Peter Jatlow

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Yale University
School of Medicine
Laboratory Medicine
Professor/Chairman, Department of Laboratory Medicine

Mailing Address

CB 407 YNHH
Yale University
New Haven, Connecticut
United States

Contact Information

Phone: (203) 785-2446
peter.jatlow@yale.edu

Qualifications

M.D., Yale University School of Medicine, 1961.
B.S., Yale University School of Medicine, 1957.
Fellowship, Yale University School of Medicine.

Expertise and Research Interests

Most cocaine abusers concurrently use ethanol, and report that euphoria is prolonged, and the dysphoria of acute withdrawal is lessened. When the two are self administered concurrently, cocaine is transesterifed in the presence of ethanol with productionof an active metabolite, cocaethylene. We have shown that this metabolite is equipotent to cocaine in its ability to block dopamine uptake, inhibit ligand binding to the dopamine transporter, increase dopamine concentration in brain microdialysate, and is equipotent to cocaine as a reinforcer in animals. Interestingly, cocaethylene is much less potent than cocaine at the serotonin transporter. We are performing basic and clinical studies of cocaethylene and its analogs both to better understand the mechanisms of combined cocaine, ethanol abuse, and to help sort out the relative roles of dopamine and serotonin systems in mediating cocaine's actions.

Other Expertise

I wish to be contacted by interested students (medical, graduate or undergraduates) as a potential research mentor/thesis advisor.

Keywords

COS Keywords:

Cocaine, Drugs Or Drug Abuse, Pharmacology.

Additional Terms:

Cocaine, Drug Abuse, Psychotropic Drugs.

