James J. Ireland

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Michigan State University
College of Agriculture & Natural Resources
Animal Science
ProfessorAppointed: 1987
Michigan State University
College of Natural Science
Physiology
ProfessorAppointed: 1987

Mailing Address

Rm. 1230C Anthony Hall
Michigan State University
East Lansing, Michigan 48824
United States

Contact Information

Phone: (517) 432-1384
Fax: (517) 353-3149
Ireland@msu.edu

Qualifications

Senior NIH Fellow, Yale University, Reproduction, 1986.
Postdoctoral Fellow, University of Michigan, Reproductive Biology, 1977.
Ph.D., University of Tennessee - Knoxville, Animal Science, 1975.
B.S., Austin Peay State University, Agriculture & Biology, 1969.

Expertise and Research Interests

Expertise in:
DNA array
Cell culture
RIA
ELISA
PCR
Immunoblot analysis
Northern blot analysis
Protein purification
Ovariectomy of cattle

Research interest in ovarian reserve, follicular growth, differentiation, atresia,fertility and aging

Other Expertise

Academic Experience:
- Organized USDA-NIH Workshops in 2004, 2007 on Advantages of Domestic Species as Biomedical Models (http://www.cafg.msu.edu/adsbm/)
- USDA-NRI Panel Manager, Animal Reproduction, 2003
- NIH Panel member, Reproductive Endocrinology, 2003
- Director, Research Excellence Fund's Center for Animal Production Enhancement, 1990-99
- Chaired scientific sessions at 7 national or international meetings
- Invited speaker and (or) consultant at 38 universities or national & international meetings
- Served on 7 federal grant review panels or site visit teams for USDA and NIH
- Member of 7 professional societies
- Editorial board for J. Animal Science, 1986-87
- Recipient of 43 federal, state, industrial, or university grants including NSF, NIH, USDA and Research Excellence Funds totaling nearly $5,000,000
- Recipient of 11 academic awards or fellowships including NICHHD Senior Fellowship, Yale University, 1986-87
Young Investigator's Award (2nd place), Society for the Study of Reproduction, 1977
- NICHHD Postdoctoral Fellowship and Ford Foundation Fellow in Reproductive Biology, University of Michigan, 1975-1976
- Postdoctoral Fellowship, Reproductive Biology, University of Michigan, 1975-77
- Senior NIH Fellow, Reproductive Biochemistry,Yale School of Medicine, 1987-88

Business Experience:
Started ReproVax INC in 1994 to focus on development of fertility vaccines for pets and domestic species.Company awarded Phase I SBIR to develop a recombinant fertility vaccine

Ford Foundation Postdoctoral F, University of Michigan, 1976
NIH Senior Fellow, Yale University, 1987

Future Research

Elucidation of extent and mechanisms whereby variation in the size of the ovarian reserve negatively impacts ovarian function and fertility using the bovine model.

Industrial Relevance

Fertility control

Keywords

COS Keywords:

Animal Reproductive Biology, Animal Science, Cell Culture, DNA, Immunobiology, Physiology, Proteins and Macromolecules, Reproduction, Reproductive Physiology, Vaccine.

Additional Terms:

Animal Fertility, Estradiol, Inhibin, Ovarian Reserve, Ovary, Protein Purification, Reproduction.

Memberships

Endocrine Society
Society for the Study of Reproduction

Honors and Awards

1995, Donald Henry Barron Lecturer, Interdisciplinary Reproductive Biology Group, University of Florida, Reproductive Biology
1987, NIH Senior Fellowship, NICHHD, Yale University, Reproductive Biology
1977, Young Investigator Award (2nd Place), Society for Study of Reproduction, Reproductive Biology
1975, Ford Foundation Fellow, Ford Foundation, University of Michigan, Reproductive Biology

Previous Positions

1990-1999, Director, Michigan State University, College of Agriculture & Natural Resources, Center for Animal Production Enhancement

Patents

Chimeric LTB Vaccines, Patent Number: 5993820, 1999, MSU, United States of America.
Inhibin-HBC Fusion Protein, Patent Number: 5990085, 1999, MSU, United States of America.

