Dr. David R. Gretch

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University of Washington
School of Medicine
Laboratory Medicine
Assistant ProfessorAppointed: 1994

Mailing Address

Box 359690
University of Washington
Seattle, Washington 98195
United States

Contact Information

Phone: (206) 548-6131
Fax: (206) 548-6189
gretch@mail.labmed.washington.edu

Qualifications

Ph.D., University of Iowa, 1990.
M.D., University of Iowa, 1990.

Keywords

COS Keywords:

AIDS, Gene Expression, Genes, Laboratory Practice or Procedure, Microbiology.

Additional Terms:

AIDS, Disease Manifestation, Gastrointestinal System, Gene Expression, Genes, Infectious Diseases, Microbiology, Regulation, Transplantation Biology, Treatment/Prevention, Viral Disease, Viruses.

Publications

  • Chang M, Marquardt AP, Wood BL, Williams O, Cotler SJ, Taylor SL, Carithers RL Jr, Gretch DR, In situ distribution of hepatitis C virus replicative-intermediate RNA in hepatic tissue and its correlation with liver disease., Journal of Virology, 74(2), 944-55, 2000 Abstract
  • Cotler SJ, Emond MJ, Gretch DR, Wilson JJ, Lin M, Bronner MP, Kowdley KV, Relationship between iron concentration and hepatitis C virus RNA level in liver tissue., Journal of Clinical Gastroenterology, 29(4), 322-6, December 1999 Abstract
  • Panther LA, Coombs RW, Aung SA, dela Rosa C, Gretch D, Corey L, Unintegrated HIV-1 circular 2-LTR proviral DNA as a marker of recently infected cells: relative effect of recombinant CD4, zidovudine, and saquinavir in vitro., Journal of Medical Virology, 58(2), 165-73, June 1999 Abstract
  • Polyak SJ, Paschal DM, McArdle S, Gale MJ Jr, Moradpour D, Gretch DR, Characterization of the effects of hepatitis C virus nonstructural 5A protein expression in human cell lines and on interferon-sensitive virus replication., Hepatology, 29(4), 1262-71, April 1999 Abstract
  • Cotler SJ, Gaur LK, Gretch DR, Wile M, Strong DM, Bronner MP, Carithers RL Jr, Emond MJ, Perkins JD, Nelson KA, Donor-recipient sharing of HLA class II alleles predicts earlier recurrence and accelerated progression of hepatitis C following liver transplantation., Tissue Antigens, 52(5), 435-43, November 1998 Abstract
  • Stehman-Breen C O, Emerson S, Gretch D, Johnson R J, Risk of death among chronic dialysis patients infected with hepatitis C virus., American Journal of Kidney Diseases, 32(4), 629-34, October 1998 Abstract
  • Gale M Jr, Blakely C M, Kwieciszewski B, Tan S L, Dossett M, Tang N M, Korth M J, Polyak S J, Gretch D R, Katze M G, Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation., Molecular and Cellular Biology, 18(9), 5208-18, September 1998 Abstract
  • Polyak S J, McArdle S, Liu S L, Sullivan D G, Chung M, Hofgartner W T, Carithers R L Jr, McMahon B J, Mullins J I, Corey L, Gretch D R, Evolution of hepatitis C virus quasispecies in hypervariable region 1 and the putative interferon sensitivity-determining region during interferon therapy and natural infection., Journal of Virology, 72(5), 4288-96, May 1998 Abstract
  • Shuhart M C, Bronner M P, Gretch D R, Thomassen L V, Wartelle C F, Tateyama H, Emerson S S, Perkins J D, Carithers R L Jr, Histological and clinical outcome after liver transplantation for hepatitis C., Hepatology, 26(6), 1646-52, December 1997 Abstract
  • Hofgartner W T, Polyak S J, Sullivan D G, Carithers R L Jr, Gretch D R, Mutations in the NS5A gene of hepatitis C virus in North American patients infected with HCV genotype 1a or 1b., Journal of Medical Virology, 53(2), 118-26, October 1997 Abstract
  • Gretch D R, Diagnostic tests for hepatitis C., Hepatology, 26(3 Suppl 1), 43S-47S, September 1997 Abstract
  • Cotler S J, Gretch D R, Bronner M P, Tateyama H, Emond M J, dela Rosa C, Perkins J D, Carithers R L Jr, Hepatitis G virus co-infection does not alter the course of recurrent hepatitis C virus infection in liver transplantation recipients., Hepatology, 26(2), 432-6, August 1997 Abstract
