Michael Hodsdon

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Yale University
School of Medicine
Laboratory Medicine
Associate ProfessorAppointed: 2007
Yale University
School of Medicine
Pharmacology
Associate ProfessorAppointed: 2007
Yale-New Haven Hospital
Laboratory Medicine
Clinical Chemistry
Associate DirectorAppointed: 2004
Professional Headshot of Michael Hodsdon

Mailing Address

Department of Laboratory Medicine
Yale University
P.O. Box 208035
333 Cedar Street
New Haven, Connecticut 06520-8035
United States

Contact Information

Phone: (203) 737-2674
Fax: (203) 688-8704
michael.hodsdon@yale.edu
http://info.med.yale.edu/labmed/faculty/hodsdonm.html

Qualifications

M.D., Washington University in St. Louis, 1997.
Ph.D., Washington University in St. Louis, Molecular Biophysics, 1997.
B.S., Indiana University Bloomington, Biochemistry, 1989.

Expertise and Research Interests

Research in our laboratory is focused on the relationship between the biophysical behavior of proteins and their biological function. We are particularly interested in protein systems with important roles in disease processes, where understanding the molecular basis of their dysfunction could contribute to improvements in either disease detection or treatment.

Along with other biophysical techniques, NMR spectroscopy is a central tool in our research program, capable of determining the three-dimensional structures of proteins in solution and to monitor a variety of molecular properties under physiological conditions.

At the moment, our primary biological focus involves the molecular regulation of cytokine function. Details on our previous and ongoing research projects are available elsewhere:
http://www.hodsdon.com/lab
http://info.med.yale.edu/labmed/faculty/hodsdonm.html

Other Expertise

Clinical laboratory medicine with an emphasis on toxicology and therapeutic drug monitoring

Keywords

COS Keywords:

Biochemistry, Biophysics, Breast Cancer, Clinical Chemistry, Drug Metabolism, Health and Medicine, Laboratory Practice or Procedure, Nuclear Magnetic Resonance, Pathobiology, Pharmacology, Spectroscopy, Structural Biology, Toxicology.

Additional Terms:

Breast Cancer, Cytokine, Drug Metabolism, Dynamics, NMR Spectroscopy, Prolactin, Structural Biology, Therapeutic Drug Monitoring, Toxicology.

Memberships

Academy of Clinical Laboratory Physicians and Scientists
American Association for Clinical Chemistry
Protein Society

Honors and Awards

2002, Teaching Award, Laboratory Medicine Residency Program, Yale-New Haven Hospital
2000, Bristol Meyers-Squibb Fellow, Irvington Institute for Immunological Research
1995, Spencer T. and Ann W. Olin Fellowship, Medical Scientist Training Program, Washington University in St. Louis
1989, Joseph B. Schwartzkopf Award, Department of Chemistry, Indiana University Bloomington
1988, William H. Bell Award, Department of Chemistry, Indiana University Bloomington
1988-1989, Harry G. Day Scholarship, Department of Chemistry, Indiana University Bloomington
1987, R. J. Grim Scholarship, Department of Chemistry, Indiana University Bloomington

Previous Positions

2001-2004, Assistant Director, Yale-New Haven Hospital, Laboratory Medicine, Clinical Chemistry
2001-2007, Assistant Professor, Yale University, School of Medicine, Laboratory Medicine
2000-2001, Associate Research Scientist, Yale University, School of Medicine, Pharmacology and Laboratory Medicine
1998-2000, Resident, Yale-New Haven Hospital, Laboratory Medicine
1997-1997, Postdoctoral Fellow, Washington University in St. Louis, Molecular Biophysics, Dr. Carl Frieden

Funding Received

  • Yale Cancer Center: Structural Determinants of Glycosaminoglycan Recognition Specificity by the SDF-1alpha Chemokine, 2006 to 2007.
  • National Institutes of Health (NIH): R01 CA108992-01 "Structural Basis of Prolactin Receptor Recognition", 2005 to 2010.
  • Charlotte Geyer Foundation: Research Grant, 2004 to 2005.
  • Connecticut State: Breast Cancer Research Award, 2003 to 2004.
  • National Blood Foundation: Research Grant, 2002 to 2003.
  • National Institutes of Health (NIH): Physician-Scientist Career Development Award (K08), 2000 to 2004.
  • Irvington Institute for Immunological Research: Postdoctoral Fellowship, 2000 to 2000.

