Ira M. Longini

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Fred Hutchinson Cancer Research Center
Public Health Sciences Division
Program of Biostatistics and Biomathematics
Full MemberAppointed: 2006
University of Washington
School of Medicine
Mathematical Modeling for HIV/STD Research
DirectorAppointed: 2006
University of Washington
School of Public Health and Community Medicine
Biostatistics
Full ProfessorAppointed: 2006

Mailing Address

Program in Biostatistics and Biomathematics
Fred Hutchinson Cancer Research Center
1100 Fairview Ave. N., LE-400
P.O. Box 19024
Seattle, Washington 98109-1024
United States

Contact Information

Phone: (206) 667-2721
Fax: (206) 667-4812
ira@scharp.org

Qualifications

Ph.D., University of Minnesota, Biometry/Biomathematics, 1977.
M.S., University of Florida, Statistics/Operations Research, 1973.
B.S., University of Florida, Engineering/Operations Research, 1971.

Expertise and Research Interests

Biostatistics
Stochastic processes
Infectious disease epidemiology

Keywords

COS Keywords:

AIDS, Biometry, Biostatistics, HIV, HIV Prevention, Infectious Diseases Or Agents, Mathematical Modeling (Medical), Operations Research, Statistics, Stochastic Processes.

Additional Terms:

Biostatistics, Infectious Disease Epidemiology, Stochastic Processes.

Honors and Awards

1996, Statistical Science Award, "Best Applied Paper", Centers for Disease Control and Prevention (CDC)
1995, Elected Fellow, American Statistical Association
1995, Howard M. Temin Award in Epidemiology, "For Scientific Excellence in the Fight Against HIV/AIDS"
1994, James H. Hakano Citation, "Outstanding scientific paper published in 1994", Centers for Disease Control and Prevention (CDC), Probability of female-to-male transmission of HIV-1 in Thailand.
1994, Statistical Science Award, "Best Theoretical Paper", Centers for Disease Control and Prevention (CDC)

Previous Positions

1993-1993, Visiting Fellow, University of Cambridge, Isaac Newton Institute for Mathematical Sciences
1988-2005, Full Professor, Emory University, Rollins School of Public Health, Biostatistics
1984-1988, Assistant Professor, Emory University, Statistics and Biometry
1982-1984, Assistant Research Scientist, University of Michigan, Public Health, Epidemiology
1982-1983, Visiting Assistant Professor, University of Michigan, Literature, Science & the Arts, Statistics
1980-1982, Postdoctoral Research Scholar, University of Michigan, Public Health, Epidemiology, Biometry and Epidemiology
1977-1979, Assistant Professor, Universidad del Valle, Information and Systems, Statistics
1977-1979, Postdoctoral Associate, International Center for Medical Research, Cali, Columbia

