Diane E. Griffin

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Johns Hopkins University
Bloomberg School of Public Health
Molecular Microbiology and Immunology
Professor / ChairAppointed: 1994
Johns Hopkins University
School of Medicine
Professor of Medicine and NeurologyAppointed: 1986

Mailing Address

J.H. Medical Institutions E. Baltimore
Hygiene
E5132
Baltimore, Maryland 21205
United States

Contact Information

Phone: (410) 955-3459
Fax: (410) 955-0105
dgriffin@welchlink.welch.jhu.edu

Qualifications

M.D., Ph.D., Stanford University, 1968.
B.A., Augustana College, Rock Island, IL, 1962.

Expertise and Research Interests

Research Interests and Activities: The pathogenesis of several viral infections: Acute viral encephalitis: We are studying the mechanism of viral neurovirulence and the role of the immune response in recovery from viral encephalitis. Sindbis virus belongs to the alphavirus group of mosquito-borne causes of viral encephalitis, and its virulence is largely determined by the viral surface glycoproteins. Recombinant viruses have been constructed to determine which changes in individual amino acids and nucleotides are important for neurovirulence. Antibody is the primary means by which virus is cleared from infected neurons; the mechanism of this clearance is being determined using monoclonal antibodies, immunodeficient mice, and neuronal cultures. Unique aspects of the mononuclear inflammatory response within the nervous system during infection are being examined by flow cytometry and functional analysis of cells.Measles: Measles is associated with immune suppression, as manifested by depressed delayed-type hypersensitivity in vivo and by suppressed proliferation of lymphocytes in vitro. Monocytes are infected with measles virus and the effects of this infection on immune function are being studied. Proliferative and cytokine responses of lymphocytes to live and inactivated measles virus are being determined.HIV: The pathogenesis of nervous system disease in AIDS is being studied through prospective studies of the clinical features of HIV-infected patients, of cerebrospinal fluid and leukocytes, and of tissues taken at autopsy. Specimens are analyzed for cytokines, for virus, and for functional abnormalities, by using PCR, immunocytochemistry, and enzyme immunoassays.Research Interests and Activities: The pathogenesis of several viral infections: Acute viral encephalitis: We are studying the mechanism of viral neurovirulence and the role of the immune response in recovery from viral encephalitis. Sindbis virus belongs to the alphavirus group of mosquito-borne causes of viral encephalitis, and its virulence is largely determined by the viral surface glycoproteins. Recombinant viruses have been constructed to determine which changes in individual amino acids and nucleotides are important for neurovirulence. Antibody is the primary means by which virus is cleared from infected neurons; the mechanism of this clearance is being determined using monoclonal antibodies, immunodeficient mice, and neuronal cultures. Unique aspects of the mononuclear inflammatory response within the nervous system during infection are being examined by flow cytometry and functional analysis of cells.Measles: Measles is associated with immune suppression, as manifested by depressed delayed-type hypersensitivity in vivo and by suppressed proliferation of lymphocytes in vitro. Monocytes are infected with measles virus and the effects of this infection on immune function are being studied. Proliferative and cytokine responses of lymphocytes to live and inactivated measles virus are being determined.HIV: The pathogenesis of nervous system disease in AIDS is being studied through prospective studies of the clinical features of HIV-infected patients, of cerebrospinal fluid and leukocytes, and of tissues taken at autopsy. Specimens are analyzed for cytokines, for virus, and for functional abnormalities, by using PCR, immunocytochemistry, and enzyme immunoassays.

Keywords

COS Keywords:

AIDS, Immunology, Nervous System, Virology.

Additional Terms:

AIDS, Encephalitis, Immunology, Measles, Neuronal Infection, Sindbis Virus, Virology.

