Jian Huang

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University of Iowa
College of Public Health
Biostatistics
ProfessorAppointed: 2007
University of Iowa
College of Liberal Arts and Sciences
Statistics & Actuarial Sciences
ProfessorAppointed: 2004

Mailing Address

University of Iowa
Statistical and Actuarial Science
241 SH
Iowa City, Iowa 52242
United States

Contact Information

Phone: (319) 335-0823
Fax: (319) 335-3017
jian-huang@uiowa.edu
http://www.stat.uiowa.edu/~jian/

Qualifications

Ph.D., University of Washington, Statistics, 1994.
M.S. equivalent, Wuhan University, Mathematical Statistics, 1987.
B.S., Wuhan University, Mathematics, 1985.

Expertise and Research Interests

Areas of Research Interest

* Statistical Genetics
* Semiparametric models
* Survival analysis
* Microarray gene expression analysis

Current Projects

* Linkage and LD analysis
* Regularized classification and survival analysis for expression profilling of cancer
* Spline smoothing methods for interval-censored and panel data
* Statistical analysis of microarray data: semiparametric methods for normalization of cDNA microarray and Affymetric genechip data
* eQTL analysis

Keywords

COS Keywords:

Gene Expression, Genetics, Mathematics, Statistics.

Memberships

American Statistical Association

Previous Positions

2006-2007, Professor (Secondary Appointment), University of Iowa, College of Public Health, Biostatistics
2004-2007, Professor, University of Iowa, College of Public Health, Program in Public Health Genetics
2003-2004, Associate Professor, University of Iowa, College of Public Health, Program in Public Health Geentics
2000-2003, Associate Professor, University of Iowa, College of Public Health, Biostatistics, Statistical Genetics
1999-2003, Associate Professor, University of Iowa, College of Liberal Arts and Sciences, Statistics & Actuarial Sciences
1994-1994, Postdoctoral Fellow, Fred Hutchinson Cancer Research Center
1994-1999, Assistant Professor, University of Iowa, Statistics and Actuarial Sciences
1988-1994, Teaching/Research Assistant, University of Washington, College of Arts and Sciences, Statistics
1987-1988, Instructor, Wuhan University, Statistics

Funding Received

  • University of Iowa Old Gold Proposal: Appropriate Statistical Tests for Detecting Genetic Anticipation, $5,000, Summer 1997 to .
  • University of Iowa Old Gold Proposal: Bootstrapping Analysis of Interval-Censored Data, $5,200, Summer 1996 to .
  • National Science Foundation (NSF): Mathematical Sciences Computing Research Environments (PI:Dale Zimmerman, Co-PI Jian Huang), , 6/1996 to 6/1997.
  • National Institute of Mental Health: Statistical Models of Genetic Anticipation in Psychiatry (PI: Jian Huang)`, $577,319, 3/15/98 to 2/28/03.
  • NSF: Penalized Methods for Variable Selection and Estimation in High-Dimensional Models (PI: J Huang), $45,000, 2007 to 2008.
  • NCI/NIH: Cancer Center Support Grant HCCC (Co-I: J Huang), $1,491,526, 2005 to 2010.
  • NIH: Transcriptional and Genetic Profiles in HNSCCs (PI: E Smith, Co-I: J Huang, $1,250,000, 2004 to 2009.
  • NIH: Filovirus Enveloped FIV: Virus-Epithelia Interactions for CF (PI: P McCray, Co-I: J Huang), $1,000,000, 2004 to 2008.
  • Carver Collaborative Pilot Project: Predicting Response to Follicular Lymphoma to Rituximab (PI: J Wooldridge, Co-PI: J Huang), $44,152, 2003 to 2004.
  • NHLBI: Shared Microarray Facility (PI: Bento Soares, Co-PI: Jian Huang), $2,879,978, 2002 to 2006.
  • Cystic Fibrosis Foundation: Functional Genomic Study of Cystic Fibrosis (PI: P McCray, Co-I: J Huang), $1,788,138, 2001 to 2006.
  • National Institute of Mental Health: Sampling Models and Methods for Complex Genetic Diseases (PI: V Vieland, Co-PI: J Huang), $775,000, 12/00 to 12/04.
  • : Testing the Reverse-Splicing Model of Intron Speed Spread with rDNA Genes (PI: D Bhattacharya, Co-PI: J Huang), $529,576, 10/01 to 9/04.
  • UI Biosciences Initiative: Using Statistical Methods to Understand Intron Origin (PI: D Bhattacharya, Co-PI: J Huang), $25,000, 1/00 to 6/02.

