Li Hsu

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Fred Hutchinson Cancer Research Center
Biostatistics
Public Health Sciences
Full MemberAppointed: 2005
University of Washington
School of Public Health and Community Medicine
Biostatistics
Affiliate Associate ProfessorAppointed: 2000

Mailing Address

Fred Hutchinson Cancer Research Center
1100 Fairview Avenue N.
PO Box 19024, MP-665
Seattle, Washington 98109-1024
United States

Contact Information

Phone: (206) 667-2854
Fax: (206) 667-7004
lih@fhcrc.org

Qualifications

Ph.D., University of Washington, Biostatistics, 1994.
M.S., University of Washington, Biostatistics, 1991.
B.S., Nanjing University, Computer Science, 1989.

Expertise and Research Interests

My principal research area is statistical genomics. These include assessing familial aggregation using variable age at onset as disease outcomes, discovering latent genes via linkage and association techniques, and characterizing the effect of the genes and their interaction with environmental risk factors on the time course of the disease. I have been involved in a number of family studies, such as case-control population based family studies of early onset breast cancer and prostate cancer and a school-based family study of learning disabilities.

I am also interested in the large scale of genomic data that are generated using the high throughput technologies. I am developing methods for evaluating the genome-wide pattern for the loss of heterzygosity (LOH) using the single nucleotide polymorphisms data from microarray chip. It is hypothesized that the genome-wide pattern of LOH may shed light on the mechanisms of tumor initiation and expansion. Complementary to the LOH study, I am also studying the methods for analyzing the gene expression data from the spotted array. Understanding the gene expression changes between tumor and normal tissues may help in clinical diagnosis, yielding useful biomarkers for early diagnosis, elucidating the genetic pathway, and mechanisms of cell cycles.

Other Expertise

Academic Experiences:

Associate Editor for Biometrics, 2000-present;
Statistical Editor for Journal of National Cancer Institute.

Industrial Relevance

drug development and preventive strategies for cancer and other diseases.

Keywords

COS Keywords:

Biostatistics, Epidemiology, Family, Genetics.

Additional Terms:

Association Analysis, Family Study, Genetic Epidemiology, Mapping Complex Traits, Multivariate Failure Time Analysis, Statistical Genetics, Statistical Genomics.

Languages

(Reading, Writing, Speaking)

Chinese, Mandarin: (Fluent, Fluent, Fluent)
English: (Fluent, Fluent, Fluent)

Memberships

American Society of Human Genetics
American Statistical Association
International Biometric Society

Honors and Awards

1991, Donovan J. Thompson Award for outstanding student in biostatistics, University of Washington
1991-1994, Merck, Sharp & Dohme Research Laboratories, Predoctoral Fellowship.,

Previous Positions

2000-2005, Associate Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Biostatistics and Biomathematics Program
1997-2000, Assistant Member, Fred Hutchinson Cancer Research Center
1996-1997, Staff Scientist, Fred Hutchinson Cancer Research Center
1996-2000, Affiliate Assistant Professor, University of Washington, School of Public Health and Community Medicine, Biostatistics
1994-1995, Research Fellow, Fred Hutchinson Cancer Research Center, Public Health Sciences

Funding Received

  • National Institutes of Health (NIH): Northwest Cancer Genetics Network (Potter), $659,993, 11/01/98 to 02/28/03.
  • DOD Idea Award: Genome-wide Examination of Allelic Loss in Lobular and Ductal Breast Cancer (Porter), 146,643, 09/01/02 to 08/31/05.
  • National Institutes of Health (NIH): Barrett's Esophagus: Predictors of Progression, Core C -- Bioinformatics and Biostatistics (Reid), 99,167, 07/01/02 to 06/30/07.
  • National Institutes of Health (NIH): Methods for Age at Onset Data in Genetic Epidemiology, $113,488, 06/01/97 to 05/31/02.
  • National Institutes of Health (NIH): Molecular Epidemiology of Testicular Carcinoma (Schwartz), 25,000, 04/01/02 to 05/31/05.
  • National Institutes of Health (NIH): Molecular Alterations in Lobular and Ductal Breast Cancer (Porter), 254,347, 04/01/02 to 03/31/06.
  • National Institutes of Health (NIH): Statistical Methods for Epidemiologic Studies(Prentice), $333,968, 01/01/01 to 12/31/05.

