Prof. Jill M. Slade

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Michigan State University
College of Osteopathic Medicine
Radiology, Osteopathic Manipulative Medicine
Anatomy and Structural Biology
Assistant ProfessorAppointed: 2006

Mailing Address

184 Radiology
East Lansing, Michigan 48824
United States

Contact Information

Phone: (517) 355-0120
Fax: (571) 432-2849
jslade@msu.edu

Qualifications

Ph.D., University of Georgia, Exercise Physiology, 2003.
M.A., University of Georgia, Exercise Physiology, 2000.
B.S., Ohio University, Biology, 1998.

Expertise and Research Interests

My primary research interests include musculoskeletal responses and adaptations in special conditions (including aging, unloading or spinal cord injury, diabetes, and statin use). My research goals are to understand and improve the knowledge and treatment in associated diseases such as osteoporosis, sarcopenia, diabetes, and hypercholesteremia. This includes, but is not limited to anatomic and functional changes ranging from changes in soft tissue structures to functional changes related to muscle energetics or on a broad scale pertaining to whole body physical functional performance. Other general interests include muscle activation, muscle injury, muscle metabolism, blood flow, and bone architecture. I believe in a multi-system approach to clinical research e.g. blood flow to target organs (vasculature and musculature); muscle activation on bone architecture (neuromuscular). I am currently working on projects to determine differences in small vessel reactivity and peripheral vascular compliance between individuals with and without diabetes and methods to measure muscle energetics during exercise with Magnetic Resonance Spectroscopy (31P). Other current projects include examining the use of statins on muscle function.
Another major research focus is on the effects of diet and exercise on cognition and brain activation. Specific focus includes age related changes in cognition in older adults and the effect of acute and long term diet and exercise manipulations on cognitive function and brain activation. Ongoing research includes the effect of acute exercise and diet on cognitive function using a battery of cognitive tests (CogState) and specifically focusing on conflict resolution using the Erikson Flanker paradigm and functional MRI to access brain activation.

Other Expertise

Gerontology Certificate
Certified Strength and Conditioning Specialist

Future Research

Exploit MRI and MRS in disease conditions. For example, improve ability to quantify tissues that are relevant to disease states/conditions. Future research interests also include non-invasively quantifying the effects of statin lowering medication on muscle integrity, structure and function with exercise testing, V02 testing, muscle damage assessment and muscle repair and recovery using NMR.

In addition, future endeavors may include determining factors that contribute to brain and muscle blood-oxygen-level-dependent (BOLD) effects and why aging may cause changes in the BOLD responses.

Keywords

COS Keywords:

Exercise Physiology, Magnetic Resonance Imaging, Musculoskeletal Diseases, Musculoskeletal System, Osteology Or Osteopathy, Physiology, Spinal Cord Injury.

Additional Terms:

Magnetic Resonance Imaging, Muscle Physiology, Musculoskeletal Research.

Memberships

American College of Sports Medicine
American Physiological Society
International Society for Magnetic Resonance in Medince
National Strength and Conditioning Association

Honors and Awards

2004-2005, Vice Chair Post Doctoral Association, Michigan State University
1999-1999, Conference Award, Georgia Gerontology Consortium, Poster award winner

Previous Positions

2005-2006, Assistant Professor, Michigan State University, College of Osteopathic Medicine, Osteopathic Manipulative Medicine
2003-2005, Research Associate, Michigan State University, College of Human Medicine, Physiology
2000-2003, Grant Specialist, Shepherd Center, Spinal Cord Injury
1998-2003, Research Assistant, University of Georgia, Health and Human Performance, Exercise Physiology
1998-2002, Teaching Assistant, University of Georgia, Health and Human Performance, Exercise Physiology and Physical Education
1997-1998, Assistant Exercise Physiologist, Ohio University, Biology

Funding Received

  • American Diabetes Association: Mechanisms of Type I Diabetes Induces Osteoporosis - the Role of Marrow Adiposity and Wnts, 300,000, 2007 to 2010.
  • Biomedical and Health Sciences Institute at UGA & Shepherd Center: The effects of spinal cord injury and menopause on bone architecture in women, $18,800, 2003 to 2003.
  • Shephard Center: High frequency electrical stimulation after spinal cord injury, $1,250, 2001 to 2002.
  • Shepherd Center: Investigation of neuromuscular fatigue in spinal cord injured patients, $5,360, 2001 to 2002.
  • Georgia Gerontology Consortium: Investigating Anaerobic Power in Older Adults, $2,500, 1999 to 2000.
  • Georgia Gerontology Consortium: Master Athlete Performance in 15K Running over Twenty Years, $2,500, 1998 to 1999.

