James P. Hughes

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Fred Hutchinson Cancer Research Center
Public Health Sciences
Member
University of Washington
School of Public Health and Community Medicine
Biostatistics
Professor

Mailing Address

Department of Biostatistics 357232
University of Washington
Seattle, Washington 98195
United States

Contact Information

jphughes@u.washington.edu

Qualifications

Ph.D., University of Washington, Statistics, 1993.
M.S., University of Washington, Biomathematics, 1980.
B.S., University of Maine, Wildlife Ecology, 1977.

Expertise and Research Interests

Statistical methods for for HIV/STI research;
community randomized trials;
hidden Markov models;

Keywords

COS Keywords:

Alzheimer's Disease, Biomedical Research (Multidisciplinary), Biostatistics, Public Health, Sexually Transmitted Diseases.

Additional Terms:

Hidden Markov Models, Longitudinal Methods, Rainfall Modelling, Sexually Transmitted Diseases.

Memberships

American Statistical Association
International Biometric Society

Publications

  • Celum C, Wald A, Hughes J, Sanchez J, Reid S, Delany-Moretlwe S, Cowan F, Casapia M, Ortiz A, Fuchs J, Buchbinder S, Koblin B, Zwerski S, Rose S, Wang J, Corey L (Jun 2008) Effect of aciclovir on HIV-1 acquisition in herpes simplex virus 2 seropositive women and men who have sex with men: a randomised, double-blind, placebo-controlled trial., Lancet, 371 (9630), 2109-19 Abstract
  • Richardson BA, Hughes JP, Benki S (Feb 2007) Statistical methods for determining the accuracy of quantitative polymerase chain reaction-based tests., Statistics in medicine, 26 (4), 895-902 Abstract
  • Hussey MA, Hughes JP (Feb 2007) Design and analysis of stepped wedge cluster randomized trials., Contemporary clinical trials, 28 (2), 182-91 Abstract
  • Musey LK, Krieger JN, Hughes JP, Schacker TW, Corey L, McElrath MJ, Early and persistent human immunodeficiency virus type 1 \(HIV-1\)-specific T helper dysfunction in blood and lymph nodes following acute HIV-1 infection., Journal of Infectious Diseases, 180(2), 278-84, August 1999 Abstract
  • Xi L F, Critchlow C W, Wheeler C M, Koutsky L A, Galloway D A, Kuypers J, Hughes J P, Hawes S E, Surawicz C, Goldbaum G, Holmes K K, Kiviat N B, Risk of anal carcinoma in situ in relation to human papillomavirus type 16 variants., Cancer Research, 58(17), 3839-44, 1 Sep 1998 Abstract
  • Garcia PJ, Gotuzzo E, Hughes JP, Holmes KK, Syndromic management of STDs in pharmacies: evaluation and randomised intervention trial., Sexually Transmitted Infections, 74 Suppl 1, S153-8, June 1998 Abstract
  • Rosen H, Michel BR, vanDevanter DR, Hughes JP, Differential effects of myeloperoxidase-derived oxidants on Escherichia coli DNA replication., Infection and Immunity, 66(6), 2655-9, 1998 Abstract
  • Schacker T W, Hughes J P, Shea T, Coombs R W, Corey L, Biological and virologic characteristics of primary HIV infection., Annals of Internal Medicine, 128(8), 613-20, 15 Apr 1998 Abstract
  • Schacker TW, Hughes JP, Shea T, Coombs RW, Corey L, Biological and virologic characteristics of primary HIV infection [see comments, Annals of Internal Medicine, 128(8), 613-20, 15 1998 Abstract
  • Coombs R W, Speck C E, Hughes J P, Lee W, Sampoleo R, Ross S O, Dragavon J, Peterson G, Hooton T M, Collier A C, Corey L, Koutsky L, Krieger J N, Association between culturable human immunodeficiency virus type 1 (HIV-1) in semen and HIV-1 RNA levels in semen and blood: evidence for compartmentalization of HIV-1 between semen and blood., Journal of Infectious Diseases, 177(2), 320-30, February 1998 Abstract
