Chinnaswamy Jagannath

(Reading, Writing, Speaking)

National Institutes of Health, NHLBI: Principal Investigator, Reactivation tuberculosis in A/J mice, $250,000/ year, Sep 30, 2001 to Aug 30, 2006.
Centers for Disease Control , USPHS, Atlanta, GA: Principal Investigator, Evaluate the virulence of Mycobacterium tuberculosis using aerosol challenge mouse model, $158,000/year, Oct 1997 to Jul 2000.
National Institutes of Health, NIA: Principal Investigator, Role of adhesion molecules during reactivation tuberculosis, $50,000, Jan 15, 2001 to Dec 15, 2001.
NIAID: Principal Investigator, Characterization of an M.tuberculosis derived vaccine, National Institutes of Health, $250,000/year, 2008 to 2012.
National Institutes of Health (NIH): Molecular Basis of Infectious Disease. T32, No funds, Student st, 2005 to 2013.
Co-Principal Investigator: CRL-1072 for treatment of Mycobacterium avium, National Institutes of Health (NIH), $137,000 per year, September 1997-September 1999
Co-Prinicipal Investigator: 'Effects of Surfactants on Tuberculosis of the Lung', National Institutes of Health (NIH), $359,000 per year, September 1995-September 2000
Principal Investigator: CRL-1072 for treatment of Mycobacterium avium, National Institutes of Health (NIH), $100,000, September 1996-March 1997