Previous Positions

1979-1986, Associate Professor of Medicine and Neurology, Johns Hopkins University, School of Medicine
1975-1982, Investigator, Howard Hughes Medical Institute
1973-1979, Assistant Professor of Medicine and Neurology, Johns Hopkins University, School of Medicine
1970-1973, Virology Fellow, Johns Hopkins University
1969-1970, Medical Resident, Stanford University Hospital, Stanford CA
1968-1969, Medical Intern, Stanford University Hospital, Stanford CA
Professor, Johns Hopkins University, School of Medicine, Neurology
Professor, Johns Hopkins University, School of Medicine, Infectious Diseases

Funding Received

  • Immune Response During Measles Virus Infection, National Institute of Allergy and Infectious Diseases, $456,794, 05/01/95-04/30/97
  • Measles Vaccines: Immune Response & Atypical Measles, National Institue of Allergy and Infectious Diseases, $587,458, 07/01/95-06/30/97
  • Determinants of Measles Virus Virulence, World Health Organization, $60,000, 09/01/95-08/31/97
  • Inflammation in Alphavirus Encephalitis, National Institute of Neurological Disorders, $523,068, 01/01/96-12/31/97
  • Determinants of Neuronal Recovery from Virus-Induced Injury, Muscular Dystrophy Association, $52,922, 07/01/96-06/30/99

