Dr. John C. Hackman

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University of Miami
School of Medicine
Neurology
ProfessorAppointed: 1995
University of Miami
Interdepartmental Neurosciences Program
Graduate Faculty MemberAppointed: 1987
VA Medical Center
Miami, Fl
Medical Research
Research PhysiologistAppointed: 1978

Mailing Address

P.O. Box 16960
University of Miami
School of Medicine
Department of Neurology (D4-5)
Miami, Florida 33101
United States

Contact Information

Phone: (305) 243-6228
Fax: (305) 545-7166
jhackman@med.miami.edu

Qualifications

Ph.D., University of Miami, Biology, 1979.
M.S., University of Miami, Biology, 1976.
B.S., University of Miami, Biology, 1969.

Expertise and Research Interests

My research involves use of intracellular and extracellular electrophysiological techniques to study the neurophysiology and neuropharmacology of spinal cord function. Recent interest has been on the interaction of catecholamine and indolamine neurotransmitters with the excitatory amino acid transmitters on the motoneuron. Other studies have investigated the interaction of transmitters and modulators with gamma aminobutyric acid (GABA) at afferent terminals. The laboratory has begun investigating the biophysical and pharmacological properties of GABA receptors located on human adult and embryonic dorsal root ganglion cells.

Keywords

COS Keywords:

Amino Acids, Central Nervous System, Electrophysiology, Nervous System, Neurology, Neuropharmacology, Neurotransmitters, Specialties of Medical and Allied Fields.

Additional Terms:

Amino Acid, Antispastic Drug, Catacholamine, Excitatory Amino Acids, Extracellular, GABA, Gamma Aminobutyric Acid, Indolamine, Intracellular Electrophysiology, Nervous System, Neuropharmacology, Neurotransmitter Action, Nmda, Potassium Ion, Serotonin, Spinal Cord, Vertebrate.

Memberships

American Association for Laboratory Animal Science
American Association for the Advancement of Science
American Physiological Society
American Society for Pharmacology and Experimental Therapeutics
New York Academy of Sciences
Scientists Center for Animal Welfare
Society for Neuroscience
Southeastern Pharmacological Society

Previous Positions

1987-1995, University of Miami School of Medicine, Associate Professor of Neurology and Pharmacology
1982-1987, Department of Neurology, University of Miami School of Medicine, Assistant Professor
1980-1982, Department of Neurology, University of Miami School of Medicine, Research Assistant Professor
1979-1980, Department of Neurology, University of Miami School of Medicine, Adjunct Assistant Professor

Funding Received

  • National Institutes of Health (NIH): Human GABA receptors, 175,000, Jun 1, 2002 to 2004.
  • Department of Veterans Affairs: Mechanisms of 5-HT2 modulation of NMDA responses in the spinal cord, 267,000, 2007 to 2011.

