John M. Harlan

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University of Washington
School of Medicine
Pathology
Adjunct ProfessorAppointed: 1990
University of Washington
School of Medicine
Medicine
Hematology
ProfessorAppointed: 1989

Mailing Address

Box 357710
University of Washington
Seattle, Washington 98195-7710
United States

Contact Information

Phone: (206) 543-3360
Fax: (206) 543-3560
jharlan@u.washington.edu

Qualifications

M.D., University of Chicago, Pritzker School of Medicine, 1973.

Expertise and Research Interests

Endothelial cel biology, leukocygte and endothelial cell adhesion molecules, neutrophil apoptosis, macrophage apoptosis, endothelial cell apoptosis, hypoxia, ischemia-reperfusion, inflammation, acute lung injury, endothelial cell adhesion molecules, leukocyte adhesion molecules, integrin receptors.

Other Expertise

Editorial Boards:
Biotechnology Therapeutics (1990-1992);
J. Immunol (Associate Editor, 1988-1992);
Blood (1990-1995);
J Lab & Clin Med (1992-present);
J Clin Invest (1992-present);
Circulatory Shock (1993-present);
Cell Adhesion and Communication(1993-present).

Consultant to and Scientific Advisory Board member of several biotechnology companies.

Keywords

COS Keywords:

Apoptosis, Cardiovascular Biology, Cardiovascular System, Cell Biology, Cell Death, Gene Expression, Gene Regulation, Hematology, Immunobiology, Immunology, Inflammation, Macrophage, Pathology.

Additional Terms:

Adhesion, Adhesion Deficiency Syndrome, Anti-death Gene, Apoptosis, Blood, Blood Cell, Cardiovascular Biology, Cell Biology, Cell Death, Cell Interaction, Endothelial Cell, Gene, Gene Expression, Gene Regulation, Immunobiology, Immunology, Inflammation, Leukocyte, Macrophage, Neutrophil, Programmed Cell Death, Tissue Injury, Vascular Disease, Vascular Injury.

Memberships

American Association of Immunologists
American Association of Physicians
American Federation for Medical Research
American Heart Association
American Society for Cell Biology
American Society for Clinical Investigation
American Society of Hematology
Western Association of Physicians
Western Society for Clinical Investigation

Previous Positions

1987-1989, Adjunct Associate Professor, University of Washington, School of Medicine, Pathology
1984-1989, Associate Professor, University of Washington, Hematology
1979-1984, Assistant Professor, University of Washington, Hematology
1978-1979, University of Washington, Hematology, Instructor