  • Stehman-Breen C O, Psaty B M, Emerson S, Gretch D, Bronner M, Marsh C, Davis C L, Association of hepatitis C virus infection with mortality and graft survival in kidney-pancreas transplant recipients., Transplantation, 64(2), 281-6, 27 Jul 1997 Abstract
  • Kendrick E A, McVicar J P, Kowdley K V, Bronner M P, Emond M J, Alpers C E, Gretch D R, Carithers R L Jr, Perkins J D, Davis C L, Renal disease in hepatitis C-positive liver transplant recipients., Transplantation, 63(9), 1287-93, 15 May 1997 Abstract
  • Polyak S J, Faulkner G, Carithers R L Jr, Corey L, Gretch D R, Assessment of hepatitis C virus quasispecies heterogeneity by gel shift analysis: correlation with response to interferon therapy., Journal of Infectious Diseases, 175(5), 1101-7, May 1997 Abstract
  • Gale M J Jr, Korth M J, Tang N M, Tan S L, Hopkins D A, Dever T E, Polyak S J, Gretch D R, Katze M G, Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein., Virology, 230(2), 217-27, 14 Apr 1997 Abstract
  • Lieber A, He C Y, Polyak S J, Gretch D R, Barr D, Kay M A, Elimination of hepatitis C virus RNA in infected human hepatocytes by adenovirus-mediated expression of ribozymes., Journal of Virology, 70(12), 8782-91, December 1996 Abstract
  • Gretch D R, Polyak S J, Wilson J J, Carithers R L Jr, Perkins J D, Corey L, Tracking hepatitis C virus quasispecies major and minor variants in symptomatic and asymptomatic liver transplant recipients., Journal of Virology, 70(11), 7622-31, November 1996 Abstract
  • Wener M H, Johnson R J, Sasso E H, Gretch D R, Hepatitis C virus and rheumatic disease [editorial], Journal of Rheumatology, 23(6), 953-9, June 1996 Abstract
  • Nelson D R, David G L, Lau J Y, Johnson R J, Gretch D, Wilson R, Mlzokami M, Anti-GOR in chronic HCV patients with membranoproliferative glomerulonephritis., Journal of Hepatology, 24(2), 248, February 1996 Abstract
  • Gretch D R, Polyak S J, Willson R A, Carithers R L Jr, Treatment of chronic hepatitis C virus infection: a clinical and virological perspective., Advances In Experimental Medicine and Biology, 394, 207-24, 1996 Abstract
  • Davis C L, Gretch D R, Carithers R L Jr, Hepatitis B and transplantation., Infectious Disease Clinics of North America, 9(4), 925-41, December 1995 Abstract
  • Brodkin C A, Daniell W, Checkoway H, Echeverria D, Johnson J, Wang K, Sohaey R, Green D, Redlich C, Gretch D, et al, Hepatic ultrasonic changes in workers exposed to perchloroethylene., Occupational and Environmental Medicine, 52(10), 679-85, October 1995 Abstract
  • Gretch D R, dela Rosa C, Carithers R L Jr, Willson R A, Williams B, Corey L, Assessment of hepatitis C viremia using molecular amplification technologies: correlations and clinical implications [see comments], Annals of Internal Medicine, 123(5), 321-9, 1 Sep 1995 Abstract
  • Yamabe H, Johnson R J, Gretch D R, Fukushi K, Osawa H, Miyata M, Inuma H, Sasaki T, Kaizuka M, Tamura N, et al, Hepatitis C virus infection and membranoproliferative glomerulonephritis in Japan., Journal of The American Society of Nephrology, 6(2), 220-3, August 1995 Abstract
  • Gretch D R, Bacchi C E, Corey L, dela Rosa C, Lesniewski R R, Kowdley K, Gown A, Frank I, Perkins J D, Carithers R L Jr, Persistent hepatitis C virus infection after liver transplantation: clinical and virological features., Hepatology, 22(1), 1-9, July 1995 Abstract
  • Wilson J J, Polyak S J, Day T D, Gretch D R, Characterization of simple and complex hepatitis C virus quasispecies by heteroduplex gel shift analysis: correlation with nucleotide sequencing., Journal of General Virology, 76 ( Pt 7), 1763-71, July 1995 Abstract
  • Wilson JJ, Polyak SJ, Day TD, Gretch DR, Characterization of simple and complex hepatitis C virus quasispecies by heteroduplex gel shift analysis: correlation with nucleotide sequencing., Journal of General Virology, 76 \( Pt 7\), 1763-71, 1995 Abstract