Publications

  • Ma SG, Huang J (2007) Combining multiple markers for classification using ROC, Biometrics, 63, 751-7
  • Lu MG, Zhang Y, Huang J (2007) Estimation of the mean function with panel count data using polynomial splines, Biometrika, 94, 705-18
  • Ma SG, Huang J (2007) Additive risk survival model with microarray data, BMC Bioinformatics, 8, 192
  • Wang DL, Soares MB, Zhang C-H, Huang J (2007) Systematic approaches for incorporating control spot and data quality information to improve normalization of cDNA microarray data, Journal of Biopharmaceutical Statistics, 17 (3), 415-31
  • Swiderski RE, Nishimura DY, Mullins RF, Olvera MA, Ross JL, Huang J, Stone EM, Sheffield VC (2007) Gene expression analysis of photoreceptor cell loss in Bbs4-knockout mice reveals an early stress gene response and photoreceptor cell damage, Investigative Ophthalmology and Visual Science, 48 (7), 3329-40
  • Song X, Ma SG, Huang J, Zhou XH (2007) A semiparametric approach for the nonparametric transformation survival model with multiple covariates, Biostatistics, 8, 197-211
  • Ma SG, Huang J (2007) Clustering threshold gradient descent regularization with applicantions to microarray studies, Bioinformatics, 23, 460-72
  • Ma SG, Song X, Huang J (2007) Supervised group Lasso with applications to microarray data analysis, BMC Bioinformatics, 8, 60
  • Samuel I, Mason EE, Renquist KE, Huang YH, Zimmerman MB, Jamal M (2006) Bariatric surgery trends: an 18-year report from the International Bariatric Surgery Registry, Am J Surg, 192 (5), 657-62
  • Ma SG, Song X, Huang J (2006) Regularized binormal ROC method for disease classification using microarray data, BMC Bioinformatics, 7, 253
  • Ma SG, Song X, Huang J (2006) Regularized binormal ROC method for disease classification using microarray data, BMC Bioinformatics, 7, 253
  • Wang D, Huang J (2006) Detecting linkage disequilibrium in the presence of locus heterogeneity, Annals of Human Genetics, 70, 397-409
  • Scheetz TE, Kim K-Y, Swiderski RE, Philpl AR, Braun TA, Knudtson KL, Dorrance AM, DiBona GF, Huang J, Casavant TL, Sheffield VC, Stone EM (2006) Regulation of gene expression in the Mammalian eye and its relevance to eye disease, Proceedings of the National Academy of Science, 103, 14429-34
  • Ma SG, Kosorok MR, Huang J, Xie HH, Manzella L, Soares MB (2006) Robust semiparametric microarray normalization and significance analysis, Biometrics, 21, 4356-62
  • Jahrsdorfer B, Blackwell SE, Wooldridge JE, Huang J, Andreski MW, Jacobus LS, Tauylor CM, Weiner GJ (2006) Activated human B cells can secrete granzyme B and gain cytotoxic potential in response to interleukin 21, Journal of Immunotherapy, 29 (6), 673-4
  • Huang J, Ma S, Xie H (2006) Regularized estimation in the accelerated failure time model with high-dimensional covariates, Biometrics, 62 (3), 813-20
  • Chiang AP, Beck JS, Yen H-J, Tayeh MK, Scheetz TE, Swiderski R, Nishimura D, Braun TA, Kim K-Y, Huang J, Elbedour K, Carmi R, Slusarski DC, Casavant TL, Stone EM, Sheffield VC (2006) Homozygosity mapping with SNP arrays identifies a novel gene for Bardet-Biedl Syndrome (BBS10), , , Proceedings of the National Academy of Sciences (USA), 6287-6292 pages
  • Huang J, Wang DL, Zhang C-H (2005) A two-way semilinear model for normalization and analysis of cDNA microarray data, J Am Stat, 100 (471), 814-29