Publications

  • Holohean AM, Hackman JC, Mechanisms Intrinsic to 5-HT2B Receptor-induced Potentiation of NMDA Receptor Responses in Frog Motoneurones., British Journal of Pharmacology, 143(3), 351-60, Oct 2004 Abstract
  • Maddox FN, Valeyev AY, Poth K, Holohean AM, Wood PM, Davidoff RA, Hackman JC, Luetje CW, GABAA receptor subunit mRNA expression in cultured embryonic and adult human dorsal root ganglion neurons, Brain Research. Developmental Brain Research, 149(2), 143-51, April 2004 Abstract
  • Valeyev AY, Hackman JC, Holohean AM, Wood PM, Davidoff RA, Pentobarbital-activated Cl(-) channels in cultured adult and embryonic human DRG neurons, Brain Research. Developmental Brain Research, 124(1-2), 137-40, November 2000 Abstract
  • Valeyev AY, Hackman JC, Holohean AM, Wood PM, Katz JL, Davidoff RA, GABA-Induced Cl- current in cultured embryonic human dorsal root ganglion neurons, Journal of Neurophysiology, 82(1), 1-9, July 1999 Abstract
  • Valeyev AY, Hackman JC, Holohean AM, Wood PM, Katz JL, Davidoff RA, Alphaxalone activates a Cl- conductance independent of GABAA receptors in cultured embryonic human dorsal root ganglion neurons, Journal of Neurophysiology, 82(1), 10-5, July 1999 Abstract
  • Valeyev AY, Hackman JC, Holohean AM, Wood PM, Katz JL, Davidoff RA, GABA-Induced Cl- current in cultured embryonic human dorsal root ganglion neurons., Journal of Neurophysiology, 82(1), 1-9, July 1999 Abstract
  • Valeyev AY, Hackman JC, Holohean AM, Wood PM, Katz JL, Davidoff RA, Alphaxalone activates a Cl- conductance independent of GABAA receptors in cultured embryonic human dorsal root ganglion neurons., Journal of Neurophysiology, 82(1), 10-5, July 1999 Abstract
  • Holohean AM, Hackman JC, Davidoff RA, Mechanisms involved in the metabotropic glutamate receptor-enhancement of NMDA-mediated motoneurone responses in frog spinal cord, British Journal of Pharmacology, 126(1), 333-41, Jan 1999 Abstract
  • Hackman JC, Holohean AM, Davidoff RA, Role of metabotropic glutamate receptors in the depression of GABA-mediated depolarization of frog primary afferent terminals, Neuroscience, 81(4), 1079-90, December 1997 Abstract
  • Valeyev AY, Hackman JC, Wood PM, Davidoff RA, Pharmacologically novel GABA receptor in human dorsal root ganglion neurons, Journal of Neurophysiology, 76(5), 3555-8, November 1996 Abstract
  • Holohean AM, Rodriguez CA, Hackman JC, Davidoff RA, Voltage-gated calcium currents in whole-cell patch-clamped bullfrog dorsal root ganglion cells: effects of cell size and intracellular solutions, Brain Research, 711(1-2), 138-45, March 1996 Abstract
  • Holohean AM, Hackman JC, Davidoff RA, Modulation of frog spinal cord interneuronal activity by activation of 5-HT3 receptors, Brain Research, 704(2), 184-90, December 1995 Abstract
  • Dalo NL, Hackman JC, Storey K, Davidoff RA, Changes in motoneuron membrane potential and reflex activity induced by sudden cooling of isolated spinal cords: differences among cold-sensitive, cold-resistant and freeze-tolerant amphibian species, Journal of Experimental Biology, 198 ( Pt 8), 1765-74, August 1995 Abstract
  • Mash DC, Staley JK, Pablo JP, Holohean AM, Hackman JC, Davidoff RA, Properties of ibogaine and its principal metabolite (12-hydroxyibogamine) at the MK-801 binding site of the NMDA receptor complex, Neuroscience Letters, 192(1), 53-6, June 1995 Abstract
  • Shope SB, Hackman JC, Holohean AM, Davidoff RA, Activation of alpha-adrenoceptors indirectly facilitates sodium pumping in frog motoneurons, Brain Research, 630(1-2), 207-13, December 1993 Abstract
  • Holohean AM, Hackman JC, Shope SB, Davidoff RA, Activation of 5-HT1C/2 receptors depresses polysynaptic reflexes and excitatory amino acid-induced motoneuron responses in frog spinal cord, Brain Research, 579(1), 8-16, May 1992 Abstract
  • Holohean AM, Hackman JC, Shope SB, Davidoff RA, Serotonin1A facilitation of frog motoneuron responses to afferent stimuli and to N-methyl-D-aspartate, Neuroscience, 48(2), 469-77, 1992 Abstract
  • Davidoff RA, Hackman JC, Aspects of spinal cord structure and reflex function, Neurologic Clinics, 9(3), 533-50, August 1991 Abstract
  • Hackman JC, Davidoff RA, Dorsal root potentials in the isolated frog spinal cord: amino acid neurotransmitters and magnesium ions, Neuroscience, 41(1), 61-9, 1991 Abstract
  • Gharagozloo A, Holohean AM, Hackman JC, Davidoff RA, Serotonin and GABA-induced depolarizations of frog primary afferent fibers, Brain Research, 532(1-2), 19-24, November 1990 Abstract
  • Holohean AM, Hackman JC, Davidoff RA, An in vitro study of the effects of serotonin on frog primary afferent terminals, Neuroscience Letters, 113(2), 175-80, May 1990 Abstract
  • Holohean AM, Hackman JC, Davidoff RA, Changes in membrane potential of frog motoneurons induced by activation of serotonin receptor subtypes, Neuroscience, 34(3), 555-64, 1990 Abstract
  • Zhang D X, Hackman J C, Davidoff R A, NMDA antagonists and potentiation of NMDA-induced motoneuron depolarizations in the isolated frog spinal cord., Brain Research, 493(1), 129-35, 24 Jul 1989 Abstract
  • Zhang D X, Hackman J C, Davidoff R A, Excitotoxicity, reflex responses, and evoked changes in extracellular potassium in the frog spinal cord., Comparative Biochemistry and Physiology. C: Comparative Pharmacology and Toxicology, 92(2), 205-10, 1989 Abstract
  • Dalo, N.L., Hackman, J.C. and Davidoff, R.A., Large depolarization and epiliptiform activity induced by rapid cooling of toad spinal cord, Comp. Biochem. Physiol., 112A:517-525, 1995

Profile Details

Last Verified: 8/23/2007

COS Expertise ID #210822
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