Dr. James Edward Swain

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Yale University
School of Medicine
Child Study Center
Assistant ProfessorAppointed: 2005
Professional Headshot of James Edward Swain

Mailing Address

Yale Child Study Center
230 South Frontage Rd.
New Haven, Connecticut 06520-7900
United States

Contact Information

Phone: (203) 785-6973
Fax: (203) 785-7611
james.swain@yale.edu

Qualifications

FRCPS, University of Ottawa, Psychiatry, 2001.
M.D., Medicine, 1997.
Ph.D., University of Toronto, Neuroscience, 1994.
M.S., University of Toronto, Cell Neurobiology, 1990.
B.Sc., University of Toronto, Physiology, 1988.

Expertise and Research Interests

Our group is interested in the cognitive neuroscience that underlies the risk, resilience and recovery associated with mental health issues. In particular, we are studying the thoughts, behaviors and brain physiology involved in human attachment. One example of human bonding that we are focussing on is the parent-infant bond. Over the last few years, we have accumulated an extensive database on parents in the early postpartum, which includes interviews, self-reports, video assessments, and brain imaging. For brain imaging, we have been conducting functional magnetic resonance imaging while parents attend to emotionally charged baby stimuli. We are beginning to describe the ways that key emotion-regulation brain circuits are activated in parents' brains by baby stimuli in ways that correlate with parenting thoughts and behaviors in healthy parents as well as vulnerable groups such as parents with postpartum depression and anxiety.

My current position is Assistant Professor in the Child Study Center at the Yale University School of Medicine. I am a clinician-scientist with a background doctorate in basic neuroscience, and clinical training as a physician, general psychiatrist and the child and adolescent psychiatry subspecialty.

I have particular clinical expertise and interest in the assessment, classification and treatment of mental health issues in children and families. In addition, I am interested in aspects of obsessive compulsive disorder, Tourette's disorder and related mood and anxiety disorders across the lifespan from infancy to adulthood. I am the author or co-author of numerous articles on these topics as well as an investigator on funded grants from the Tourette Syndrome Association (TSA), and National Alliance for Research on Schizophrenia and Depression (NARSAD).

Other Expertise

From my child and adult psychiatry clinical training and practice, I am comfortable with the diagnosis and treatment of psychiatric illness using psychopharmacology and psychotherapy.

From my basic research work, I have experience in a range of cellular neurophysiology techniques such as electrophyiology and confocal microspopy.

Future Research

Ongoing combination of psychometric and a variety of neuroimaging techniques to study complex human experiences in health, and illness across the lifespan. In future, we would like to study families and children at different developmental stages and vulnerabilities to mental health problems.

Industrial Relevance

I am interested in in the application of brain imaging, computers and virtual reality in psychiatry diagnosis, treatments and assessment of recovery. Experimental treatments that interest me include transcranial magnetic fields to treat mental illness. From a psychopharmacology perspective I am interested in mechanisms by which mood modulating drugs work. I wonder about the possible use of hormones related to becoming a parent, such as oxytocin, as future medications.

Keywords

COS Keywords:

Child Psychiatry, Child Psychology, Cognitive Psychology, Cognitive Science, Compulsive Behavior, Emotions, Infant Psychology, Neuroimaging, Neuroscience, Psychiatry, Psychology of Women.

Additional Terms:

Attachment, Cognitive Neuroscience, Compulsive Behavior, Congitive Psychology, Emotions, Infant Psychology, Neuroimaging, Obsessive-Compulsive Disorder, Psychology of Women.

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)
Spanish: (Functional, Functional, Fluent)
French: (Basic, Basic, Basic)
German: (Basic, Basic, Basic)

Memberships

American Academy of Child and Adolescent Psychiatry
American Medical Association
American Psychiatric Association
Canadian Medical Association
Canadian Medical Protective Association
Cognitive Neuroscience Society
International Society for Magnetic Resonance in Medicine
New York Academy of Sciences
Ontario Medical Association
Society for Biological Psychiatry