Funding Received

  • United States Department of Agriculture (USDA): The Impact of Variation in FSH Secretion during Follicular Waves on Dominant Follicle Function in Cattle, $330,000, 2007 to 2009.
  • United States Department of Agriculture (USDA): Significance of Numbers of Antral Follicles in Ovarian Follicular Waves in Cattle, $310,000, 2004 to 2007.
  • National Institutes of Health (NIH): Advantages of Domestic Species as Biomedical Models, $8,500, 2004 to 2005.
  • United States Department of Agriculture (USDA): Envisioning the Opportunity for an Interagency Workshop on Use of Agriculturally Important Species as Biomedical Models, $20,000, 2004 to 2005.
  • United States Department of Agriculture (USDA): Intrafollicular role of alpha-2 macroglobulin in regulation of estradiol production, $240,000, 2001 to 2004.
  • United States Department of Agriculture (USDA): Inhibin Regulation of Intrafollicular Estradiol Production, $220,000, 2000 to 2003.
  • United States Department of Agriculture (USDA): Effects of Inhibins and Their Subunits on Gonadal Function in Heifers, $261,000, 1994 to 1999.
  • NIH-Cooperative Specialized Infertility Research Center Program: U-54, Ovulatory Dysfunction Infertility Research Center, Key Investigator & Associate Director, Assay Core, $36,212, 1991 to 1996.
  • United States Department of Agriculture (USDA): The Role of Inhibin in Ovarian Function, $260,000, 1990 to 1994.
  • United States Department of Agriculture (USDA): Regulation of Inhibin and Its Genes During Development of Dominant Follicles, $184,000, 1988 to 1991.
  • National Institutes of Health (NIH): NIH Senior Fellowship, Purification of a GnRH-like ovarian factor, $22,000, 1986 to 1987.
  • National Institutes of Health (NIH): Estradiol Regulation of FSH Action in the Ovary, $159,344, 1980 to 1983.
  • National Science Foundation (NSF): Follicular Development During the Bovine Estrous Cycle, $88,128, 1979 to 1982.

