Jason Glenn Knott

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Michigan State University
College of Agriculture & Natural Resources
Animal Science
Laboratory of Developmental Epigenetics and Reproductive Biology
Assistant ProfessorAppointed: 2007

Mailing Address

1230H Anthony Hall
East Lansing, Michigan 48824-0210
United States

Contact Information

Phone: (517) 432-5446
knottj@msu.edu

Qualifications

Ph.D., University of Massachusetts Amherst, Reproductive and Developmental Biology, 2002.

Expertise and Research Interests

early embryonic development, stem cells, epigenetics, calcium signaling

Industrial Relevance

Infertility treatment, biotechnology, nuclear transfer in cattle

Keywords

Additional Terms:

Developmental Biology, Epigenetics, Preimplantation.

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)

Memberships

American Society for Reproductive Medicine
Gordon Research Conference

Honors and Awards

2006, Adjunct Assistant Professor, Dr. Yi-Tao Zeng, Shanghai Institute of Medical Genetics, Reproductive Biology

Previous Positions

2006-2007, Principal Investigator, EMD-Serono, Inc., Reproductive Health
2005-2006, Post-doctoral fellow, EMD-Serono, Inc., Reproductive Health
2003-2005, Post-doctoral fellow, University of Pennsylvania, Biology

Publications

  • Kidder B.L., Palmer S, Knott J.G. (2008) SWI/SNF-Brg1 Regulates Self-Renewal and Occupies Core Pluripotency-Related Genes in Embryonic Stem Cells, Stem Cells, 27 (2), 317-28
  • Gardner AJ, Knott JG, Jones KT, Evans JP. (2007) CaMKII can participate in but is not sufficient for the establishment of the membrane block to polyspermy in mouse eggs., Journal of Cellular Physiology, 212 (2), 275-280
  • Igarashi H, Knott JG, Schultz RM, Williams CJ (2007) Alterations of PLC beta1 in mouse eggs change calcium oscillatory behavior following fertilization, Developmental Biology, 312 (1), 321-30
  • Knott JG, Gardner AJ, Madgwick S, Jones KT, Williams CJ, Schultz RM. (2006) Calmodulin-dependent protein kinase II triggers mouse egg activation and embryo development in the absence of Ca2+ oscillations., Developmental Biology, 296 (2), 388-395
  • Malcuit C, Knott JG, He C, Wainwright T, Parys JB, Robl JM, Fissore RA. (2005) Fertilization and inositol 1,4,5-trisphosphate (IP3)-induced calcium release in type-1 inositol 1,4,5-trisphosphate receptor down-regulated bovine eggs., Biology of Reproduction, 73 (1), 2-13
  • Ozil JP, Markoulaki S, Toth S, Matson S, Banrezes B, Knott JG, Schultz RM, Huneau D, Ducibella T. (2005) Egg activation events are regulated by the duration of a sustained [Ca2+]cyt signal in the mouse., Developmental Biology, 282 (1), 39-54
  • Knott JG, Kurokawa M, Fissore RA, Schultz RM, Williams CJ. (2005) Transgenic RNA interference reveals role for mouse sperm phospholipase Czeta in triggering Ca2+ oscillations during fertilization., Biology of Reproduction, 72 (4), 992-996
  • Knott JG, Kurokawa M, Fissore RA. (2003) Release of the Ca(2+) oscillation-inducing sperm factor during mouse fertilization., Developmental Biology, 262 (2), 536-547
  • Fissore RA, Kurokawa M, Knott J, Zhang M, Smyth J. (2002) Mechanisms underlying oocyte activation and postovulatory ageing., Reproduction, 124 (6), 745-754
  • Kuroiwa Y, Kasinathan P, Choi YJ, Naeem R, Tomizuka K, Sullivan EJ, Knott JG, Duteau A, Goldsby RA, Osborne BA, Ishida I, Robl JM. (2002) Cloned transchromosomic calves producing human immunoglobulin., Nature Biotechnology, 20 (9), 899-894
  • Knott JG, Poothapillai K, Wu H, He CL, Fissore RA, Robl JM. (2002) Porcine sperm factor supports activation and development of bovine nuclear transfer embryos., Biology of Reproduction, 66 (4), 1095-1113
  • Kasinathan P, Knott JG, Wang Z, Jerry DJ, Robl JM. (2001) Production of calves from G1 fibroblasts., Nature Biotechnology, 19 (12), 1176-1178
  • Kasinathan P, Knott JG, Moreira PN, Burnside AS, Jerry DJ, Robl JM. (2001) Effect of fibroblast donor cell age and cell cycle on development of bovine nuclear transfer embryos in vitro., Biology of Reproduction, 64 (5), 1487-1493

Profile Details

Last Updated: 3/1/2009

COS Expertise ID #1275529
Reference this profile directly: http://myprofile.cos.com/jgknott