Publications

  • Byrnes AP, Durbin JE, Griffin DE, Control of Sindbis virus infection by antibody in interferon-deficient mice., Journal of Virology, 74(8), 3905-8, 2000 Abstract
  • Byrnes AP, Griffin DE, Large-plaque mutants of Sindbis virus show reduced binding to heparan sulfate, heightened viremia, and slower clearance from the circulation., Journal of Virology, 74(2), 644-51, 2000 Abstract
  • Valsamakis A, Auwaerter PG, Rima BK, Kaneshima H, Griffin DE, Altered virulence of vaccine strains of measles virus after prolonged replication in human tissue., Journal of Virology, 73(10), 8791-7, October 1999 Abstract
  • Conant K, McArthur JC, Griffin DE, Sjulson L, Wahl LM, Irani DN, Cerebrospinal fluid levels of MMP-2, 7, and 9 are elevated in association with human immunodeficiency virus dementia., Annals of Neurology, 46(3), 391-8, September 1999 Abstract
  • Piyasirisilp S, Hemachudha T, Griffin DE, B-cell responses to myelin basic protein and its epitopes in autoimmune encephalomyelitis induced by Semple rabies vaccine., Journal of Neuroimmunology, 98(2), 96-104, 3 Aug 1999 Abstract
  • Moss WJ, Cutts F, Griffin DE, Implications of the human immunodeficiency virus epidemic for control and eradication of measles., Clinical Infectious Diseases, 29(1), 106-12, July 1999 Abstract
  • Polack FP, Auwaerter PG, Lee SH, Nousari HC, Valsamakis A, Leiferman KM, Diwan A, Adams RJ, Griffin DE, Production of atypical measles in rhesus macaques: evidence for disease mediated by immune complex formation and eosinophils in the presence of fusion-inhibiting antibody., Nat Med, 5(6), 629-34, June 1999 Abstract
  • Piyasirisilp S, Schmeckpeper BJ, Chandanayingyong D, Hemachudha T, Griffin DE, Association of HLA and T-cell receptor gene polymorphisms with Semple rabies vaccine-induced autoimmune encephalomyelitis., Annals of Neurology, 45(5), 595-600, May 1999 Abstract
  • Griffin DE, Hardwick JM, Perspective: virus infections and the death of neurons., Trends in Microbiology, 7(4), 155-60, April 1999 Abstract
  • Imani F, Proud D, Griffin D E, Measles virus infection synergizes with IL-4 in IgE class switching, JOURNAL OF IMMUNOLOGY, 162(3), 1597-602, 1 1999 Abstract
  • Rowell J F, Griffin D E, The inflammatory response to nonfatal Sindbis virus infection of the nervous system is more severe in SJL than in BALB c mice and is associated with low levels of IL-4 mRNA and high levels of IL-10-pr, JOURNAL OF IMMUNOLOGY, 162(3), 1624-32, 1 1999 Abstract
  • Imani F, Proud D, Griffin DE, Measles virus infection synergizes with IL-4 in IgE class switching., Journal of Immunology, 162(3), 1597-602, 1 Feb 1999 Abstract
  • Rowell JF, Griffin DE, The inflammatory response to nonfatal Sindbis virus infection of the nervous system is more severe in SJL than in BALB/c mice and is associated with low levels of IL-4 mRNA and high levels of IL-10-pr, Journal of Immunology, 162(3), 1624-32, 1 Feb 1999 Abstract
  • Kelder W, McArthur J C, Nance-Sproson T, McClernon D, Griffin D E, Beta-chemokines MCP-1 and RANTES are selectively increased in cerebrospinal fluid of patients with human immunodeficiency virus-associated dementia, ANNALS OF NEUROLOGY, 44(5), 831-5, 1998 Abstract
  • Valsamakis A, Schneider H, Auwaerter P G, Kaneshima H, Billeter M A, Griffin D E, Recombinant measles viruses with mutations in the C, V, or F gene have altered growth phenotypes in vivo., Journal of Virology, 72(10), 7754-61, October 1998 Abstract
  • Griffin D E, A review of alphavirus replication in neurons, NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 22(6), 721-3, 1998 Abstract
  • Griffin DE, A review of alphavirus replication in neurons., Neuroscience and Biobehavioral Reviews, 22(6), 721-3, October 1998 Abstract