Publications

  • Huq A, Sack RB, Nizam A, Longini IM, Nair GB, Ali A, Morris JG Jr, Khan MN, Siddique AK, Yunus M, Albert MJ, Sack DA, Colwell RR (Aug 2005) Critical factors influencing the occurrence of Vibrio cholerae in the environment of Bangladesh., Applied and Environmental Microbiology, 71 (8), 4645-54 Abstract
  • Longini IM Jr, Nizam A, Xu S, Ungchusak K, Hanshaoworakul W, Cummings DA, Halloran ME (Aug 2005) Containing pandemic influenza at the source., Science, 309 (5737), 1083-7 Abstract
  • Regoes RR, Longini IM, Feinberg MB, Staprans SI (Aug 2005) Preclinical assessment of HIV vaccines and microbicides by repeated low-dose virus challenges., Plos Medicine / Public Library of Science, 2 (8), e249 Abstract
  • Patel R, Longini IM Jr, Halloran ME (May 2005) Finding optimal vaccination strategies for pandemic influenza using genetic algorithms., Journal of Theoretical Biology, 234 (2), 201-12 Abstract
  • Longini IM Jr, Halloran ME (Feb 2005) Strategy for distribution of influenza vaccine to high-risk groups and children., American Journal of Epidemiology, 161 (4), 303-6 Abstract
  • Weycker D, Edelsberg J, Halloran ME, Longini IM Jr, Nizam A, Ciuryla V, Oster G (Jan 2005) Population-wide benefits of routine vaccination of children against influenza., Vaccine, 23 (10), 1284-93 Abstract
  • Glezen WP, Piedra PA, Longini IM, Halloran ME, Safety of cold-adapted live influenza vaccine., The Pediatric Infectious Disease Journal, 23(6), 593-4; author reply, Jun 2004 Abstract
  • Longini IM Jr, Halloran ME, Nizam A, Yang Y (Apr 2004) Containing pandemic influenza with antiviral agents., American Journal of Epidemiology, 159 (7), 623-33 Abstract
  • Gaglani MJ, Piedra PA, Herschler GB, Griffith ME, Kozinetz CA, Riggs MW, Fewlass C, Halloran ME, Longini IM Jr, Glezen WP (Jan 2004) Direct and total effectiveness of the intranasal, live-attenuated, trivalent cold-adapted influenza virus vaccine against the 2000-2001 influenza A(H1N1) and B epidemic in healthy children., Archives of Pediatrics & Adolescent Medicine, 158 (1), 65-73 Abstract
  • Halloran ME, Longini IM Jr, Gaglani MJ, Piedra PA, Chu H, Herschler GB, Glezen WP (Aug 2003) Estimating efficacy of trivalent, cold-adapted, influenza virus vaccine (CAIV-T) against influenza A (H1N1) and B using surveillance cultures., American Journal of Epidemiology, 158 (4), 305-11 Abstract
  • Sack RB, Siddique AK, Longini IM Jr, Nizam A, Yunus M, Islam MS, Morris JG Jr, Ali A, Huq A, Nair GB, Qadri F, Faruque SM, Sack DA, Colwell RR (Jan 2003) A 4-year study of the epidemiology of Vibrio cholerae in four rural areas of Bangladesh., The Journal of Infectious Diseases, 187 (1), 96-101 Abstract
  • Hill AN, Longini IM Jr (Jan 2003) The critical vaccination fraction for heterogeneous epidemic models., Mathematical Biosciences, 181 (1), 85-106 Abstract
  • Halloran ME, Longini IM Jr, Nizam A, Yang Y (Nov 2002) Containing bioterrorist smallpox., Science, 298 (5597), 1428-32 Abstract
  • Halloran ME, Longini IM, Cowart DM, Nizam A (Sep 2002) Community interventions and the epidemic prevention potential., Vaccine, 20 (27-28), 3254-62 Abstract
  • Longini IM Jr, Yunus M, Zaman K, Siddique AK, Sack RB, Nizam A (Jul 2002) Epidemic and endemic cholera trends over a 33-year period in Bangladesh., The Journal of Infectious Diseases, 186 (2), 246-51 Abstract
  • Longini IM Jr, Halloran ME, Nizam A (Feb 2002) Model-based estimation of vaccine effects from community vaccine trials., Statistics in Medicine, 21 (4), 481-95 Abstract
  • Hudgens MG, Longini IM Jr, Vanichseni S, Hu DJ, Kitayaporn D, Mock PA, Halloran ME, Satten GA, Choopanya K, Mastro TD (Jan 2002) Subtype-specific transmission probabilities for human immunodeficiency virus type 1 among injecting drug users in Bangkok, Thailand., American Journal of Epidemiology, 155 (2), 159-68 Abstract
  • Halloran ME, Longini IM Jr (Sep 2001) Using validation sets for outcomes and exposure to infection in vaccine field studies., American Journal of Epidemiology, 154 (5), 391-8 Abstract
  • Hudgens MG, Satten GA, Longini IM Jr (Mar 2001) Nonparametric maximum likelihood estimation for competing risks survival data subject to interval censoring and truncation., Biometrics, 57 (1), 74-80 Abstract