Publications

  • Forde N, Rogers M, Canty MJ, Lonergan P, Smith GW, Coussens PM, Ireland JJ, Evans AC (Feb 2008) Association of the prion protein and its expression with ovarian follicle development in cattle., Molecular reproduction and development, 75 (2), 243-9 Abstract
  • Bettegowda A, Yao J, Sen A, Li Q, Lee KB, Kobayashi Y, Patel OV, Coussens PM, Ireland JJ, Smith GW (Nov 2007) JY-1, an oocyte-specific gene, regulates granulosa cell function and early embryonic development in cattle., Proceedings of the National Academy of Sciences of the United States of America, 104 (45), 17602-7 Abstract
  • Zielak AE, Canty MJ, Forde N, Coussens PM, Smith GW, Lonergan P, Ireland JJ, Evans AC (Oct 2007) Differential expression of genes for transcription factors in theca and granulosa cells following selection of a dominant follicle in cattle. Abstract
  • Sen A, Bettegowda A, Jimenez-Krassel F, Ireland JJ, Smith GW (Sep 2007) Cocaine- and amphetamine-regulated transcript regulation of follicle-stimulating hormone signal transduction in bovine granulosa cells., Endocrinology, 148 (9), 4400-10 Abstract
  • Ireland JJ, Ward F, Jimenez-Krassel F, Ireland JL, Smith GW, Lonergan P, Evans AC (Jun 2007) Follicle numbers are highly repeatable within individual animals but are inversely correlated with FSH concentrations and the proportion of good-quality embryos after ovarian stimulation in cattle., Human reproduction (Oxford, England), 22 (6), 1687-95 Abstract
  • Li Q, Jimenez-Krassel F, Bettegowda A, Ireland JJ, Smith GW (Mar 2007) Evidence that the preovulatory rise in intrafollicular progesterone may not be required for ovulation in cattle., The Journal of endocrinology, 192 (3), 473-83 Abstract
  • Patel OV, Bettegowda A, Ireland JJ, Coussens PM, Lonergan P, Smith GW (Jan 2007) Functional genomics studies of oocyte competence: evidence that reduced transcript abundance for follistatin is associated with poor developmental competence of bovine oocytes., Reproduction (Cambridge, England), 133 (1), 95-106 Abstract
  • Zielak AE, Forde N, Park SD, Doohan F, Coussens PM, Smith GW, Ireland JJ, Lonergan P, Evans AC (2007) Identification of novel genes associated with dominant follicle development in cattle., Reproduction, fertility, and development, 19 (8), 967-75 Abstract
  • Saama PM, Patel OV, Bettegowda A, Ireland JJ, Smith GW (Dec 2006) Novel algorithm for transcriptome analysis., Physiological genomics, 28 (1), 62-6 Abstract
  • Burns DS, Jimenez-Krassel F, Ireland JL, Knight PG, Ireland JJ (Jul 2005) Numbers of antral follicles during follicular waves in cattle: evidence for high variation among animals, very high repeatability in individuals, and an inverse association with serum follicle-stimulating hormone concentrations., 73 (1), 54-62 Abstract
  • Patel OV, Suchyta SP, Sipkovsky SS, Yao J, Ireland JJ, Coussens PM, Smith GW (May 2005) Validation and application of a high fidelity mRNA linear amplification procedure for profiling gene expression., 105 (3-4), 331-42 Abstract
  • Ireland JL, Jimenez-Krassel F, Winn ME, Burns DS, Ireland JJ, Evidence for autocrine or paracrine roles of alpha2-macroglobulin in regulation of estradiol production by granulosa cells and development of dominant follicles, Endocrinology, 145(6), 2784-94, 2004 Abstract
  • Evans AC, Ireland JL, Winn ME, Lonergan P, Smith GW, Coussens PM, Ireland JJ, Identification of genes involved in apoptosis and dominant follicle development during follicular waves in cattle, Biology of Reproduction, 70(5), 1475-84, 2004 Abstract
  • Yao J, Ren X, Ireland JJ, Coussens PM, Smith GS, Generation of a bovine oocyte cDNA library and microarray: resources for identification of genes important for follicular development and early embryogenesis, Physiological Genomics, 19, 84-92, 2004
  • Drummond AE, Findlay JK, Ireland JJ, Animal models of inhibin action, Seminars in Reproductive Medicine, 22(3), 243-252, 2004
  • Kobayashi Y, Jimenez-Krassel, F, Li Q, Yao J, Huang R, Ireland JJ, Coussens PM, Smith GW, Evidence that cocaine and amphetamine regulated transcript is a novel intraovarian regulator of follicular atresia, Endocrinology, 2004
  • Jimenez-Krassel F, Winn ME, Burns D, Ireland JLH, Ireland JJ, Evidence for a negative intrafollicular role for inhibin in regulation of estradiol production by granulosa cells, Endocrinology, 144, 1876-1886, 2003
  • Austin EJ, Mihm M, Evans ACO, Ireland JLH, Ireland JJ, and Roche JF, Effects of oestradiol and progesterone on secretion of gonadotrophins and health of first wave follicles during the oestrous cycle of beef heifers, Reproduction, 124, 531-541, 2002
  • Weber PSD, Madsen SA, Smith GW, Ireland JJ, and Burton JL, Pre-translational regulation of neutrophil L-selectin in glucocorticoid-challenged cattle, Veterinary Immunology and Immunopathology, 83, 213-240, 2002
  • Jimenez-Krassel F, Ireland JJ, Development of a short-term culture system for bovine granulosa cells: Evaluation of the effects of somatotropin and growth hormone-releasing factor on estradiol production, Journal of Dairy Science, 85, 68-78, 2002