Publications

  • Slade JM, DeLano M, Meyer RA (2006) Muscle Phosphodiester content in statin users, Muscle & Nerve, 34 (6), 782
  • Elder CP, Mahoney ET, Black CD, Slade JM, Dudley GA (2006) Oxygen cost of dynamic or isometric exercise relative to recruited muscle mass, Dynamic Medicine, 5 (9)
  • Towse TF, Slade JM, Meyer RA (Aug 2005) Effect of physical activity on MRI-measured blood oxygen level-dependent transients in skeletal muscle after brief contractions, Journal of Applied Physiology (bethesda, Md. : 1985), 99 (2), 715-22
  • Slade, JM, Towse, TF, Wiseman, R, Delano, M, Meyer, RA (2005) A gated 31P-NMR method for estimation of phosphocreatine recovery time and contractile ATP cost in human muscle, NMR Biomed, 19 (5), 573-580
  • Slade JM, Bickel CS, Modlesky CM, Majumdar S, Dudley GA, Trabecular Bone Is More Deteriorated in Spinal Cord Injured Versus Estrogen-free Postmenopausal Women., Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the Usa., 16(3), 263-72, Mar 2005 Abstract
  • Bickel CS, Slade J, Mahoney E, Haddad F, Dudley GA, Adams GR, Time Course of Molecular Responses of Human Skeletal Muscle to Acute Bouts of Resistance Exercise., Journal of Applied Physiology (bethesda, Md. : 1985), 98(2), 482-8, Feb 2005 Abstract
  • Modlesky CM, Slade JM, Bickel CS, Meyer RA, Dudley GA, Deteriorated Geometric Structure and Strength of the Midfemur in Men With Complete Spinal Cord Injury., Bone, 36(2), 331-9, Feb 2005 Abstract
  • Mahoney ET, Scott CS, Elder CE, Black C, Slade JM, Apple DA, Dudley, GA, Changes in Skeletal Muscle Size and Glucose Tolerance With Electrically Stimulated Resistance Training With Chronic Spinal Cord Injury, Archives of Physical Medicine and Rehabilitation, 86, 1502-1504, 2005
  • Slade JM, Bickel CS, Dudley GA, The Effect of a Repeat Bout of Exercise on Muscle Injury in Persons With Spinal Cord Injury., European Journal of Applied Physiology, 92(3), 363-6, Jul 2004 Abstract
  • Bickel CS, Slade JM, Dudley GA, Long-term Spinal Cord Injury Increases Susceptibility to Isometric Contraction-induced Muscle Injury., European Journal of Applied Physiology, 91(2-3), 308-13, Mar 2004 Abstract
  • Olive JL, Slade JM, Bickel CS, Dudley GA, McCully KK, Increasing Blood Flow Before Exercise in Spinal Cord-injured Individuals Does Not Alter Muscle Fatigue., Journal of Applied Physiology (bethesda, Md. : 1985), 96(2), 477-82, Feb 2004 Abstract
  • Modlesky CM, Bickel CS, Slade JM, Meyer RA, Cureton KJ, Dudley GA, Assessment of Skeletal Muscle Mass in Men With Spinal Cord Injury Using Dual-energy X-ray Absorptiometry and Magnetic Resonance Imaging., Journal of Applied Physiology (bethesda, Md. : 1985), 96(2), 561-5, Feb 2004 Abstract
  • Bickel SB, Slade JM, VanHiel LL, Warren GL, Dudley GA, Variable-frequency- Train Stimulation of Skeletal Muscle After Spinal Cord Injury, Journal of Rehabilition Research and Development, 41(1), 33-40, 2004
  • Bickel CS, Slade JM, Haddad F, Adams GR, Dudley GA, Acute Molecular Responses of Skeletal Muscle to Resistance Exercise In Able-bodied and Spinal Cord-injured Subjects., Journal of Applied Physiology (bethesda, Md. : 1985), 94(6), 2255-62, Jun 2003 Abstract
  • Bickel CS, Slade JM, Warren GL, Dudley GA, Fatigability and Variable-frequency Train Stimulation of Human Skeletal Muscles., Physical Therapy, 83(4), 366-73, Apr 2003 Abstract
  • Olive JL, Slade JM, Dudley GA, McCully KK, Blood Flow and Muscle Fatigue in SCI Individuals During Electrical Stimulation., Journal of Applied Physiology (bethesda, Md. : 1985), 94(2), 701-8, Feb 2003 Abstract
  • Miszko TA, Cress ME, Slade JM, Covey CJ, Agrawal SK, Doerr CE, Effect of Strength and Power Training on Physical Function In Community-dwelling Older Adults., The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences., 58(2), 171-5, Feb 2003 Abstract
  • Slade JM, Bickel CS, Warren GL, Dudley GA, Variable Frequency Trains Enhance Torque Independent of Stimulation Amplitude., Acta Physiologica Scandinavica, 177(1), 87-92, Jan 2003 Abstract
  • Slade, JM, De los Santos, H, Cress, ME, Twenty Years of Road Racing: Characteristics of Lifetime Runners, Trends in Running Performance, and Implications for Physical Activity Promotion., Journal of Aging and Physical Activity, 11, 190-205, 2003
  • Slade JM, Miszko TA, Laity JH, Agrawal SK, Cress ME, Anaerobic Power and Physical Function in Strength-trained And Non-strength-trained Older Adults., The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences., 57(3), M168-72, Mar 2002 Abstract
  • Slade JM, The Gary A. Dudley Symposium. Muscle Biology from Basic Science to Applied Practice: Musculoskeletal adaptations after SCI: impacts on cardiovascular and metabolic health, National Strength and Conditioning Association National Conference, NSCA, Unpublished

Profile Details

Last Updated: 9/5/2007

COS Expertise ID #1203192
Reference this profile directly: http://myprofile.cos.com/jmslade