Honors and Awards

2007, One of America's Top Psychiatrists, Consumer's Research Council of America
2007, Top 10 Poster, 13th Annual Meeting of Human Brain Mapping, Organization of Human Brain Mapping
2007, Top Abstract plus selection of Public Education & Communication Committee, Society for Neuroscience, 37th Society for Neuroscience Annual Meeting
2006, Young Investigator Colloquium Award, American Psychiatric Association Annual Meeting, American Psychiatric Association, Neuroimaging Research
2004, International Donald Cohen Fellowship Program Award, International Academy of Child and Adolescent Psychiatry and Allied Professions, Child and Adolescent Psychiatry
2004, Best Research Poster Presentation, Annual Meeting of the Canadian Psychiatric Association, Canadian Psychiatric Association, Human Brain Physiology and Psychology of Parent-Infant Attachment in the Postpartum
2003, Clinical Resident Award, International Society for Medical Resonance in Medicine, Magnetic Resonance Research
2003-2005, Postdoctoral Fellowship Travel Award, National Institute of Mental Health, American College of Neuropsychopharmacology, Psychiatry Research
2002-2005, Travel Award/Scholar Award, Annual Wisconsin Symposia on Emotion, University of Wisconsin, Emotion Research
2001, Canadian Resident Award, Wyeth-Ayerst, University of Ottawa, Psychiatry Residency
1999, Outstanding Resident Award, National Institute of Mental Health, National Institute of Health, Psychiatry Academics
1998, Clinical Excellence Award, Psychiatry Department, University of Ottawa, Psychiatry Inpatient Service
1994, Crocker Foundation Award, Faculty of Medicine, University of Toronto, Medicine Award
1994-1997, Samuel Castrilli Research Award, Faculty of Medicine, University of Toronto, Medical Research
1993, Dr. Francesco Lamensa Award, Faculty of Medicine, University of Toronto, Protein Phosphatases and Signal Transduction
1992, Best Oral Presentation, Upjohn Canada, University of Toronto
1988, Summer Undergraduate Life Sciences Award, University of Toronto, University of Toronto
1983, Canadian Delegate, Youth Science Foundation, 8th Annual Stockholm International Youth Science Seminar & Nobel prizes
1980, Gold Medal, Canada Wide Science Fair, Youth Science Foundation, Magnetic Field and Plants

Previous Positions

2002, Post-doctoral Fellow, University of Ottawa, Faculty of Medicine, Psychiatry, Child Psychitry
2002-2005, Research Fellow, Yale University, School of Medicine, Child Study Center

Funding Received

  • National Alliance for Research on Scizophrenia and Depression: Young Investigator Award, $59,773, 2007 to 2009.
  • Faculty of Medicine, University of Toronto: Deans Fund: "Virtual" Computerized Simulation Tasks: A Pilot Study", Can$10,000, 2006 to 2007.
  • Tourette's Syndrome Association: Research Grant: "Functional Neuroimaging Studies of Prepulse Inhibition in Tourette's Syndrome", $68,004, 2005 to 2006.
  • National Alliance for Research on Schizophrenia and Depression: Young Investigator Award: "Effects of Postpartum Depression on the Functional Neuroanatomy of Parenting", $59,202, 2004 to 2006.
  • The Institute for Research on Unlimited Love: Private Foundation Research Grant: "Toward an Understanding of the Neurobiology of Parental Love", US$99,956, 2003 to 2005.
  • Yale Child Study Center: Postdoctoral Fellowship Startup Grant, US$25,000, 2002 to 2004.
  • University of Toronto: Fidlar Doctoral Fellowship, Can$6,000, 1992 to 1993.
  • Savoy Epilepsy Foundation: Graduate Student Fellowship, Can$12-15,000, 1989 to 1992.
  • University of Toronto: Open Doctoral Fellowship, Can$10,000, 1988 to 1989.