Publications

  • Rochon YP, Kavanagh TJ, Harlan JM, Analysis of integrin \(CD11b/CD18\) movement during neutrophil adhesion and migration on endothelial cells., Journal of Microscopy, 197 \( Pt 1\), 15-24, 2000 Abstract
  • Bombeli T, Schwartz BR, Harlan JM, Endothelial cells undergoing apoptosis become proadhesive for nonactivated platelets., Blood, 93(11), 3831-8, 1 Jun 1999 Abstract
  • Stempien-Otero A, Karsan A, Cornejo CJ, Xiang H, Eunson T, Morrison RS, Kay M, Winn R, Harlan J, Mechanisms of hypoxia-induced endothelial cell death. Role of p53 in apoptosis., Journal of Biological Chemistry, 274(12), 8039-45, 19 Mar 1999 Abstract
  • Lorenzon P, Vecile E, Nardon E, Ferrero E, Harlan J M, Tedesco F, Dobrina A, Endothelial cell E- and P-selectin and vascular cell adhesion molecule-1 function as signaling receptors., Journal of Cell Biology, 142(5), 1381-91, 7 Sep 1998 Abstract
  • Heckbert S R, Vedder N B, Hoffman W, Winn R K, Hudson L D, Jurkovich G J, Copass M K, Harlan J M, Rice C L, Maier R V, Outcome after hemorrhagic shock in trauma patients., Journal of Trauma, 45(3), 545-9, September 1998 Abstract
  • Chuang P I, Yee E, Karsan A, Winn R K, Harlan J M, A1 is a constitutive and inducible Bcl-2 homologue in mature human neutrophils., Biochemical and Biophysical Research Communications, 249(2), 361-5, 19 Aug 1998 Abstract
  • Choi K B, Wong F, Harlan J M, Chaudhary P M, Hood L, Karsan A, Lipopolysaccharide mediates endothelial apoptosis by a FADD-dependent pathway., Journal of Biological Chemistry, 273(32), 20185-8, 7 Aug 1998 Abstract
  • Talbott G A, Sharar S R, Paulson J C, Harlan J M, Winn R K, Antibiotic therapy determines subcutaneous Escherichia coli abscess formation after CD18 inhibition in rabbits., Journal of Burn Care and Rehabilitation, 19(4), 284-91, July 1998 Abstract
  • Karsan A, Cornejo C J, Winn R K, Schwartz B R, Way W, Lannir N, Gershoni-Baruch R, Etzioni A, Ochs H D, Harlan J M, Leukocyte Adhesion Deficiency Type II is a generalized defect of de novo GDP-fucose biosynthesis. Endothelial cell fucosylation is not required for neutrophil rolling on human nonlymphoid endothelium., Journal of Clinical Investigation, 101(11), 2438-45, 1 Jun 1998 Abstract
  • Winn R, Vedder N, Ramamoorthy C, Sharar S, Harlan J, Endothelial and leukocyte adhesion molecules in inflammation and disease., Blood Coagulation and Fibrinolysis, 9 Suppl 2, S17-23, April 1998 Abstract
  • Bombeli T, Schwartz B R, Harlan J M, Adhesion of activated platelets to endothelial cells: evidence for a GPIIbIIIa-dependent bridging mechanism and novel roles for endothelial intercellular adhesion molecule 1 (ICAM-1), alphavbeta3 inte, Journal of Experimental Medicine, 187(3), 329-39, 2 Feb 1998 Abstract
  • Bombeli T, Schwartz BR, Harlan JM, Adhesion of activated platelets to endothelial cells: evidence for a GPIIbIIIa-dependent bridging mechanism and novel roles for endothelial intercellular adhesion molecule 1 \(ICAM-1\), alphavbeta3 in, Journal of Experimental Medicine, 187(3), 329-39, 2 1998 Abstract
  • Winn R K, Ramamoorthy C, Vedder N B, Sharar S R, Harlan J M, Leukocyte-endothelial cell interactions in ischemia-reperfusion injury., Annals of The New York Academy of Sciences, 832, 311-21, 15 Dec 1997 Abstract
  • Henderson W R Jr, Chi E Y, Albert R K, Chu S J, Lamm W J, Rochon Y, Jonas M, Christie P E, Harlan J M, Blockade of CD49d (alpha4 integrin) on intrapulmonary but not circulating leukocytes inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma., Journal of Clinical Investigation, 100(12), 3083-92, 15 Dec 1997 Abstract