Publications

  • Yasui Y, Pepe M, Hsu L, Feng Z, Partially supervised learning using an EM-boosting algorithm, Biometrics, In Press, 2006
  • Yang S, Hsu L, Zhao LP, Combining asymptotically normal tests: Case studies in comparison of two groups, Journal of Statistical Planning and Inference, In Press, 2006
  • Hsu L, Yu X, Houwing-Duistermaat JJ, Uh HW, Elgalta R, Lebrec JJP, Tang H, Locally weighted transmission/disequilibrium test for genetic association analysis, BMC Genetics, In Press, 2006
  • Houwing-Duistermaat JJ, Uh HW, Lebrec JJP, Putter H, Hsu L, Modeling the effect of an associated single nucleotide polymorphism in linkage studies, BMC genetics, In Press, 2006
  • Starr JR, Chen C, Doody DR, Hsu L, Ricks S, Weiss NS, Schwartz SM (Sep 2005) Risk of testicular germ cell cancer in relation to variation in maternal and offspring cytochrome p450 genes involved in catechol estrogen metabolism., Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology., 14 (9), 2183-90 Abstract
  • Starr JR, Hsu L, Schwartz SM (May 2005) Assessing maternal genetic associations: a comparison of the log-linear approach to case-parent triad data and a case-control approach., Epidemiology (cambridge, Mass.), 16 (3), 294-303 Abstract
  • Hsu L, Self SG, Grove D, Randolph T, Wang K, Delrow JJ, Loo L, Porter P (Apr 2005) Denoising array-based comparative genomic hybridization data using wavelets., Biostatistics (oxford, England), 6 (2), 211-26 Abstract
  • Hsu L, Faulkner J, Grove D, Pauler DK, Some practical considerations for analysis of spotted microarray data, Handbook of Statistics in Clinical Oncology, 2nd edition revised, 2005
  • Starr JR, Hsu L, Schwartz SM (Jan 2005) Performance of the log-linear approach to case-parent triad data for assessing maternal genetic associations with offspring disease: type I error, power, and bias., American Journal of Epidemiology, 161 (2), 196-204 Abstract
  • Loo LW, Grove DI, Williams EM, Neal CL, Cousens LA, Schubert EL, Holcomb IN, Massa HF, Glogovac J, Li CI, Malone KE, Daling JR, Delrow JJ, Trask BJ, Hsu L, Porter PL (Dec 2004) Array comparative genomic hybridization analysis of genomic alterations in breast cancer subtypes., Cancer Research, 64 (23), 8541-9 Abstract
  • Hsu L, Chen L, Gorfine M, Malone K (Dec 2004) Semiparametric estimation of marginal hazard function from case-control family studies., Biometrics, 60 (4), 936-44 Abstract
  • Yasui Y, Pepe M, Hsu L, Adam BL, Feng Z (Mar 2004) Partially supervised learning using an EM-boosting algorithm., Biometrics, 60 (1), 199-206 Abstract
  • Gorfine M, Hsu L, Prentice RL (Jan 2004) Nonparametric correction for covariate measurement error in a stratified Cox model., Biostatistics (oxford, England), 5 (1), 75-87 Abstract
  • Houwing-Duistermaat JJ, Bijkerk C, Hsu L, Stijnen T, Slagboom EP, van Duijn CM (Sep 2003) A unified approach to modelling linkage to quantitative and qualitative traits., Annals of Human Genetics, 67 (Pt 5), 457-63 Abstract
  • Hsu L (Feb 2003) Genetic association tests with age at onset., Genetic Epidemiology, 24 (2), 118-27 Abstract
  • Gorfine M, Hsu L, Prentice RL, Estimation of dependence between paired correlated failure times in the presence of covariate measurement error, J Royal Stat Soc, B, 65, 643-661, 2003
  • Hsu L, Wijsman EM, Berninger VW, Thomson JB, Raskind WH (May 2002) Familial aggregation of dyslexia phenotypes. II: paired correlated measures., American Journal of Medical Genetics, 114 (4), 471-8 Abstract
  • Hsu L, Prentice RL, Stanford JL (Mar 2002) Some further results on incorporating risk factor information in assessing the dependence between paired failure times arising from case-control family studies: an application to prostate cancer., Statistics in Medicine, 21 (6), 863-76 Abstract
  • Hsu L, Li H, Houwing-Duistermaat JJ (2002) A method for incorporating ages at onset in affected sibpair linkage studies., Human Heredity, 54 (1), 1-12 Abstract