  • Edelstein R E, Arcuino L A, Hughes J P, Melvin A J, Mohan K M, King P D, McLellan C L, Murante B L, Kassman B P, Frenkel L M, Risk of mother-to-infant transmission of HIV-1 is not reduced in CCR5/delta32ccr5 heterozygotes., Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 16(4), 243-6, 1 Dec 1997 Abstract
  • Musey L, Hughes J, Schacker T, Shea T, Corey L, McElrath M J, Cytotoxic-T-cell responses, viral load, and disease progression in early human immunodeficiency virus type 1 infection [see comments], New England Journal of Medicine, 337(18), 1267-74, 30 Oct 1997 Abstract
  • Musey L, Hughes J, Schacker T, Shea T, Corey L, McElrath MJ, Cytotoxic-T-cell responses, viral load, and disease progression in early human immunodeficiency virus type 1 infection [see comments, New England Journal of Medicine, 337(18), 1267-74, 30 Oct 1997 Abstract
  • Schwartz M A, Lafferty W E, Hughes J P, Handsfield H H, Risk factors for urethritis in heterosexual men. The role of fellatio and other sexual practices., Sexually Transmitted Diseases, 24(8), 449-55, September 1997 Abstract
  • Smith H S, Hughes J P, Hooton T M, Roberts P, Scholes D, Stergachis A, Stapleton A, Stamm W E, Antecedent antimicrobial use increases the risk of uncomplicated cystitis in young women., Clinical Infectious Diseases, 25(1), 63-8, July 1997 Abstract
  • Xi L F, Koutsky L A, Galloway D A, Kuypers J, Hughes J P, Wheeler C M, Holmes K K, Kiviat N B, Genomic variation of human papillomavirus type 16 and risk for high grade cervical intraepithelial neoplasia [see comments], Journal of The National Cancer Institute, 89(11), 796-802, 4 Jun 1997 Abstract
  • Lafferty W E, Hughes J P, Handsfield H H, Sexually transmitted diseases in men who have sex with men. Acquisition of gonorrhea and nongonococcal urethritis by fellatio and implications for STD/HIV prevention., Sexually Transmitted Diseases, 24(5), 272-8, May 1997 Abstract
  • Melvin A J, Burchett S K, Watts D H, Hitti J, Hughes J P, McLellan C L, King P D, Johnson E J, Williams B L, Frenkel L M, Coombs R W, Effect of pregnancy and zidovudine therapy on viral load in HIV-1-infected women., Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 14(3), 232-6, 1 Mar 1997 Abstract
  • Patton D L, Sweeney Y C, Bohannon N J, Clark A M, Hughes J P, Cappuccio A, Campbell L A, Stamm W E, Effects of doxycycline and antiinflammatory agents on experimentally induced chlamydial upper genital tract infection in female macaques., Journal of Infectious Diseases, 175(3), 648-54, March 1997 Abstract
  • Paxton W B, Coombs R W, McElrath M J, Keefer M C, Hughes J, Sinangil F, Chernoff D, Demeter L, Williams B, Corey L, Longitudinal analysis of quantitative virologic measures in human immunodeficiency virus-infected subjects with > or = 400 CD4 lymphocytes: implications for applying measurements to individual patient, Journal of Infectious Diseases, 175(2), 247-54, February 1997 Abstract
  • Hooton T M, Scholes D, Hughes J P, Winter C, Roberts P L, Stapleton A E, Stergachis A, Stamm W E, A prospective study of risk factors for symptomatic urinary tract infection in young women [see comments], New England Journal of Medicine, 335(7), 468-74, 15 Aug 1996 Abstract
  • Schacker T, Collier A C, Hughes J, Shea T, Corey L, Clinical and epidemiologic features of primary HIV infection [published erratum appears in Ann Intern Med 1997 Jan 15;126(2):174], Annals of Internal Medicine, 125(4), 257-64, 15 Aug 1996 Abstract
  • Garnett G P, Hughes J P, Anderson R M, Stoner B P, Aral S O, Whittington W L, Handsfield H H, Holmes K K, Sexual mixing patterns of patients attending sexually transmitted diseases clinics., Sexually Transmitted Diseases, 23(3), 248-57, May 1996 Abstract