  • Austin EJ, Mihm M, Evans ACO, Knight PG, Ireland JLH, Ireland JJ, and JF Roche, Alterations in intrafollicular regulatory factors and apoptosis during selection of follicles in the first follicular wave of the bovine estrous cycle, Biology of Reproduction, 64, 839-848, 2001
  • Mihm M, Austin EA, Good TEM, Ireland JLH, Knight P, Roche JF, and JJ Ireland, Identification of potential intrafollicular factors involved in selection of dominant follicles in heifers, Biology of Reproduction, 63, 811-819, 2000
  • Ireland JJ, Mihm M, Austin E, Diskin MG, Roche JF, A historical perspective of dominant follicle turnover in cattle: key concepts, studies, advancements and terms, Journal of Dairy Science, 83, 1648-1658, 2000
  • Bame JH, JC Dalton, SD Degelos, TEM Good, JLH Ireland, F Jimenez-Krassel, T Sweeney, RG Saacke, JJ Ireland, Effect of long-term immunization against inhibin on sperm output in bulls, Biology of Reproduction, 60, 1360-1366, 1999
  • Jimenez-Krassel F, Binelli M, Tucker HA, Ireland JJ, Effect of long-term infusion with recombinant growth hormone-releasing factor and recombinant bovine somatotropin on development and function of dominant follicles and corpora lutea in Holstein cows, Journal of Dairy Science, 82, 1917-1926, 1999
  • Roche JF, Mihm M, Diskin M and JJ Ireland, A review of regulation of follicle growth in cattle, Journal of Animal Science, 76(Suppl 3), 16-29, 1998
  • Sewani CR, Bagdasarian MM, Ireland JJ, Bagdasarian M, Display of an inhibin epitope in a surface-exposed loop of the E. coli heat-labile enterotoxin B subunit, Vaccine, 16, 1611-9, 1998
  • Guthrie HD, JLH Ireland, TEM Good, JJ Ireland, Expression of different molecular mass forms of inhibin in atretic and non-atretic follicles during the early luteal phase and altrenogest-synchronized follicular phase in pigs, Biology of Reproduction, 56, 870-877, 1997
  • Mihm M, Good TE, Ireland JL, Ireland JJ, Knight PG, Roche JF, Decline in serum follicle-stimulating hormone concentrations alters key intrafollicular growth factors involved in selection of the dominant follicle in heifers, Biology of Reproduction, 57, 1328-37, 1997
  • Ireland JJ, TEM Good, JLH Ireland, PG Knight, RL de la Sota, WW Thatcher, M Mihm and JF Roche, Alterations in inhibins and activins during turnover of the first-wave dominant non-ovulatory follicle in cattle, Journal of Reproduction and Development, 42 (Suppl), 41- 45, 1996
  • Sunderland SJ, PG Knight, MP Boland, JF Roche, and JJ Ireland, Alterations in intrafollicular levels of different molecular mass forms of inhibin during development of follicular- and luteal-phase dominant follicles in heifers, Biology of Reproduction, 54, 453-462, 1996
  • McConnell, DS, V Padmanabhan, TB Pollak, NP Groome, JJ Ireland and AR Midgley Jr, Development of a two-site solid-phase immunochemiluminescent assay for measurement of dimeric inhibin in human serum and other biological fluids, Clinical Chemistry, 42, 1159-1167, 1996
  • Good TEM, JLH. Ireland, PSD Weber, J Pulaski, DS McConnell, V Padmanabhan, AL Schneyer, G Lambert-Messerlian, N Groome, BR Ghosh, WL Miller, and JJ Ireland, Isolation of nine different biologically and immunologically active molecular weight variants of bovine inhibin, Biology of Reproduction, 53, 1478-1488, 1995
  • King B F, Britt JH, Esbenshade KL, Flowers WL, Ireland JJ, Evidence for a local role of inhibin or inhibin alpha subunits in compensatory ovarian hypertrophy, Journal of Reproduction and Fertility, 104, 291-295, 1995
  • Sunderland SJ, Crowe MA, Boland MP, Roche JF, Ireland JJ, Selection, dominance and atresia of follicles during the oestrous cycle of heifers, Journal of Reproduction and Fertility, 101, 547-555, 1994
  • Scanlon A R, Sunderland S J, Martin T L, Goulding D, O'Callaghan D, Williams D H, Headon D R, Boland M P, Ireland J J, Roche J F, Active immunization of heifers against a synthetic fragment of bovine inhibin., Journal of Reproduction and Fertility, 97(1), 213-22, January 1993 Abstract
  • King BF, Britt JH, Esbenshade KL, Flowers WL, Sesti LA, Martin TL, Ireland JJ, Ovulatory and endocrine responses after active immunization of gilts against a synthetic fragment of bovine inhibin, Journal of Animal Science, 71, 975-982, 1993
  • Ireland JJ, Martin TL, Ireland JL, Aulerich RJ, Immunoneutralization of inhibin suppresses reproduction in female mink, Biology of Reproduction, 47, 746-750, 1992
  • Martin T L, Fogwell R L, Ireland J J, Concentrations of inhibins and steroids in follicular fluid during development of dominant follicules in heifers., Biology of Reproduction, 44(4), 693-700, April 1991 Abstract
  • Martin TL, Williams GL, Lunstra DD, Ireland JJ, Immunoneutralization of inhibin modifies hormone secretion and sperm production in bulls, Biology of Reproduction, 45, 73-77, 1991
  • Ireland JJ, Milvae RA, Martin TL, Aten RF, Behrman HR, Effect of histone H2A on progesterone production by bovine luteal cells, Biology of Reproduction, 43, 1058-1063, 1990
  • Behrman HR, Aten RF, Ireland JJ, Milvae RA, Characteristics of an antigonadotrophic GnRH-like protein in the ovaries of diverse mammals, Journal of Reproduction and Fertility, 37, 189-194, 1989

Profile Details

Last Updated: 1/29/2008

COS Expertise ID #413160
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