  • Huang J, Zhang CH (2005) Semilinear high-dimensional model for normalization of microarray data: A theoretical analysis and partial consistency (Comment), Journal of the American Statistical Association, 100 (471), 800-4
  • Zabner J, Scheetz T, Abdulkawy H, Casavant T, Huang J, Keshavjee S, McCray PB (2005) The CFTR F508 mutation has minimal effect on the gene expression profile of differentiated human airway epithelia, Am J Physiol Lung Cell Mol Physiol
  • Abrevaya J, Huang J (2005) On the bootstrap of the maximum score estimator, Econometrica, 73, 1175-1204
  • Yang X, Huang J, Logue MW, Vieland VJ (2005) The posterior probability of linkage allowing for linkage disequilibrium and a new estimate of disequilibrium between a trait and a marker, 59 (4), 210-9
  • Wang D, Huang J, Xie H, Manzella L, Soares MB (Jan 2005) A robust two-way semi-linear model for normalization of cDNA microarray data, 6 (1), 14
  • Yang X, Wang K, Huang J, Vieland VJ (2003) Genome-wide linkage analysis of blood pressure under locus heterogeneity, BMC Genet, 4 (Suppl 1), S78
  • Vieland VJ, Huang J, Two-locus heterogeneity cannot be distinguished from two-locus epistasis on the basis of affected-sib-pair data, American Journal of Human Genetics, 73(223-32), 2003
  • Vieland VJ, Huang J, Affected-sib-pair data can be used to distinguish two-locus heterogeneity from two-locus epistasis - Reply [Letter], American Journal of Human Genetics, 73(6), 1471-3, 2003
  • Zhang H, Huang J (2003) Development of Modern Statistics and Related Topics: In Celebration of Prof Yaoting Zhang's 70th Birthday, Singapore, World Scientific Publishing Co.
  • Huang J, Wang K (2003) A semiparametric method for mapping quantitative trait loci, Development of Modern Statistics and Related Topics: In Celebration of Prof Yaoting Zhang's 70th Birthday, Singapore, World Scientific Publishing Co., 262-71 pages (bookchapter)
  • Wang K, Huang J (2002) Score test for mapping quantitative-trait loci with sibships of arbitrary size when the dominance effect is not negligible, Genetic Epidemiology, 23 (4), 398-412
  • Wang K, Huang J, A score-statistic approach for the mapping of quantitative-trait loci with sibships of arbitrary size, American Journal of Human Genetics, 70(2), 412-24, 2002
  • Wassink TH, Piven J, Vieland VJ, Huang J, Swiderski RE, Pietila J, Braun T, Beck G, Folstein SE, Haines JL, Sheffield VC, Evidence supporting WNT2 as an autism susceptibility gene, American Journal of Medical Genetics (Neuropsychiatric Genetics), 105, 406-13, 2001
  • Huang J, Vieland VJ, Comparison of 'model-free' and 'model-based' linkage statistics in the presence of locus heterogeneity: single data set and multiple data set applications, Human Heredity, 51(4), 217-25, 2001 Abstract
  • Vieland VJ, Wang K, Huang J, Power to detect linkage based on multiple sets of data in the presence of locus heterogeneity: comparative evaluation of model-based linkage methods for affected sib pair data, Human Heredity, 51(4), 199-208, 2001 Abstract
  • Huang J, Vieland VJ, The null distribution of the heterogeneity lod score does depend on the assumed genetic model for the trait, Human Heredity, 52(4), 217-22, 2001 Abstract
  • Huang J, Jiang Y, The score statistic of the LD-lod analysis: detecting linkage adaptive to linkage disequilibrium, Human Heredity, 52(2), 83-98, 2001 Abstract
  • Wang K, Huang J, Logue M, Vieland VJ, Combined multipoint analysis of multiple asthma data sets based on the posterior probability of linkage. In:Wijsman, Almasy, et al. Analysis of complex genetic traits:Applications to asthma & simulate, 21 (Suppl 1), S1-S853, 2001