  • Quigg R J, Brathwaite M, Gardner D F, Gretch D R, Ruddy S, Successful cyclophosphamide treatment of cryoglobulinemic membranoproliferative glomerulonephritis associated with hepatitis C virus infection., American Journal of Kidney Diseases, 25(5), 798-800, May 1995 Abstract
  • Stehman-Breen C, Willson R, Alpers C E, Gretch D, Johnson R J, Hepatitis C virus-associated glomerulonephritis., Current Opinion In Nephrology and Hypertension, 4(3), 287-94, May 1995 Abstract
  • Davis C L, Gretch D R, Perkins J D, Harris A W, Wener M H, Alpers C E, Lesniewski R, Lee W, dela Rosa C, Johnson R J, et al, Hepatitis C--associated glomerular disease in liver transplant recipients., Liver Transplantation and Surgery, 1(3), 166-75, May 1995 Abstract
  • Conrad E U, Gretch D R, Obermeyer K R, Moogk M S, Sayers M, Wilson J J, Strong D M, Transmission of the hepatitis-C virus by tissue transplantation., Journal of Bone and Joint surgery. American Volume, 77(2), 214-24, February 1995 Abstract
  • Yamabe H, Johnson R J, Gretch D R, Osawa H, Inuma H, Sasaki T, Kaizuka M, Tamura N, Tsunoda S, Fujita Y, et al, Membranoproliferative glomerulonephritis associated with hepatitis C virus infection responsive to interferon-alpha., American Journal of Kidney Diseases, 25(1), 67-9, January 1995 Abstract
  • Johnson R J, Gretch D R, Couser W G, Alpers C E, Wilson J, Chung M, Hart J, Willson R, Hepatitis C virus-associated glomerulonephritis. Effect of alpha-interferon therapy., Kidney International, 46(6), 1700-4, December 1994 Abstract
  • Johnson R J, Willson R, Yamabe H, Couser W, Alpers C E, Wener M H, Davis C, Gretch D R, Renal manifestations of hepatitis C virus infection., Kidney International, 46(5), 1255-63, November 1994 Abstract
  • DuBois D B, Gretch D, dela Rosa C, Lee W, Fine J, Blagg C R, Corey L, Quantitation of hepatitis C viral RNA in sera of hemodialysis patients: gender-related differences in viral load., American Journal of Kidney Diseases, 24(5), 795-801, November 1994 Abstract
  • Gretch D, Corey L, Wilson J, dela Rosa C, Willson R, Carithers R Jr, Busch M, Hart J, Sayers M, Han J, Assessment of hepatitis C virus RNA levels by quantitative competitive RNA polymerase chain reaction: high-titer viremia correlates with advanced stage of disease., Journal of Infectious Diseases, 169(6), 1219-25, June 1994 Abstract
  • Davis C L, Gretch D R, Carithers R L, Hepatitis C virus in renal disease., Current Opinion In Nephrology and Hypertension, 3(2), 164-73, March 1994 Abstract
  • Sayers M H, Gretch D R, Recombinant immunoblot and polymerase chain reaction testing in volunteer whole blood donors screened by a multi-antigen assay for hepatitis C virus antibodies., Transfusion, 33(10), 809-13, October 1993 Abstract
  • Johnson R J, Gretch D R, Yamabe H, Hart J, Bacchi C E, Hartwell P, Couser W G, Corey L, Wener M H, Alpers C E, et al, Membranoproliferative glomerulonephritis associated with hepatitis C virus infection [see comments], New England Journal of Medicine, 328(7), 465-70, 18 Feb 1993 Abstract
  • Gretch D R, Wilson J J, Carithers R L Jr, dela Rosa C, Han J H, Corey L, Detection of hepatitis C virus RNA: comparison of one-stage polymerase chain reaction (PCR) with nested-set PCR., Journal of Clinical Microbiology, 31(2), 289-91, February 1993 Abstract
  • Gretch D R, Warren J J, Bacina R M, Stefansson E D, Fritsche T R, Performance characteristics of a commercial antibody-capture enzyme immunoassay for detection of Toxoplasma-specific IgM antibodies., Diagnostic Microbiology and Infectious Disease, 15(7), 587-93, Autumn 1992 Abstract
  • Gretch D, Lee W, Corey L, Use of aminotransferase, hepatitis C antibody, and hepatitis C polymerase chain reaction RNA assays to establish the diagnosis of hepatitis C virus infection in a diagnostic virology laboratory., Journal of Clinical Microbiology, 30(8), 2145-9, August 1992 Abstract

Profile Details

Last Updated: 5/24/2006

COS Expertise ID #307526
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