Publications

  • Swain JE, Tasgin E, Mayes LC, Feldman R, Constable RT, Leckman JF (2008) Cesarean Delivery Affects Maternal Brain Responses to Own Baby Cry, Journal of Child Psychology and Psychiatry, Submitted
  • Swain JE, Leckman JF, Mayes LC, Feldman R, Hoyt E, Kang H, Kim P, David D, Nguyen S, Constable RT, Schultz RT (2008) Parents Have Specific Brain Activations in Response to Own Baby Cry, Submitted
  • Shulman S, Mayes LC, Cohen T, Swain JE, Leckman JF (2008) The Interplay between Love Relationships and Attraction among Late Adolescent and Early Adult Romantic Couples and Its Change Over-Time, Journal of Social and Personal Relationships, In Press
  • Swain JE, Mayes LC, Leckman JF (2008) Parent-Infant Attachment Systems Neural Circuits, Genes, and Early-Life Programming, Reflecting on the Future of Psychoanalysis: Mentalization, Internalization and Representation, New York, Karnac Press, In Press (bookchapter)
  • Swain JE, Swain JD (2008) Creativity or Mental Illness: Possible Errors of Relational Priming In Neural Networks of the Brain, Behavioral and Brain Sciences, In Press
  • Swain JE, Leckman JF, Mayes LC, Feldman R, Schultz RT (2007) The Development of Human Parent-Infant Attachment: Functional Brain Imaging During the Early Postpartum, American College of Neuropsychopharmacology 46th Annual Meeting, ACNP
  • Swain JE, Leckman JF, Mayes LC, Feldman R, Hoyt E, Kang H, Kim P, Schultz RT (2007) Parent Brains are Activated by Baby Stimuli According to Relationship, Canadian Academy of Child and Adolescent Psychiatry 27th Annual Meeting, CPA
  • Swain JE, Leckman JF, Mayes LC, Feldman R, Hoyt E, Kang H, Kim P, Schultz RT (2007) Baby cry and picture stimuli activate parent brains according to gender, experience, psychology and dyadic relationship, Society for Neuroscience 37th Annual Meeting, SFN
  • Swain JE, Leckman JF, Mayes LC (2007) Own Baby Cry and Picture Stimuli Activate Parent Brains According to Gender, Experience, Psychology and Dyadic Relationship, American Academy of Child and Adolescent Psychiatry 54st Annual Meeting, APA
  • Swain JE, Leckman JF, Mayes LC, Feldman R, Hoyt E, Kang H, Kim P, Schultz RT (2007) Own Baby Cry and Picture Stimuli Activate Parent Brains According to Gender, Experience, Psychology and Dyadic Relationship, European Society for Child and Adolescent Psychiatry 13th International Congress, ESCAP
  • Newman M.-A,, Kim P, Mayes LC, Feldman R, Leckman JF, Swain JE (2007) The Effect of Early Experience on Mental Health and Parental Sensitivity during Early Postpartum, Yale BioSTEP Research Program, Yale University
  • Swain JE, Scahill LD, Lombroso PJ, King RA, Leckman, JF (2007) Tourette's Syndrome and Tic Disorders: Ten Years of Progress, Journal of the American Academy of Child and Adolescent Psychiatry, 46 (8), 947-956
  • Swain JE, Leckman JF, Mayes LC, Feldman R, Hoyt E, Kang H, Kim P, Schultz (2007) Own Baby Cry and Picture Stimuli Activate Parent Brains According to Gender, Experience, Psychology and Dyadic Relationship, Organization for Human Brain Mapping 13th Annual Meeting, OHBM
  • Swain JE, Leckman JF, Mayes LC, Feldman R, Schultz (2007) Baby Cry and Picture Activations of Parent Brains Vary with Gender, Experience, and Dyadic Relationship, Society for Biological Psychiatry 62nd Annual Meeting, SOBP
  • Swain JE, Leckman JF, Mayes LC, Feldman R, Hoyt E, Kang H, Kim P, Schultz (2007) Parental Brains Activate to Own Baby Cries and Pictures According to Psychology, Experience, Timing and Dyadic Relationship, Cognitive Neuroscience Society 14th Annual Meeting, CNS
  • Swain, JE, Lorberbaum JP, Kose S, Strathearn L (2007) The Brain Basis of Early Parenthood: Psychology and in vivo Functional Neuroimaging Studies, Journal of Child Psychology and Psychiatry, 43 (3), 262-287