  • Huang J, Wang K, Vieland VJ, Nonparametric estimation of marginal distributions under bivariate truncation with application to testing for age-of-onset anticipation, Statistica Sinica, 11(4), 1047-68, 2001
  • Slager SL, Huang J, Vieland VJ, Power comparisons between the TDT and two likelihood-based methods for complex traits, Genetic Epidemiology, 20, 192-209, 2001
  • Wang K, Huang J, Vieland VJ, The consistency of the posterior probability of linkage, Annals of Human Genetics, 64(Pt 6), 533-53, November 2000 Abstract
  • Slager SL, Huang J, Vieland VJ, The effect of allelic heterogeneity on the power of transmission disequilibrium test, Genetic Epidemiology, 18, 143-56, 2000
  • Huang J, Jiang Y, Linkage detection adaptive to linkage disequilibrium: the disequilibrium maximum-likelihood-binomial test for affected-sibship data, American Journal of Human Genetics, 65(6), 1741-59, December 1999 Abstract
  • Paterson AD, Naimark DM, Huang J, Vachon C, Petronis A, King RA, Anderson VE, Sellers TA, Genetic anticipation and breast cancer: a prospective follow-up study, Breast Cancer Research and Treatment, 55(1), 21-8, May 1999 Abstract
  • Wang K, Vieland V, Huang J, A Bayesian approach to replication of linkage findings., Genetic Epidemiology, 17 Suppl 1, S749-54, 1999 Abstract
  • Huang J, Efficient estimation of the partly linear additive Cox model, Annals of Statistics, 27, 1536-63, 1999
  • Huang J, Asymptotic properties of nonparametric estimation based on partly interval-censored data, Statistica Sinica, 9, 501-19, 1999
  • Li H, Huang J, Semiparametric linkage analysis using pseudolikelihoods on neighbouring sets, Annals of Human Genetics, 62 ( Pt 4), 323-36, July 1998 Abstract
  • Vieland V J, Huang J, Statistical evaluation of age-at-onset anticipation: a new test and evaluation of its behavior in realistic applications., American Journal of Human Genetics, 62(5), 1212-27, May 1998 Abstract
  • Huang J, Vieland V, A new statistical test for age-of-onset anticipation: application to bipolar disorder., Genetic Epidemiology, 14(6), 1091-6, 1997 Abstract
  • Huang J, Asymptotic properties of the NPMLE of a distribution function based on ranked set samples, Annals of Statistics, 1036-1049, 1997
  • Huang J, Rossini AJ, Sieve estimation for the proportional odds failure-time regression model with interval censoring, Journal of the American Statistical Association, 960-7, 1997
  • Praestgaard JT, Huang J, Asymptotic theory for nonparametric estimation of survival curves under order restrictions, Annals of Statistics, 24, 1679-1716, 1996
  • Huang J, Efficient estimation for the proportional hazards model with interval censoring, Annals of Statistics, 24, 540-68, 1996
  • Huang J, Maximum likelihood estimation of proportional odds regression model with current status data, Proceedings of the International Workshop on the Analysis of Censored Data. IMS Lecture Notes-Monograph Series, 129-145, 1996
  • Huang J, Wellner JA, Asymptotic normality of the NPMLE of linear functionals for interval censored data, case 1, Statistica Neerlandica, 49, 153-63, 1995
  • Huang J, Wellner JA, Estimation of a monotone density or monotone hazard under random censoring, Scandinavian Journal of Statistics, 22, 3-33, 1995

Profile Details

Last Updated: 2/20/2008

COS Expertise ID #321159
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