  • Karsan A, Yee E, Poirier G G, Zhou P, Craig R, Harlan J M, Fibroblast growth factor-2 inhibits endothelial cell apoptosis by Bcl-2-dependent and independent mechanisms., American Journal of Pathology, 151(6), 1775-84, December 1997 Abstract
  • Chuang P I, Young B A, Thiagarajan R R, Cornejo C, Winn R K, Harlan J M, Cytoplasmic domain of E-selectin contains a non-tyrosine endocytosis signal., Journal of Biological Chemistry, 272(40), 24813-8, 3 Oct 1997 Abstract
  • Repo H, Rochon Y P, Schwartz B R, Sharar S R, Winn R K, Harlan J M, Binding of human peripheral blood polymorphonuclear leukocytes to E-selectin (CD62E) does not promote their activation., Journal of Immunology, 159(2), 943-51, 15 Jul 1997 Abstract
  • Thiagarajan R R, Winn R K, Harlan J M, The role of leukocyte and endothelial adhesion molecules in ischemia-reperfusion injury., Thrombosis and Haemostasis, 78(1), 310-4, July 1997 Abstract
  • Bombeli T, Karsan A, Tait J F, Harlan J M, Apoptotic vascular endothelial cells become procoagulant., Blood, 89(7), 2429-42, 1 Apr 1997 Abstract
  • Ramamoorthy C, Kovarik W D, Winn R K, Harlan J M, Sharar S R, Neutrophil adhesion molecule expression is comparable in perinatal rabbits and humans., Anesthesiology, 86(2), 420-7, February 1997 Abstract
  • Ramamoorthy C, Sasaki S S, Su D L, Sharar S R, Harlan J M, Winn R K, CD18 adhesion blockade decreases bacterial clearance and neutrophil recruitment after intrapulmonary E. coli, but not after S. aureus., Journal of Leukocyte Biology, 61(2), 167-72, February 1997 Abstract
  • Cornejo C J, Winn R K, Harlan J M, Anti-adhesion therapy., Advances In Pharmacology, 39, 99-142, 1997 Abstract
  • Ramamoorthy C, Sharar S R, Harlan J M, Tedder T F, Winn R K, Blocking L-selectin function attenuates reperfusion injury following hemorrhagic shock in rabbits., American Journal of Physiology, 271(5 Pt 2), H1871-7, November 1996 Abstract
  • Karsan A, Yee E, Harlan J M, Endothelial cell death induced by tumor necrosis factor-alpha is inhibited by the Bcl-2 family member, A1., Journal of Biological Chemistry, 271(44), 27201-4, 1 Nov 1996 Abstract
  • Sharar S R, Chapman N N, Flaherty L C, Harlan J M, Tedder T F, Winn R K, L-selectin (CD62L) blockade does not impair peritoneal neutrophil emigration or subcutaneous host defense to bacteria in rabbits., Journal of Immunology, 157(6), 2555-63, 15 Sep 1996 Abstract
  • Karsan A, Yee E, Kaushansky K, Harlan J M, Cloning of human Bcl-2 homologue: inflammatory cytokines induce human A1 in cultured endothelial cells., Blood, 87(8), 3089-96, 15 Apr 1996 Abstract
  • Seki J, Koyama N, Kovach N L, Yednock T, Clowes A W, Harlan J M, Regulation of beta1-integrin function in cultured human vascular smooth muscle cells., Circulation Research, 78(4), 596-605, April 1996 Abstract
  • Koyama N, Seki J, Vergel S, Mattsson E J, Yednock T, Kovach N L, Harlan J M, Clowes A W, Regulation and function of an activation-dependent epitope of the beta 1 integrins in vascular cells after balloon injury in baboon arteries and in vitro., American Journal of Pathology, 148(3), 749-61, March 1996 Abstract
  • Karsan A, Harlan J M, Modulation of endothelial cell apoptosis: mechanisms and pathophysiological roles., Journal of Atherosclerosis and Thrombosis, 3(2), 75-80, 1996 Abstract
  • Kling D, Fingerle J, Harlan J M, Lobb R R, Lang F, Mononuclear leukocytes invade rabbit arterial intima during thickening formation via CD18-and VLA-4-dependent mechanisms and stimulate smooth muscle migration., Circulation Research, 77(6), 1121-8, December 1995 Abstract
  • Phillips M L, Schwartz B R, Etzioni A, Bayer R, Ochs H D, Paulson J C, Harlan J M, Neutrophil adhesion in leukocyte adhesion deficiency syndrome type 2., Journal of Clinical Investigation, 96(6), 2898-906, December 1995 Abstract