  • Schubert EL, Hsu L, Cousens LA, Glogovac J, Self S, Reid BJ, Rabinovitch PS, Porter PL (Jan 2002) Single nucleotide polymorphism array analysis of flow-sorted epithelial cells from frozen versus fixed tissues for whole genome analysis of allelic loss in breast cancer., The American Journal of Pathology, 160 (1), 73-9 Abstract
  • Barrett MT, Yeung KY, Ruzzo WL, Hsu L, Blount PL, Sullivan R, Zarbl H, Delrow J, Rabinovitch PS, Reid BJ (Mar-Apr 2002) Transcriptional analyses of Barrett's metaplasia and normal upper GI mucosae., Neoplasia (new York, N.y.), 4 (2), 121-8 Abstract
  • Pritchard CC, Hsu L, Delrow J, Nelson PS (Nov 2001) Project normal: defining normal variance in mouse gene expression., Proceedings of the National Academy of Sciences of the United States of America., 98 (23), 13266-71 Abstract
  • Miller EA, Stanford JL, Hsu L, Noonan E, Ostrander EA, Polymorphic repeats in the androgen receptor gene in high-risk sibships, Prostate, 48(3), 200-5, 2001 Abstract
  • Kooperberg C, Ruczinski I, LeBlanc ML, Hsu L (2001) Sequence analysis using logic regression., Genetic Epidemiology, 21 Suppl 1, S626-31 Abstract
  • Hsu L, Prentice RL, Zhao LP, Li S (2001) Incorporating age at onset information into the transmission/disequilibrium test., Genetic Epidemiology, 21 Suppl 1, S347-52 Abstract
  • Raskind WH, Hsu L, Berninger VW, Thomson JB, Wijsman EM, Familial aggregation of dyslexia phenotypes, Behavior Genetics, 30(5), 385-96, September 2000 Abstract
  • Li H, Hsu L, Effects of age at onset on the power of the affected sib pair and transmission/disequilibrium tests, Annals of Human Genetics, 64(Pt 3), 239-54, May 2000 Abstract
  • Hsu L, Aragaki C, Quiaoit F, Wang X, Xu Z, Zhao LP, A genome wide scan of SM disease using two newly developed methods, Genetic Epidemiology, 17, 621--6, 2000
  • Fan J, Prentice RL, Hsu L, A class of weighted dependence measures for bivariate failure time data, Journal of the Royal Statistical Society, Series B, 62, 181--90, 2000
  • Wijsman EM, Peterson D, Leutenegger AL, Thomson JB, Goddard KA, Hsu L, Berninger VW, Raskind WH, Segregation analysis of phenotypic components of learning disabilities. I. Nonword memory and digit span, American Journal of Human Genetics, 67, 631-646, 2000
  • Hsu L, Zhao LP, Malone KE, Daling JR (Jan 2000) Assessing changes in ages at onset over successive generation: an application to breast cancer., Genetic Epidemiology, 18 (1), 17-32 Abstract
  • Hsu L, Zhao LP, Aragaki C (May-Jun 2000) A note on a conditional-likelihood approach for family-based association studies of candidate genes., Human Heredity, 50 (3), 194-200 Abstract
  • Hsu L, Prentice RL, Zhao LP, Fan J, On dependence estimation of correlated failure time data from case-control family studies, Biometrika, 86, 743--53, 1999
  • Zhao LP, Hsu L, Holte S, Chen Y, Combined association and aggregation analysis of case-control family data, Biometrika, 85, 229-315, 1998
  • Prentice RL, Hsu L, Regression on hazard ratios and cross ratios in multivariate failure time analysis, Biometrika, 84, 349-63, 1997
  • Wang Cy, Hsu L, Feng ZD, Prentice RL, Regression calibration in failure time regression with surrogate variables, Biometrics, 53, 131-45, 1997
  • Prentice RL, Hsu L, Multivariate failure time data: Representation and analysis, Survival Analysis. Lin DY, Fleming TR, 1997
  • Zhao LP, Hsu L, Davidov O, Potter J, Elston R, Prentice RL, Population-based family study designs: An interdisciplinary research framework for genetic epidemiology, Genetic Epidemiology, 14, 365-388, 1997
  • Hsu L, Zhao LP, Assessing familial aggregation of age-of-onset using estimating equations: with application to breast cancer, American Journal of Human Genetics, 58, 1057-71, 1996
  • Hsu L, Prentice RL, On assessing the strength of dependency between failure time variates, Biometrika, 83, 491-06, 1996
  • Hsu L, Prentice RL, A generalization of Mantel-Haenszel test to bivariate failure time data, Biometrika, 83, 905-11, 1996
  • Liu SL, Rodrigo AG, Shankarappa R, Gearn GH, Hsu L, Davidov O, Zhao LP, Mullins JI, HIV quasispecies resampling, Science, 273, 415-6, 1996

Profile Details

Last Updated: 8/7/2006

COS Expertise ID #675806
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