  • Swain JE, Leckman JF, Mayes LC, Hoyt E, Kim P, Schultz RT (2007) Longitudinal study of breastfeeding vs. formula-feeding mothers' brain response to infant stimuli during the early postpartum period, Society for Research on Child Development Biannual Meeting, SRCD
  • Kim P, Mayes LC, Leckman JF, Feldman R, Swain JE (2007) Longitudinal study of breastfeeding vs. formula-feeding mothers' brain response to infant stimuli during the early postpartum period, Society for Research on Child Development Biannual Meeting, SRCD
  • Kim P, Swain JE (2007) Sad Dads: Postpartum Paternal Depression, Psychiatry 2007, 4 (2), 36-47
  • Leckman JF, Swain JE, Mayes LC (2007) Primary Parental Preoccupations: Revisited, Developmental Science and Psychoanalysis, London, Karnac Press, 89-108 pages, ISBN=1855754401 (bookchapter)
  • Swain JE, Leckman JF, Mayes LC, Feldman R, Hoyt E, Kang H, Kim P, Schultz RT (2006) Baby Stimuli Activate Parental Brains According to Psychology, Experience, Postpartum Timing and Relationship, Canadian Psychiatric Association 56th Annual Meeting, CPA
  • Crowley MJ, Bloch MH, Leckman JF, Mayes LC, Swain JE (2006) Functional Neuroimaging of Prepulse Inhibition in Tourette Syndrome, Society for Psychophysiological Research 46th Annual Meeting, SPR
  • Swain JE, Leckman JF, Mayes LC, Feldman R, Hoyt E, Kang H, Kim P, Schultz RT (2006) Own baby stimuli activate parental brains according to psychology, experience, postpartum timing and relationship, 17th World Congress of the International Association for Child and Adolescent Psychiatry and Allied Professions, IACAPAP
  • Taylor J, Kim P, Hoyt E, Swain JE (2006) Endocrine influence on the neural substrates of human parental behaviors, Yale BioSTEP Research Program, Yale University
  • Swain JE, Leckman JF, Mayes LC, Feldman R, Hoyt E, Kang H, Kim P, Schultz RT (2006) Parental psychology, experience and postpartum timing influence brain response to own baby stimuli, World Psychiatric Association International Congress, World Psychiatric Association
  • Swain JE (2006) Epigenetic Effects of Child Abuse and Neglect Propagate Human Cruelty, Behavioral and Brain Sciences, 29 (3), 242-243
  • Feygin D, Swain JE, Leckman, JF (2006) The Normalcy of Neurosis: Evolutionary Origins of Obsessive-Compulsive Disorder and Related Behaviors, Progress in Neuro-Psychopharmacology & Biological Psychiatry, 5, 854-864
  • Swain JE (2006) Critical Developmental Periods of Increased Plasticity Program Ritualized Behavior, Behavioral and Brain Sciences, 29 (6), 630-631, In Press
  • Swain JE, Leckman JF, Mayes, Feldman R, Hoyt E, Kang H, Kim P, Schultz RT (2006) Own baby stimuli activate parental emotion centers according to psychology, experience and postpartum timing, Organization for Human Brain Mapping 12th Annual Meeting, Organization for Human Brain Mapping
  • Kim P, Leckman JF, Mayes LC, Swain JE (2006) Breastfeeding vs. formula-feeding mothers' brain response to infant cry during early postpartum period, Cognitive Neuroscience Society 13th Annual Meeting, Cognitive Neuroscience Society
  • Swain JE, Leckman JF, Mayes LC, Feldman R, Schultz RT (2006) Own baby pictures induce parental brain activations according to psychology, experience and postpartum timing, Society for Biological Psychiatry 61st Annual Meeting, Society for Biological Psychiatry
  • Swain JE, Leckman, JF, Volkmar, FR (2005) The Wolf-Boy: A Case of Reactive Attachment Disorder in an Adolescent Boy, Psychiatry 2005, 2 (11), 55-61
  • Mayes, LC, Swain, JE, Leckman, JF (2005) Parental Attachment Systems: Neural Circuits, Genes, and Experiential, Clinical Neuroscience Research, 4, 301-313
