different phenotype than previously isolated point mutations., Current Genetics, 15 (2), 75-81 Abstract
  • Smith JC, Cooke J, Green JB, Howes G, Symes K (1989) Inducing factors and the control of mesodermal pattern in Xenopus laevis., Development (cambridge, England), 107 Suppl, 149-59 Abstract
  • Green JB, Wright AP, Cheung WY, Lancashire WE, Hartley BS, The structure and regulation of phosphoglucose isomerase in Saccharomyces cerevisiae, Molecular & General Genetics : Mgg, 215(1), 100-6, Dec 1988 Abstract

Profile Details

Last Updated: 7/24/2008

COS Expertise ID #100045
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