  • Park S W, Royal W 3rd, Semba R D, Wiegand G W, Griffin D E, Expression of adhesion molecules and CD28 on T lymphocytes during human immunodeficiency virus infection, CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 5(4), 583-7, 1998 Abstract
  • Clem R J, Cheng E H, Karp C L, Kirsch D G, Ueno K, Takahashi A, Kastan M B, Griffin D E, Earnshaw W C, Veliuona M A, Hardwick J M, Modulation of cell death by Bcl-XL through caspase interaction, Proceedings of the National Academy of Sciences (USA), 95(2), 554-9, 20 1998 Abstract
  • Griffin D E, Cytokines in the brain during viral infection: clues to HIV-associated dementia, JOURNAL OF CLINICAL INVESTIGATION, 100(12), 2948-51, 15 1997 Abstract
  • Griffin DE, Cytokines in the brain during viral infection: clues to HIV-associated dementia., Journal of Clinical Investigation, 100(12), 2948-51, 15 Dec 1997 Abstract
  • Griffin D, Levine B, Tyor W, Ubol S, Despres P, The role of antibody in recovery from alphavirus encephalitis, IMMUNOLOGICAL REVIEWS, 159(0105-2896), 155-61, 1997 Abstract
  • Dropulic L K, Hardwick J M, Griffin D E, A single amino acid change in the E2 glycoprotein of Sindbis virus confers neurovirulence by altering an early step of virus replication, JOURNAL OF VIROLOGY, 71(8), 6100-5, 1997 Abstract
  • Tucker P C, Lee S H, Bui N, Martinie D, Griffin D E, Amino acid changes in the Sindbis virus E2 glycoprotein that increase neurovirulence improve entry into neuroblastoma cells, JOURNAL OF VIROLOGY, 71(8), 6106-12, 1997 Abstract
  • Gorrell M D, Lemm J A, Rice C M, Griffin D E, Immunization with nonstructural proteins promotes functional recovery of alphavirus-infected neurons, JOURNAL OF VIROLOGY, 71(5), 3415-9, 1997 Abstract
  • McGuinness MC, Powers JM, Bias WB, Schmeckpeper BJ, Segal AH, Gowda VC, Wesselingh SL, Berger J, Griffin DE, Smith KD, Human leukocyte antigens and cytokine expression in cerebral inflammatory demyelinative lesions of X-linked adrenoleukodystrophy and multiple sclerosis., Journal of Neuroimmunology, 75(1-2), 174-82, 1997 Abstract
  • Wesselingh SL, Takahashi K, Glass JD, McArthur JC, Griffin JW, Griffin DE, Cellular localization of tumor necrosis factor mRNA in neurological tissue from HIV-infected patients by combined reverse transcriptase/polymerase chain reaction in situ hybridization and immunohistoc, Journal of Neuroimmunology, 74(1-2), 1-8, 1997 Abstract
  • Irani D N, Lin K I, Griffin D E, Regulation of brain-derived T cells during acute central nervous system inflammation, JOURNAL OF IMMUNOLOGY, 158(5), 2318-26, 1 1997 Abstract
  • Griffin D E, Hardwick J M, Regulators of apoptosis on the road to persistent alphavirus infection, ANNUAL REVIEW OF MICROBIOLOGY, 51(0066-4227), 565-92, 1997 Abstract
  • Irani D N, Lin K I, Griffin D E, Brain-derived gangliosides regulate the cytokine production and proliferation of activated T cells, JOURNAL OF IMMUNOLOGY, 157(10), 4333-40, 15 1996 Abstract
  • Kuhn R J, Griffin D E, Owen K E, Niesters H G, Strauss J H, Chimeric Sindbis-Ross River viruses to study interactions between alphavirus nonstructural and structural regions., Journal of Virology, 70(11), 7900-9, November 1996 Abstract
  • Karp C L, Wysocka M, Wahl L M, Ahearn J M, Cuomo P J, Sherry B, Trinchieri G, Griffin D E, Mechanism of suppression of cell-mediated immunity by measles virus published erratum appears in Science 1997 Feb 21;275(5303):1053, SCIENCE, 273(5272), 228-31, 12 1996 Abstract
  • Hussey G D, Goddard E A, Hughes J, Ryon J J, Kerran M, Carelse E, Strebel P M, Markowitz L E, Moodie J, Barron P, Latief Z, Sayed R, Beatty D, Griffin D E, The effect of Edmonston-Zagreb and Schwarz measles vaccines on immune response in infants., Journal of Infectious Diseases, 173(6), 1320-6, June 1996 Abstract
  • Takahashi K, Wesselingh S L, Griffin D E, McArthur J C, Johnson R T, Glass J D, Localization of HIV-1 in human brain using polymerase chain reaction in situ hybridization and immunocytochemistry, ANNALS OF NEUROLOGY, 39(6), 705-11, 1996 Abstract