• Copenhaver RH, Sepulveda E, Armitige LY, Actor JK, Wanger A, Norris SJ, Hunter RL, Jagannath C (Dec 2004) A mutant of Mycobacterium tuberculosis H37Rv that lacks expression of antigen 85A is attenuated in mice but retains vaccinogenic potential., Infection and Immunity, 72 (12), 7084-95
• Douglas T, Daniel DS, Parida BK, Jagannath C, Dhandayuthapani S (Jun 2004) Methionine sulfoxide reductase A (MsrA) deficiency affects the survival of Mycobacterium smegmatis within macrophages, Journal of Bacteriology, 186 (11), 3590-8
• Actor JK, Breij, E., Hoffmann, H, Sepulveda, S, Wetsel, RA, Hunter, R.L. Jr., Jagannath, C., A role for Complement C5 in organism containment and granulomatous response during murine tuberculosis, Scandinavian Journal of Immunology, 53, 464-474, 2001
• Armitige, L., Jagannath, C., Wanger, A., and Norris, S, Disruption of the genes encoding antigen 85A and antigen 85B of Mycobacterium tuberculosis H37Rv, Infection and Immunity, 68, 767-778, 2000
• Watson, VE,Hill, LL, Owen Schaub, LB, Davis, DW, McConkey, DJ, Jagannath, C, Hunter, RL and Actor JK., Apoptosis in Mycobacterium tuberculosis infection in mice exibiting varied immunopathology, Journal of Pathology, 190, 211-220, 2000
• Jagannath, C, Actor, JK, Luxem F and Hunter RL., The effect of CRL-1072 on the drug uptake and nitric oxide mediated killing of Mycobacterium avium in macrophages, Immunopharmacology, 48, 187-197, 01 2000
• Jagannath, C., Hoffmann, H, Sepulveda, S, Actor JK, Wetsel, RA, Hunter, R.L. Jr., Hypersusceptibility of A/J mice to tuberculosis is in part due to a deficiency in the fifth Complement component (C5), Scandinavian Journal of Immunology, 52, 369-379, 2000
• Pai, S., Actor, J.K., Sepulveda, E., Hunter, R.L., and Jagannath. C, Identification of viable and non-viable Mycobacterium tuberculosis in mouse organs by directed RT-PCR for antigen 85B mRNA, Microbial Pathogenesis, 28, 335-342, 2000
• Jagannath, C., Emanuele, R.M., Hunter, R.L. Jr., Activity of poloxamer CRL1072 against drug sensitive and drug resistant strains of Mycobacterium tuberculosis in macrophages and mice, International Journal of Antimicrobial Agents, 15, 55-63, 2000
• Jagannath, C., et al., CRL-1072 enhances the antimycobacterial activity of human macrophages through IL-8, Journal of Interferon and Cytokine Research, 19, 67-76, 1999
• Jagannath, C, Wells, A, Mshilvdadze, M, Olsen, M, Emanule RM, Hunter RL and Dasgupta, A., Significantly improved oral uptake of amikacin in FVB mice in the presence of copolymer CRL-1605, Lifesciences, 64, 1773-1738, 1999
• Jagannath, C., Actor, J.K., R.L.Hunter, Induction of nitric oxide in human monocytes and monocyte cell lines by Mycobacterium tuberculosis, Nitric Oxide: Biology and Chemistry, 2, 174-186, 1998
• Newman M J, Actor J K, Balusubramanian M, Jagannath C, Use of nonionic block copolymers in vaccines and therapeutics., Critical Reviews In Therapeutic Drug Carrier Systems, 15(2), 89-142, 1998
• Jagannath C, Allaudeen H S, Hunter R L, Activities of poloxamer CRL8131 against Mycobacterium tuberculosis in vitro and in vivo, Antimicrobial Agents and Chemotherapy, 39(6), 1349-54, June 1995
• Jagannath C, Reddy MV, Kailasam S, O'Sullivan JF, Gangadharam PR, Chemotherapeutic activity of clofazimine and its analogues against Mycobacterium tuberculosis. In vitro, intracellular, and in vivo studies, American Journal of Respiratory and Critical Care Medicine, 151(4), 1083-6, April 1995
• Jagannath C, Reddy V M, Gangadharam P R, Enhancement of drug susceptibility of multi-drug resistant strains of Mycobacterium tuberculosis by ethambutol and dimethyl sulphoxide, Journal of Antimicrobial Chemotherapy, 35(3), 381-90, March 1995
• Hunter R L, Jagannath C, Tinkley A, Behling C A, Nolte F, Enhancement of antibiotic susceptibility and suppression of Mycobacterium avium complex growth by poloxamer 331, Antimicrobial Agents and Chemotherapy, 39(2), 435-9, February 1995
• Xu,Y, C.Jagannath & Tony Eissa., Toll-like receptor 4 is a sensor for autophagy associated with innate immunity. Immunity; 2007 (in press).
• Jacek Szeliga, Daniel D. Sundarsingh, Ching-Hui Yang, Zvjezdana Sever-Chroneos, Chinnaswamy Jagannath, Zissis Chroneos., Granulocyte macrophage colony stimulating factor-mediated innate responses in tuberculosis. Tuberculosis (Edin) TUBE-D-07-00020. 2007 (in press).
• Rachel Moulton, Mary Anne Connelly,Amanda K. Smith, Devin R.Lindsey, Rick A.Wetsel, David L.Haviland, Robert L Hunter. Jr. & C. Jagannath., Complement C5a anaphylatoxin is an innate determinant of dendritic cell mediated Th1 immunity during Mycobacterium bovis BCG infection in mice.
• Hunter, R. L., C. Jagannath, and J. K. Actor. (2007) Pathology of Postprimary Tuberculosis in Humans and Mice: Contradiction of long-held beliefs, Tuberculosis (Edin), 87, 267-78
• Connelly.M.A*, Moulton.R.A*, Smith.A.K, Lindsey.D.R, Zwirner,J & C. Jagannath. (2007) Mycobacteria primed macrophages and dendritic cells induce an up- regulation of Complement C5a anaphylatoxin receptor (CD88) in CD3+ murine T cells, J.Leucocyte Biology, 81, 212-20
• Sundarsingh Daniel*, Guixiang Dai*, Devin R. Lindsey, Christopher R.Singh, Amanda K. Smith, S..Dhandayuthapani, Robert L Hunter. Jr. & C. Jagannath. (2006) Reduced bactericidal function of Complement C5 deficient murine macrophages is in part due to a defective assembly of phagocyte oxidase, J.Immunology, 177, 4688-98
• Christopher R.Singh, Lisa Y. Armitige, Amanda K. Smith, S.Dhandayuthapani, Akil Bidani. Robert L Hunter. Jr. & C. Jagannath (2006) Processing and presentation of a mycobacterial antigen 85B epitope by murine macrophages is dependent upon the phagosomal acquisition of vacuolar proton ATPase and in situ activation of Cathepsin D, J.Immunology, 177, 3250-9
• Marek Fol, Ashwini Chauhan, Erin Maloney, Meredith Moomey, Murty V. Madiraju , C. Jagannath and Malini Rajagopalan. (2006) Modulation of Mycobacterium tuberculosis proliferation by MtrA, an essential two-component response regulator, Molecular Microbiology, 60, 643-57
• Hunter, R. L., M. R. Olsen, C. Jagannath, and J. K. Actor. (2006) Multiple roles of cord factor in the pathogenesis of primary, secondary, and cavitary tuberculosis, including a revised description of the pathology of secondary disease, Ann Clin Lab Sci, 36, 371-386
• Hunter.R.L, Olsen, M, C. Jagannath, & J.K.Actor. (2006) Trehalose 6,6' dimycolate and lipid in the pathogenesis of caseating granulomas of tuberculosis in mice, Amer.J.Pathology, 168, 1249-61