  • Han K T, Sharar S R, Phillips M L, Harlan J M, Winn R K, Sialyl Lewis(x) oligosaccharide reduces ischemia-reperfusion injury in the rabbit ear., Journal of Immunology, 155(8), 4011-5, 15 Oct 1995 Abstract
  • McCarty J M, Yee E K, Deisher T A, Harlan J M, Kaushansky K, Interleukin-4 induces endothelial vascular cell adhesion molecule-1 (VCAM-1) by an NF-kappa b-independent mechanism., Febs Letters, 372(2-3), 194-8, 25 Sep 1995 Abstract
  • Winn R K, Sharar S R, Vedder N B, Harlan J M, Leukocyte and endothelial adhesion molecules in ischaemia/reperfusion injuries., Ciba Foundation Symposium, 189, 63-71; discussion 72, 1995 Abstract
  • Sharar S R, Winn R K, Harlan J M, The adhesion cascade and anti-adhesion therapy: an overview., Springer Seminars In Immunopathology, 16(4), 359-78, 1995 Abstract
  • Kovach N L, Lin N, Yednock T, Harlan J M, Broudy V C, Stem cell factor modulates avidity of alpha 4 beta 1 and alpha 5 beta 1 integrins expressed on hematopoietic cell lines., Blood, 85(1), 159-67, 1 Jan 1995 Abstract
  • Etzioni A, Phillips L M, Paulson J C, Harlan J M, Leukocyte adhesion deficiency (LAD) II., Ciba Foundation Symposium, 189, 51-8; discussion 58-, 1995 Abstract
  • Winn R K, Paulson J C, Harlan J M, A monoclonal antibody to P-selectin ameliorates injury associated with hemorrhagic shock in rabbits., American Journal of Physiology, 267(6 Pt 2), H2391-7, December 1994 Abstract
  • Talbott G A, Sharar S R, Harlan J M, Winn R K, Leukocyte-endothelial interactions and organ injury: the role of adhesion molecules., New Horizons, 2(4), 545-54, November 1994 Abstract
  • Mihelcic D, Schleiffenbaum B, Tedder T F, Sharar S R, Harlan J M, Winn R K, Inhibition of leukocyte L-selectin function with a monoclonal antibody attenuates reperfusion injury to the rabbit ear., Blood, 84(7), 2322-8, 1 Oct 1994 Abstract
  • Kovach N L, Lindgren C G, Fefer A, Thompson J A, Yednock T, Harlan J M, Pentoxifylline inhibits integrin-mediated adherence of interleukin-2- activated human peripheral blood lymphocytes to human umbilical vein endothelial cells, matrix components, and cultured tumor cell, Blood, 84(7), 2234-42, 1 Oct 1994 Abstract
  • Carlos T M, Harlan J M, Leukocyte-endothelial adhesion molecules., Blood, 84(7), 2068-101, 1 Oct 1994 Abstract
  • Price T H, Ochs H D, Gershoni-Baruch R, Harlan J M, Etzioni A, In vivo neutrophil and lymphocyte function studies in a patient with leukocyte adhesion deficiency type II., Blood, 84(5), 1635-9, 1 Sep 1994 Abstract
  • Sharar S R, Mihelcic D D, Han K T, Harlan J M, Winn R K, Ischemia reperfusion injury in the rabbit ear is reduced by both immediate and delayed CD18 leukocyte adherence blockade., Journal of Immunology, 153(5), 2234-8, 1 Sep 1994 Abstract
  • Bucky L P, Vedder N B, Hong H Z, Ehrlich H P, Winn R K, Harlan J M, May J W Jr, Reduction of burn injury by inhibiting CD18-mediated leukocyte adherence in rabbits., Plastic and Reconstructive Surgery, 93(7), 1473-80, June 1994 Abstract
  • Kuijpers T W, Raleigh M, Kavanagh T, Janssen H, Calafat J, Roos D, Harlan J M, Cytokine-activated endothelial cells internalize E-selectin into a lysosomal compartment of vesiculotubular shape. A tubulin-driven process., Journal of Immunology, 152(10), 5060-9, 15 May 1994 Abstract
  • Faull R J, Kovach N L, Harlan J M, Ginsberg M H, Stimulation of integrin-mediated adhesion of T lymphocytes and monocytes: two mechanisms with divergent biological consequences., Journal of Experimental Medicine, 179(4), 1307-16, 1 Apr 1994 Abstract