  • Tucker P C, Griffin D E, Choi S, Bui N, Wesselingh S, Inhibition of nitric oxide synthesis increases mortality in Sindbis virus encephalitis, JOURNAL OF VIROLOGY, 70(6), 3972-7, 1996 Abstract
  • Auwaerter P G, Kaneshima H, McCune J M, Wiegand G, Griffin D E, Measles virus infection of thymic epithelium in the SCID-hu mouse leads to thymocyte apoptosis, JOURNAL OF VIROLOGY, 70(6), 3734-40, 1996 Abstract
  • Irani D N, Griffin D E, Regulation of lymphocyte homing into the brain during viral encephalitis at various stages of infection, JOURNAL OF IMMUNOLOGY, 156(10), 3850-7, 15 1996 Abstract
  • Levine B, Goldman J E, Jiang H H, Griffin D E, Hardwick J M, Bc1-2 protects mice against fatal alphavirus encephalitis, Proceedings of the National Academy of Sciences (USA), 93(10), 4810-5, 14 1996 Abstract
  • Mokhtarian F, Wesselingh S L, Choi S, Maeda A, Griffin D E, Sobel R A, Grob D, Production and role of cytokines in the CNS of mice with acute viral encephalomyelitis, JOURNAL OF NEUROIMMUNOLOGY, 66(1-2), 11-22, 1996 Abstract
  • Auwaerter P G, Hussey G D, Goddard E A, Hughes J, Ryon J J, Strebel P M, Beatty D, Griffin D E, Changes within T cell receptor V beta subsets in infants following measles vaccination, CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 79(2), 163-70, 1996 Abstract
  • Ubol S, Park S, Budihardjo I, Desnoyers S, Montrose M H, Poirier G G, Kaufmann S H, Griffin D E, Temporal changes in chromatin, intracellular calcium, and poly(ADP-ribose) polymerase during Sindbis virus-induced apoptosis of neuroblastoma cells, JOURNAL OF VIROLOGY, 70(4), 2215-20, 1996 Abstract
  • Lewis J, Wesselingh S L, Griffin D E, Hardwick J M, Alphavirus-induced apoptosis in mouse brains correlates with neurovirulence, JOURNAL OF VIROLOGY, 70(3), 1828-35, 1996 Abstract
  • Despres P, Griffin J W, Griffin D E, Effects of anti-E2 monoclonal antibody on sindbis virus replication in AT3 cells expressing bcl-2, JOURNAL OF VIROLOGY, 69(11), 7006-14, 1995 Abstract
  • Esolen L M, Takahashi K, Johnson R T, Vaisberg A, Moench T R, Wesselingh S L, Griffin D E, Brain endothelial cell infection in children with acute fatal measles, JOURNAL OF CLINICAL INVESTIGATION, 96(5), 2478-81, 1995 Abstract
  • Despres P, Griffin J W, Griffin D E, Antiviral activity of alpha interferon in Sindbis virus-infected cells is restored by anti-E2 monoclonal antibody treatment, JOURNAL OF VIROLOGY, 69(11), 7345-8, 1995 Abstract
  • Despres P, Griffin JW, Griffin DE, Effects of anti-E2 monoclonal antibody on sindbis virus replication in AT3 cells expressing bcl-2., Journal of Virology, 69(11), 7006-14, November 1995 Abstract
  • Hendrix C W, Petty B G, Woods A, Kuwahara S K, Witter F R, Soo W, Griffin D E, Lietman P S, Modulation of alpha-interferon's antiviral and clinical effects by aspirin, acetaminophen, and prednisone in healthy volunteers, ANTIVIRAL RESEARCH, 28(2), 121-31, 1995 Abstract
  • McGuinness M C, Griffin D E, Raymond G V, Washington C A, Moser H W, Smith K D, Tumor necrosis factor-alpha and X-linked adrenoleukodystrophy., Journal of Neuroimmunology, 61(2), 161-9, September 1995 Abstract
  • Elfont R M, Griffin D E, Goldstein G W, Enhanced endothelial cell adhesion of human cerebrospinal fluid lymphocytes, ANNALS OF NEUROLOGY, 38(3), 405-13, 1995 Abstract
  • Tyor W R, Wesselingh S L, Griffin J W, McArthur J C, Griffin D E, Unifying hypothesis for the pathogenesis of HIV-associated dementia complex, vacuolar myelopathy, and sensory neuropathy, JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY, 9(4), 379-88, 1 1995 Abstract
  • Esolen L M, Park S W, Hardwick J M, Griffin D E, Apoptosis as a cause of death in measles virus-infected cells, JOURNAL OF VIROLOGY, 69(6), 3955-8, 1995 Abstract