  • Guihenneuc-Jouyaux C, Richardson S, Longini IM Jr (Sep 2000) Modeling markers of disease progression by a hidden Markov process: application to characterizing CD4 cell decline., Biometrics, 56 (3), 733-41 Abstract
  • Longini IM, Halloran ME, Nizam A, Wolff M, Mendelman PM, Fast PE, Belshe RB (Mar 2000) Estimation of the efficacy of live, attenuated influenza vaccine from a two-year, multi-center vaccine trial: implications for influenza epidemic control., Vaccine, 18 (18), 1902-9 Abstract
  • Datta S, Halloran ME, Longini IM Jr (Sep 1999) Efficiency of estimating vaccine efficacy for susceptibility and infectiousness: randomization by individual versus household., Biometrics, 55 (3), 792-8 Abstract
  • Golm GT, Halloran ME, Longini IM Jr (Mar 1999) Semiparametric methods for multiple exposure mismeasurement and a bivariate outcome in HIV vaccine trials., Biometrics, 55 (1), 94-101 Abstract
  • Longini IM Jr, Hudgens MG, Halloran ME, Sagatelian K (Jan 1999) A Markov model for measuring vaccine efficacy for both susceptibility to infection and reduction in infectiousness for prophylactic HIV vaccines., Statistics in Medicine, 18 (1), 53-68 Abstract
  • Halloran ME, Longini IM Jr, Struchiner CJ (1999) Design and interpretation of vaccine field studies., Epidemiologic Reviews, 21 (1), 73-88 Abstract
  • Golm GT, Halloran ME, Longini IM Jr (Oct 1998) Semi-parametric models for mismeasured exposure information in vaccine trials., Statistics in Medicine, 17 (20), 2335-52 Abstract
  • Durham LK, Longini IM Jr, Halloran ME, Clemens JD, Nizam A, Rao M (May 1998) Estimation of vaccine efficacy in the presence of waning: application to cholera vaccines., American Journal of Epidemiology, 147 (10), 948-59 Abstract
  • Longini IM Jr, Sagatelian K, Rida WN, Halloran ME (May 1998) Optimal vaccine trial design when estimating vaccine efficacy for susceptibility and infectiousness from multiple populations., Statistics in Medicine, 17 (10), 1121-36 Abstract
  • Datta S, Halloran ME, Longini IM Jr (Jan 1998) Augmented HIV vaccine trial design for estimating reduction in infectiousness and protective efficacy., Statistics in Medicine, 17 (2), 185-200 Abstract
  • Halloran ME, Struchiner CJ, Longini IM Jr (Nov 1997) Study designs for evaluating different efficacy and effectiveness aspects of vaccines., American Journal of Epidemiology, 146 (10), 789-803 Abstract
  • Longini IM Jr, Datta S, Halloran ME (Dec 1996) Measuring vaccine efficacy for both susceptibility to infection and reduction in infectiousness for prophylactic HIV-1 vaccines., Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association., 13 (5), 440-7 Abstract
  • Halloran ME, Longini IM Jr, Struchiner CJ (Jul 1996) Estimability and interpretation of vaccine efficacy using frailty mixing models., American Journal of Epidemiology, 144 (1), 83-97 Abstract
  • Hendriks JC, Satten GA, Longini IM, van Druten HA, Schellekens PT, Coutinho RA, van Griensven GJ (Jun 1996) Use of immunological markers and continuous-time Markov models to estimate progression of HIV infection in homosexual men., Aids (london, England), 10 (6), 649-56 Abstract
  • Haber M, Orenstein WA, Halloran ME, Longini IM Jr (May 1995) The effect of disease prior to an outbreak on estimates of vaccine efficacy following the outbreak., American Journal of Epidemiology, 141 (10), 980-90 Abstract
  • Longini IM Jr, Halloran ME, AIDS: modeling epidemic control., Science, 267(5202), 1250-1; author reply, Mar 1995 Abstract
  • Jacquez JA, Koopman JS, Simon CP, Longini IM Jr (Nov 1994) Role of the primary infection in epidemics of HIV infection in gay cohorts., Journal of Acquired Immune Deficiency Syndromes, 7 (11), 1169-84 Abstract
  • Satten GA, Mastro TD, Longini IM Jr (Oct 1994) Modelling the female-to-male per-act HIV transmission probability in an emerging epidemic in Asia., Statistics in Medicine, 13 (19-20), 2097-106 Abstract
  • Statten GA, Longini IM Jr (Sep 1994) Estimation of incidence of HIV infection using cross-sectional marker surveys., Biometrics, 50 (3), 675-88 Abstract