  • Schlossman S F, Boumsell L, Gilks W, Harlan J M, Kishimoto T, Morimoto C, Ritz J, Shaw S, Silverstein R L, Springer T A, et al, CD antigens 1993., Immunology Today, 15(3), 98-9, March 1994 Abstract
  • McFeely J, Embree L, Harlan J, Albert R, Adhesion to fibronectin augments tumor necrosis factor production by human alveolar macrophages., Chest, 105(3 Suppl), 100S-101S, March 1994 Abstract
  • Schlossman S F, Boumsell L, Gilks W, Harlan J M, Kishimoto T, Morimoto C, Ritz J, Shaw S, Silverstein R L, Springer T A, et al, CD antigens 1993., Blood, 83(4), 879-80, 15 Feb 1994 Abstract
  • Etzioni A, Gershoni-Baruch R, Harlan J M, Sialyl Lewis X and neutrophil aggregation [letter; comment], Blood, 83(3), 876-7, 1 Feb 1994 Abstract
  • Sasaki S S, Sharar S R, Harlan J M, Rice C L, Winn R K, Mild hemorrhagic shock does not enhance the risk of CD18 blockade to S. aureus skin inoculations., Journal of Applied Physiology, 76(1), 86-90, January 1994 Abstract
  • Schlossman S F, Boumsell L, Gilks W, Harlan J M, Kishimoto T, Morimoto C, Ritz J, Shaw S, Silverstein R L, Springer T A, et al, CD antigens 1993., Journal of Immunology, 152(1), 1-2, 1 Jan 1994 Abstract
  • Kuijpers T W, Harlan J M, Monocyte-endothelial interactions: insights and questions., Journal of Laboratory and Clinical Medicine, 122(6), 641-51, December 1993 Abstract
  • Sharar S R, Sasaki S S, Flaherty L C, Paulson J C, Harlan J M, Winn R K, P-selectin blockade does not impair leukocyte host defense against bacterial peritonitis and soft tissue infection in rabbits., Journal of Immunology, 151(9), 4982-8, 1 Nov 1993 Abstract
  • Deisher T A, Haddix T L, Montgomery K F, Pohlman T H, Kaushansky K, Harlan J M, The role of protein kinase C in the induction of VCAM-1 expression on human umbilical vein endothelial cells., Febs Letters, 331(3), 285-90, 4 Oct 1993 Abstract
  • Alpers C E, Hudkins K L, Davis C L, Marsh C L, Riches W, McCarty J M, Benjamin C D, Carlos T M, Harlan J M, Lobb R, Expression of vascular cell adhesion molecule-1 in kidney allograft rejection., Kidney International, 44(4), 805-16, October 1993 Abstract
  • Winn R K, Liggitt D, Vedder N B, Paulson J C, Harlan J M, Anti-P-selectin monoclonal antibody attenuates reperfusion injury to the rabbit ear., Journal of Clinical Investigation, 92(4), 2042-7, October 1993 Abstract
  • Winn R K, Harlan J M, CD18-independent neutrophil and mononuclear leukocyte emigration into the peritoneum of rabbits., Journal of Clinical Investigation, 92(3), 1168-73, September 1993 Abstract
  • Deisher T A, Kaushansky K, Harlan J M, Inhibitors of topoisomerase II prevent cytokine-induced expression of vascular cell adhesion molecule-1, while augmenting the expression of endothelial leukocyte adhesion molecule-1 on human umbilical, Cell Adhesion and Communication, 1(2), 133-42, September 1993 Abstract
  • Winn R K, Mihelicic D, Vedder N B, Sharar S R, Harlan J M, Monoclonal antibodies to leukocyte and endothelial adhesion molecules attenuate ischemia-reperfusion injury., Behring Institute Mitteilungen, 229-37, August 1993 Abstract
  • O'Brien K D, Allen M D, McDonald T O, Chait A, Harlan J M, Fishbein D, McCarty J, Ferguson M, Hudkins K, Benjamin C D, et al, Vascular cell adhesion molecule-1 is expressed in human coronary atherosclerotic plaques. Implications for the mode of progression of advanced coronary atherosclerosis [see comments], Journal of Clinical Investigation, 92(2), 945-51, August 1993 Abstract
  • Kuijpers T W, Mul E P, Blom M, Kovach N L, Gaeta F C, Tollefson V, Elices M J, Harlan J M, Freezing adhesion molecules in a state of high-avidity binding blocks eosinophil migration., Journal of Experimental Medicine, 178(1), 279-84, 1 Jul 1993 Abstract