  • Ubol S, Levine B, Lee S H, Greenspan N S, Griffin D E, Roles of immunoglobulin valency and the heavy-chain constant domain in antibody-mediated downregulation of Sindbis virus replication in persistently infected neurons, JOURNAL OF VIROLOGY, 69(3), 1990-3, 1995 Abstract
  • Griffin D E, Immune responses during measles virus infection, CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY, 191(0070-217X), 117-34, 1995 Abstract
  • Griffin D E, Arboviruses and the central nervous system, SPRINGER SEMINARS IN IMMUNOPATHOLOGY, 17(2-3), 121-32, 1995 Abstract
  • Power C, McArthur J C, Johnson R T, Griffin D E, Glass J D, Dewey R, Chesebro B, Distinct HIV-1 env sequences are associated with neurotropism and neurovirulence, CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY, 202(0070-217X), 89-104, 1995 Abstract
  • Griffin D E, The Gordon Wilson lecture: unique interactions between viruses, neurons and the immune system, TRANSACTIONS OF THE AMERICAN CLINICAL AND CLIMATOLOGICAL ASSOCIATION, 107(0065-7778), 89-98, 1995 Abstract
  • Griffin D E, Ward B J, Esolen L M, Pathogenesis of measles virus infection: an hypothesis for altered immune responses, JOURNAL OF INFECTIOUS DISEASES, 170 Suppl 1(0022-1899), S24-31, 1994 Abstract
  • Power C, McArthur J C, Johnson R T, Griffin D E, Glass J D, Perryman S, Chesebro B, Demented and nondemented patients with AIDS differ in brain-derived human immunodeficiency virus type 1 envelope sequences, JOURNAL OF VIROLOGY, 68(7), 4643-49, 1994 Abstract
  • Ubol S, Tucker P C, Griffin D E, Hardwick J M, Neurovirulent strains of Alphavirus induce apoptosis in bcl-2-expressing cells: role of a single amino acid change in the E2 glycoprotein, Proceedings of the National Academy of Sciences (USA), 91(11), 5202-6, 24 1994 Abstract
  • Griffin D E, Wesselingh S L, McArthur J C, Elevated central nervous system prostaglandins in human immunodeficiency virus-associated dementia, ANNALS OF NEUROLOGY, 35(5), 592-7, 1994 Abstract
  • Wesselingh S L, Levine B, Fox R J, Choi S, Griffin D E, Intracerebral cytokine mRNA expression during fatal and nonfatal alphavirus encephalitis suggests a predominant type 2 T cell response, JOURNAL OF IMMUNOLOGY, 152(3), 1289-97, 1 1994 Abstract
  • Levine B, Hardwick J M, Griffin D E, Persistence of alphaviruses in vertebrate hosts, TRENDS IN MICROBIOLOGY, 2(1), 25-8, 1994 Abstract
  • Griffin J W, Wesselingh S L, Griffin D E, Glass J D, McArthur J C, Peripheral nerve disorders in HIV infection Similarities and contrasts with CNS disorders, RESEARCH PUBLICATIONS - ASSOCIATION FOR RESEARCH IN NERVOUS AND MENTAL DISEASE, 72(0091-7443), 159-82, 1994 Abstract
  • Wesselingh S L, Glass J, McArthur J C, Griffin J W, Griffin D E, Cytokine dysregulation in HIV-associated neurological disease, ADVANCES IN NEUROIMMUNOLOGY, 4(3), 199-206, 1994 Abstract
  • Griffin D E, Levine B, Tyor W R, Tucker P C, Hardwick J M, Age-dependent susceptibility to fatal encephalitis: alphavirus infection of neurons, ARCHIVES OF VIROLOGY. SUPPLEMENTUM, 9(0939-1983), 31-9, 1994 Abstract
  • Griffin D E, Levine B, Ubol S, Hardwick J M, The effects of alphavirus infection on neurons, ANNALS OF NEUROLOGY, 35 Suppl(0364-5134), S23-7, 1994 Abstract
  • Levine B, Griffin D E, Molecular analysis of neurovirulent strains of Sindbis virus that evolve during persistent infection of scid mice, JOURNAL OF VIROLOGY, 67(11), 6872-5, 1993 Abstract
  • Tyor W R, Griffin D E, Virus specificity and isotype expression of intraparenchymal antibody-secreting cells during Sindbis virus encephalitis in mice, JOURNAL OF NEUROIMMUNOLOGY, 48(1), 37-44, 1993 Abstract
  • Griffin D E, Ward B J, Differential CD4 T cell activation in measles, JOURNAL OF INFECTIOUS DISEASES, 168(2), 275-81, 1993 Abstract
