Lorraine Iacovitti

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Thomas Jefferson University
Jefferson Medical College
Department of Neurology
ProfessorAppointed: 1998
Thomas Jefferson University
Thomas Jefferson University Hospital
Neurology

Mailing Address

Thomas Jefferson University
Department of Neurology
1025 Walnut Street
Philadelphia, Pennsylvania 19107-5587
United States

Contact Information

Phone: (215) 955-8118
Fax: (215) 955-2992
Lorraine.Iacovitti@jefferson.edu

Qualifications

Cornell University Medical College, Neurobiology, 1979.
B.S., Monmouth College, Biology, 1973.

Other Expertise

INTRAMURAL COMMITTEES AND ACTIVITIES (1997-present)
1995-1998 University Grievance Committee
1997-1998 University Steering Committee for the Faculty (elected)
1998-2000 Chairman, Research Committee, Department of Neurology
1998-2000 University Research Council
2000-2001 Co-chairman, University Research Committee
2001- Chairman, University Research Committee

EXTRAMURAL COMMITTEES AND ACTIVITIES (1997-present)
NSF Grant Reviewer - 1983-present
NIH Study Section Subcommittee NLS 1 - 1991, 1992, 1993, 1997
NIH NRSA Study Section- 1997
NIH Special Review Panel- Parkinson's Disease Center Grants- 1998
Philadelphia Chapter of the Society for Neuroscience 1996-1998
Drexel University Honors Program in Science, Consultant 1997-1999
Board of Trustees, Educational Committee, Germantown Academy 1997-1999
Advisor, The Lee Foundation 1998

OTHER PROFESSIONAL ACTIVITIES (1997-present)
1983-present NSF Grant Reviewer
1991, 1992, 1993, 1997 NIH Study Section Subcommittee NLS 1
1998,1999, 2000 NIH Special Review Panel- Parkinson's Disease Center of Excellence Grants

EDITORIAL ACTIVITIES
Journal of Neuroscience, Neuroscience, Journal of Neurochemistry, Developmental Biology, Neuroscience Letters, Journal of Neurobiology, Anatomy and Embryology, Journal of Neurocytology, Neuroendocrinology, Biotechniques

Keywords

COS Keywords:

Neurology.

Patents

Muscle-derivable Differentiation Factor for Treatment of Catecholamine Deficiencies of the Central Nervous System, Patent Number: 538, 146, 7933-11, 1990, , United States.