  • Deisher T A, Sato T T, Pohlman T H, Harlan J M, A protein kinase C agonist, selective for the beta I isozyme, induces E-selectin and VCAM-1 expression on HUVEC but does not translocate PKC., Biochemical and Biophysical Research Communications, 193(3), 1283-90, 30 Jun 1993 Abstract
  • Harlan J M, Leukocyte adhesion deficiency syndrome: insights into the molecular basis of leukocyte emigration., Clinical Immunology and Immunopathology, 67(3 Pt 2), S16-24, June 1993 Abstract
  • von Andrian U H, Berger E M, Ramezani L, Chambers J D, Ochs H D, Harlan J M, Paulson J C, Etzioni A, Arfors K E, In vivo behavior of neutrophils from two patients with distinct inherited leukocyte adhesion deficiency syndromes., Journal of Clinical Investigation, 91(6), 2893-7, June 1993 Abstract
  • Langdale L A, Flaherty L C, Liggitt H D, Harlan J M, Rice C L, Winn R K, Neutrophils contribute to hepatic ischemia-reperfusion injury by a CD18-independent mechanism., Journal of Leukocyte Biology, 53(5), 511-7, May 1993 Abstract
  • Faull R J, Kovach N L, Harlan J M, Ginsberg M H, Affinity modulation of integrin alpha 5 beta 1: regulation of the functional response by soluble fibronectin., Journal of Cell Biology, 121(1), 155-62, April 1993 Abstract
  • Winn R K, Mileski W J, Kovach N L, Doerschuk C M, Rice C L, Harlan J M, Role of protein synthesis and CD11/CD18 adhesion complex in neutrophil emigration into the lung., Experimental Lung Research, 19(2), 221-35, Spring 1993 Abstract
  • Mileski W J, Raymond J F, Winn R K, Harlan J M, Rice C L, Inhibition of leukocyte adherence and aggregation for treatment of severe cold injury in rabbits., Journal of Applied Physiology, 74(3), 1432-6, March 1993 Abstract
  • Bacchi C E, Marsh C L, Perkins J D, Carithers R L Jr, McVicar J P, Hudkins K L, Benjamin C D, Harlan J M, Lobb R, Alpers C E, Expression of vascular cell adhesion molecule (VCAM-1) in liver and pancreas allograft rejection., American Journal of Pathology, 142(2), 579-91, February 1993 Abstract
  • Winn R K, Vedder N B, Mihelcic D, Flaherty L C, Langdale L, Harlan J M, The role of adhesion molecules in reperfusion injury., Agents and actions. Supplements, 41, 113-26, 1993 Abstract
  • Deisher T A, Garcia I, Harlan J M, Cytokine-induced adhesion molecule expression on human umbilical vein endothelial cells is not regulated by cyclic adenosine monophosphate accumulation., Life Sciences, 53(4), 365-70, 1993 Abstract
  • Etzioni A, Harlan J M, Pollack S, Phillips L M, Gershoni-Baruch R, Paulson J C, Leukocyte adhesion deficiency (LAD) II: a new adhesion defect due to absence of sialyl Lewis X, the ligand for selectins., Immunodeficiency, 4(1-4), 307-8, 1993 Abstract
  • Thomas J R, Harlan J M, Rice C L, Winn R K, Role of leukocyte CD11/CD18 complex in endotoxic and septic shock in rabbits., Journal of Applied Physiology, 73(4), 1510-6, October 1992 Abstract
  • Kling D, Fingerle J, Harlan J M, Inhibition of leukocyte extravasation with a monoclonal antibody to CD18 during formation of experimental intimal thickening in rabbit carotid arteries., Arteriosclerosis and Thrombosis, 12(9), 997-1007, September 1992 Abstract
  • Mileski W J, Winn R K, Harlan J M, Rice C L, Sensitivity to endotoxin in rabbits is increased after hemorrhagic shock., Journal of Applied Physiology, 73(3), 1146-9, September 1992 Abstract
  • Kuijpers T W, Hoogerwerf M, Kuijpers K C, Schwartz B R, Harlan J M, Cross-linking of sialophorin (CD43) induces neutrophil aggregation in a CD18-dependent and a CD18-independent way., Journal of Immunology, 149(3), 998-1003, 1 Aug 1992 Abstract