  • Koopman JS, Longini IM Jr (May 1994) The ecological effects of individual exposures and nonlinear disease dynamics in populations., American Journal of Public Health, 84 (5), 836-42 Abstract
  • Halloran ME, Longini IM Jr, Haber MJ, Struchiner CJ, Brunet RC (Feb 1994) Exposure efficacy and change in contact rates in evaluating prophylactic HIV vaccines in the field., Statistics in Medicine, 13 (4), 357-77 Abstract
  • Mastro TD, Satten GA, Nopkesorn T, Sangkharomya S, Longini IM Jr (Jan 1994) Probability of female-to-male transmission of HIV-1 in Thailand., Lancet, 343 (8891), 204-7 Abstract
  • Sullivan KM, Monto AS, Longini IM Jr (Dec 1993) Estimates of the US health impact of influenza., American Journal of Public Health, 83 (12), 1712-6 Abstract
  • Longini IM Jr, Clark WS, Karon JM (Jun 1993) Effect of routine use of therapy in slowing the clinical course of human immunodeficiency virus (HIV) infection in a population-based cohort., American Journal of Epidemiology, 137 (11), 1229-40 Abstract
  • Longini IM Jr, Halloran ME, Haber M, Chen RT (Feb 1993) Measuring vaccine efficacy from epidemics of acute infectious agents., Statistics in Medicine, 12 (3-4), 249-63 Abstract
  • Longini IM Jr, Halloran ME, Haber M (Sep-Oct 1993) Estimation of vaccine efficacy from epidemics of acute infectious agents under vaccine-related heterogeneity., Mathematical Biosciences, 117 (1-2), 271-81 Abstract
  • Halloran ME, Haber M, Longini IM Jr (Aug 1992) Interpretation and estimation of vaccine efficacy under heterogeneity., American Journal of Epidemiology, 136 (3), 328-43 Abstract
  • Longini IM Jr, Byers RH, Hessol NA, Tan WY (Apr 1992) Estimating the stage-specific numbers of HIV infection using a Markov model and back-calculation., Statistics in Medicine, 11 (6), 831-43 Abstract
  • Rampey AH Jr, Longini IM Jr, Haber M, Monto AS (Mar 1992) A discrete-time model for the statistical analysis of infectious disease incidence data., Biometrics, 48 (1), 117-28 Abstract
  • Hethcote HW, Van Ark JW, Longini IM Jr (Oct 1991) A simulation model of AIDS in San Francisco: I. Model formulation and parameter estimation., Mathematical Biosciences, 106 (2), 203-22 Abstract
  • Haber M, Longini IM Jr, Halloran ME (Oct 1991) Estimation of vaccine efficacy in outbreaks of acute infectious diseases., Statistics in Medicine, 10 (10), 1573-84 Abstract
  • Addy CL, Longini IM Jr, Haber M (Sep 1991) A generalized stochastic model for the analysis of infectious disease final size data., Biometrics, 47 (3), 961-74 Abstract
  • Koopman JS, Prevots DR, Vaca Marin MA, Gomez Dantes H, Zarate Aquino ML, Longini IM Jr, Sepulveda Amor J (Jun 1991) Determinants and predictors of dengue infection in Mexico., American Journal of Epidemiology, 133 (11), 1168-78 Abstract
  • Koopman JS, Longini IM Jr, Jacquez JA, Simon CP, Ostrow DG, Martin WR, Woodcock DM (Jun 1991) Assessing risk factors for transmission of infection., American Journal of Epidemiology, 133 (12), 1199-209 Abstract
  • Haber M, Longini IM Jr, Halloran ME (Mar 1991) Measures of the effects of vaccination in a randomly mixing population., International Journal of Epidemiology, 20 (1), 300-10 Abstract
  • Halloran ME, Haber M, Longini IM Jr, Struchiner CJ (Feb 1991) Direct and indirect effects in vaccine efficacy and effectiveness., American Journal of Epidemiology, 133 (4), 323-31 Abstract
  • Longini IM Jr, Clark WS, Gardner LI, Brundage JF (1991) The dynamics of CD4+ T-lymphocyte decline in HIV-infected individuals: a Markov modeling approach., Journal of Acquired Immune Deficiency Syndromes, 4 (11), 1141-7 Abstract
  • Flanders WD, Longini IM Jr (Aug 1990) Estimating benefits of screening from observational cohort studies., Statistics in Medicine, 9 (8), 969-80 Abstract
  • Longini IM Jr, Haber MJ, Halloran ME (Jul 1990) [Direct and indirect effects of vaccines: an annotation on the estimation of the vaccine efficacy from outbreaks caused by acute infection agents such as measles], Boletin Medico Del Hospital Infantil De Mexico, 47 (7), 516-9 Abstract
  • Ackerman E, Longini IM Jr, Seaholm SK, Hedin AS (Jun 1990) Simulation of mechanisms of viral interference in influenza., International Journal of Epidemiology, 19 (2), 444-54 Abstract
