Prof. Harlan Robins

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Fred Hutchinson Cancer Research Center
Computational Biology
Public Health Sciences
Assistant MemberAppointed: 2006

Mailing Address

Fred Hutchinson Cancer Research Center
1100 Fairview Ave N.
Public Health Sciences
M2 B876
Seattle, Washington 98109
United States

Contact Information

Phone: (206) 667-2571
Fax: (206) 667-1319
hrobins@fhcrc.org

Qualifications

Ph.D., University of California, Berkeley, Physics, 2001.
M.A., University of California, Berkeley, Physics, 1997.
A.B., Harvard University, Physics, 1995.

Expertise and Research Interests

My research is computationally based and focuses on the adaptive immune system and its response to viral infection, with HIV a particular area of interest. Taking advantage of new high-throughput sequencing technology, in collaboration with experimental groups, we are isolating and sequencing millions of t-cell receptor VDJ rearrangements from different clonotypes. With this new technology, we can attempt a comprehensive description of the t-cell repertoire and ask what how this repertoire is modified during an immune response.

Keywords

COS Keywords:

Bioinformatics, Computational Biology.

Additional Terms:

Bioinformatics, Computational Biology, Statistical Methods.

Previous Positions

2002-2006, Post-doctoral fellow, Institute for Advanced Study, Princeton, NJ
2001-2002, Post-doctoral fellow, Weizmann Institute of Science, Particle Theory Group

Publications

  • Robins H, Krasnitz M, Levine A (2008) The computational detection of fuctional nucleotide sequence motifs in the coding regions of organisms., Exp Biol Med, 233, 6
  • Murphy E, Vanicek J, Robins H, Shenk T, Levine AJ (2008) Suppression of immediate-early viral gene expression by herpesvirus-coded microRNAs: implications for latency, PNAS, 105 (14), 5453-8
  • Huang Y, Krasnitz M, Rabadan R, Witten DM, Song Y, Levine AJ, Ho DD, Robins H (2008) A recoding method to improve the humoral immune response to an HIV DNA vaccine, PLoS ONE, In Press
  • Robins H (2008) Robustness can increase the rate of evolution, Submitted
  • Campregher P, Srivastava S, Robins H, Warren E (2008) T cell receptor oligoclonality in advanced Myelodysplastic Syndrome, Submitted
  • Rabadan R, Robins H (2007) Evolution of the Influenza A virus: some new advances, Evolutionary Bioinformatics, 3
  • Rabadan R, Levine A, Robins H (2006) Comparison between avian and human influenza A virus reveals a mutational bias on the viral genomes, J Virol, 80 (23), 1187-91
  • Press WH, Robins H (2006) Isochores Exhibit Evidence of Genes Interacting with the Large-scale Genomic Environment, Genetics, 147 (2), 1029-40
  • Bond G, Hirshfield K, Kirchoff T, Alexe G, Bond G, Robins H, Bartel F, Taubert H, Wuerl P, Hait W, Toppmeyer D, Offit K, Levine J (2006) MDM2 SNP309 Accelerates Tumor Formation in a Gender Specific and Hormonal Dependent Manner, Cancer Research, 66 (10), 5104-10
  • Ibanez-Ventoso C, Yang M, Guo S, Robins H, Padgett R, Driscoll M (2006) Modulated MicroRNA Expression During Adult Lifespan in C. elegans, Aging Cell, 5 (3), 235-46
  • Harris S, Gil G, Hu W, Robins H, Bond E, Hirshfield K, Feng Z, Yu X, Teresky A, Bond G, Levine A (2005) Single-nucleotide polymorphisms in the p53 pathway, Cold Spring Harb Symp Quant Biol, 70, 111-9
  • Robins H, Krasnitz M, Barak H, Levine AJ (2005) A Relative Entropy Algorithm for Genomic Fingerprinting Captures Host-Phage Similarities, J Bacteriol, 187 (24), 8370-4
  • Harris S, Gil G, Robins H, Hu W, Hirshfield K, Bond E, Bond G, Levine A (2005) Detection of functional single nucleotide polymorphisms that affect apoptosis, Proc Natl Acad Sci USA, 102 (45), 16297-302
  • Robins H, Press WH (2005) Human microRNAs target a functionally distinct population of genes with AT-rich 3'UTRs, Proc Natl Acad Sci USA. 2005, 102 (43), 15557-62
  • Robins H, Li Y, Padgett RW (2005) Incorporating structure to predict microRNA targets, Proc Natl Acad Sci USA, 102 (11), 4006-9
  • Bond GL, Hu W, Bond EE, Robins H, Lutzker SG, Arva NC, Bargonetti J, Bartel F, Taubert H, Wuerl P, Onel K, Yip L, Hwang SJ, Strong LC, Lozano G, Levine AJ (2004) A single nucleotide polymorphism in the MDM2 Promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans, Cell, 119 (5), 591-602
  • Plotkin J, Robins H, Levine AJ (2004) Tissue-specific codon usage and the expression of human genes, Proc Natl Acad Sci USA, 101 (34), 12588-91
  • Robins H, The first twenty-five years of p53 Research, , The first twenty-five years of p53 Research (bookchapter)

Profile Details

Last Updated: 8/28/2008

COS Expertise ID #1242785
Reference this profile directly: http://myprofile.cos.com/hrobins