  • Bishop M J, Kowalski T F, Guidotti S M, Harlan J M, Antibody against neutrophil adhesion improves reperfusion and limits alveolar infiltrate following unilateral pulmonary artery occlusion., Journal of Surgical Research, 52(3), 199-204, March 1992 Abstract
  • Kovach N L, Carlos T M, Yee E, Harlan J M, A monoclonal antibody to beta 1 integrin (CD29) stimulates VLA-dependent adherence of leukocytes to human umbilical vein endothelial cells and matrix components., Journal of Cell Biology, 116(2), 499-509, January 1992 Abstract
  • Bevilacqua M, Butcher E, Furie B, Furie B, Gallatin M, Gimbrone M, Harlan J, Kishimoto K, Lasky L, McEver R, et al, Selectins: a family of adhesion receptors [letter], Cell, 67(2), 233, 18 Oct 1991 Abstract
  • Harlan J M, Vedder N B, Winn R K, Rice C L, Mechanisms and consequences of leukocyte-endothelial interaction., Western Journal of Medicine, 155(4), 365-9, October 1991 Abstract
  • Montgomery K F, Osborn L, Hession C, Tizard R, Goff D, Vassallo C, Tarr P I, Bomsztyk K, Lobb R, Harlan J M, et al, Activation of endothelial-leukocyte adhesion molecule 1 (ELAM-1) gene transcription., Proceedings of the National Academy of Sciences (USA), 88(15), 6523-7, 1 Aug 1991 Abstract
  • Sharar S R, Winn R K, Murry C E, Harlan J M, Rice C L, A CD18 monoclonal antibody increases the incidence and severity of subcutaneous abscess formation after high-dose Staphylococcus aureus injection in rabbits., Surgery, 110(2), 213-9; discussion 21, August 1991 Abstract
  • Dobrina A, Menegazzi R, Carlos T M, Nardon E, Cramer R, Zacchi T, Harlan J M, Patriarca P, Mechanisms of eosinophil adherence to cultured vascular endothelial cells. Eosinophils bind to the cytokine-induced ligand vascular cell adhesion molecule-1 via the very late activation antigen-4 inte, Journal of Clinical Investigation, 88(1), 20-6, July 1991 Abstract
  • Carlos T, Kovach N, Schwartz B, Rosa M, Newman B, Wayner E, Benjamin C, Osborn L, Lobb R, Harlan J, Human monocytes bind to two cytokine-induced adhesive ligands on cultured human endothelial cells: endothelial-leukocyte adhesion molecule-1 and vascular cell adhesion molecule-1., Blood, 77(10), 2266-71, 15 May 1991 Abstract
  • Mileski W J, Winn R K, Harlan J M, Rice C L, Transient inhibition of neutrophil adherence with the anti-CD18 monoclonal antibody 60.3 does not increase mortality rates in abdominal sepsis., Surgery, 109(4), 497-501, April 1991 Abstract
  • Koch A E, Burrows J C, Haines G K, Carlos T M, Harlan J M, Leibovich S J, Immunolocalization of endothelial and leukocyte adhesion molecules in human rheumatoid and osteoarthritic synovial tissues., Laboratory Investigation, 64(3), 313-20, March 1991 Abstract
  • Harlan J M, Leukocyte--endothelial cell interactions., Schweizerische Medizinische wochenschrift. Supplementum, 43, 7-10, 1991 Abstract
  • Carlos T M, Dobrina A, Ross R, Harlan J M, Multiple receptors on human monocytes are involved in adhesion to cultured human endothelial cells., Journal of Leukocyte Biology, 48(5), 451-6, November 1990 Abstract
  • Mileski W J, Winn R K, Vedder N B, Pohlman T H, Harlan J M, Rice C L, Inhibition of CD18-dependent neutrophil adherence reduces organ injury after hemorrhagic shock in primates., Surgery, 108(2), 206-12, August 1990 Abstract
  • Kovach N L, Yee E, Munford R S, Raetz C R, Harlan J M, Lipid IVA inhibits synthesis and release of tumor necrosis factor induced by lipopolysaccharide in human whole blood ex vivo., Journal of Experimental Medicine, 172(1), 77-84, 1 Jul 1990 Abstract
  • Mileski W, Harlan J, Rice C, Winn R, Streptococcus pneumoniae-stimulated macrophages induce neutrophils to emigrate by a CD18-independent mechanism of adherence., Circulatory Shock, 31(3), 259-67, July 1990 Abstract