Publications

  • Murphy JW, Cho Y, Sachpatzidis A, Fan C, Hodsdon ME, Lolis E (2007) Structural and Functional Basis of CXCL12 (Stromal Cell-derived Factor-1{alpha}) Binding to Heparin., J Biol Chem., 282 (13), 10018-27
  • Keeler C, Jablonski EM, Albert YB, Taylor BD, Myszka DG, Clevenger CV, Hodsdon ME (2007) The Kinetics of Binding Human Prolactin, but Not Growth Hormone, to the Prolactin Receptor Vary over a Physiologic pH Range., Biochemistry, 46 (9), 2398-410
  • Devine L, Thakral D, Nag S, Dobbins J, Hodsdon ME, Kavathas PB (2006) Mapping the binding site on CD8 beta for MHC class I reveals mutants with enhanced binding., J Immunol., 177 (6), 3930-8
  • Guarracino DA, Chiang HR, Banks TN, Lear JD, Hodsdon ME, Schepartz A (2006) Relationship between salt-bridge identity and 14-helix stability of beta3-peptides in aqueous buffer., Org Lett., 8 (5), 807-10
  • Tettamanzi MC, Yu C, Bogan JS, Hodsdon (2006) Solution structure and backbone dynamics of an N-terminal ubiquitin-like domain in the GLUT4-regulating protein, TUG., Protein Science, 15 (3), 498-508
  • Stephens OM, Kim S, Welch BD, Hodsdon ME, Kay MS, Schepartz A (Sep 2005) Inhibiting HIV fusion with a beta-peptide foldamer., Journal of the American Chemical Society, 127 (38), 13126-7 Abstract
  • Mao Y, Senic-Matuglia F, Di Fiore PP, Polo S, Hodsdon ME, De Camilli P (Sep 2005) Deubiquitinating function of ataxin-3: insights from the solution structure of the Josephin domain., Proceedings of the National Academy of Sciences of the United States of America., 102 (36), 12700-5 Abstract
  • Kritzer JA, Hodsdon ME, Schepartz A, Solution Structure of a Beta-peptide Ligand for HDM2., Journal of the American Chemical Society, 127(12), 4118-9, Mar 2005 Abstract
  • Hsiao AL, Santucci KA, Seo-Mayer P, Mariappan MR, Hodsdon ME, Banasiak KJ, Baum CR (2005) Pediatric fatality following ingestion of dinitrophenol: postmortem identification of a "dietary supplement"., Clin Toxicol (phila), 43 (4), 281-5 Abstract
  • Scheuermann TH, Keeler C, Hodsdon ME, Consequences of Binding An S-adenosylmethionine Analogue on the Structure and Dynamics of the Thiopurine Methyltransferase Protein Backbone., Biochemistry, 43(38), 12198-209, Sep 2004 Abstract
  • Kritzer JA, Lear JD, Hodsdon ME, Schepartz A, Helical Beta-peptide Inhibitors of the P53-hDM2 Interaction., Journal of the American Chemical Society, 126(31), 9468-9, Aug 2004 Abstract
  • Devine L, Hodsdon ME, Daniels MA, Jameson SC, Kavathas PB, Location of the Epitope for An Anti-CD8alpha Antibody 53.6.7 Which Enhances CD8alpha-MHC Class I Interaction Indicates Antibody Stabilization of a Higher Affinity CD8 Conformation., Immunology Letters, 93(2-3), 123-30, May 2004 Abstract
  • Keeler C, Hodsdon ME, Dannies PS, Is There Structural Specificity in the Reversible Protein Aggregates That Are Stored in Secretory Granules?, Journal of Molecular Neuroscience : Mn, 22(1-2), 43-9, 2004 Abstract
  • Scheuermann TH, Lolis E, Hodsdon ME, Tertiary Structure of Thiopurine Methyltransferase From Pseudomonas Syringae, a Bacterial Orthologue of a Polymorphic, Drug-metabolizing Enzyme., Journal of Molecular Biology, 333(3), 573-85, Oct 2003 Abstract
  • Keeler C, Dannies PS, Hodsdon ME, The Tertiary Structure and Backbone Dynamics of Human Prolactin., Journal of Molecular Biology, 328(5), 1105-21, May 2003 Abstract
  • Sankoorikal BJ, Zhu YL, Hodsdon ME, Lolis E, Dannies PS, Aggregation of Human Wild-type and H27A-prolactin in Cells and In Solution: Roles of Zn(2+), Cu(2+), and PH., Endocrinology, 143(4), 1302-9, Apr 2002 Abstract
  • Hodsdon ME, Frieden C, Intestinal Fatty Acid Binding Protein: the Folding Mechanism As Determined By NMR Studies., Biochemistry, 40(3), 732-42, Jan 2001 Abstract
  • Steele RA, Emmert DA, Kao J, Hodsdon ME, Frieden C, Cistola DP, The Three-dimensional Structure of a Helix-less Variant of Intestinal Fatty Acid-binding Protein., Protein Science : a Publication of the Protein Society, 7(6), 1332-9, Jun 1998 Abstract
  • Hodsdon ME, Cistola DP, Ligand Binding Alters the Backbone Mobility of Intestinal Fatty Acid-binding Protein As Monitored By 15N NMR Relaxation and 1H Exchange., Biochemistry, 36(8), 2278-90, Feb 1997 Abstract
  • Hodsdon ME, Cistola DP, Discrete Backbone Disorder in the Nuclear Magnetic Resonance Structure Of Apo Intestinal Fatty Acid-binding Protein: Implications for the Mechanism of Ligand Entry., Biochemistry, 36(6), 1450-60, Feb 1997 Abstract
  • Hodsdon ME, Ponder JW, Cistola DP, The NMR Solution Structure of Intestinal Fatty Acid-binding Protein Complexed With Palmitate: Application of a Novel Distance Geometry Algorithm., Journal of Molecular Biology, 264(3), 585-602, Dec 1996 Abstract
  • Hodsdon ME, Toner JJ, Cistola DP, 1H, 13C and 15N Assignments and Chemical Shift-derived Secondary Structure of Intestinal Fatty Acid-binding Protein., Journal of Biomolecular Nmr, 6(2), 198-210, Sep 1995 Abstract

Profile Details

Last Verified: 7/5/2007

COS Expertise ID #350903
Reference this profile directly: http://myprofile.cos.com/hodsdon