Publications

  • Fujita M, Verhoeff NP, Varrone A, Zoghbi SS, Baldwin RM, Jatlow PA, Anderson GM, Seibyl JP, Innis RB, Imaging extrastriatal dopamine D(2\) receptor occupancy by endogenous dopamine in healthy humans., European Journal of Pharmacology, 387(2), 179-88, 10 2000 Abstract
  • Bradberry CW, Lee T, Jatlow P, Rapid induction of behavioral and neurochemical tolerance to cocaethylene, a model compound for agonist therapy of cocaine dependence., Psychopharmacology \(Berl\), 146(1), 87-92, 1 Sep 1999 Abstract
  • Fujita M, Woods SW, Verhoeff NP, Abi-Dargham A, Baldwin RM, Zoghbi SS, Soares JC, Jatlow PA, Krystal JH, Rajeevan N, Charney DS, Seibyl JP, Innis RB, Changes of benzodiazepine receptors during chronic benzodiazepine administration in humans., European Journal of Pharmacology, 368(2-3), 161-72, 5 Mar 1999 Abstract
  • Brodkin ES, Kosten TA, Haile CN, Heninger GR, Carlezon WA Jr, Jatlow P, Remmers EF, Wilder RL, Nestler EJ, Dark Agouti and Fischer 344 rats: differential behavioral responses to morphine and biochemical differences in the ventral tegmental area., Neuroscience, 88(4), 1307-15, 1999 Abstract
  • Cappiello A, McDougle CJ, Delgado PL, Malison RT, Jatlow P, Charney DS, Heninger GR, Price LH, Lithium and desipramine versus desipramine alone in the treatment of severe major depression: a preliminary study., Int Clin Psychopharmacol, 13(5), 191-8, September 1998 Abstract
  • McCance-Katz E F, Rainey P M, Jatlow P, Friedland G, Methadone effects on zidovudine disposition (AIDS Clinical Trials Group 262)., Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 18(5), 435-43, 15 Aug 1998 Abstract
  • Lustbader A S, Mayes L C, McGee B A, Jatlow P, Roberts W L, Incidence of passive exposure to crack/cocaine and clinical findings in infants seen in an outpatient service., Pediatrics Electronic Pages, 102(1), e5, July 1998 Abstract
  • Mazure C M, Nelson J C, Jatlow P I, Bowers M B Jr, Acute neuroleptic treatment in elderly patients without dementia., American Journal of Geriatric Psychiatry, 6(3), 221-9, 1 Jul 1998 Abstract
  • McCance-Katz E F, Kosten T R, Jatlow P, Chronic disulfiram treatment effects on intranasal cocaine administration: initial results., Biological Psychiatry, 43(7), 540-3, 1 Apr 1998 Abstract
  • Kosten T A, Miserendino M J, Haile C N, DeCaprio J L, Jatlow P I, Nestler E J, Acquisition and maintenance of intravenous cocaine self-administration in Lewis and Fischer inbred rat strains., Brain Research, 778(2), 418-29, 19 Dec 1997 Abstract
  • Laruelle M, D'Souza C D, Baldwin R M, Abi-Dargham A, Kanes S J, Fingado C L, Seibyl J P, Zoghbi S S, Bowers M B, Jatlow P, Charney D S, Innis R B, Imaging D2 receptor occupancy by endogenous dopamine in humans., Neuropsychopharmacology, 17(3), 162-74, September 1997 Abstract
  • Stine S M, Krystal J H, Petrakis I L, Jatlow P I, Heninger G R, Kosten T R, Charney D S, Effect of alpha-methyl-para-tyrosine on response to cocaine challenge., Biological Psychiatry, 42(3), 181-90, 1 Aug 1997 Abstract
  • Silverman D G, Kosten T R, Jatlow P I, Gutter V, Fleming J, O'Connor T Z, Byck R, Decreased digital flow persists after the abatement of cocaine-induced hemodynamic stimulation., Anesthesia and Analgesia, 84(1), 46-50, January 1997 Abstract
  • Horger B A, Taylor J R, Elsworth J D, Jatlow P I, Roth R H, Sensitization to the locomotor activating effects of cocaine following cocaethylene-preexposure., Brain Research, 733(1), 133-7, 9 Sep 1996 Abstract
  • Jatlow P, McCance E F, Bradberry C W, Elsworth J D, Taylor J R, Roth R H, Alcohol plus cocaine: the whole is more than the sum of its parts., Therapeutic Drug Monitoring, 18(4), 460-4, August 1996 Abstract
  • Gawin F H, Khalsa-Denison M E, Jatlow P, Flupentixol-induced aversion to crack cocaine [letter], New England Journal of Medicine, 334(20), 1340-1, 16 May 1996 Abstract
  • Hansson A G, Mitchell S, Jatlow P, Rainey P M, Rapid high-performance liquid chromatographic assay for atovaquone., Journal of chromatography. B, Biomedical Applications, 675(1), 180-2, 12 Jan 1996 Abstract
  • Jatlow P, Cocaethylene. What is it? [editorial; comment], American Journal of Clinical Pathology, 104(2), 120-1, August 1995 Abstract
  • Roberts W L, Reynolds K M, Heimer R, Jatlow P I, Rainey P M, Pyrimethamine analysis by enzyme inhibition and HPLC assays., American Journal of Clinical Pathology, 104(1), 82-8, July 1995 Abstract
  • McCance E F, Price L H, Kosten T R, Jatlow P I, Cocaethylene: pharmacology, physiology and behavioral effects in humans., Journal of Pharmacology and Experimental Therapeutics, 274(1), 215-23, July 1995 Abstract
  • Iyer R N, Nobiletti J B, Jatlow P I, Bradberry C W, Cocaine and cocaethylene: effects on extracellular dopamine in the primate., Psychopharmacology, 120(2), 150-5, July 1995 Abstract
  • Aronson S C, Black J E, McDougle C J, Scanley B E, Jatlow P, Kosten T R, Heninger G R, Price L H, Serotonergic mechanisms of cocaine effects in humans., Psychopharmacology, 119(2), 179-85, May 1995 Abstract
  • Hameedi F A, Rosen M I, McCance-Katz E F, McMahon T J, Price L H, Jatlow P I, Woods S W, Kosten T R, Behavioral, physiological, and pharmacological interaction of cocaine and disulfiram in humans., Biological Psychiatry, 37(8), 560-3, 15 Apr 1995 Abstract
  • Nelson J C, Mazure C M, Jatlow P I, Desipramine treatment of major depression in patients over 75 years of age., Journal of Clinical Psychopharmacology, 15(2), 99-105, April 1995 Abstract
  • Nobiletti J B, Jatlow P I, Bradberry C W, Differences in bioavailability between cocaine and cocaethylene and their implications for drug-reward studies., Psychopharmacology, 116(3), 273-8, November 1994 Abstract