Publications

  • Zhou J, Iacovitti L, Mechanisms governing the differentiation of a serotonergic phenotype in culture, Brain Research, 877(1), 37-46, 2000 Abstract
  • Iacovitti L, Stull ND, Mishizen A, Neurotransmitters, KCl and antioxidants rescue striatal neurons from apoptotic cell death in culture, Brain Research, 816(2), 276-85, Jan 1999 Abstract
  • Guo Z, Du X, Iacovitti L, Regulation of tyrosine hydroxylase gene expression during transdifferentiation of striatal neurons: changes in transcription factors binding the AP-1 site, Journal of Neuroscience, 18(20), 8163-74, October 1998 Abstract
  • Du X, Iacovitti L, Multiple signaling pathways direct the initiation of tyrosine hydroxylase gene expression in cultured brain neurons, Brain Research. Molecular Brain Research, 50(1-2), 1-8, October 1997 Abstract
  • Iacovitti L, Stull ND, Johnston K, Melatonin rescues dopamine neurons from cell death in tissue culture models of oxidative stress, Brain Research, 768(1-2), 317-26, September 1997 Abstract
  • Schinstine M, Iacovitti L, 5-Azacytidine and BDNF enhance the maturation of neurons derived from EGF-generated neural stem cells, Experimental Neurology, 144(2), 315-25, April 1997 Abstract
  • Iacovitti L, Stull ND, Expression of tyrosine hydroxylase in newly differentiated neurons from a human cell line (hNT), Neuroreport, 8(6), 1471-4, April 1997 Abstract
  • Du X, Iacovitti L, Protein kinase C activators work in synergy with specific growth factors to initiate tyrosine hydroxylase expression in striatal neurons in culture, Journal of Neurochemistry, 68(2), 564-9, February 1997 Abstract
  • Stull ND, Iacovitti L, Acidic fibroblast growth factor and catecholamines synergistically up-regulate tyrosine hydroxylase activity in developing and damaged dopamine neurons in culture, Journal of Neurochemistry, 67(4), 1519-24, October 1996 Abstract
  • Schinstine M, Iacovitti L, Expression of neuronal antigens by astrocytes derived from EGF-generated neuroprogenitor cells, Experimental Neurology, 141(1), 67-78, September 1996 Abstract
  • Jin BK, Iacovitti L, Dopamine differentiation factors increase striatal dopaminergic function in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mice, Journal of Neuroscience Research, 43(3), 331-4, February 1996 Abstract
  • Max SR, Bossio A, Iacovitti L, Co-expression of tyrosine hydroxylase and glutamic acid decarboxylase in dopamine differentiation factor-treated striatal neurons in culture, Brain Research. Developmental Brain Research, 91(1), 140-2, January 1996 Abstract
  • Du X, Iacovitti L, Synergy between growth factors and transmitters required for catecholamine differentiation in brain neurons, Journal of Neuroscience, 15(7 Pt 2), 5420-7, July 1995 Abstract
  • Du X, Stull ND, Iacovitti L, Brain-derived neurotrophic factor works coordinately with partner molecules to initiate tyrosine hydroxylase expression in striatal neurons, Brain Research, 680(1-2), 229-33, May 1995 Abstract
  • Jin BK, Iacovitti L, Dopamine differentiation factors produce partial motor recovery in 6-hydroxydopamine lesioned rats, Neurobiology of Disease, 2(1), 1-12, February 1995 Abstract
  • Du X, Stull ND, Iacovitti L, Novel expression of the tyrosine hydroxylase gene requires both acidic fibroblast growth factor and an activator, Journal of Neuroscience, 14(12), 7688-94, December 1994 Abstract
  • Kerr CW, Lee LJ, Romero AA, Stull ND, Iacovitti L, Purification of dopamine neurons by flow cytometry, Brain Research, 665(2), 300-6, December 1994 Abstract
  • Stull ND, Schneider JS, Iacovitti L, GM1 ganglioside partially rescues cultured dopaminergic neurons from MPP( )-induced damage: dependence on initial damage and time of treatment, Brain Research, 640(1-2), 308-15, March 1994 Abstract
  • Iacovitti L, Centrally active differentiation factors in the nervous system, Pharmacology and Therapeutics, 62(3), 373-83, 1994 Abstract
  • Iacovitti L, Evinger MJ, Stull ND, Muscle-derived differentiation factor increases expression of the tyrosine hydroxylase gene and enzyme activity in cultured dopamine neurons from the rat midbrain, Brain Research. Molecular Brain Research, 16(3-4), 215-22, December 1992 Abstract
  • Shirao T, Evinger MJ, Iacovitti L, Reis DJ, Lesions of nigrostriatal pathway reduce expression of tyrosine hydroxylase gene in residual dopaminergic neurons of substantia nigra, Neuroscience Letters, 141(2), 208-12, July 1992 Abstract
  • Iacovitti L, Effects of a novel differentiation factor on the development of catecholamine traits in noncatecholamine neurons from various regions of the rat brain: studies in tissue culture, Journal of Neuroscience, 11(8), 2403-9, August 1991 Abstract
  • Katz IR, Iacovitti LM, Reis DJ, In vitro studies on the characterization of cellular proliferation following neuronal injury in the adult rat brain, Journal of Neuroimmunology, 29(1-3), 33-48, 1990 Abstract
  • Ernsberger P, Iacovitti L, Reis DJ, Astrocytes cultured from specific brain regions differ in their expression of adrenergic binding sites, Brain Research, 517(1-2), 202-8, May 1990 Abstract
  • Iacovitti L, Evinger MJ, Joh TH, Reis DJ, A muscle-derived factor(s) induces expression of a catecholamine phenotype in neurons of cultured rat cerebral cortex, Journal of Neuroscience, 9(10), 3529-37, October 1989 Abstract
  • Katz IR, Iacovitti L, Reis DJ, Cells proliferating in vitro to local brain injury are primarily of hematic origin and differ from those associated with anterograde degeneration, Annals of the New York Academy of Sciences, 540, 413-5, 1988 Abstract
  • Iacovitti L, Teitelman G, Joh TH, Reis DJ, Chick eye extract promotes expression of a cholinergic enzyme in sympathetic ganglia in culture, Brain Research, 430(1), 59-65, May 1987 Abstract
  • Iacovitti L, Lee J, Joh TH, Reis DJ, Expression of tyrosine hydroxylase in neurons of cultured cerebral cortex: evidence for phenotypic plasticity in neurons of the CNS, Journal of Neuroscience, 7(4), 1264-70, April 1987 Abstract
  • Iacovitti L, Joh TH, Albert VR, Park DH, Reis DJ, Teitelman G, Partial expression of catecholaminergic traits in cholinergic chick ciliary ganglia: studies in vivo and in vitro, Developmental Biology, 110(2), 402-12, August 1985 Abstract
  • Teitelman G, Joh TH, Grayson L, Park DH, Reis DJ, Iacovitti L, Cholinergic neurons of the chick ciliary ganglia express adrenergic traits in vivo and in vitro, Journal of Neuroscience, 5(1), 29-39, January 1985 Abstract
  • Higgins D, Iacovitti L, Burton H, Fetal rat sympathetic neurons maintained in a serum-free medium retain induced cholinergic characteristics, Brain Research, 316(1), 71-82, May 1984 Abstract
  • Iacovitti L, Johnson MI, Joh TH, Bunge RP, Biochemical and morphological characterization of sympathetic neurons grown in a chemically-defined medium, Neuroscience, 7(9), 2225-39, 1982 Abstract
  • Iacovitti L, Joh TH, Park DH, Bunge RP, Dual expression of neurotransmitter synthesis in cultured autonomic neurons, Journal of Neuroscience, 1(7), 685-90, July 1981 Abstract
  • Higgins D, Iacovitti L, Joh TH, Burton H, The immunocytochemical localization of tyrosine hydroxylase within rat sympathetic neurons that release acetylcholine in culture, Journal of Neuroscience, 1(2), 126-31, February 1981 Abstract
  • Iacovitti L, Reis DJ, Joh TH, Reactive proliferation of brain stem noradrenergic nerves following neonatal cerebellectomy in rats: role of target maturation on neuronal response to injury during development, Brain Research, 227(1), 3-24, January 1981 Abstract
  • Iacovitti L, Gershon MD, Induction of lipid droplet accumulation in cardiac muscle cells of guinea pigs and mice: an analysis of the effects of reserpine and fasting, Anatomical Record, 191(3), 327-43, July 1978 Abstract

Profile Details

Last Updated: 3/14/2006

COS Expertise ID #942116
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