Leland H. Hartwell

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Fred Hutchinson Cancer Research Center
Human Biology Division
PresidentAppointed: 1997
Fred Hutchinson Cancer Research Center
Human Biology Division
DirectorAppointed: 1997
University of Washington
College of Arts and Sciences
Genetics
ProfessorAppointed: 1973
Professional Headshot of Leland H. Hartwell

Mailing Address

Fred Hutchinson Cancer Research Center
1100 Fairview Avenue N., D1-060
P.O. Box 19024
Seattle, Washington 98109-1024
United States

Contact Information

Phone: (206) 667-5670
Fax: (206) 667-5268
lhartwel@fhcrc.org

Qualifications

Ph.D., Massachusetts Institute of Technology, 1964.

Expertise and Research Interests

My interests have increasingly turned to how we can use the enormous knowledge that has accumulated over the last 50 years in genetics and biochemistry to benefit cancer patients. I believe the most efficient path is to improve molecular diagnostics to identify individuals at high risk for disease, detect cancer and other disease at an early stage when they can be cured, provide prognostic information and monitor therapeutic response. Over the last 10 years we have experienced advances in nucleic acid diagnostics that provide answers for some of these questions and demonstrate the potential for additional insights. However, proteins will likely provide deeper diagnostic information because of their greater diversity and because their state reflects biological function. The technology for protein diagnostics, however, is in its infancy. My efforts are directed toward improving the field of protein diagnostics. To do so, I am involved in national and international projects to increase the number of laboratories working in the area, develop more team science, improve the availability of informatics for data sharing, provide standardized reagents, and stimulate new technology development.

Keywords

COS Keywords:

Cancer Biology, Evolution, Genetics.

Additional Terms:

Maintenance and Expression of Genetic Variation in Yeast.