  • Koszycki D, Torres, S, Swain, JE, Bradwejn, J (2005) Central Cholecystokinin Activity in Irritable Bowel, Psychosomatic Medicine, 67, 590-595
  • Swain, JE, Leckman, JF (2005) Tourette Syndrome and Tic Disorders: Overview and Practical Guide to Diagnosis and Treatment, Psychiatry 2005, 1 (7), 26-36
  • Swain, JE, Mayes, LC, Leckman, JF (2005) Endogenous and Exogenous Opiates Modulate the Development of Parent-Infant Attachment, Behavioral and Brain Sciences, 28 (3), 367-368
  • Swain JD, Swain JE (2005) "To do or not to do?" Modeling the control of behavior, Behavioral and Brain Sciences, 28 (5), 662-663
  • Feldman R, Swain JE, Mayes JE (2005) Interaction Synchrony and Neural Circuits Contribute to Shared Intentionality, Behavioral and Brain Sciences, 28 (5), 697-698
  • Swain JE, King RA, Leckman JF (2005) Gilles de la Tourette Syndrome and Tic Disorders: From the Molecules and Cells to Symptoms and Management, Manual of Neuropsychiatric Disorders, New York, Humana Press, 151-170 pages, ISBN=1-58829-369-6 (bookchapter)
  • Swain JE (2005) Parental and Romantic Attachment Systems Neural Circuits, Genes and Experiential Contributions to Interpersonal Engagement, 2nd International Congress on Brain & Behaviour, International Society on Brain & Behaviour
  • Swain JE, Leckman JF, Mayes LC, Feldman, Constable RT, Schultz RT (2005) Early Human Parent-Infant Bond Development: fMRI, thoughts and behaviors, Society for Biological Psychiatry 60th Annual Meeting, Society for Biological Psychiatry
  • Swain JE, Leckman JF, Mayes LC, Feldman R, Constable RT, Schultz RT (2005) The development of parental brain circuits correlated with the thoughts and behaviors in mothers and fathers after the birth of a baby, Organization for Human Brain Mapping 11th Annual Meeting, Organization for Human Brain Mapping
  • Swain JE, Leckman JF, Mayes LC, Feldman R, Constable RT, Schultz RT (2005) Functional Neuroimaging and Psychology of Parent-Infant Attachment, Joint Annual Meeting of the American Academy of Child and Adolescent Psychiatry (51st) and Canadian Academy of Child and Adolescent Psychiatry (25th), American Academy of Child and Adolescent Psychiatry + Canadian Academy of Child and Adolescent Psychiatry
  • Swain JE, Leckman JF, Mayes LC, Feldman R, Schultz RT (2005) The Development of Human Parent-Infant Attachment: Functional Brain Imaging During the Early Postpartum, American College of Neuropsychopharmacology 44th Annual Meeting, American College of Neuropsychopharmacology
  • Swain JE, Leckman JF, Mayes LC, Feldman R, Constable, RT, Schultz RT (2005) Longitudnal Functional Brain Imaging of the Postpartum Human Parent-Infant Bond, Cognitive Neuroscience Society 12th Annual Meeting, Cognitive Neuroscience Society
  • Swain JE (2005) Functional Neuroimaging and Psychology of Parent-Infant Attachment, Joint Annual Meeting of the American Academy of Child and Adolescent Psychiatry (51st) and Canadian Academy of Child and Adolescent Psychiatry (25th), American Academy of Child and Adolescent Psychiatry + Canadian Academy of Child and Adolescent Psychiatry
  • Gallardo, KA, Swain, JE, Leckman, JF (2004) Developmental Psychobiology of Gilles de la Tourette Syndrome, APPI Review of Psychiatry, 23, 111-141
  • Leckman, JF, Feldman, R, Swain, JE, Eicher, VE, Thompson, N, Mayes, LC (2004) Primary Parental Preoccupation:, Journal of Neural Transmission, 111, 753-771
  • Swain, JE, Mayes, LC, Leckman, JF (2004) The Development of Parent-Infant Attachment through Dynamic and, Behavioral and Brain Sciences, 27 (4), 472-473
  • Swain JE, Leckman JF, Mayes LC, Feldman R, Constable RT, Schultz RT (2004) Functional Brain Imaging and Psychology of Human Parent Infant Attachment, American College of Neuropsychopharmacology 43nd Annual Meeting, American College of Neuropsychopharmacology