  • Tucker P C, Strauss E G, Kuhn R J, Strauss J H, Griffin D E, Viral determinants of age-dependent virulence of Sindbis virus for mice, JOURNAL OF VIROLOGY, 67(8), 4605-10, 1993 Abstract
  • Esolen L M, Ward B J, Moench T R, Griffin D E, Infection of monocytes during measles, JOURNAL OF INFECTIOUS DISEASES, 168(1), 47-52, 1993 Abstract
  • Wesselingh S L, Power C, Glass J D, Tyor W R, McArthur J C, Farber J M, Griffin J W, Griffin D E, Intracerebral cytokine messenger RNA expression in acquired immunodeficiency syndrome dementia, ANNALS OF NEUROLOGY, 33(6), 576-82, 1993 Abstract
  • Ward B J, Griffin D E, Changes in cytokine production after measles virus vaccination: predominant production of IL-4 suggests induction of a Th2 response, CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 67(2), 171-7, 1993 Abstract
  • Levine B, Huang Q, Isaacs J T, Reed J C, Griffin D E, Hardwick J M, Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene, NATURE, 361(6414), 739-42, 25 1993 Abstract
  • Semba R D, Muhilal, Ward B J, Griffin D E, Scott A L, Natadisastra G, West K P Jr, Sommer A, Abnormal T-cell subset proportions in vitamin-A-deficient children [see comments], Lancet, 341(8836), 5-8, 2 Jan 1993 Abstract
  • Tyor W R, Wesselingh S, Levine B, Griffin D E, Long term intraparenchymal Ig secretion after acute viral encephalitis in mice, JOURNAL OF IMMUNOLOGY, 149(12), 4016-20, 15 1992 Abstract
  • Kuhn R J, Griffin D E, Zhang H, Niesters H G, Strauss J H, Attenuation of Sindbis virus neurovirulence by using defined mutations in nontranslated regions of the genome RNA., Journal of Virology, 66(12), 7121-7, December 1992 Abstract
  • Levine B, Griffin D E, Persistence of viral RNA in mouse brains after recovery from acute alphavirus encephalitis, JOURNAL OF VIROLOGY, 66(11), 6429-35, 1992 Abstract
  • Griffin D E, Ward B J, Juaregui E, Johnson R T, Vaisberg A, Immune activation during measles: beta 2-microglobulin in plasma and cerebrospinal fluid in complicated and uncomplicated disease, JOURNAL OF INFECTIOUS DISEASES, 166(5), 1170-3, 1992 Abstract
  • McArthur J C, Nance-Sproson T E, Griffin D E, Hoover D, Selnes O A, Miller E N, Margolick J B, Cohen B A, Farzadegan H, Saah A, The diagnostic utility of elevation in cerebrospinal fluid beta 2-microglobulin in HIV-1 dementia. Multicenter AIDS Cohort Study., Neurology, 42(9), 1707-12, September 1992 Abstract
  • Griffin D E, Levine B, Tyor W R, Irani D N, The immune response in viral encephalitis, SEMINARS IN IMMUNOLOGY, 4(2), 111-9, 1992 Abstract
  • Tyor W R, Glass J D, Griffin J W, Becker P S, McArthur J C, Bezman L, Griffin D E, Cytokine expression in the brain during the acquired immunodeficiency syndrome, ANNALS OF NEUROLOGY, 31(4), 349-60, 1992 Abstract
  • Ubol S, Griffin D E, Identification of a putative alphavirus receptor on mouse neural cells., Journal of Virology, 65(12), 6913-21, December 1991 Abstract
  • Levine B, Hardwick J M, Trapp B D, Crawford T O, Bollinger R C, Griffin D E, Antibody-mediated clearance of alphavirus infection from neurons, SCIENCE, 254(5033), 856-60, 8 1991 Abstract
  • Ward B J, Johnson R T, Vaisberg A, Jauregui E, Griffin D E, Cytokine production in vitro and the lymphoproliferative defect of natural measles virus infection, CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 61(2 Pt 1), 236-48, 1991 Abstract
  • Irani D N, Griffin D E, Isolation of brain parenchymal lymphocytes for flow cytometric analysis Application to acute viral encephalitis, JOURNAL OF IMMUNOLOGICAL METHODS, 139(2), 223-31, 3 1991 Abstract
  • Tucker P C, Griffin D E, Mechanism of altered Sindbis virus neurovirulence associated with a single-amino-acid change in the E2 Glycoprotein, JOURNAL OF VIROLOGY, 65(3), 1551-7, 1991 Abstract