  • Snowden M B, Bowen J D, Hughes J, Larson E B, Study of Alzheimer's dementia patients with parkinsonian features., Journal of Geriatric Psychiatry and Neurology, 8(3), 154-8, July 1995 Abstract
  • Mirra S S, Gearing M, McKeel D W Jr, Crain B J, Hughes J P, van Belle G, Heyman A, Interlaboratory comparison of neuropathology assessments in Alzheimer's disease: a study of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) [published erratum appears in J Neuro, Journal of Neuropathology and Experimental Neurology, 53(3), 303-15, May 1994 Abstract
  • Davis P C, Gray L, Albert M, Wilkinson W, Hughes J, Heyman A, Gado M, Kumar A J, Destian S, Lee C, et al, The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part III. Reliability of a standardized MRI evaluation of Alzheimer's disease., Neurology, 42(9), 1676-80, September 1992 Abstract
  • Welsh K A, Butters N, Hughes J P, Mohs R C, Heyman A, Detection and staging of dementia in Alzheimer's disease. Use of the neuropsychological measures developed for the Consortium to Establish a Registry for Alzheimer's Disease., Archives of Neurology, 49(5), 448-52, May 1992 Abstract
  • Edwards J K, Larson E B, Hughes J P, Kukull W A, Are there clinical and epidemiological differences between familial and non-familial Alzheimer's disease?, Journal of The American Geriatrics Society, 39(5), 477-83, May 1991 Abstract
  • Mirra S S, Heyman A, McKeel D, Sumi S M, Crain B J, Brownlee L M, Vogel F S, Hughes J P, van Belle G, Berg L, The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease., Neurology, 41(4), 479-86, April 1991 Abstract
  • Welsh K, Butters N, Hughes J, Mohs R, Heyman A, Detection of abnormal memory decline in mild cases of Alzheimer's disease using CERAD neuropsychological measures., Archives of Neurology, 48(3), 278-81, March 1991 Abstract
  • Kalman D A, Hughes J, van Belle G, Burbacher T, Bolgiano D, Coble K, Mottet N K, Polissar L, The effect of variable environmental arsenic contamination on urinary concentrations of arsenic species., Environmental Health Perspectives, 89, 145-51, November 1990 Abstract
  • Polissar L, Lowry-Coble K, Kalman D A, Hughes J P, van Belle G, Covert D S, Burbacher T M, Bolgiano D, Mottet N K, Pathways of human exposure to arsenic in a community surrounding a copper smelter., Environmental Research, 53(1), 29-47, October 1990 Abstract
  • Kukull W A, Larson E B, Reifler B V, Lampe T H, Yerby M S, Hughes J P, The validity of 3 clinical diagnostic criteria for Alzheimer's disease., Neurology, 40(9), 1364-9, September 1990 Abstract
  • Larson E B, Hughes J P, Kukull W A, New data gathering, instrument selection, and evaluation of existing information for determining entry., Aging, 2(2), 215-22, June 1990 Abstract
  • Teri L, Hughes J P, Larson E B, Cognitive deterioration in Alzheimer's disease: behavioral and health factors., Journal of Gerontology, 45(2), P58-63, March 1990 Abstract
  • Shy K K, Luthy D A, Bennett F C, Whitfield M, Larson E B, van Belle G, Hughes J P, Wilson J A, Stenchever M A, Effects of electronic fetal-heart-rate monitoring, as compared with periodic auscultation, on the neurologic development of premature infants [see comments], New England Journal of Medicine, 322(9), 588-93, 1 Mar 1990 Abstract
  • Kukull W A, Larson E B, Reifler B V, Lampe T H, Yerby M, Hughes J, Interrater reliability of Alzheimer's disease diagnosis., Neurology, 40(2), 257-60, February 1990 Abstract
  • Van Belle G, Uhlmann R F, Hughes J P, Larson E B, Reliability of estimates of changes in mental status test performance in senile dementia of the Alzheimer type., Journal of Clinical Epidemiology, 43(6), 589-95, 1990 Abstract

Profile Details

Last Updated: 2/10/2009

COS Expertise ID #373537
Reference this profile directly: http://myprofile.cos.com/hughesj37