Publications

  • Hartman JL, Garvik B, Hartwell L, Principles for the Buffering of Genetic Variation, Science, 291, 1001-1004, 9 Feb 2001
  • Simon JA, Szankasi P, Nguyen DK, Ludlow C, Dunstan HM, Roberts CJ, Jensen EL, Hartwell LH, Friend SH, Differential toxicities of anticancer agents among DNA repair and checkpoint mutants of Saccharomyces cerevisiae, Cancer Research, 60(2), 328-33, Jan 2000 Abstract
  • Hartwell, L.H., Hopfield, J.J., Leibler, S., Murray, A.W., From molecular to modular cell Biology, Nature 402 supplement, 6761, C47-C52, 1999
  • Marton MJ, DeRisi JL, Bennett HA, Iyer VR, Meyer MR, Roberts CJ, Stoughton R, Burchard J, Slade D, Dai H, Bassett DE Jr, Hartwell LH, Brown PO, Friend SH, Drug target validation and identification of secondary drug target effects using DNA microarrays, Nature Medicine, 4(11), 1293-301, November 1998 Abstract
  • Paulovich AG, Armour CD, Hartwell LH, The Saccharomyces cerevisiae RAD9, RAD17, RAD24 and MEC3 genes are required for tolerating irreparable, ultraviolet-induced DNA damage, Genetics, 150(1), 75-93, September 1998 Abstract
  • Brown PO, Hartwell L, Genomics and human disease--variations on variation, Nature Genetics, 18(2), 91-3, February 1998 Abstract
  • Hartwell LH, Szankasi P, Roberts CJ, Murray AW, Friend SH, Integrating genetic approaches into the discovery of anticancer drugs, Science, 278(5340), 1064-8, November 1997 Abstract
  • Toczyski D P, Galgoczy D J, Hartwell L H, CDC5 and CKII control adaptation to the yeast DNA damage checkpoint., Cell, 90(6), 1097-106, 19 Sep 1997 Abstract
  • Schrick K, Garvik B, Hartwell L H, Mating in Saccharomyces cerevisiae: the role of the pheromone signal transduction pathway in the chemotropic response to pheromone., Genetics, 147(1), 19-32, September 1997 Abstract
  • Hartwell L, Theoretical biology. A robust view of biochemical pathways, Nature, 387(6636), 855 857, June 1997 Abstract
  • Dorer R, Boone C, Kimbrough T, Kim J, Hartwell L H, Genetic analysis of default mating behavior in Saccharomyces cerevisiae., Genetics, 146(1), 39-55, May 1997 Abstract
  • Wooden JM, Hartwell LH, Vasquez B, Sibley CH, Analysis in yeast of antimalaria drugs that target the dihydrofolate reductase of Plasmodium falciparum., Molecular and Biochemical Parasitology, 85(1), 25-40, 1997 Abstract
  • Paulovich A G, Toczyski D P, Hartwell L H, When checkpoints fail., Cell, 88(3), 315-21, 7 Feb 1997 Abstract
  • Paulovich A G, Margulies R U, Garvik B M, Hartwell L H, RAD9, RAD17, and RAD24 are required for S phase regulation in Saccharomyces cerevisiae in response to DNA damage., Genetics, 145(1), 45-62, January 1997 Abstract
  • Dorer R, Pryciak P M, Hartwell L H, Saccharomyces cerevisiae cells execute a default pathway to select a mate in the absence of pheromone gradients., Journal of Cell Biology, 131(4), 845-61, November 1995 Abstract
  • Garvik B, Carson M, Hartwell L, Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint [published erratum appears in Mol Cell Biol 1996 Jan;16\(1\):457, Molecular and Cellular Biology, 15(11), 6128-38, November 1995 Abstract
  • Paulovich A G, Hartwell L H, A checkpoint regulates the rate of progression through S phase in S. cerevisiae in response to DNA damage., Cell, 82(5), 841-7, 8 Sep 1995 Abstract
  • Hartwell L H, Kastan M B, Cell cycle control and cancer., Science, 266(5192), 1821-8, 16 Dec 1994 Abstract
  • Weinert T A, Kiser G L, Hartwell L H, Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair., Genes and Development, 8(6), 652-65, 15 Mar 1994 Abstract
  • Weinert T A, Hartwell L H, Cell cycle arrest of cdc mutants and specificity of the RAD9 checkpoint., Genetics, 134(1), 63-80, May 1993 Abstract
  • Kadyk L C, Hartwell L H, Replication-dependent sister chromatid recombination in rad1 mutants of Saccharomyces cerevisiae., Genetics, 133(3), 469-87, March 1993 Abstract
  • Hartwell L, Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells., Cell, 71(4), 543-6, 13 Nov 1992 Abstract
  • Hartwell L H, Alfred P. Sloan, Jr. Prize. Role of yeast in cancer research., Cancer, 69(10), 2615-21, 15 May 1992 Abstract
  • Neiman P E, Hartwell L H, Malignant instability. Workshop on Genetic Instability and its Role in Carcinogenesis sponsored by the Programs in Molecular Medicine of the Fred Hutchinson Cancer Research Center and the University o, New Biologist, 3(4), 347-51, April 1991 Abstract
  • Jackson C L, Hartwell L H, Courtship in S. cerevisiae: both cell types choose mating partners by responding to the strongest pheromone signal., Cell, 63(5), 1039-51, 30 Nov 1990 Abstract
  • Jackson C L, Hartwell L H, Courtship in Saccharomyces cerevisiae: an early cell-cell interaction during mating., Molecular and Cellular Biology, 10(5), 2202-13, May 1990 Abstract
  • Hartwell LH, Weinert TA, Checkpoints: controls that ensure the order of cell cycle events, Science, 246(4930), 629-34, November 1989 Abstract
  • Weinert TA, Hartwell LH, The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae, Science, 241(4863), 317-22, July 1988 Abstract
  • Hartwell LH, Culotti J, Pringle JR, Reid BJ, Genetic control of the cell division cycle in yeast, Science, 183(120), 46-51, January 1974 Abstract

Profile Details

Last Updated: 1/6/2005

COS Expertise ID #320046
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