  • Longini IM Jr, Modeling the decline of CD4+ T-lymphocyte counts in HIV-infected individuals., Journal of Acquired Immune Deficiency Syndromes, 3(9), 930-1, 1990 Abstract
  • Koopman JS, Monto AS, Longini IM Jr (Oct 1989) The Tecumseh Study. XVI: Family and community sources of rotavirus infection., American Journal of Epidemiology, 130 (4), 760-8 Abstract
  • Longini IM Jr, Haber M, Koopman JS, Re: "Use of Modeling in Infectious Disease Epidemiology"., American Journal of Epidemiology, 130(3), 619-21, Sep 1989 Abstract
  • Horsburgh CR Jr, Ou CY, Jason J, Holmberg SD, Longini IM Jr, Schable C, Mayer KH, Lifson AR, Schochetman G, Ward JW, Et Al. (Sep 1989) Duration of human immunodeficiency virus infection before detection of antibody., Lancet, 2 (8664), 637-40 Abstract
  • Longini IM Jr, Clark WS, Byers RH, Ward JW, Darrow WW, Lemp GF, Hethcote HW (Jul 1989) Statistical analysis of the stages of HIV infection using a Markov model., Statistics in Medicine, 8 (7), 831-43 Abstract
  • Longini IM Jr, Koopman JS, Haber M, Cotsonis GA (Oct 1988) Statistical inference for infectious diseases. Risk-specific household and community transmission parameters., American Journal of Epidemiology, 128 (4), 845-59 Abstract
  • Longini IM Jr, Monto AS (Sep 1988) Efficacy of virucidal nasal tissues in interrupting familial transmission of respiratory agents. A field trial in Tecumseh, Michigan., American Journal of Epidemiology, 128 (3), 639-44 Abstract
  • Haber M, Longini IM Jr, Cotsonis GA (Mar 1988) Models for the statistical analysis of infectious disease data., Biometrics, 44 (1), 163-73 Abstract
  • Longini IM Jr, Fine PE, Thacker SB (Mar 1986) Predicting the global spread of new infectious agents., American Journal of Epidemiology, 123 (3), 383-91 Abstract
  • Monto AS, Koopman JS, Longini IM Jr (Jun 1985) Tecumseh study of illness. XIII. Influenza infection and disease, 1976-1981., American Journal of Epidemiology, 121 (6), 811-22 Abstract
  • Longini IM Jr, Seaholm SK, Ackerman E, Koopman JS, Monto AS (Dec 1984) Simulation studies of influenza epidemics: assessment of parameter estimation and sensitivity., International Journal of Epidemiology, 13 (4), 496-501 Abstract
  • Longini IM Jr, Higgins MW, Hinton PC, Moll PP, Keller JB (Dec 1984) Genetic and environmental sources of familial aggregation of body mass in Tecumseh, Michigan., Human Biology; an International Record of Research, 56 (4), 733-57 Abstract
  • Longini IM Jr, Higgins MW, Hinton PC, Moll PP, Keller JB (Jul 1984) Environmental and genetic sources of familial aggregation of blood pressure in Tecumseh, Michigan., American Journal of Epidemiology, 120 (1), 131-44 Abstract
  • Longini IM Jr, Monto AS, Koopman JS (Mar 1984) Statistical procedures for estimating the community probability of illness in family studies: rhinovirus and influenza., International Journal of Epidemiology, 13 (1), 99-106 Abstract
  • Higgins MW, Longini IM (1984) The Tecumseh Community Health Study., Progress in Clinical and Biological Research, 147, 43-5 Abstract
  • Monto AS, Koopman JS, Longini IM, Isaacson RE (Aug 1983) The Tecumseh study. XII. Enteric agents in the community, 1976-1981., The Journal of Infectious Diseases, 148 (2), 284-91 Abstract
  • Longini IM Jr (1983) Models of epidemics and endemicity in genetically variable host populations., Journal of Mathematical Biology, 17 (3), 289-304 Abstract
  • Longini IM Jr, Koopman JS, Monto AS (Mar-Apr 1983) [Procedures for estimating transmission parameters from influenza epidemics: use of serological data], Voprosy Virusologii (2), 176-82 Abstract
  • Longini IM Jr, Koopman JS, Monto AS, Fox JP (May 1982) Estimating household and community transmission parameters for influenza., American Journal of Epidemiology, 115 (5), 736-51 Abstract
  • Longini IM Jr, Koopman JS (Mar 1982) Household and community transmission parameters from final distributions of infections in households., Biometrics, 38 (1), 115-26 Abstract

Profile Details

Last Updated: 6/1/2009

COS Expertise ID #1237153
Reference this profile directly: http://myprofile.cos.com/iralongini