  • Rinder H M, Ault K A, Jatlow P I, Kosten T R, Smith B R, Platelet alpha-granule release in cocaine users., Circulation, 90(3), 1162-7, September 1994 Abstract
  • Carroll K M, Rounsaville B J, Gordon L T, Nich C, Jatlow P, Bisighini R M, Gawin F H, Psychotherapy and pharmacotherapy for ambulatory cocaine abusers., Archives of General Psychiatry, 51(3), 177-87, March 1994 Abstract
  • Roberts W L, Buckley T J, Rainey P M, Jatlow P I, Solid-phase extraction combined with radioimmunoassay for measurement of zalcitabine (2',3'-dideoxycytidine) in plasma and serum., Clinical Chemistry, 40(2), 211-5, February 1994 Abstract
  • Nelson J C, Mazure C M, Jatlow P I, Characteristics of desipramine-refractory depression., Journal of Clinical Psychiatry, 55(1), 12-9, January 1994 Abstract
  • Jatlow P, Cocaethylene: pharmacologic activity and clinical significance., Therapeutic Drug Monitoring, 15(6), 533-6, December 1993 Abstract
  • Bradberry C W, Nobiletti J B, Elsworth J D, Murphy B, Jatlow P, Roth R H, Cocaine and cocaethylene: microdialysis comparison of brain drug levels and effects on dopamine and serotonin., Journal of Neurochemistry, 60(4), 1429-35, April 1993 Abstract
  • McCance-Katz E F, Price L H, McDougle C J, Kosten T R, Black J E, Jatlow P I, Concurrent cocaine-ethanol ingestion in humans: pharmacology, physiology, behavior, and the role of cocaethylene., Psychopharmacology, 111(1), 39-46, 1993 Abstract
  • Bowers M B Jr, Mazure C M, Nelson J C, Jatlow P I, Lithium in combination with perphenazine: effect on plasma monoamine metabolites., Biological Psychiatry, 32(12), 1102-7, 15 Dec 1992 Abstract
  • Kosten T, Gawin F H, Silverman D G, Fleming J, Compton M, Jatlow P, Byck R, Intravenous cocaine challenges during desipramine maintenance., Neuropsychopharmacology, 7(3), 169-76, November 1992 Abstract
  • Kosten T, Silverman D G, Fleming J, Kosten T A, Gawin F H, Compton M, Jatlow P, Byck R, Intravenous cocaine challenges during naltrexone maintenance: a preliminary study., Biological Psychiatry, 32(6), 543-8, 15 Sep 1992 Abstract
  • Mazure C M, Nelson J C, Jatlow P I, Bowers M B Jr, Drug-responsive symptoms during early neuroleptic treatment., Psychiatry Research, 41(2), 147-54, February 1992 Abstract
  • Bowers M B, Mazure C M, Nelson J C, Jatlow P, Studies of plasma catecholamine metabolites in acute psychosis., Clinical Neuropharmacology, 15 Suppl 1 Pt A, 518A, 1992 Abstract
  • Mazure C M, Nelson J C, Jatlow P I, Bowers M B, Plasma free homovanillic acid (HVA) as a predictor of clinical response in acute psychosis., Biological Psychiatry, 30(5), 475-82, 1 Sep 1991 Abstract
  • Nelson J C, Mazure C M, Bowers M B Jr, Jatlow P I, A preliminary, open study of the combination of fluoxetine and desipramine for rapid treatment of major depression [see comments], Archives of General Psychiatry, 48(4), 303-7, April 1991 Abstract
  • Jatlow P, Elsworth J D, Bradberry C W, Winger G, Taylor J R, Russell R, Roth R H, Cocaethylene: a neuropharmacologically active metabolite associated with concurrent cocaine-ethanol ingestion., Life Sciences, 48(18), 1787-94, 1991 Abstract
  • Jatlow P, Hearn W L, Elsworth J D, Roth R H, Bradberry C W, Taylor J R, Cocaethylene inhibits uptake of dopamine and can reach high plasma concentrations following combined cocaine and ethanol use., Nida Research Monograph, 105, 572-3, 1991 Abstract
  • Pickett G, Kosten T R, Gawin F H, Byck R, Fleming J, Silverman D, Kosten T A, Jatlow P, Concurrent effects of acute intravenous cocaine in context of chronic desipramine in humans., Nida Research Monograph, 105, 508-9, 1991 Abstract
  • Nelson J C, Mazure C M, Jatlow P I, Value of the DST for predicting response of patients with major depression to hospitalization and desipramine., American Journal of Psychiatry, 147(11), 1488-92, November 1990 Abstract
  • Kosten T R, Gawin F H, Morgan C, Nelson J C, Jatlow P, Desipramine and its 2-hydroxy metabolite in patients taking or not taking methadone [letter; comment], American Journal of Psychiatry, 147(10), 1379-80, October 1990 Abstract
  • Jatlow P, Nadim H, Determination of cocaine concentrations in plasma by high-performance liquid chromatography [published erratum appears in Clin Chem 1991 Jun;37(6):886], Clinical Chemistry, 36(8 Pt 1), 1436-9, August 1990 Abstract
  • Mazure C M, Nelson J C, Jatlow P I, Kincare P, Bowers M B Jr, The relationship between blood perphenazine levels, early resolution of psychotic symptoms, and side effects., Journal of Clinical Psychiatry, 51(8), 330-4, August 1990 Abstract
  • Mazure C M, Nelson J C, Jatlow P I, Predictors of hospital outcome without antidepressants in major depression., Psychiatry Research, 33(1), 51-8, July 1990 Abstract
  • Nelson J C, Mazure C M, Jatlow P I, Does melancholia predict response in major depression?, Journal of Affective Disorders, 18(3), 157-65, March 1990 Abstract
  • Kosten T R, Gawin F H, Morgan C, Nelson J C, Jatlow P, Evidence for altered desipramine disposition in methadone-maintained patients treated for cocaine abuse., American Journal of Drug and Alcohol Abuse, 16(3-4), 329-36, 1990 Abstract
  • Bowers M B Jr, Mazure C M, Nelson J C, Jatlow P I, Psychotogenic drug use and neuroleptic response., Schizophrenia Bulletin, 16(1), 81-5, 1990 Abstract
  • McCance EF, Price LH, Kosten TR, JatlowĘPI. Cocaethylene: Pharmacology, physiology and behavioral effects in humans. J Pharmacol Exp Ther 274:215-223, 1995

Profile Details

Last Updated: 6/19/1997

COS Expertise ID #397138
Reference this profile directly: http://myprofile.cos.com/jatlowp38