  • Schwartz B R, Wayner E A, Carlos T M, Ochs H D, Harlan J M, Identification of surface proteins mediating adherence of CD11/CD18-deficient lymphoblastoid cells to cultured human endothelium., Journal of Clinical Investigation, 85(6), 2019-22, June 1990 Abstract
  • Desch C E, Dobrina A, Aggarwal B B, Harlan J M, Tumor necrosis factor-alpha exhibits greater proinflammatory activity than lymphotoxin in vitro., Blood, 75(10), 2030-4, 15 May 1990 Abstract
  • Carlos T M, Harlan J M, Membrane proteins involved in phagocyte adherence to endothelium., Immunological Reviews, 114, 5-28, April 1990 Abstract
  • Vedder N B, Winn R K, Rice C L, Chi E Y, Arfors K E, Harlan J M, Inhibition of leukocyte adherence by anti-CD18 monoclonal antibody attenuates reperfusion injury in the rabbit ear., Proceedings of the National Academy of Sciences (USA), 87(7), 2643-6, April 1990 Abstract
  • Doerschuk C M, Winn R K, Coxson H O, Harlan J M, CD18-dependent and -independent mechanisms of neutrophil emigration in the pulmonary and systemic microcirculation of rabbits., Journal of Immunology, 144(6), 2327-33, 15 Mar 1990 Abstract
  • Dobrina A, Carlos T M, Schwartz B R, Beatty P G, Ochs H D, Harlan J M, Phorbol ester causes down-regulation of CD11/CD18-independent neutrophil adherence to endothelium., Immunology, 69(3), 429-34, March 1990 Abstract
  • Schwartz B R, Harlan J M, Sulfhydryl reducing agents promote neutrophil adherence without increasing surface expression of CD11b/CD18 (Mac-1, Mo1)., Biochemical and Biophysical Research Communications, 165(1), 51-7, 30 Nov 1989 Abstract
  • Dobrina A, Schwartz B R, Carlos T M, Ochs H D, Beatty P G, Harlan J M, CD11/CD18-independent neutrophil adherence to inducible endothelial-leucocyte adhesion molecules (E-LAM) in vitro., Immunology, 67(4), 502-8, August 1989 Abstract
  • Schwartz B R, Harlan J M, Neutrophil membrane sulfhydryl groups are involved in stimulated neutrophil adherence to endothelium., Journal of Leukocyte Biology, 45(3), 177-82, March 1989 Abstract
  • Toth K M, Harlan J M, Beehler C J, Berger E M, Parker N B, Linas S L, Repine J E, Dimethylthiourea prevents hydrogen peroxide and neutrophil mediated damage to lung endothelial cells in vitro and disappears in the process., Free Radical Biology and Medicine, 6(5), 457-66, 1989 Abstract
  • Vedder N B, Winn R K, Rice C L, Harlan J M, Neutrophil-mediated vascular injury in shock and multiple organ failure., Progress In Clinical and Biological Research, 299, 181-91, 1989 Abstract
  • Kujipers TW, Raleigh M, Kavanagh T, Janssen H, Calafat J, Roos D, Harlan JM, "Cytokine-activated Endothelial Cells Internalize E-selectin into a Lysosomal Compartment of Tubular Shape: A Tubulin-driven Process," J Immunol, 152:5060, 1994
  • Winn RK, Harlan JM, "CD18-independant Neutrophil and Mononuclear Leukocyte Emigration Into the Peritoneum of Rabbits," J Clin Invest, 92:1168-1173, 1993
  • Harlan JM, et al., "Freezing Adhesion Molecules in a State of High-avidity Binding Blocks Eosinophil Migration," J Exp Med, 178:279-284, 1993
  • Kling D, Fingerle J, Harlan JM, "Inhibition of Leukocyte Extravasation with a Monoclonal Antibody CD18 During Formation of Experimental Intimal Thickening in Rabbit Carotid Arteries," Arterioscler Thromb, 12:997-1007, 1992
  • Kovach NL, Carlos TM, Yee E, Harlan JM, "A Monoclonal Antibody to Beta-1 Integrin (CD29) stimulates VLA-dependent Adherence of Leukocytes to Human Umbilical Vein Endothelial Cells and Matrix Components," J Cell Biol, 166:499-509, 1992

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