  • Chesebro B, Wehrly K, Metcalf J, Griffin D E, Use of a new CD4-positive HeLa cell clone for direct quantitation of infectious human immunodeficiency virus from blood cells of AIDS patients., Journal of Infectious Diseases, 163(1), 64-70, January 1991 Abstract
  • Griffin D E, Therapy of viral infections of the central nervous system, ANTIVIRAL RESEARCH, 15(1), 1-10, 1991 Abstract
  • Griffin D E, Immunologic abnormalities accompanying acute and chronic viral infections, REVIEWS OF INFECTIOUS DISEASES, 13 Suppl 1(0162-0886), S129-33, 1991 Abstract
  • Griffin D E, McArthur J C, Cornblath D R, Neopterin and interferon-gamma in serum and cerebrospinal fluid of patients with HIV-associated neurologic disease, NEUROLOGY, 41(1), 69-74, 1991 Abstract
  • Griffin D E, Ward B J, Jauregui E, Johnson R T, Vaisberg A, Natural killer cell activity during measles, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 81(2), 218-24, 1990 Abstract
  • Chaisson R E, Griffin D E, Progressive multifocal leukoencephalopathy in AIDS clinical conference, JAMA, 264(1), 79-82, 4 1990 Abstract
  • Griffin D E, McArthur J C, Cornblath D R, Soluble interleukin-2 receptor and soluble CD8 in serum and cerebrospinal fluid during human immunodeficiency virus-associated neurologic disease, JOURNAL OF NEUROIMMUNOLOGY, 28(2), 97-109, 1990 Abstract
  • McArthur J C, Griffin J W, Cornblath D R, Griffin D E, Tesoriero T, Kuncl R, Gibbs C J, Farzadegan H, Johnson R T, Steroid-responsive myeloneuropathy in a man dually infected with HIV-1 and HTLV-I., Neurology, 40(6), 938-44, June 1990 Abstract
  • Sherman L A, Griffin D E, Pathogenesis of encephalitis induced in newborn mice by virulent and avirulent strains of Sindbis virus, JOURNAL OF VIROLOGY, 64(5), 2041-6, 1990 Abstract
  • Ward B J, Johnson R T, Vaisberg A, Jauregui E, Griffin D E, Spontaneous proliferation of peripheral mononuclear cells in natural measles virus infection: identification of dividing cells and correlation with mitogen responsiveness, CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 55(2), 315-26, 1990 Abstract
  • Griffin D E, Ward B J, Jauregui E, Johnson R T, Vaisberg A, Immune activation during measles: interferon-gamma and neopterin in plasma and cerebrospinal fluid in complicated and uncomplicated disease, JOURNAL OF INFECTIOUS DISEASES, 161(3), 449-53, 1990 Abstract
  • Ubol S, Hemachudha T, Whitaker J N, Griffin D E, Antibody to peptides of human myelin basic protein in post-rabies vaccine encephalomyelitis sera, JOURNAL OF NEUROIMMUNOLOGY, 26(2), 107-11, 1990 Abstract
  • Cornblath D R, Griffin D E, Welch D, Griffin J W, McArthur J C, Quantitative analysis of endoneurial T-cells in human sural nerve biopsies, JOURNAL OF NEUROIMMUNOLOGY, 26(2), 113-8, 1990 Abstract
  • Tyor W R, Stoll G, Griffin D E, The characterization of Ia expression during Sindbis virus encephalitis in normal and athymic nude mice, JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 49(1), 21-30, 1990 Abstract
  • Griffin D E, Monophasic autoimmune inflammatory diseases of the CNS and PNS, RESEARCH PUBLICATIONS - ASSOCIATION FOR RESEARCH IN NERVOUS AND MENTAL DISEASE, 68(0091-7443), 91-104, 1990 Abstract
  • Tyor W R, Moench T R, Griffin D E, Characterization of the local and systemic B cell response of normal and athymic nude mice with Sindbis virus encephalitis., Journal of Neuroimmunology, 24(3), 207-15, October 1989 Abstract
  • McArthur J C, Sipos E, Cornblath D R, Welch D, Chupp M, Griffin D E, Johnson R T, Identification of mononuclear cells in CSF of patients with HIV infection., Neurology, 39(1), 66-70, January 1989 Abstract
  • Griffin D E, Molecular pathogenesis of Sindbis virus encephalitis in experimental animals., Advances In Virus Research, 36, 255-71, 1989 Abstract

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Last Updated: 4/15/2005

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