  • Swain JE, Leckman JF, Mayes LC, Feldman R, Constable RT, Schultz RT (2004) Functional Brain Imaging and Psychology of Human Parent Infant Attachment, American Academy of Child and Adolescent Psychiatry 51st Annual Meeting, American Academy of Child and Adolescent Psychiatry
  • Swain JE, Leckman JF, Mayes LC, Feldman R, Constable RT, Schultz RT (2004) Brain Circuitry and Psychology of Postpartum Human Parent-Infant Attachment, International Association for Child and Adolescent Psychiatry and Allied Profession 16th World Congress, International Association for Child and Adolescent Psychiatry and Allied Professions
  • Swain JE, Leckman JF, Mayes LC, Feldman R, Constable RT, Schultz RT (2004) Functional Brain Imaging of Postpartum Human Parent-Infant Attachment, American Psychiatric Association 157th Annual Meeting, American Psychiatric Association
  • Swain JE, Leckman JF, Mayes LC, Feldman R, Constable RT, Schultz RT (2004) Human Brain Physiology and Psychology of Parent-Infant Attachment in the Postpartum, Canadian Psychiatric Association 54th Annual Meeting, Canadian Psychiatric Association
  • Swain JE, Leckman JF, Mayes LC, Feldman R, Constable RT, Schultz RT (2004) Functional Brain Imaging of Postpartum Human Parent-Infant Attachment, American Psychiatric Association 157th Annual Meeting, American Psychiatric Association
  • Swain JE, Leckman JF, Mayes LC, Feldman R, Constable RT, Schultz RT (2004) Neural Substrates of Human Parent-Infant Attachment in the Postpartum, Society for Biological Psychiatry 59th Annual Meeting, Society for Biological Psychiatry
  • Swain, JE, Leckman, MP (2003) Tourette's Syndrome in Children., Current Treatment Options in Neurology, 5 (4), 299-308
  • Swain JE, Schlik J, Koszycki D, Bradwejn J (2003) Pharmacological challenge agents in Anxiety, Anxiety Disorders, London, Blackwell Press, 269-295 pages, ISBN=0632059389 (bookchapter)
  • Swain JE (2003) Frontiers in Psychiatric Computerology, American Psychiatric Association Annual Meeting 156th Annual Meeting, American Psychiatric Association Annual Meeting
  • Swain JE, Leckman JF, Mayes LC, Feldman R, Eicher V, Schultz RT (2003) Neural Circuitry of Human Parent-Infant Attachment in the Early Postpartum, American College of Neuropsychopharmacology 42nd Annual Meeting, American College of Neuropsychopharmacology
  • Swain JE, Charlton MP (1993) Protein Phosphatses and Synaptic Transmission, Neuroscience Facts, 4 (3), 2-4
  • Swain JE, Robitaille R, Charlton MP (1992) Phosphatase Inhibitors Interact With Protein Kinases to Regulate Neurotransmitter Release, But Do Not Affect Ca++ Homeostasis, Society for Neuroscience 22nd Annual Meeting, Society for Neuroscience
  • Swain JE, Robitaille R, Dass, GR, Charlton MP (1991) Phosphatases Modulate Inhibitor Okadaic Acid, Journal of Neurobiology, 22 (8), 855-864
  • Swain JE, Robitaille R, Charlton MP (1991) Effects of Okadaic Acid, a Phosphatase Inhibitor, on Synaptic Transmission at Crayfish Neuromuscular Junction, Biophysical Society 36th Annual Meeting, Biophysical Society
  • Swain JE, Robitaille R, Dass, GR, Charlton. MP (1991) The Effects of Okadaic Acid, a Protein Phosphatase Inhibitor, on Neurotransmitter Release at the Crayfish Neuromuscular Junction, International Brain Research Organization World Congress of Neuroscience, International Brain Research Organization
  • Swain JE, Charlton MP (1990) Phosphatase Inhibitor Okadaic Acid Increases Synaptic Transmission at the Crayfish Neuromuscular Junction, Society for Neuroscience 20th Annual Meeting, Society for Neuroscience

Profile Details

Last Updated: 1/25/2008

COS Expertise ID #1208359
Reference this profile directly: http://myprofile.cos.com/jameseswain