Jason H. Bielas

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Fred Hutchinson Cancer Research Center
Public Health Sciences Division
Molecular Diagnostics
Assistant MemberAppointed: 2008
University of Washington
School of Medicine
Pathology
Affiliate Assistant ProfessorAppointed: 2008

Mailing Address

Fred Hutchinson Cancer Research Center
Public Health Sciences
Molecular Diagnostics
1100 Fairview Avenue North, M5-A864
Seattle, Washington 98109-1024
United States

Contact Information

jbielas@fhcrc.org

Qualifications

Postdoctoral Fellow, University of Washington, The Joseph Gottstein Memorial Cancer Research Laboratory, 2006.
Ph.D., York University, Genetics, 2004.

Expertise and Research Interests

The Bielas lab studies (http://labs.fhcrc.org/bielas) the fundamental and clinical implications of nuclear and mitochondrial DNA mutations in the pathogenesis of cancer and age-related disease.

Honors and Awards

2007-2010, Terry Fox Foundation Postdoctoral Research Fellowship, National Cancer Institute of Canada (NCIC)
2006-2007, Postdoctoral Fellowship, Canadian Institutes of Health Research (CIHR)
2004-2005, Postdoctoral Fellowship, Natural Sciences and Engineering Research Council of Canada (NSERC)
2004, Gold Medal, Governor General's Academic Medal, Her Excellency the Right Honourable Adrienne Clarkson, Governor General of Canada
2003, Scholarship, Haynes Scholarship for Academic Excellence in Doctoral Studies
2002-2003, Scholarship, Ontario Graduate Scholarship in Science and Technology
2001, Graduate Fellowship, International Association of Environmental Mutagen Societies
2000-2002, Graduate Scholarship, Natural Sciences and Engineering Research Council of Canada (NSERC)
2000, Dean's Academic Excellence Scholarship, Faculty of Graduate Studies, York University
2000, Health Science International Award, CANTOX
1999-2000, Scholarship, Ontario Graduate Scholarship (OGS)
1998-1999, Graduate Fellowship, Cancer Research Society Inc.

Previous Positions

2006-2008, Acting Instructor, University of Washington, School of Medicine, Department of Pathology

Publications

  • Bielas JH, Fox EJ, Loeb LA (2008) Mutator Phenotype In Schwab M (eds), Encyclopedia of Cancer 2nd Edition, Springer (bookchapter)
  • Vermulst M, Bielas JH, Loeb LA (Oct 2008) Quantification of random mutations in the mitochondrial genome., Methods (San Diego, Calif.) Abstract
  • Loeb LA, Bielas JH, Beckman RA (May 2008) Cancers exhibit a mutator phenotype: clinical implications., Cancer research, 68 (10), 3551-7; discussion 3 Abstract
  • Bodmer W, Bielas JH, Beckman RA (May 2008) Genetic instability is not a requirement for tumor development., Cancer research, 68 (10), 3558-60; discussion Abstract
  • Vermulst M, Wanagat J, Kujoth GC, Bielas JH, Rabinovitch PS, Prolla TA, Loeb LA (Apr 2008) DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice., Nature genetics, 40 (4), 392-4 Abstract
  • Bielas JH, Venkatesan RN, Loeb LA (Apr 2007) LOH-proficient embryonic stem cells: a model of cancer progenitor cells?, Trends in genetics : TIG, 23 (4), 154-7 Abstract
  • Vermulst M, Bielas JH, Kujoth GC, Ladiges WC, Rabinovitch PS, Prolla TA, Loeb LA (Apr 2007) Mitochondrial point mutations do not limit the natural lifespan of mice., Nature genetics, 39 (4), 540-3 Abstract
  • Loeb LA, Bielas JH (Feb 2007) Limits to the Human Cancer Genome Project?, Science (New York, N.Y.), 315 (5813), 762; author reply 76 Abstract
  • Bielas JH, Loeb KR, Rubin BP, True LD, Loeb LA (Nov 2006) Human cancers express a mutator phenotype., Proceedings of the National Academy of Sciences of the United States of America, 103 (48), 18238-42 Abstract
  • Venkatesan RN, Bielas JH, Loeb LA (Mar 2006) Generation of mutator mutants during carcinogenesis., DNA repair, 5 (3), 294-302 Abstract
  • Bielas JH (Jan 2006) Non-transcribed strand repair revealed in quiescent cells., Mutagenesis, 21 (1), 49-53 Abstract
  • Bielas JH, Loeb LA (Apr 2005) Quantification of random genomic mutations., Nature methods, 2 (4), 285-90 Abstract
  • Bielas JH, Loeb LA (2005) Mutator phenotype in cancer: timing and perspectives., Environmental and molecular mutagenesis, 45 (2-3), 206-13 Abstract
  • Heddle JA, Bielas JH (2005) Unifying concept of DNA repair: the polymerase scanning hypothesis., Environmental and molecular mutagenesis, 45 (2-3), 143-9 Abstract
  • Bielas JH, Heddle JA (Jul 2004) Quiescent murine cells lack global genomic repair but are proficient in transcription-coupled repair., DNA repair, 3 (7), 711-7 Abstract
  • Bielas JH, Heddle JA (Oct 2003) Elevated mutagenesis and decreased DNA repair at a transgene are associated with proliferation but not apoptosis in p53-deficient cells., Proceedings of the National Academy of Sciences of the United States of America, 100 (22), 12853-8 Abstract
  • Bielas JH (Jul 2002) A more efficient Big Blue protocol improves transgene rescue and accuracy in a adduct and mutation measurement., Mutation research, 518 (2), 107-12 Abstract
  • Bielas JH, Heddle JA (Oct 2000) Proliferation is necessary for both repair and mutation in transgenic mouse cells., Proceedings of the National Academy of Sciences of the United States of America, 97 (21), 11391-6 Abstract
  • Swiger RR, Cosentino L, Shima N, Bielas JH, Cruz-Munoz W, Heddle JA (1999) The cII locus in the MutaMouse system., Environmental and molecular mutagenesis, 34 (2-3), 201-7 Abstract

Profile Details

Last Updated: 2/21/2009

COS Expertise ID #1321040
Reference this profile directly: http://myprofile.cos.com/jbielas